Building Blocks

Applications Lactams inhibit type Q arylesterase activity of human serum paraoxonase PON1.
References Aldridge, W., et al.: Biochem. J., 53, 110 (1953), Antikainen, M., et al.: J. Clin. Invest., 98, 883 (1996), Aviram, M., et al.: J. Clin. Invest., 101, 1581 (1998), Biggadike, K., et al.: J. Med. Chem., 43, 19 (2000),

Applications Semustine is an alkylating agent and interstrand DNA cross linker. Anti-cancer chemotherapeutic agents, which are used in the treatment of different types of cancer such as brain tumors, resistant Hodgkin’s disease, lung cancer and malignant melanoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Agarwal, S., et al.: J. Photochem. Photobiol. B, Biol., 166, 1-11 (2017)

Applications n-Butyl-3,3,4,4,4-d5 Alcohol (CAS# 64118-16-7) is a useful isotopically labeled research compound.

Applications cis-1-Butene-1,4-diol is used in the synthesis of bezoxazinyl-oxazolidinones as promising antbacterial agents. Also used in the preparation of AMF-26, an antitumor agent for inhibition of the golgi system, targeting a specific ribosylation factor.
References Guo, B. et al.: J. Med. CHem., 56, 2642 (2013); Shiina, I. et al.: J. Med. CHem., 56, 150 (2013);

Stability Light Sensitive
Applications Cis-1-Bromo-2-ethoxyethylene

Applications 1-Bromoheptane-d15 (CAS# 98195-42-7) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications 3'-Azido-3'-deoxythymidine 5’-Triphosphate Tetraammonium Salt, is used for the preparation of drug against human retroviruses.
References Rideout, J.L., et al.: Ger. Offen., 3608606 (1986)

Applications Pyruvaldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Shankar, S. et al.: Tetrahedron Lett., 54, 6137 (2013); Tora, G. et al.: Bioorg. Med. Chem. Lett., 23, 5684 (2013);

Impurity Abacavir - In House Impurity
Applications rac 2-Azabicyclo[2.2.1]hept-5-en-3-one (Abacavir - In House Impurity) is a useful reagent in the synthesis of carbocyclic sugar amines, carbanucleosides, and carbocyclic dinucleotide analogues (1). rac 2-Azabicyclo[2.2.1]hept-5-en-3-one is also an intermediate of Abacavir (A104990), a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Slama, J.T., et al.: Biochemistry, 27, 183 (1988) (2) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (3) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Applications p-Xylene-d4 (ring-d4) (CAS# 16034-43-8) is a useful isotopically labeled research compound.

Applications trans-Campestanyl Ferulate is used for synthesis of trans-feruloyl-β-sitostanol.
References Condo, A., et al.: J. Agric. Food Chem., 49, 4961 (2001);

Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.

Applications 8-Hydroxyquinoline-5-carboxylic Acid is an inhibitor of KDM2/7 histone demethylase. 8-Hydroxyquinoline-5-carboxylic acid has also shown potential to be used as a regulator of plant growth.
References Rose, N.R., et al.: J. Med. Chem., 55, 6639 (2012); Flashman, E., et al.: J. Biol. Chem., 283, 3808 (2007);

Applications Intermediate used to produce a variety of pharmaceutical agents, such as analgesic compounds and retinoic acid receptor (RAR) antagonists.
References Caldwell, J.; et al.: Bioorg. Med. Chem. Lett., 17, 2281 (2007), Tashiro, T., et al.: Biosci., Biotechnol., Biochem., 72, 2398 (2008),

Applications 3-(Methylamino)propanoic acid HCl