Compostos Deuterados

Applications 1,4-Dibromobutane-1,1,4,4-d4 (CAS# 36684-45-4) is a useful isotopically labeled research compound.

24,25-Dihydroxy vitamin D2 is a form of vitamin D that has been shown to be effective in the treatment of biliary cirrhosis and neonatal cirrhosis. It is synthesized from 25-hydroxyvitamin D3 by the enzyme 24-hydroxylase. The assay sensitivity for this compound is 10 ng/mL. This form of vitamin D has been shown to have an effect on serum bilirubin levels in patients with biliary cirrhosis. 24,25-Dihydroxy vitamin D2 can also be used to treat patients with chronic renal failure who are deficient in vitamin D3. The plasma concentration of 24,25-dihydroxyvitamin D2 is lower than that of 25-hydroxyvitamin D2 and 1,25-dihydroxyvitamin D2 because it is more rapidly metabolized by the liver.

Alprazolam is a benzodiazepine drug used as an anxiolytic, anticonvulsant, and sedative. It is one of the most commonly prescribed drugs in the United States. Alprazolam-d5 solution is a solution that contains alprazolam labeled with D5. It can be used for wastewater treatment to identify the presence of trifluoroacetic acid (TFA) in wastewater samples. The dispersive solid-phase extraction method was validated for use with this labeled compound by detecting alprazolam-d5 at concentrations of 0.0025 µg/mL or less in urine samples within 10 minutes. Alprazolam-d5 solution has been shown to be stable in acidic pH environments and can be used for detection times up to 2 hours.

3-Amino-2-oxazolidinone-d4 is a methanol solvent that can be used to analyze the muscle tissue. 3-Amino-2-oxazolidinone-d4 can be synthesized by reacting oxalyl chloride and 2 nitrobenzaldehyde in acetonitrile. It can also be prepared by dehydrating and analyzing the synthesis of 3 amino 2 oxazolidinones in chloroform and bromoacetic acid. 3 - Amino - 2 - oxazolidinone - d4 is deuterated, which means it has an extra neutron in its nucleus.

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Halobetasol propionate-d3 is a biocompatible polymer that binds to the effector proteins of the inflammatory response. It is used in the treatment of inflammatory bowel disease, psoriasis, and other skin diseases. Halobetasol propionate-d3 has been shown to be effective against plaque and cutaneous lesions in patients with psoriasis. This drug also inhibits the production of proinflammatory cytokines (IL-1β, IL-6, IL-8) and chemokines (MCP-1) by monocytes. The drug has been shown to be effective against autoimmune diseases due to its ability to inhibit TNFα production from macrophages. Halobetasol propionate-d3 is compatible with blood group A, B, and AB.

Benzidine D8 is a benzidine compound that has been shown to be carcinogenic. It is used in the production of dyes and colorants, and it is found in wastewater from dyeing factories. Benzidine D8 has been detected in human urine, which may be due to occupational exposure. This chemical can also be found in the environment as a result of industrial discharge. The carcinogenicity of benzidine D8 is mediated by its ability to produce reactive metabolites that bind to DNA, forming adducts. These adducts inhibit DNA replication and transcription, leading to cell death through inhibition of protein synthesis. Benzidine D8 undergoes metabolism via oxidative reactions with amines or hydrolysis with hydrophilic compounds such as alcohols or phenols, which are present at high levels in the bladder tissue. The risk of bladder cancer increases when benzidine D8 binds to these amines or hydrophilic compounds, resulting in the formation of reactive metabolites that can bind to DNA