Bioquímicos e reagentes

<p>Mucin antibody was raised in mouse using Mucin isolated from ovarian mucinous cysts and colonic mucosa as the immunogen.</p>

<p>PF2562 is a potent and selective activator of the metabotropic glutamate receptor mGluR5. It is a competitive antagonist at AMPA receptors, with no activity at NMDA or kainate receptors. PF2562 is known to inhibit protein interactions between the proteins encoded by the gene for the metabotropic glutamate receptor mGluR5 and its ligands, such as l-glutamic acid and d-serine. This inhibition leads to activation of these receptors, which may be important in research on neurological disorders and other diseases involving glutamate signaling.</p>

<p>8-(3-Chlorostyryl)caffeine is a caffeine derivative that binds to the adenosine A3 receptor. It has been shown to inhibit locomotor activity and increase diastolic pressure in knockout mice lacking the adenosine A3 receptor. 8-(3-Chlorostyryl)caffeine has also been shown to have inhibitory properties on cyclase, which is necessary for the production of cAMP, the second messenger in cells. This drug also inhibits dopamine release from neurons and hydrogen bond formation with DNA, protein, and other biomolecules. Lastly, 8-(3-Chlorostyryl)caffeine can bind to both A1 and A2A receptors as well as to dna binding sites.</p>

<p>LY 117018 is a dopamine analog that binds to the toll-like receptor and blocks the production of proinflammatory cytokines. LY 117018 also inhibits epidermal growth factor (EGF) in liver cells and cyclin D2, which is involved in cell cycle regulation. This drug has been shown to be effective in a model system using fetal bovine serum with angiogenic factors, such as vascular endothelial growth factor (VEGF). The effect on blood vessels was dose-dependent for LY 117018. This drug potentiates the actions of 17β-estradiol on mcf-7 cells and serum prolactin levels are significantly decreased in vivo by this compound.</p>

<p>Isodesmosine is an amino acid and naturally occurring cross-linking compound, which is primarily found in elastin, a key protein in connective tissues. Its source is the structural protein elastin, where it forms stable cross-links that contribute to the elasticity and resilience of various tissues, notably the skin, lungs, and blood vessels. The mode of action of isodesmosine involves its integration into the elastin matrix, providing durability and elasticity through covalent bonding within and between polypeptide chains.</p>

<p>FluM1 (58-66) is a short part of the matrix protein of Influenza A virus which is the most abundant component of this enveloped virus localized under the viral lipid envelope. The GILGFVFTL epitope is highly conserved in Influenza A virus strains at a rate of 93% for 69 strains tested. Human Influenza epitopes may bind MHC molecules and then may be recognized by CD8+ cytotoxic T cells. Applications of FluM1 (58-66): FluM1 (58-66) is used to stimulate CTL responses in peripheral blood mononuclear cells (PBMCs). Then, ELISPOT assay is used to quantify peptide epitope specificity and IFN-γ releasing effector cells. FluM1 (58-66) has shown CTL responses qualified of immunodominant with restriction by HLA-A*02:01. It has also been detected CTL responses when FluM1 (58-66) is restricted by all HLA-C. Therefore, FluM1 (58-66) may help to understand the reaction of immune system against Influenza virus of each populations having different HLA type. FluM1 (58-66) has indeed prompted research to develop T-cell vaccine strategies capable of inducing specific CTL responses in patients upon immunization with Influenza M1 antigenic epitope. MVA-NP+M1 vaccine use GILGFVFTL epitope and is tested in clinical trial. Potential cross-reactivity with HIV-1 p17 Gag (77-85): Moreover, FluM1 (58-66) share similarities with HIV-1 p17 Gag (77-85) which can potentially show a cross-reactivity between these epitopes. It has been demonstrated a cross-reactivity and results suggest that immunity following infection by Influenza virus causes specific immune response to HIV-1 p17 Gag (77-85).</p>

<p>PI3K-gamma inhibitor 1 is a small molecule inhibitor, which is selectively synthesized for targeting the PI3K-gamma isoform. This inhibitor is derived through precise medicinal chemistry, involving the synthesis of compounds that specifically interact with the catalytic domain of the phosphoinositide 3-kinase gamma (PI3K-γ) enzyme. Its mode of action involves the selective inhibition of the PI3K-γ pathway, a critical signaling route responsible for modulating immune cell functions and inflammatory responses.</p>

<p>The hCG protein is a growth factor that plays a crucial role in various biological processes. It is involved in the regulation of cell growth, differentiation, and development. This protein has been extensively studied in the field of Life Sciences and has shown promising results in various applications. One of the key characteristics of the hCG protein is its ability to interact with arginase, an enzyme involved in the metabolism of arginine. Through molecular docking studies, it has been shown that hCG can bind to arginase and modulate its activity, leading to potential therapeutic applications. Monoclonal antibodies targeting the hCG protein have been developed for research purposes. These antibodies are highly specific and can be used in immunoassays to detect and quantify hCG levels in human serum samples. They have also been used for the immobilization of hCG on electrodes, enabling the development of biosensors for diagnostic purposes. Furthermore, studies have demonstrated that the hCG protein plays a role in the regulation of mes</p>

<p>Vancomycin methyl ester is an analog of the antibiotic vancomycin that has been shown to have anticancer properties. It induces apoptosis in cancer cells, particularly in Chinese hamster ovary (CHO) cells and human tumor cell lines. Vancomycin methyl ester acts as a cyclin-dependent kinase inhibitor by binding to the ATP-binding site of these kinases, thereby inhibiting their activity. This protein kinase inhibition leads to the downregulation of proteins involved in cell cycle progression, such as cyclin D1 and E2F1, ultimately leading to cell death. Vancomycin methyl ester has also been found to inhibit the growth of certain types of cancer cells by blocking angiogenesis, which is the formation of new blood vessels that tumors need for their growth and survival. Additionally, this compound has been detected in human urine after administration and may have potential therapeutic applications in cancer treatment.</p>

<p>Retroprogesterone is a human urine-derived compound that has shown promising results in the field of cancer research. It is an analog of oseltamivir and acts as a kinase inhibitor, which makes it an effective anticancer agent. Retroprogesterone has been shown to induce apoptosis in cancer cells by inhibiting protein kinases that are essential for cell survival and proliferation. This compound has demonstrated potent tumor growth inhibition in Chinese hamster ovary cells, making it a potential candidate for cancer therapy. Retroprogesterone has also been studied as an inhibitor of various kinases involved in cancer development and progression. Its ability to target multiple pathways involved in cancer makes it a valuable tool for future research and drug development.</p>

<p>Please enquire for more information about Opiorphin trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cagrilintide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3-Indolepropionyl-coa is a potent inhibitor of cancer cell cycle and has been found to induce apoptosis in human cancer cells. This compound is an analog of the naturally occurring urinary metabolite, indole-3-acetic acid, which has been shown to have anticancer properties. 3-Indolepropionyl-coa is a promising medicinal compound for the development of novel anticancer drugs due to its ability to inhibit protein kinase activity in Chinese hamster ovary cells. It has also been reported to inhibit tumor growth and proliferation by blocking the production of cyclin-dependent kinases, which are essential for cell division. The potential use of 3-Indolepropionyl-coa as a therapeutic agent for cancer treatment warrants further investigation.</p>

<p>Please enquire for more information about 3-Bromo-L-thyroxine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Vasopressin receptor agonist; antidiuretic</p>

<p>L-a-Phosphatidylcholine (PC) is a phospholipid that is present in all living cells. It is the major component of biological membranes and is essential for maintaining cell membrane integrity. PC 20 is a purified form of L-a-Phosphatidylcholine, made from soybean extract. The purity of PC 20 has been shown by its ability to inhibit nitrite ion production from soybean extract in vitro. PC 20 also has low bioavailability, meaning that it may not be absorbed well into the bloodstream following oral consumption. This may be due to the uptake of PC 20 by other organs and tissues in the body, such as the liver or spleen, before it can be transported to the blood stream. Further research is needed to determine how PC 20 affects colorectal adenocarcinoma cells.</p>

<p>Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt is an experimental model system that has been shown to replicate the physiological effects of thymopoietin in vitro. It has also been shown to inhibit the growth of Candida glabrata, a fungus that causes infection in patients with HIV or AIDS. Thymopentin acetate salt H-Arg-Lys-Asp-Val-Tyr-OH acetate salt has been shown to activate both toll like receptor and IL2 receptor, which may be due to its ability to stimulate polyamine synthesis.</p>

<p>Please enquire for more information about Taurolithocholic acid-d4 sodium including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide H-ASCLYGQLPK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Alpha-glucosidase inhibitor; anti-diabetic</p>

<p>Guaiacin is a guaianolide that is an inhibitor of the protein phosphatase 1 (PP1). It has been shown to bind to PP1 and inhibit its activity, leading to increased levels of the cellular messenger cAMP. Guaiacin has also been shown to activate PP2A, which may contribute to its anti-inflammatory effects. Guaiacin has been used as a research tool in cell biology and pharmacology studies. It is available in high purity and can be used as an antibody reagent for immunocytochemistry.</p>

<p>Please enquire for more information about H-Gln-pNA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>This peptide is a research tool that has been shown to activate the ATP-sensitive potassium ion channel, which is found in the membranes of many cells. This peptide also binds to the beta2-adrenergic receptor and has been shown to inhibit the activity of protein kinase C. The CAS number for this peptide is 400863-77-6.</p>

<p>Please enquire for more information about Ethyl N,N,N',N'-Tetraisopropylphosphorodiamidite including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about IR-806 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Methotrexate Conjugate for use in immunoassays</p>

<p>Please enquire for more information about (Pyr³)-Amyloid B-protein (3-42) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Oligopeptide-51 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Acetylpiperazine-N-(4-phenol) ketoconazole is an analog inhibitor that has been shown to inhibit the activity of several kinases. This compound has been tested against a variety of cancer cells and has demonstrated potent anticancer activity, inducing apoptosis in Chinese hamster ovary cells. N-Acetylpiperazine-N-(4-phenol) ketoconazole also inhibits the activity of dapoxetine, a drug used to treat premature ejaculation. In addition to its anticancer properties, this compound has shown promise as an anti-inflammatory agent due to its ability to inhibit the production of prostaglandins. This inhibitor can be detected in urine and may have potential therapeutic applications in the treatment of various cancers.</p>

<p>The Tetracycline antibody is a highly specific monoclonal antibody that binds to tetracycline, a broad-spectrum antibiotic. This antibody has a high receptor binding affinity and can be used in various applications, such as polymerase chain reactions (PCR), immunohistochemistry, and Western blotting. It specifically targets tetracycline residues in biological samples, allowing for the detection and quantification of this antibiotic. In addition to its use in research, the Tetracycline antibody has potential applications in the field of medicine. It can be used to study the cellular localization of tetracycline within cells or tissues, providing valuable insights into its mechanism of action. Furthermore, this antibody can be utilized to investigate protein-protein interactions involving tetracycline or its derivatives. The Tetracycline antibody is produced using advanced techniques in monoclonal antibody production. It exhibits high specificity and sensitivity, ensuring reliable and accurate results. This antibody is compatible with various sample types, including</p>

<p>Mycosubtilin is a potent antifungal lipopeptide, which is a secondary metabolite produced by the bacterium Bacillus subtilis. It is characterized by its ability to disrupt fungal cell membranes, leading to cell lysis and eventual death of the fungus. This mode of action is attributed to its amphiphilic structure, which allows it to integrate into the lipid bilayers of fungal cells, compromising the integrity of the membrane and altering its permeability.Mycosubtilin finds applications in various scientific and agricultural fields due to its efficacy against a broad spectrum of fungal pathogens. It is particularly useful in plant disease management, where it plays a role in biocontrol strategies against phytopathogenic fungi. Additionally, its antifungal properties make it a subject of interest in pharmaceutical research, where it is investigated for potential therapeutic applications in combating fungal infections. Researchers also explore Mycosubtilin as a model compound to understand lipopeptide interactions with membranes, contributing to the broader knowledge of antimicrobial agents.</p>

<p>Faradiol 3-laurate is an analog that has been shown to induce apoptosis in cancer cells. It is a promising compound for the treatment of tumors due to its ability to inhibit proteins that are involved in cancer cell growth and survival. Faradiol 3-laurate has been found in medicinal plants and human urine, and has been used as a Chinese traditional medicine for centuries. This compound is also a potent inhibitor of kinases, which are enzymes that play a critical role in the regulation of cellular processes such as cell growth and differentiation. Its anticancer properties make it an attractive candidate for further research in the development of novel cancer therapies.</p>

<p>S-Lenalidomide is a drug that is used to treat cancer and autoimmune diseases. It is an immunomodulatory agent that induces cytokine release and inhibits the production of interleukin-2 (IL-2) by T cells. This drug also has a concentration-dependent effect on the activity of oxidative enzymes, such as benzalkonium chloride and light emission. S-Lenalidomide has been shown to be clinically relevant in infectious diseases, with concentrations producing significant effects on disease activity. The water vapor stability of this drug makes it suitable for use in humid environments such as those found in developing countries. S-Lenalidomide has been shown to induce antitumor responses without causing immunosuppression or toxicity in rats.</p>

<p>Please enquire for more information about Bromantane-d5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Foslevodopa is a prodrug that is converted to levodopa in the body. This drug has been shown to be safe and effective for the treatment of Parkinson's disease with minimal side effects, although it does not affect the progression of the disease. Foslevodopa is a synthetic compound that has been synthesized using chemical methods. It can be manufactured in large quantities, making it a scalable pharmaceutical formulation.</p>

<p>DTR-I is an analog of ghrelin, a protein hormone that regulates appetite and energy balance. It is a potent inhibitor of kinases, which are enzymes that play a crucial role in cancer cell growth and survival. DTR-I has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells. This anticancer effect is thought to be due to its ability to inhibit the activity of protein kinases that are overexpressed in human tumors. In addition, DTR-I has been found in urine samples from Chinese cancer patients, indicating its potential as a diagnostic marker for certain types of cancer. The development of DTR-I as a novel anticancer agent holds promise for the treatment of various types of cancer in the future.</p>

<p>Please enquire for more information about Coibamide A including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A naturally isolated steroid</p>

<p>Cys-Gly-3M3SH is a cationic antimicrobial peptide that has been shown to be effective against Staphylococcus aureus. Cys-Gly-3M3SH binds to the bacterial enzyme urease, which is responsible for converting urea into ammonia and carbon dioxide. The binding of this peptide prevents the hydrolysis of urea, leading to cell death by disruption of the proton motive force. Cys-Gly-3M3SH is also biotransformed by bacteria in humans and can be used as a probe for transport studies in vitro. It can also be used as a molecular probe for structural biology research, such as protein crystallization and electron microscopy studies.</p>

<p>Purified native Human CEA protein (Preservative-free)</p>

<p>H-Met-Gln-OH TFA salt is a recombinant human metalloproteinase that has been shown to activate polymorphonuclear and mononuclear cells. H-Met-Gln-OH TFA salt enhances the production of reactive oxygen species and induces the release of proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1, and interleukin 6. This protein also cleaves sulfoxide bonds in proteins, which may be due to its ability to catalyze the oxidation of sulfhydryl groups in proteins. H-Met-Gln-OH TFA salt has been shown to be effective in enhancing red blood cell production, which may be due to its ability to cleave hemoglobin S bonds in erythrocytes.</p>

<p>Cortisol antibody was raised in mouse using cortisol-3 BSA as the immunogen.</p>

<p>1-Demethylcolchicine is a research tool for the study of ligand-receptor interactions and cell biology. It has also been used to study ion channels in the central nervous system, as well as antibody production. 1-Demethylcolchicine is a potent inhibitor of protein synthesis and is used to study peptides and proteins. 1-Demethylcolchicine binds to the receptor site on cells, which inhibits the activity of the ion channels that are responsible for generating an action potential. This inhibition leads to decreased nerve impulses in neurons, which may contribute to its sedative effects.</p>

<p>Please enquire for more information about 1,8-Dinitropyrene-d8 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>S 25585 is a psychostimulant that has been shown to modulate the function of animals. It can be used in the treatment of cancer and autoimmune diseases, as well as to induce overfeeding in animals. S 25585 is an endogenous molecule with a cyclic structure. The affinity for binding of S 25585 to its receptor may depend on whether it is bound or unbound at the time of binding. This drug also has anti-cancer effects, which are due to its ability to inhibit uptake and stabilize cells that are not undergoing cell division. 6-Fluoro-3-indoxyl-beta-D-galactopyranoside (Rifapentine) is an antituberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing</p>

<p>L-MobileTrex is an advanced analytical technology platform, which is a product of cutting-edge research in data science and computational modeling. This platform operates by integrating multi-dimensional datasets through sophisticated algorithms, providing enhanced data visualization and interpretability.</p>

<p>Please enquire for more information about Bantag-1 trifluoroacetate salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-[(1S)-1-(3-Fluorophenyl)-3-[(1R,5S)-3-[2-methyl-5-(2-methylpropanoyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridin-1-yl]-8-azabicyclo[3.2. 1]octan-8-yl]propyl]acetamide is a research tool for use in cell biology and pharmacology studies. It is an activator that binds to the receptor or ligand and stimulates the activity of the protein. It has been shown to bind to ion channels, which are proteins that regulate the flow of ions across a biological membrane. This drug also interacts with antibodies and peptides (small chains of amino acids), which are important in life sciences as they are involved in many cellular functions including enzyme regulation and energy production.</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Aryl hydrocarbon receptor (AhR) agonist</p>

<p>Alvameline is a muscarinic receptor agonist, which is a small molecule drug derived from synthetic chemistry processes. Its primary source is the intricate design of pharmacologically active compounds targeting the central nervous system. Alvameline exerts its effects through selective agonism of muscarinic acetylcholine receptors, playing a pivotal role in modulating neurotransmission. Specifically, by activating these receptors, it enhances cholinergic signaling, which is crucial for cognitive functions such as memory and attention.</p>

<p>a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response</p>

<p>L-leucine with a lipid chain.</p>

<p>Please enquire for more information about 4-[3-[5-Amino-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl]propyl]phenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about MS67N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Pheromone Cymit Quimicaesis Activating Neuropeptide (Helicoverpa assulta, Heliothis zea) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pseudoisoeugenyl 2-methylbutyrate is an analog of astaxanthin that has shown promising results in inhibiting tumor growth and inducing apoptosis in cancer cells. It acts as a kinase inhibitor, preventing the replication of cancer cells and promoting anticancer effects. Pseudoisoeugenyl 2-methylbutyrate has been tested on human and Chinese hamster ovary cell lines, demonstrating its potential as a potent anticancer agent. This compound has also been found in urine samples, suggesting that it may have natural sources in the body. Its ability to inhibit kinases makes it a promising candidate for further research into cancer treatment.</p>

<p>N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.</p>

<p>VS1 is a novel synthetic peptide, which is engineered to function as an antimicrobial agent. This peptide originates from recombinant DNA technology, providing a customizable approach to target specific microbial strains. Its mode of action involves the selective disruption of microbial cell membranes, leading to the lysis and consequent death of the target cell. The specificity of VS1 for microbial cells over mammalian cells minimizes off-target effects, making it a highly effective agent for infection control.</p>

<p>Diethoxy disulfide is a cyclin-dependent kinase inhibitor that induces apoptosis in cancer cells. It is an analog of the medicinal plant compound, alliin, and has been found to have potent anticancer activity. Diethoxy disulfide inhibits the activity of Chinese hamster ovary cell cycle kinases and human tumor-associated kinases, leading to cell cycle arrest and inhibition of cancer cell growth. This compound has been shown to be effective against a variety of cancer types, including breast, lung, and prostate cancer. Additionally, it has been found to sensitize cancer cells to other anticancer drugs by enhancing their cytotoxic effects. Overall, diethoxy disulfide is a promising candidate for the development of novel anticancer therapies.</p>

<p>Please enquire for more information about Cyclo(L-alanyl-L-tryptophyl) trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>D-Hyoscyamine is a potent anticancer agent that has been shown to induce apoptosis in cancer cells. It works by inhibiting kinases, which are enzymes that play a key role in the regulation of cell growth and division. D-Hyoscyamine has been tested on both human and Chinese hamster ovary cells, and has demonstrated significant anticancer activity. It is an analog of several kinase inhibitors, including cyclin-dependent kinase (CDK) inhibitors, which are commonly used in cancer therapy. In addition to its anticancer properties, D-Hyoscyamine has also been found to have potential therapeutic applications for other diseases such as Alzheimer's disease and Parkinson's disease. It is derived from urine and acts as a potent inhibitor of protein kinases.</p>

<p>1,2-Dipalmitoyl-3-dimethylammonium-propane is a cationic lipid, which is a type of synthetic lipid commonly used in biochemical and biophysical research. It is sourced from chemical synthesis, involving the formulation of lipid molecules with specific chemical modifications to confer particular properties. The mode of action of this compound involves its ability to integrate into lipid bilayers and form liposomes. These liposomes can encapsulate nucleic acids, facilitating their delivery into cells by merging with cell membranes, which is crucial for gene delivery applications.</p>

<p>Please enquire for more information about Fmoc-D-Asp(OtBu)-(Dmb)β-Ala-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.</p>

<p>Fentanyl p Conjugate for use in immunoassays</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TPCN1 antibody, catalog no. 70R-5158</p>

<p>Sheep polyclonal Mescaline antibody</p>

<p>The POLR3A protein (His &amp; Thioredoxin tag) is a highly versatile and essential component in Life Sciences research. This medicament is a Conjugated Protein that offers numerous applications in various fields. It can be used as a valuable tool for studying protein-protein interactions, carbon quantum dynamics, chemokine signaling pathways, and influenza hemagglutinin structure and function. Additionally, the POLR3A protein (His &amp; Thioredoxin tag) has been employed in the development of novel therapeutic strategies. Its unique properties make it an ideal candidate for the production of Proteins and Antigens, collagen-based scaffolds for tissue engineering, peptide agents for drug delivery systems, and as a carrier for endogenous erythropoietin. Furthermore, this product can be utilized as a reliable reagent in monoclonal antibody production and neutralizing assays against TGF-beta. Its exceptional binding affinity ensures accurate results in these experiments. The POLR3A protein (</p>

<p>Lactimidomycin is a peptide antibiotic that blocks the activity of ion channels, which are proteins that control the flow of ions across cell membranes. Lactimidomycin binds to specific ligands on the surface of cells and inhibits membrane depolarization. It has been shown to inhibit the activity of calcium-gated potassium channels, hyperpolarize nerve cells, and inhibit neuronal excitability. Lactimidomycin has also been shown to be an inhibitor of protein interactions with antibodies and other cellular factors. This drug can be used as a research tool for studying protein interactions in living cells. Lactimidomycin is available in high purity and at CAS No. 134869-15-1.</p>

<p>A novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors</p>

<p>3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is a potent and selective inhibitor of the ion channel TRPM8. It reduces pain and inflammation by inhibiting the action of TRPV1 and TRPA1. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone is an inhibitor of the TRPM8 ion channel with IC50 value of 0.06 μM. 3,4-Dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]methanone inhibits TRPA1 with IC50 value of</p>

<p>Secologanate is a peptide that has been used as a research tool to study the interactions between proteins and ligands. Secologanate is an inhibitor of ion channels, which are membrane-spanning proteins that control the flow of ions in and out of cells. It also inhibits protein interactions by blocking the binding site on one molecule for a second molecule. Secologanate has been shown to inhibit the ion channel TRPV1, which is involved in pain sensation. Secologanate has also been shown to be a ligand for the human angiotensin II receptor type 1 (AT1R).</p>

<p>N-Desethyl N-methyl rivastigmine is an analog of rivastigmine and a potent inhibitor of kinases. It has been shown to induce apoptosis in cancer cells, making it a promising candidate for the treatment of various types of tumors. This medicinal compound is excreted through urine and has been found to have anticancer properties by inhibiting protein kinases. In Chinese hamster ovary cells, N-Desethyl N-methyl rivastigmine was found to inhibit the activity of several kinases involved in cell proliferation and survival. This inhibitor has potential therapeutic applications for cancer treatment due to its ability to target specific kinases that are essential for tumor growth and progression.</p>

<p>Osmanthuside H is a natural compound, specifically a phenylethanoid glycoside, which is predominantly sourced from the plant Osmanthus fragrans, as well as other related species. This compound is characterized by a specific glycosidic linkage that contributes to its stability and bioactivity. The mode of action of Osmanthuside H primarily involves its significant antioxidant properties, attributed to the presence of its phenolic structure and glycosidic moiety. This facilitates its role in scavenging free radicals and reducing oxidative stress within biological systems.</p>

<p>Please enquire for more information about HYYYGAAPPGQKGQANATRIPAKTPPAPK{pT}PPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLP{pT}PPTREPKKVA-OH including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A negative allosteric modulator of Flt-3 receptor tyrosine kinase</p>

<p>Crt0066101 hydrochloride is a peptide that has been shown to inhibit the activity of receptors for the neurotransmitter acetylcholine. It binds to the receptor and blocks access by acetylcholine, which prevents activation of the receptor. Crt0066101 hydrochloride is a ligand that inhibits ion channels in cells, including potassium channels, calcium channels, and sodium channels. This drug can be used as a research tool to study protein interactions in cell biology and pharmacology as well as to identify new drugs with potential therapeutic benefits. Crt0066101 hydrochloride is an inhibitor of G-protein coupled receptors (GPCRs) that has been shown to block the activation of muscarinic receptors on heart tissue. It also inhibits calcium-activated potassium channels on smooth muscle cells, leading to reduced blood pressure in animal models.</p>

<p>Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is a fluorescent marker that can be used in immunohistochemical staining. It binds to endogenous vasoactive intestinal peptide, calcitonin and other proteins in tissues and can be detected using immunostaining. Dansyl-D-Ala-Gly-4-nitro-Phe-Gly-OH trifluoroacetate salt is optimised for use as a substrate for neutral endopeptidase and metalloendopeptidase enzymes, which are responsible for the degradation of vasoactive intestinal peptide.</p>

<p>The CYFRA21-1 antibody is a powerful tool in the field of Life Sciences. This antibody specifically targets fibronectin, a protein involved in cell adhesion and migration. It has cytotoxic properties, making it useful for studying cellular processes and identifying potential therapeutic targets. Additionally, the CYFRA21-1 antibody can be used to detect inhibitory factors or antiphospholipid antibodies in biological samples. It is also effective in detecting insulin antibodies, autoantibodies, and antibodies involved in glycosylation processes. With its high specificity and sensitivity, this monoclonal antibody is an invaluable tool for researchers looking to uncover new insights into various biological pathways and disease mechanisms.</p>

<p>1-Oleoyl-2-docosahexaenoyl phosphatidylcholine is a fatty acid derived from the biogenesis of phosphatidylcholine, which is an important component of all cell membranes.</p>

<p>Muscarine chloride hydrate is a receptor agonist. Muscarine binds to the acetylcholine receptors on the surface of muscle cells and nerve cells, causing an influx of calcium ions into the cell. Muscarine is used as a research tool for studying ion channels, proteins interactions, and peptides. It has been shown to be an activator of phospholipase C and phosphatidylinositol-specific phospholipase C in pancreatic acinar cells.</p>

<p>CB-1158 is an arginase inhibitor, which is a small molecule derived from a synthetic source designed to modulate immune functions. Its mode of action involves the inhibition of the arginase enzyme, a key player in the urea cycle responsible for the hydrolysis of arginine into ornithine and urea. By blocking arginase, CB-1158 effectively prevents the depletion of extracellular arginine, a vital amino acid required for the activation and proliferation of T cells within the immune system. This inhibition leads to enhanced immune responses against tumors.</p>

<p>Primate-specific Mas-related G protein-coupled receptor-X1 (MRGPR-X1) is highly enriched in dorsal root ganglia (DRG) neurones as well as in connective tissue mast cells (CTMC) and the leukaemia-derived human mast cell line (LAD)-2. MRGPR-X1 activation induces acute pain and therefore represents a promising target for future pain therapy. MRGPR-X1 is activated by bovine adrenal medulla peptide-8-22 (BAM 8-22) which is cleaved from pro-enkephalin by pro-hormone convertases. Unlike most if not all Gq-coupled receptors MRGPR-X1 does not undergo agonist-promoted endocytosis. Data: Western blot analysis of rat brain preparation. Lane 1: Rat brain preparation (20µg). Secondary: Goat anti-rabbit IgG conjugated to HRP 1:5000.</p>

<p>MCOPPB is a new type of drug that is used to treat chronic neuropathic pain and other syndromes. MCOPPB has shown an analgesic effect in vivo, which may be due to its ability to stimulate the release of endogenous opioids. MCOPPB also reduces the pain threshold and increases tolerance to pain by stimulating the release of endorphins. This drug has been shown to have no effects on locomotor activity in knockout mice and has been tested for efficacy in clinical studies with humans.</p>

<p>Anti-Trop2</p>

<p>Extracellular signal-regulated kinase 1/2 (ERK1/2) is a mitogen-activated protein kinase (MAPK) family protein and part of the Ras-Raf-MEK-ERK signalling pathway which plays a key role in controlling cell proliferation, differentiation and cell survival. ERK1/2 acts downstream of activated growth factor receptors, RAF protein kinases and mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1 and MEK2 activate ERK1/2 by phosphorylation and once activated ERK1/2 enters the nucleus and phosphorylates transcription factors to induce changes in gene expression. In addition to this active ERK1/2 also translocates to other organelles including the endoplasmic reticulum, endosomes, golgi and mitochondria where it influences cell physiology. Overall ERK1/2 phosphorylates more than 200 different substrates including other protein kinases, transcription factors, RNA-binding proteins, regulators of mRNA translation and regulators of cell death. ERK1/2 pathway is strongly implicated in cancer where its hyperactivation underpins the growth and maintenance of many tumour types. Data: Western blot analysis of whole cell extract of Mouse embryonic Fibroblasts (MEFs).</p>

<p>Sotirimod is a monocytic degradable drug that has been shown to be effective in the treatment of skin cancer. It is also used as a diagnostic agent for prostate, colorectal, and breast cancer. Sotirimod binds to fatty acid molecules on the surface of cells. The drug then enters the cell where it forms crosslinks with DNA or RNA, which prevents cell division and replication. This causes cell death by apoptosis. Sotirimod can also be conjugated with affinity ligands such as antibodies or peptides to target specific types of cells.</p>

<p>Indicaxanthin is a natural pigment that has been found to possess potent anticancer properties. It is an analog of oseltamivir, a drug used to treat influenza by inhibiting the neuraminidase enzyme. Indicaxanthin has been shown to inhibit the activity of kinases, which are enzymes involved in cell signaling pathways that regulate cell growth and proliferation. This inhibition leads to apoptosis (programmed cell death) in cancer cells. Studies have demonstrated that indicaxanthin has anticancer effects against various types of cancer, including breast, colon, and prostate cancer. Additionally, it has been detected in human urine following ingestion of foods containing this pigment, suggesting that it may have potential as a dietary supplement for cancer prevention and treatment.</p>

<p>BCR-ABL-IN-2 is a small molecule inhibitor, which is synthetically derived for precision-targeted therapeutic applications. It functions as a selective inhibitor of the BCR-ABL fusion protein, a tyrosine kinase that is constitutively active in certain leukemias, particularly chronic myeloid leukemia (CML). The product is engineered via chemical synthesis to ensure high specificity and selectivity in binding to the ATP-binding site of the BCR-ABL protein, effectively inhibiting its kinase activity.</p>

<p>Pigment Red 48 (C.I. 15865) is a red organic pigment that is soluble in water and most organic solvents. It has a melting point of 200°C and is used in paints, plastics, textiles, paper, and other products. Pigment Red 48 (C.I. 15865) can be synthesized by the diazonium salt coupling reaction between an aromatic amine and an acid chloride. The pigment also has a hydroxyl group that enables it to form covalent bonds with other molecules such as polymers or proteins. Pigment Red 48 (C.I. 15865) is used in many products because of its high stability, excellent heat resistance, low toxicity, non-irritating properties, high transparency, and good color fastness to light and washing.BR&gt; Pigment Red 48 (C.I. 15865) is not considered hazardous according to the Globally Harmonized System of Classification and Lab</p>

<p>Panulisib is a Toll-like receptor (TLR) modulator that inhibits the TLR signaling pathway. It has been shown to inhibit the replication of certain viruses and to induce significant cytotoxicity in cancer cells. Panulisib binds to the toll-like receptor 7 (TLR7) and prevents it from activating downstream signaling pathways, which may be due to its ability to inhibit endothelial cell proliferation. The drug also shows some activity against hepatitis B virus-induced hepatitis in preclinical studies. In addition, panulisib inhibits growth factor signaling pathways and suppresses tumorigenesis by inhibiting the downstream effects of angiogenesis.</p>

<p>FR-190809 is a peptide that acts as an inhibitor of protein interactions. It binds to the receptor and blocks the activation of phospholipase C. FR-190809 also stimulates the production of cyclic AMP, which in turn activates protein kinase A, thereby inhibiting the production of cAMP. FR-190809 has been shown to have a high purity and is used as a research tool for studying protein interactions.</p>

<p>2A peptide-linked polycistronic vectors can be used to express multiple proteins from a single open reading frame (ORF). The small 2A peptide sequences, when cloned between genes, allows for efficient, stoichiometric production of discrete protein products within a single vector through a novel "cleavage" event within the 2A peptide sequence. 2A was discovered in the foot-and-mouth disease virus (FMDV, a picornavirus). The 2A peptide acts through ribosomal skipping to allow for the encoding of polyproteins which can dissociate into individual proteins upon translation. Anti-T2A antibody recognises 2A tagged recombinant proteins and is an excellent tool for researchers using 2A peptide based expression systems.<br>0.2mg/ml TEA (Rb L02T), 0.5mg/ml Glycine (Rb L02G). Used for ELISA (1:1000). Reacts with T2A tag.</p>

<p>PF-06658607 is an investigational drug that is classified as a small molecule inhibitor. It is developed from synthetic chemical sources with a specific mode of action targeting aggrecanases, enzymes that degrade aggrecan, a critical component of cartilage. By inhibiting these enzymes, PF-06658607 aims to prevent the breakdown of cartilage in joints.</p>

<p>L 162389 is a synthetic, non-steroidal, anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase. It inhibits the production of prostaglandins, which are known to cause pain and inflammation in the body. L 162389 is used for the treatment of inflammatory conditions such as rheumatoid arthritis and osteoarthritis.</p>

<p>1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphatidylethanolamine is a broad spectrum antimicrobial that has been shown to have binding properties to peptides. This compound can be used as a potential antimicrobial for the treatment of bacterial infections and gramicidin, an antibiotic that is active against bacteria. It has also been shown to permeabilize cell membranes, which may lead to its function as an antimicrobial agent. 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-Phosphatidylethanolamine is water soluble and has been shown to have conformational properties. These conformational properties are responsible for its binding activity with peptides. 1POGPE is stable in both calorimetric assays and bilayers, which allows it to maintain its structure when interacting with other compounds. 1POGPE also has a high affinity for</p>

<p>Please enquire for more information about 1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranose including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>