Reagentes Sintéticos

<p>Stability Hygroscopic<br>Applications N10-Trifluoroacetylpteroic acid is a derivative of Pteroic acid (P840110), both of which are used as reagents to synthesize target ligands, like Folic acid (F680300), that have the ability to deliver chemotherapeutic agents specifically to cancer cells.<br>References Leamon, C., et al.: Bioconjugate Chem., 14, 738 (2003); Leamon, C., et al.: J. Drug Target., 7, 157 (1999); Yonghua, Z., et al.: Anal. Biochem., 332, 168 (2004)<br></p>

<p>Applications 3,3-Dimethylacryloyl Chloride is a reactant in the synthesis of novel 4-substituted coumarin derivative, which exhibits significant antiproliferative activity toward tumor cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cao, Dong., et al.: J. Med. Chem., 59, 5721-5739 (2016)<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.<br>References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);<br></p>

<p>Stability Volatile<br>Applications N-Ethylbutylamine is used as a reagent in the synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kuppast, B., et al.: Eur. J. Med. Chem., 78, 1 (2014)<br></p>

<p>Applications (3-Aminopropyl)trimethoxysilane is used in the synthesis of aspirin imprinted polymer on silica gel surface and appreciation on drug sustained release. Fluorine-doped; lectin functionalized ZnO nanoarrays as 3D nano-biointerface for bacterial detection.<br>References Lu, P., et al.: Gaofenzi Cailiao Kexue Yu Gongcheng, 33, 130 (2017); Zheng, L., Talanta, 167, 600 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Amino-6-nitroquinoline is a reagent used in the synthesis of benzodiazepine sulfonamide-based bombesin receptor 3 agonists. It is also used in the synthesis of quinoxalinediones.<br>References Liu, P. et al.: ACS. Med. Chem. Lett., 2, 933 (2011); Bigge, C. et al.: J. Med. Chem., 38, 5720 (1995);<br></p>

<p>Applications PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.<br>References Bryant, D.D. et al.: Psychopharmacology, 203, 703 (2009); Badura, L. et al.: J. Pharmacol. Exp. Therap., 322, 730 (2007); Sprouse, J. et al.: Psychopharmacology, 210, 569 (2010):<br></p>

<p>Stability Hygroscopic<br>Applications 2,4-Dinitrophenylsulfonyl Chloride, can be used to protect primary amines. It is also used as starting material in the synthesis of tert-butyl 2-[(2,4-dinitrophenyl) sulfonyl]aminoacetate.<br>References Rachel J Ball et. al.: Artificial DNA, PNA &amp; XNA, 1(1), undefined (2011-6-21);<br></p>

<p>Applications Dichlorobis(triphenylphosphine) Palladium (II) is used primarily in organometallic catalytic reactions due to the palladium content of the compound. It is also involved in crystalized structures of metallacyclic complexes which show antiinflammatory and antifungal properties.<br>References Paul, P. et al.: J. Organometal. Chem., 724, 281 (2013); Pandiarajan, D. et al.: J. Organometal. Chem., 708-709, 18, (2012); Shhaheen, F. et al.: J. Organometal. Chem., 693, 315 (2010);<br></p>

<p>Applications The paullones are a novel class of kinase inhibitors, initially identified as CDK inhibitors. Kenpaullone has been found to be a useful GSK-3ß inhibitor (IC50=23nM).<br>References Zaharevitz, D.W., et al.: Cancer Res., 59, 2566 (1999), Leclerc, S., et al.: J. Biol. Chem., 276, 251 (2001), Bain, J., et al.: Biochem. J., in press.<br></p>

<p>Applications Alpha-(trifluoromethyl)styrene<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists useful in pharmaceutical application.<br>References Asano, M. et al.: Tetra. Asymm., 24, 449 (2013);<br></p>

<p>Applications Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.<br>References Lee, H., et al.: Drugs, 76, 1015 (2016)<br></p>

<p>Applications Sildenafil (S435000) derivative.<br></p>

<p>Applications 6-Methyl-3-pyridinol is a reagent in the preparation of anilino(pyridyl)quinolinecarbonitriles which has Src kinase inhibitiion and antitumor properties.<br>References Zhang, N., et al.: Bioorg. Med. Chem. Lett., 19, 5071 (2009); Blume-Jensen, P., et al.: Nature, 411, 355 (2001)<br></p>

<p>Applications Phosphorothioic Acid Trisodium Salt Hydrate can be involved in reactions of alkali hexafluoroaluminates.<br>References Bukhalova, G. A., et al.: Issled. v Obl. Khim. i Technol. Mineral'n. Solei i Okislov, Akad. Nauk SSSR, Sb. Statei, 124 (1965)<br></p>

<p>Applications 4-​Methoxy-​6-​methyl-​2H-​pyran-​2-​one acts as a potential selective agonist for the ghrelin receptor (GHS-​R1a), a receptor which plays in a role in appetite.<br>References Pastor-Cavada, E., et al.: Sci. Rep., 6, 36456 (2016);<br></p>

<p>Applications A Wittig reagent.<br></p>

<p>Stability Hygroscopic<br>Applications Lodoxamide is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications Procinolol is a beta adrenergic receptor antagonist. It is also an intermediate in synthesizing (±)-Procinolol Hydrochloride (P755815).<br>References Singh, K.: Indian J. Phsiol. Pharmacol., 27, 311 (1983)<br></p>

<p>Applications (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.<br>References Agouridas, C., et al.: J. Med. Chem., 41, 4080 (1998);<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>

<p>Stability Unstable in Solution, Air Sensitive<br>Applications 2-HYDROXYTHIOPHENOL (cas# 1121-24-0) is a useful research chemical.<br></p>

<p>Applications MKT-077 is used in the treatment of Alzheimer’s diseases and other tauopathie’s. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance<br>References Jinwal, U. K., et al.: Pharm. Nanotechnol., 2, 217, (2014); Koren, J., et al. : PLoS One, 7, 35566 (2012)<br></p>

<p>Applications Calcium Sulfate is used in the biofilm prevention and management of gram-negative bacterial pathogens involved in periprosthetic infection by using antibiotic-loaded calcium sulfate beads in vitro. Calcium Sulfate is used in the bioactive calcium sulfate-based formulation “Biocas” for bone filler applications. Calcium Sulfate is also used as an antibiotic impregnated calcium sulphate in combination with internal fixation for the treatment of open fractures of extremities that prevents infections and promotes the healing of fractures.<br>References Howlin, R., et al.: Biomed.l Mater., 12, 1 (2017); Sandhya, S., et al.: Biomedical Materials, 12, 015022 (2017); Liao, H., et al.: Guangxi Yixue, 37, 1491 (2015)<br></p>

<p>Applications (S)-(-)-Alpha-Methoxy-Alpha-(Trifluoromethyl)Phenylacetic Acid (cas# 17257-71-5) is a useful research chemical.<br></p>

<p>Applications 2-Aminomethyl-1,4-benzodioxane is used in the synthesis of N-substituted (dihydrobenzodioxinyl)methylamine derivatives as D2 antagonists/5-HT1A partial agonists with potential as atypical antipsychotic agents in relation to affinity for α1 adrenoceptors.<br>References Birch, A. M., et al.: J. Med. Chem., 42, 3342 (1999);<br></p>

<p>Applications Potassium Iodide is used primarily used in the treatment of radiation poisoning due to environmental contamination by iodine-131.<br>References Wolff, J. et al.: Pharmacol. Rec., 50, 89 (1998);<br></p>

<p>Stability Air Sensitive<br>Applications Can be used as a building block for chiral ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ruthenium(IV) Oxide Anhydrous is a research reagent and applied for exfoliation of layered metal oxide nanosheets.<br>References Lee, J.M., et al.: App. Mat. Interfaces, 11, 12121 (2019)<br></p>

<p>Applications Ethyl Isobutyrylacetate is used in the synthesis of piperazine derivatives as possible multireceptor atypical antipsychotics, affecting dopamine and serotonin receptor properties . Also used in the synthesis of pyrazinecarboxamide DGAT1 (diacylglycerol acyltransferase 1) inhibitors used in the treatment of obesity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, Y. et al.: J. Med. Chem., 56, 4671 (2013); J. Med. Chem., 55, 10610 (2012);<br></p>

<p>Applications 2-Cl-IB-MECA acts as an A3 adenosine receptor-selective nucleoside.<br>References Tosh, D. et al.: J. Med. Chem., 55, 4847 (2012);<br></p>

<p>Applications 1-(azidomethyl)-3-methoxybenzene (cas# 123767-44-2) is a useful research chemical.<br></p>

<p>Applications 1-Phenyl-1-cyclohexene is metabolite of Phencyclidine (P295500), an anesthetic.<br>References Wong, L.K., et al.L Biomed. Sci. Spec., 2, 204 (1975); Chen, G., et al.: J. Pharmacol. Exp. Ther., 127, 241 (1959); Bailey, K., et al.: J. Pharm. Pharmacol., 28, 713 (1976); Balster, R.L., J. Psychedelic Drugs., 10115 (1978); Johnson, K.M., et al.: Annu. Rev. Pharmacol. Toxicol., 30, 707 (1990)<br></p>

<p>Applications Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.<br>References Gavine, P., et al.: Mol. Oncol., 9, 323 (2015); Jia, H., et al.: J. Med. Chem., 57, 7577 (2014);<br></p>

<p>Applications 4-(Aminomethyl)-Cyclohexanecarboxylic Acid (cas# 701-54-2) is a useful research chemical.<br></p>

<p>Applications Tetramethylammonium Tetrafluoroborate (cas# 661-36-9) is a useful research chemical.<br></p>

<p>Applications 1,1,3,3-Tetramethyldisiloxane is an organosilane reducing agent and can be used in several reduction reactions including reductive formation of sulfides and reductive etherification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pesti, J., et al.: Org. Process Res. Dev., pages ahead of print (2016);<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-​(Chloromethyl)​allyl-​trimethylsilane is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).<br></p>

<p>Applications Cyclopropylmethanol used to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A, inhibitors against phosphodiesterase 3 (PDE3). Also used in the synthesis of benzodiazapin-2-ones<br>References Hu, E. et al.: Bioorg. Med. Chem. Lett., 22, 6938 (2012);<br></p>

<p>Applications 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)-β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and TGF-β2-induced endothelial cell differentiation in iPSCs (1,2).<br>References (1) Jinnin, M., et al. Mol.Pharmacol. 69 597 (2006). (2) Di Bernardini, M., et al.: J.Biol.Chem. 289 3383 (2014).<br></p>

<p>Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.<br>References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),<br></p>

<p>Applications (1S,2S)-1,2-Diphenyl-1,2-ethanediamine (cas# 29841-69-8) is a compound useful in organic synthesis.<br></p>

<p>Applications An Aurora kinase inhibitor, used to treat patients with advanced solid tumors.<br></p>

<p>Stability Light Sensitive<br>Applications GFT-505 is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders.<br>References Carious, B., et al.: Diabetes Care 36, 2923 (2013); Carious, B., et al.: Diabetes Care 34, 2008 (2011)<br></p>

<p>Applications 15-Crown-5 is a catalyst used in the synthesis of organic molecules and lanthanide complexes. It can induce cytotoxicity and oxidative stress markers in WI38 cells. Studies show that 15-Crown-5 is also an effective chelating agent used for removing cesium in cesium-exposed mice.<br>References Li, L. et al.: J. Organometal. Chem., 794, 231 (2015); Gonzalez-Bello, C. et al.: J. Am Chem. Soc., 137, 9333 (2015); Llobet, J.M., et al.: Metal Ions Biol. Med., 4, 487 (1996)<br></p>

<p>Applications 2-Bromophenylacetic Acid is used as the starting material in the synthesis of 2,3,3a,12b-Tetradehydro Asenapine (T291630); a degredation product of Asenapine (A788000) which is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist structurally related to Mianserin (M341500, HCl). Also used as an antipsychotic.<br>References Meltzer, H., et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A., et al.: Brain Res., 631, 191 (1993); Andree, B., et al.: Psychopharmacology, 131, 339 (1997); Richelson, E., et al.: Life Sci., 68, 29 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Omeprazole Sodium Salt is the salt analogue of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications Brincidofovir is an antiviral inhibitor, working against BK polymavirus replication in primary human urothelial cells. Cytostatic, cytotoxic agent.<br>References Tylden, G. et al.: Antimicrob. Agent. Chemother., 59, 3306 (2015); Cardile, A. et al.: Recent Patents Anti-Infect. Drug DIscov., 9, 97 (2014)<br></p>

<p>Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.<br>References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),<br></p>

<p>Applications Diethyl Bromomalonate is a chemical constituent of the asymmetric cyclopropanation of chalcones. Also used in the preparation of nanaplatforms for NIR imaging-guided photodynamic therapy of cancer cells.<br>References Herchl, R. et al.: Tetra. Lett., 54, 2472 (2013); Liu, X. et al.: Chem. Comm., 49, 3224 (2013);<br></p>

<p>Applications N-Carbethoxyphthalimide is used in the synthetic preparation of a novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.<br>References Hua, Z., et al.: J. Med. Chem., 56, 10003 (2013);<br></p>

<p>Impurity Atomoxetine EP Impurity C<br>Applications p-Methyl Atomoxetine Hydrochloride (Atomoxetine EP Impurity C) is an impurity of Atomoxetine (A791400), a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications N-Acetyl-DL-Valine is an amino acid.<br>References Hirschmann R., et al.: Science, 265, 234 (1994); Gu Z. T., et al.: J. Magn. Reson., 140, 340 (1999); Bodalo, A., et al.: Enzyme Microb. Technol., 24, 381 (1999)<br></p>

<p>Applications R-(+)-1,1'-Bi-2-Naphthol is used in biosynthetic preparation for enantioselective oxidation of naphthols to binaphthyldiols with horseradish peroxidase catalyst.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sridhar, M., et al.: Tetrahedron Lett., 38, 5695 (1997)<br></p>

<p>Applications Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).<br>References Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001), Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2003),<br></p>

<p>Applications AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.<br>References Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007), Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2009),<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 5-Methyltryptamine is a methylated derivative of tryptamine. 5-Methyltryptamine is a weak antagonist of 5-Hydroxytryptamine (H974990) with weak potency as stimulants of the cardiac sympathetic nerves. 5-Methyltryptamine is also used in the preparation of inhibitors of kinesin spindle protein (KSP), a promising class of anticancer agents.<br>References Fozard, J.R. et al.: Naun.-Schmied. Arch. Pharmacol., 301, 223 (1978); Slotkin, T. et al.: Mol. Pharmacol., 15, 607 (1979); Liu, F. et al.: Bioorg. Med, Chem., 18, 4167 (2010);<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (cas# 60875-16-3) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.<br>References Andrade, R.J., et al.: Hepatol., 44, 1581 (2006); Wajima, T., et al.: J. Pharma. Sci., 92, 2427 (2003); Sentellas, S.. et al.: J. Chroma., 976, 221 (2002);<br></p>

<p>Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 &gt;100nM).<br>References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)<br></p>