Antibióticos

Impurity Piperacillin EP Impurity B
Stability Hygroscopic, Temperature Sensitive
Applications Piperacilloic Acid (Piperacillin EP Impurity B) is a degradation product of Piperacillin (P479950), a new β-lactam antibiotic.
References Waxman, D.J., et al.: J. Biol. Chem., 255, 3964 (1980), Waley, S.G., et al.: Biochem. J., et al.: 205, 631 (1982),

Stability Hygroscopic
Applications A new constituent of bacterial polyhydroxyalkanoic acids.
References Bollard, M., et al.: Toxicol. Appl. Pharmacol., 204, 135 (2005), Slupsky, C., et al.: Anal. Chem., 79, 6995 (2007),

Applications 2,3-Bis[(acetyloxy)methyl]-1-oxoquinoxalin-1-ium-4(1H)-olate is an antibiotic.
References Marrero-Ponce, Yovani, et al.: Bioorg. & Med. Chem., 13(8), 2881-2899 (2005)

Applications The labelled trans-alcohol metabolite of Loxoprofen (L472900).
References Choo, K.-S. et al.: J. Pharmac. Biomed. Anal., 25, 639 (2001); Cho, H.-Y. et al.: J. Chrom. B Anal. Technol. Biomed Life Sci., 835, 27 (2006); Riendeau, D. et al.: Bioorg. Med. Chem. Lett., 14, 1201 (2004);

Applications Nisin Z Hydrochloride is a peptide antibiotic synthesized by Lactococcus lactis. Nisin Z interacts with lipid II, a lipid component of cell wall, to form pores in the plasma membrane.
References Kuipers, O. P., et al.: J. Biol. Chem. 270, 27299 (1995); Breukink, E., et al.: Science 286, 2361 (1999); Breukink, E., et al.: Biochemistry 36, 6968 (1997)

Applications Surfactin is a lipopeptide antibiotic and biosurfactant.

Applications n-Pentyl 4-Hydroxybenzoate-2,3,5,6-d4 (CAS# 1219798-66-9) is a useful isotopically labeled research compound.

Applications Telocinobufagin is isolated as a major component from skin secretion of the toad Bufo rubescens. Telocinobufogenin is a novel antibiotic cardiotonic.
References Akizawa, T., et al.: Chem. Pharm. Bull., 42, 754 (1994); Hancock, R., et al.: Antimicrob. Agents Chemother., 43, 1317 (1999); Jing, Y., et al.: J. Cancer Res., 85, 645 (1994); Kamano, Y., et al.: J. Med. Chem., 45, 5440 (2002); Schoner, W., et al.: Eur. J. Biochem., 269, 2440 (2002); Cunha Filho, G., et al.: Toxicon, 45, 777 (2005)

Membrane pore-forming agent; H+, K+, Pb2+ ionophore; polyether antibiotic

Herbicidin C is an antibiotic, which is derived from a microbial source, specifically from certain strains of actinobacteria. This compound functions as an inhibitor, interfering with specific metabolic pathways within target organisms. Its mode of action involves disrupting the synthesis of critical proteins, which are essential for cell survival and growth.

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate is an antibacterial compound with a broad spectrum of activity against Gram-positive and Gram-negative bacteria. It is active against strains resistant to other antibiotics, such as, tetracycline and penicillin. 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate has been shown to be effective in vitro against Campylobacter jejuni - the most common cause of bacterial gastroenteritis in humans. The compound also inhibits the growth cycle of Campylobacter jejuni by arresting the cells at the G1 phase. The molecule has been shown to inhibit DNA synthesis in E. coli and S. typhimurium with IC50 values of 1 ÎŒM and 0.8 ÎŒM respectively. This molecule has been tested for its surface active properties and it can be used as an additive in personal care products for improved wetting and spreading on surfaces. The compound is also researched for its antifungal efficacy against Candida albicans by inhibiting the growth cycle of the fungus.

Inhibitor of cell-wall synthesis; carbapenem class

Epioxytetracycline is a degradation product of the antibiotic oxytetracycline. It has been found in wastewater.

Inhibitor of RNA synthesis