Heterociclos com Nitrogénio (N)

<p>Applications Used in oligonucleotide synthesis. Also a radiosensitizer of hypoxic cells in vitro.<br>References Nagao, Y., et al.: Chem. Pharm. Bull., 37, 1951 (1989), Takaoka, M., et al.: J. Vet. Med. Sci., 56, 341 (1994),<br></p>

<p>Applications 5-Chloro-2-pyridinamine-3,4,6-d3 is labelled 5-Chloro-2-pyridinamine which is an intermediate used to synthesize zopiclone (Z700500), a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.<br>References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications 2,6-Dimethoxypyridine-3,5-diamine hydrochloride (cas# 56216-28-5) is useful component in hair dyes. Has cosmetic applications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Krohn, R., et al.: PCT Int. Appl. (2020), WO 2020089365 A1<br></p>

<p>Applications 2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laleu, B., et al.: J. Med. Chem., 53, 7715 (2010); Velankar, A., et al.: Bioorg. Med. Chem., 18, 4547 (2010)<br></p>

<p>Applications 4-Aminoimidazole is used as a building block for the synthesis vitamin B12-analogs via Eubacterium limosu.<br>References Endres, B. et al.: Biol. Chem. Hop.-Sey., 376, 595 (1995);<br></p>

<p>Applications 2,4-Diaminopyrimidine 3-N-Oxide is a useful organic synthetic reagent for the preparation of pyrimidines and in the making of hair loss and skin care compositions.<br>References von, A. S., et al.: Science of Synthesis, 16, 379 (2004); Mahe, Y., et al.: Skin Pharmacol., 9, 177 (1996); Hocquaux, M., et al.: From PCT Int. Appl. (1992), WO 9201437 A1 19920206<br></p>

<p>Impurity Terazosin EP Impurity M<br>Applications 1,4-Di-2-furoyl-piperazine (Terazosin EP Impurity M) can be used in biological studies to examine the relationship of structure to parasiticide activity of nitrated derivatives.<br>References Cavier, R., et al.: Chimica Therapeutica 5, 270 (1970)<br></p>

<p>Applications N-Methylsuccinimide is used as a model compound to investigate the mechanism of enolization step by density-functional theory (DFT) calculations. N-Methylsuccinimide is a metabolite of N-methyl-2-pyrrolidone (NMP) and its presence in plasma and urine can be used as a biomarker of exposure to NMP<br>References Takahashi, O., et al.: Chem. Biodivers., 7, 1349 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Used in the preparation of indolizine compounds for use in antifungal combination therapy.<br></p>

<p>Applications 1,3-dimethylpyrrolidin-2-one (cas# 19597-07-0) is a useful research chemical.<br></p>

<p>Applications 1,2-Dimethyl-1H-imidazole-5-sulphonyl Chloride (cas# 849351-92-4) is a useful research chemical.<br></p>

<p>Applications 1-(4-Nitrophenyl)-2-piperidinone is used in the synthesis of inhibitors of blood coagulation factor Xa.<br>References Pinto, D., et al.: J. Med. Chem., 50, 5339 (2007); Xing, J., et al.: Eur. J. Med. Chem., 95, 388 (2015)<br></p>

<p>Stability Light Sensitive<br>Applications 1-[4-bromo-2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (cas# 1179507-09-5) is a useful research chemical.<br></p>

<p>Stability Air Sensitive, Light Sensitive<br>Applications 3,4-DIETHYLPYRROLE (cas# 16200-52-5) is a useful research chemical.<br></p>

<p>Applications 5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.<br>References Di Nunno, L., et al.: J. Med. Chem., 47, 4881 (2004); Reddy, A. R., et al.: Synth. Commun., 42, 639 (2012); Huang, Y., et al.: Zhongguo Xiandai Yingyong, 26, 456 (2009)<br></p>

<p>Applications 1-(1-phenylpropan-2-yl)-1H-pyrrole-2-carboxylic acid (cas# 1432680-68-6) is a useful research chemical.<br></p>

<p>Applications 3-(4-iodo-1H-pyrazol-1-yl)propanenitrile (cas# 88393-88-8) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2-chloro-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 30161-95-6) is a compound useful in organic synthesis.<br>References Nagahara, K., et al.: J. Med. Chem., 33, 407 (1990),<br></p>

<p>Applications 4-Nitro-1H-imidazole-1-ethanol<br></p>

<p>Applications 2-chloro-3-hydrazinylpyrazine (cas# 63286-28-2) is a useful research chemical.<br></p>

<p>Impurity Temozolomide USP Related Compound A<br>Applications Temozolomide USP Related Compound A<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxy-1,1-dimethylpiperidinium Bromide is a derivative of 4-Hydroxypiperidine (H950845); a reagent used for the synthesis of Acridine (A190900) derivatives and fibrinogen receptor antagonists.<br>References Yang, D. et al.: Macromol., 35, 5304 (2002); Harrison, R.J. et al.: Bioorg. Med. Chem. Lett., 9, 2463 (1999)<br></p>

<p>Applications 1H-1,2,4-triazole-3-sulfonamide (cas# 89517-96-4) is a useful research chemical.<br></p>

<p>Applications 5,6-Dimethylbenzimidazole (cas# 582-60-5) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxycytosine, is been identified as an anomalous base of phage H-17 DNA. It is also a monosubstituted cytosine, as nucleotide-base antimetabolite-type potential anticarcinogen.<br>References Khromov, I. S. Doklady Akademii Nauk SSSR, 240, 1486 (1978); Ladik, J., et al.: Magyar Kemiai Folyoirat, 76, 589 (1970);<br></p>

<p>Applications An intemediate of Clopidogrel and Prasugrel.<br>References Yadav, G., et al.: Biochem. Eng. J., 19, 101(2004), Wang, P., et al.: Enzyme Microb. Technol., 39, 930 (2006),<br></p>

<p>Applications methyl 1-(2,4-difluorophenyl)-3-phenyl-1H-pyrazole-5-carboxylate (cas# 1202030-37-2) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),<br></p>

<p>Impurity Voriconazole EP Impurity A; Voriconazole USP Related Compound C<br>Applications 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosis<br>References Upadhayaya, R., et al.: Eur. J. Med. Chem., 39, 579 (2004), Sheng, C., et al.: J. Med. Chem., 49, 2512 (2006),<br></p>

<p>Applications 2-[(p-chlorobenzyl)amino]-pyridine is a useful synthetic intermediate. It can be prepared via selective iridium-catalyzed alkylation of (hetero)aromatic amines.<br>References Blank, B., et al.: Chem. Eur. J., 15, 3790 (2009); Liu, C., et al.: J. Org. Chem., 76, 5759 (2011)<br></p>

<p>Applications 2,6-Dichloropyridine-1-oxide (cas# 2587-00-0) is a compound useful in organic synthesis.<br></p>

<p>Impurity Carglumic Acid Impurity B<br>Applications 3-(2,5-Dioxoimidazolidin-4-yl)propanoic Acid is defined as combinational markers to distinguish hepatocellular carcinoma (HCC) from cirrhosis (CIR).<br>References Shao, Y., et al.: J. Proteome Res., 14, 906-916 (2015)<br></p>

<p>Applications 5-Benzylthio-1H-tetrazole is used in the preparation of organosilicon compounds that have antibacterial activity.<br>References Baghershiroudi, Mahrokh. et al., J. IRAN. CHEM. SOC. 15,1279-1286(2018);<br></p>

<p>Applications 4-Vinylpyridine is used as a reagent in the synthesis of 4,4'-[9H-Carbazole-3,6-diyldi-(1E)-2,1-ethenediyl]bis[1-methyl-pyridinium Diiodide (C176070); a human quadruplex DNA stabilizer and telomerase inhibitor. 4-Vinylpyridine is also used as a reagent in the synthesis of spiro[cyclopropane[3H]indol]ones as polo-like kinase 4 inhibitors and orally bioavailable antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, D., et al.: J. Phys. Chem. A, 111, 9224 (2007); Chang, C., et al.: J. Chin. Chem. Soc-Taip., 50, 185 (2003); Sampson, P.B., et al.: J. Med. Chem., no vol., no pp., (2014 ahead of print)<br></p>

<p>Applications 2-Ethylpyridine can be used to prepare Dimethindene Maleate (D460460). It is also used to study its effect on the proliferation and survival of human umbilical vein endothelial cells (HUVECs), HMVECs from lung, and NIH 3T3 cells.2-Ethylpyridine linked with silica is a popular stationary phase for chiral and achiral separations in supercritical fluid chromatography.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Richard, Y., et al.: Toxicol. Sci., 93, 82 (2006); Speybrouck, D., et a.: Curr. Topics in Med. Chem., 12, 1250(2012)<br></p>

<p>Applications 6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(piperidin-4-yl)imidazo[1,5-a]pyridine (cas# 301221-44-3) is a useful research chemical.<br></p>

<p>Applications 1-Hydroxy-7-azabenzotriazole (cas# 39968-33-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]-triazolium chloride (cas# 153851-71-9) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 5,5-Dimethyl-4-hydroxymethyl-1-pyrroline N-Oxide (cas# 176793-52-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Phenyl-1H-benzimidazole is a reagent used in the synthesis of various aryl-substituted benzimidazole derivatives. Also used in the synthesis of benzimidazole and quinocaline derivatives<br>References Saleh, V. et al.: Org. Chem. Int., 1, (2015); Hasanpour, M. et al.: J. Chin. CHem. Soc., 62, 412 (2015);<br></p>

<p>Applications Pyridin-3-yl dimethylcarbamate (cas# 51581-32-9) is a useful research chemical.<br></p>

<p>Applications 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (cas# 545445-44-1) is a useful research chemical.<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.<br></p>

<p>Applications Oxidation and chlorination reagent.<br></p>

<p>Applications 3-Chloro-2-hydrazinopyridine (cas# 22841-92-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Pyrrole-2,3-dicarboxylic Acid Monohydrate is a degradation product of melanins.<br>References Shen, X., et al.: J. Med. Chem., 39, 2018 (1996), Xin, W., et a: Chem. Res. Toxicol., 13, 749 (2000), An, L., et al.: Food Chem. Toxicol., 44, 436 (2006),<br></p>

<p>Applications 2,4,6-Tris[bis(methoxymethyl)amino]-1,3,5-triazine (cas# 3089-11-0) is a useful research chemical.<br></p>

<p>Applications 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (cas# 29529-99-5) is a useful research chemical.<br></p>

<p>Impurity Azathioprine EP Impurity C<br>Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.<br>References Xia, J., et. al.: Bioorg. Med. Chem. Lett., 21, 3894 (2011)<br></p>

<p>Applications 4-(2-Hydroxyethyl)piperazin-2-one (cas# 23936-04-1) is a useful research chemical.<br></p>

<p>Applications 5-methyl-2-(1H-pyrrol-1-yl)aniline (cas# 59194-21-7) is a useful research chemical.<br></p>

<p>Applications 5-Chlorobenzotriazole is a good inhibitor; it decreases anodic and cathodic reaction rates, and the highest inhibition efficiency was 91.2%. The inhibitory effect of 5-chlorobenzotriazole is explained by the formation of the layer on the copper surface.<br>References Simonovic, Ana T., et al.: ACS Omeg., 5, 12832-12841 (2020);<br></p>

<p>Applications A free radical scavenger; may be used for prophylaxis and treatment of IRI.<br>References Flather, M., et al.: Lancet, 355, 1575 (2000), Sasso, F., et al.: Metabolism, 52, 675 (2003), Kass, D., et al.: Circ. Res., 94, 1533 (2004), Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006),<br></p>

<p>Applications 5-Phenyl-1H-1,2,3-triazole (cas# 1680-44-0) is a useful research chemical.<br></p>

<p>Applications An intermediate in the preparation of Piperidinyloxy free radical derivatives.<br>References Irie, O., et al.: Bioorg. Med. Chem. Lett., 18, 5280 (2008),<br></p>

<p>Applications 1-(2-Aminoethyl)pyrrolidin-2-one<br></p>

<p>Applications [2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazol-1-yl]acetic acid (cas# 1171565-50-6) is a useful research chemical.<br></p>

<p>Applications 2,4,6-Triallyloxy-1,3,5-triazine, 99% (cas# 101-37-1) is a useful research chemical.<br></p>

<p>Applications Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.<br>References Erkelenz, M. et al.: J. Am. Chem. Soc., 133, 16111 (2011);<br></p>

<p>Applications 1-(9-Fluorenylmethyl)piperidine is an intermediate when synthesizing 9-​Fluorenylmethoxycarbonyl group (FMOC), which is a new amino-protecting group.<br>References Carpino, L., et al.: J. Org. Chem., 37, 3404 (1972)<br></p>

<p>Applications 5-Amino-6-methylbenzimidazolone<br></p>

<p>Applications Methyl 4,6-dichloropyridazine-3-carboxylate<br></p>

<p>Applications (3-Chloropyrazin-2-yl)methanol (cas# 89283-32-9) is a useful reagent for the preparation of indazolylquinazolinones as inhibitors of human immunodeficiency virus replication.<br>References Gillis, E. P., et al.: PCT Int. Appl. (2020), WO 2020084492 A1<br></p>

<p>Applications 4-Cyanopyridine is a reagent for the synthesis of 1-tolyl-5-benzylthiotetrazole and 2-hexylthio-4-pyridinecarbonitrile, an antituberculotics. Preparation of the antihypertensive agent Pinacidil using the chemoselective and green oxidative rearrangement of an amidine and addition of an amine to a guanidine as the key step. Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking. Human L-xylulose reductase (XR) is an enzyme of the glucuronic acid/uronate cycle of glucose metabolism with the possible target for treatment of the long-term complications of diabetes.<br>References Waisser, K., et al.: Folia Pharmaceutica Universitatis Carolinae, 18, 31 (1995); Carbone, V., et al.: Bioorg. Med. Chem., 13, 301 (2004); Baeten, M., et al.: Adv. Synth. Catal., 358, 826 (2016)<br></p>

<p>Impurity Piracetam EP Impurity C<br>Applications Ethyl 2-(2-oxopyrrolidin-1-yl)acetate is a reagent in the preparation of N-substituted-2-oxopyrrolidinylacetamides which have anticonvulsant activities.<br>References Al-Obaid, A. M., et al.: Med. Chem. Res., 9, 696 (1999);<br></p>

<p>Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.<br></p>

<p>Applications (2-oxo-4-phenylpyrrolidin-1-yl)acetic Acid (cas# 67118-34-7) is a useful research chemical.<br></p>

<p>Applications 4-Acetylpyridine is a acetylated pyridine used in the preparation of nitrogen containing bicyclic heterocycles and other organic compounds. 4-Acetylpyridine is also present in mainstream cigarette smoke.<br>References Kulshreshtha, N.P. et al.: J. Chrom. A, 985, 303 (2003); Scian, M. et al.: Inhal. Toxicol., 21, 1040 (2009);<br></p>

<p>Applications 1-Piperidineethanol (cas# 3040-44-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Mercaptopyridine N-oxide sodium salt is a bidentate complexing agent used to chelate transition metals at a pH range of 0.7-7.4. 2-Mercaptopyridine N-oxide sodium salt is also used as a selective absorptiometric reagent in the determination of palladium.<br>References Edrissi, M., et al.: J. Mater. Sci.-Mater. El., 22, 328 (2011); Edrissi, M., et al.: Microchem. J., 16, 526 (1971); Thakur, M., et al.: J. Nucl. Med., 26, 510 (1985)<br></p>

<p>Applications Isotope Labelled 2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaMontagne, M.P. et al.: J. Med. Chem., 17, 519 (1974); Yoshizaki, S. et al.: Chem. Pharm. Bull., 37, 3430 (1989);<br></p>

<p>Applications 1-butylpiperidine-2-carboxylic acid (cas# 856838-98-7) is a useful research chemical.<br></p>

<p>Applications Succinimide is a reagent that is used in the synthesis of Lumiflavin (L473900), which is a toxic photolysis product of vitamin B2 (R415000).<br>References Zhao, X. et al.: Chemosphere, 63, 1116 (2006); Litke, S.V. et al.: Khim. Fiz., 10, 48 (1991); Ye, W. et al.: Guang. Yaox. Xueb., 12, 175 (1996);<br></p>

<p>Impurity Rabeprazole EP Impurity F<br>Applications An antidegradant, protecting rubber from oxidation. An intermediate in the synthesis of Rabeprazole (R070500)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beheshti, A., et al.: J. Food Sci., 75, C135 (2010), Rohrig, U., et al.: J. Med. Chem., 53, 1172 (2010),<br></p>

<p>Applications 1-Amino-imidazolidine-2,4-dione (cas# 6301-02-6) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-2-methyl-1H-imidazole-1-ethanol is a degradation product of Metronidazole (M338880), an antibiotic.<br>References Perez, Tzayam, et al.: Electrochimica Acta, 165, 173-181 (2015)<br></p>

<p>Applications N-Octylpyridin-4-amine is used in the synthesis of antimicrobial agent Octenidine (O239150), as chelating agent.<br>References Bailey, D.M., et al.: J. Med. Chem., 27, 1457 (1984),<br></p>

<p>Stability Hygroscopic<br>Applications 1H-Pyrrolo[3,2-b]pyridine-2,3-dione (cas# 153072-89-0) is a useful research chemical.<br></p>

<p>Applications Pyridine-2-aldoxime (cas# 873-69-8) is a useful research chemical.<br></p>

<p>Applications 2-Aminopyrimidine is used in the synthesis of sulfonamides as isoform-selective inhibitors with efficacy in rodent pain models.<br>References Focken, T. et al.: ACS Med. Chem., 7, 277 (2016); Reddy, M. et al.: Bioorg. Med. Chem., 24, 521 (2016);<br></p>

<p>Applications 1,3,5-trimethyl-1H-pyrazole-4-carboxylic acid (cas# 1125-29-7) is a useful research chemical.<br></p>

<p>Applications 5-(2-Fluorophenyl)-1H-tetrazole is used in the synthetic preparation of novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors useful in treatment and prevention of CNS diseases and diseases-modulated by mGluR5 receptors.<br>References Gagliardi, S.; et al.: PCT Int. Appl. 45 pp. Patent 2006 CODEN:PIXXD2<br></p>

<p>Applications An impurity arising in the synthesis of zoledronic acid (Z623500).<br></p>

<p>Applications 4-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a useful synthetic intermediate. It can be used to prepare pyridine carboxamides as palm site inhibitors of HCV NS5B polymerase. It can also be used to synthesize pyrazolylcarboxanilides as Ca2+ release-activated Ca2+ (CRAC) channel inhibitors.<br>References Cheng, C., et al.: ACS Med. Chem. Lett., 1, 466 (2010); Yonetoku, Y., et al.: Bioorg. Med. Chem., 16, 9457 (2008)<br></p>

<p>Applications L-Dihydroorotic acid is used as a reactant in the preparation of long acting Gonadotrophin-releasing hormone (GnRH) antagonist containing p-ureido-phenylalanine.<br>References Jiang, G., et al.: J. Med. Chem., 44, 453 (2001);<br></p>