Antibióticos

<p>N-Desisobutyl-N-propyl rifabutin is a synthetic derivative of rifabutin, which is an antibiotic belonging to the rifamycin class. This compound is sourced from modifications of the parent molecule rifabutin, itself derived from the rifamycin family produced by the bacterium Amycolatopsis, traditionally used for its antimicrobial properties. The mode of action involves the inhibition of bacterial RNA polymerase, effectively preventing the transcription process necessary for bacterial replication and protein synthesis. This disruption of RNA synthesis provides potent antimicrobial activity.</p>

<p>Vancomycin aglycon is a glycopeptide antibiotic, which is a derivative of vancomycin. It is sourced from the fermentation products of certain Amycolatopsis species, a genus of actinobacteria. The mode of action of vancomycin aglycon involves the inhibition of bacterial cell wall synthesis. It specifically binds to the D-Ala-D-Ala terminus of nascent peptidoglycan chains, thereby preventing the cross-linking that is crucial for maintaining cell wall integrity.</p>

<p>N-Biotinyl-12-aminododecanoyltobramycin amide is a synthetic bioconjugate, which is derived from the aminoglycoside antibiotic tobramycin. This compound is chemically modified by the addition of a biotin moiety linked through a 12-aminododecanoyl spacer. The source of this product is rooted in the conjugation of biotin to tobramycin, allowing for targeted delivery and potential hybrid applications in both therapeutic and diagnostic fields.</p>

<p>Sitafloxacin is an antibacterial agent belonging to the fluoroquinolone class of antibiotics, which is synthetically derived from chemical processes involving fluorinated quinolones. Its mode of action involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA replication and transcription. By interfering with these enzymes, Sitafloxacin effectively hampers bacterial DNA synthesis, leading to the eventual demise of the bacterial cell.</p>

Cefazolin is a semi-synthetic, non-beta lactam antibiotic used for the treatment of a variety of bacterial infections. It inhibits cell wall synthesis by binding to one or more of penicillin-binding proteins (PBPs), which are bacterial transpeptidases that crosslink peptidoglycan strands. Cefazolin binds to PBPs present on the surface of all Gram-negative bacteria as well as many Gram-positive bacteria. It is not effective against methicillin-resistant staphylococcus and MRSA unless combined with another antibiotic such as vancomycin or flucloxacillin. A study showed that cefazolin can decrease inflammation and tumor necrosis factor-beta levels in pregnant women with systemic inflammatory disease. It has been tested in the development of an anti-inflammatory agent for use in patients with autoimmune diseases such as rheumatoid arthritis and lupus erythe.

<p>Inhibitor of protein synthesis; macrolide class</p>

<p>25-Desacetyl rifapentin is a derivative of rifapentin, an antibiotic belonging to the rifamycin class, sourced from the bacterial species *Amycolatopsis rifamycinica*. This compound functions by inhibiting bacterial DNA-dependent RNA polymerase, which is crucial for transcription in susceptible bacterial strains. By inhibiting this enzyme, 25-Desacetyl rifapentin effectively hampers RNA synthesis, ultimately leading to bacterial cell death.</p>

Imipenem acts as an antimicrobial through inhibiting cell wall synthesis of various gram-positive and gram-negative bacteria. It remains very stable in the presence of beta-lactamase (both penicillinase andcephalosporinase) produced by some bacteria, and is a strong inhibitor of beta-lactamases from some gram-negative bacteria that are resistant to most beta-lactam antibiotics.

<p>Trovafloxacin mesylate is a synthetic antibiotic belonging to the fluoroquinolone class, which is derived from chemical synthesis processes rather than natural sources. The mode of action of trovafloxacin mesylate involves the inhibition of bacterial enzymes DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication, repair, and transcription within the bacterial cell. By inhibiting these enzymes, trovafloxacin mesylate disrupts bacterial DNA processes, leading to cell death and exerting its antibacterial effects.</p>

<p>Mitomycin D is an antibiotic and chemotherapeutic agent known for its ability to inhibit DNA synthesis, making it a potent antitumor agent. It is derived from the bacterium *Streptomyces caespitosus*. Mitomycin D functions as a DNA crosslinking agent by alkylating the DNA strands, which interferes with DNA replication and transcription. This mechanism leads to the cessation of cellular division and ultimately induces apoptosis in rapidly dividing cells.</p>

<p>Nigericin transports cations across the membrane of the cell and it is used to study anion transport. It can be used as a buffer to control pH value inside of the cell.</p>

<p>Polymyxin B nonapeptide hydrochloride is a potent antibiotic compound derived from the bacterium *Bacillus polymyxa*. As a cationic polypeptide, it exhibits its antibacterial activity by interacting with the lipopolysaccharides and phospholipids in the bacterial cell membrane, leading to increased permeability and ultimately causing cell lysis. The compound is specifically effective against a broad range of Gram-negative bacteria, making it crucial in studying antibiotic resistance mechanisms.</p>

<p>6,11-Di-O-methyl erythromycin is a semi-synthetic derivative of erythromycin, which is a macrolide antibiotic originally sourced from the bacterium *Saccharopolyspora erythraea*. This compound is produced through chemical modification of the natural antibiotic to improve its pharmacokinetic properties, such as stability and absorption.</p>

<p>Tigemonam is a synthetic beta-lactam antibiotic, which is derived from chemical synthesis processes. This compound operates by inhibiting bacterial cell wall synthesis, specifically targeting the penicillin-binding proteins (PBPs). The disruption of the cell wall synthesis ultimately leads to cell lysis and death of the bacteria, making it effective primarily against gram-negative bacterial infections.</p>

<p>A macrolide, broad-spectrum antibiotic that targets cytochrome P4503A4 (CYP3A4). Clarithromycin has been used to potentiate the pharmacological effects of some drugs that are metabolised by the cytochrome P450.</p>

7-Deazaadenosine is a chemical compound used as an antibiotic for culture media, which is a synthetic nucleoside analog derived from adenosine. Its structure is modified by replacing a nitrogen atom in the purine ring with a carbon atom, thus altering its biological interactions. The primary mode of action of 7-Deazaadenosine involves its incorporation into nucleic acids, where it acts as an inhibitor of nucleic acid-processing enzymes. This interference can effectively impede processes like DNA and RNA synthesis.

Erythromycin, Antibiotic for Culture Media Use Only, is a macrolide antibiotic derived from the bacterium *Saccharopolyspora erythraea*. It functions by inhibiting protein synthesis, specifically targeting the 50S ribosomal subunit in susceptible bacteria. This action results in the prevention of peptide chain elongation, effectively halting bacterial growth and proliferation.

<p>Antibacterial agent with the ability to permeate bacterial membranes and cause cell death. Colistin is a cationic peptide also known as polymyxin E. Colistin is effective in multidrug resistant Gram-positive bacteria such as P. aeruginosa, A. baumannii and K. pneumoniae.</p>

<p>Aclacinomycin HCl is a cytotoxic antibiotic that inhibits the growth of tumor cells. It has been shown to induce apoptosis in human leukemia cells by altering the transmembrane potential and inhibiting cell proliferation. Aclacinomycin HCl also induces DNA damage response, which leads to caspase activities and cell death. This drug is highly selective for tumor cells, with no effect on normal cells. It has been shown to be effective against primary liver cancer in animal models, as well as developmental disorders such as autism spectrum disorder (ASD).</p>

<p>Ascomycin is an immunosuppressant macrolide lactone, which is derived from the soil bacterium *Streptomyces hygroscopicus*. It functions primarily by inhibiting the T-cell activation pathway. The mechanism involves binding to the immunophilin FKBP-12, forming a complex that inhibits the calcium-dependent phosphatase, calcineurin. This inhibition prevents the dephosphorylation and subsequent translocation of nuclear factor of activated T cells (NFAT), which is crucial for the transcription of interleukin-2 and other cytokines. Consequently, this suppresses the activation and proliferation of T-cells, which are essential components of the adaptive immune response.</p>