Padrões Farmacêuticas

Applications (4-Chloro-2-methylphenoxy)acetic Acid-d3 is the deuterated version of (4-Chloro-2-methylphenoxy)acetic Acid (C369470), which is a herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Elliott, B., et al.: Mutagenesis, 20, 3 (2005); Pfleeger, T., et al.: Environ. Toxicol. Chem., 30, 455 (2010);

Applications 2-Bromo-2’-hydroxyacetophenone (cas# 2491-36-3) is a compound useful in organic synthesis.
References Kumar, S., et al.: J. Med. Chem., 51, 4968 (2008), Emami, S., et al.: Bioorg. Med. Chem. Lett., 18, 141 (2008),

Applications 4,4'-(1Z)-Diaminostilbene-2,2'-disulfonic Acid Disodium Salt is a reactant in the synthesis of (arylamino)triazinylamino-substituted stilbenedisulfonic acid, to be used as an optical brightener.
References Okuom, Macduff, et al.: Inter. J. of Org. Chem., 3(4), 256-261 (2013)

Applications 4-Nitrobiphenyl-2’,3’,4’,5’,6’-d5 (cas# 64421-02-9) is a compound useful in organic synthesis.

Applications N,N'-Bis[3-(trifluoromethyl-4-cyanophenyl)thiourea can be obtained from 5-Amino-2-cyanobenzotrifluoride (A603630) which is used for the preparation of benzene derivatives as non-steroidal androgen receptor modulators.
References Xiao, H.-Y., et al.: Bioorg. Med. Chem. Lett., 20, 4491 (2010)

Applications 2-Isonitrosoacetophenone is used to make a complex with copper and amino acids. These complexes has shown to have more antimicrobial activities against gram positive bacteria than gram negative bacteria and the complexes also have antioxidant activity.
References Tidjani-Rahmouni, N., et. al.: J. Mol. Struct., 1075, 254 (2014)

Applications Isotope labelled N-1-Naphthylethylenediamine Dihydrochloride, is an organic building block used for the chemical synthesis. It can also be used as highly selective organic fluorescent probe for azide ion.
References Sahana, A., et al.: Analyst , 137, 1544 (2012);

Applications 1,5-Dinitronaphthalene-d6 (CAS# 1219804-48-4) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications Ginsenoside C-K is reported to exhibit anti-wrinkle effects. Also, it potentiates tumor necrosis factor (TNF)-related apotosis-inducing ligand (TRAIL)-induced apotosis in HCT116 colon cancer.
References Han, S., et al.: J. Cell. Biochem., (2017); Chen, L., et al.: Cell Death Diff., 7, 2334 (2016)

Applications Labelled Dihydroisoferulic Acid 3-O-Sulfate, the sulfate conjugate of Dihydroisoferulic Acid (H946365). Dihydroisoferulic Acid 3-O-Sulfate is a minor circulating metabolite in human plasma after coffee consumption.
References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);

Applications Anthracene is obtained from coal tar. It is an important source of many dyes.This compound is a contaminant of emerging concern (CECs)
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6,7-Dimethoxynaphth-1-yl Trifluoromethanesulfonate is used as a reagent in the synthesis of tripeptide Grb2-SH2 domain inhibitors containing 4-(phosphonomethyl)phenylalanine and naphthalene.
References Schoepfer, J., et al.: Bioorg. Med. Chem. Lett., 11, 1201 (2001)

Applications L-2-Nitrophenylalanine is a derivative of L-phenylalanine (P319415), and is used in the photocleavage of polypeptide backbones. L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine.
References Peters, F. et al.: Chem. Biol., 16, 148 (2009); Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications β-Elemene is an active constituent of Delonix regia and an anti-inflammatory agent. β-Elemene is a useful compound for investigating the toll-like receptor 4 signaling pathway and the inhibition of TNF-​a, IL-​1b, IL-​6 and IL-​12 expressions.
References Satajit, P., et al.: Int Immunopharmacol 34, 199 (2016);

Applications 5-(BROMOMETHYL)-2-NITROPYRIDINE (cas# 448968-52-3) is a useful research chemical.

Applications (5S)-5-Hydroxy-6-heptynoic Acid 1-Methylethyl Ester is an intermediate in synthesizing Resolvin E1 Sodium Salt (R144690), which is an omega-3 polyunsaturated fatty acid derivative that exhibits potent anti-inflammatory, pro-resolution, and anti-nociceptive effects. Resolvin E1 has been shown to inhibit neuropathic pain and spinal cord microgial activation following peripheral nerve injury.
References Xu, Z.Z. et al.: J. Neuroimm. Pharamcol., 2012; Schwab, J.M. et al.: Nature, 447, 869 (2007);

Applications (2-Deoxy-β-D-erythro-pentofuranosyl)urea is used as a reactant in the deoxyguanosine oxidation by singlet oxygen.
References Cadet, J., et al.: Photochem, Photobiol., 28, 661 (1978)

Applications N-(Cinnamoyl)-4-methoxyaniline (cas# 76228-15-4) is a compound useful in organic synthesis.

Applications 2,6-dibromoanthracene (cas# 186517-01-1) is a useful research chemical.

Applications (αE)-α-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-β-oxo-1-piperidinepropanenitrile is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
References Karlsson, M., et al.: J. Pharm. Biomed. Anal., 10, 593 (1992), Nissinen, E., et al.: Arch. Pharmacol., 346, 262 (1992), Wikberg, T., et al.: Eur. J. Drug Metab. Pharmacokinet., 18, 359 (1993),

Stability Light Sensitive
Applications 3,3'-Bipyridine-6,6'-dicarbonitrile

Applications Intermediate in the production of Losartan impurities

Applications 3-Bromo-2-naphthoic Acid is used as a reagent for prepartion of isochromanones.
References Wen, Z.K., et al.: Advanced Synthesis and Catalysis, 361,963 (2019)

Applications 1-Naphthyl Acetate (cas# 830-81-9) is a useful research chemical.

Applications 3,20-Disemicarbazone-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione can be used in synthetic preparation of prednisolone acetate. Intermediate in the synthesis of prednisolone.
References Liao, J., et al.: Faming Zhuanli Shenqing, CN 105503986 A 20160420 (2016)

Applications 7-Methoxy-1-naphthalenol is used in the synthesis of Agomelatine (A430000).

Applications 6,9,12,15,18-Heneicosapentaynoic Acid Methyl Ester is a methyl analog of 6,9,12,15,18-Heneicosapentaynoic Acid.

Applications Intermediate for the synthesis of 2-Hydroxymethyl Loratadine.
References Cerrada, V., et al.: ARKIVOC, 9, 200 (2005).

Applications 2'-​Amino-​5'-​(4-​carboxyphenyl)​-[1,​1':3',​1''-​terphenyl]​-​4,​4''-​dicarboxylic Acid is used in the synthesis of Zinc Imidazolate Tris(carboxyphenyl)aniline Metal Organic Frameworks (MOFs).
References Fu, H., et al.: Inorg. Chem., 55, 3928 (2016)

Applications 2-Hydroxybutanoic-d3 Acid Sodium Salt is the labeled analogue of a degredation product of isotactic P[(R)-2-hydroxybutyrate] and Its copolymer with (R)-Lactate.
References Matsumoto, K., et. al.: Biomacromolecules, 14, 1913 (2013)

Stability Moisture Sensitive
Applications 1-Naphthyl Isocyanate was used in the preparation of cationic aromatic urethane.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References McEntyre, C.J., et al.: Anal. Chim. Acta, 644, 90-94 (2009)

Applications Bromo-2’-nitroacetophenone is used in the novel synthesis of 5-pyridylindolizine derivatives.
References Georgescu, E. et al.: J. Hetero. Chem., 50, 78 (2013);

Applications 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide-d3 is the isotope labelled analog of 4-Hydroxymethylbicyclo[2.2.2]octane-1-carboxylic Acid Methylamide (H946935); a useful synthetic intermediate.

Applications 2,2',4,4'-Tetranitro-1,1'-biphenyl is an intermediate used in the synthesis of substituted dibenzophospholes.
References Cornforth, J., et al.: J. Chem. Soc. Perkin Transactions 1:  Organic and Bio-Organic Chemistry, 10, 2299 (1982)

Applications 4-Bromotoluene-d3 is isotopically labelled form of 4-Bromotoluene (B688235), which is used as a reagent in the preparation of aromatic diselenides that are useful for generating anticancer lead compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rizvi, M.A., et al.: Bioorg. Med. Chem. Lett., 24, 3440 (2014); Leung, C., et al.: Angew Chem., Int. Ed., 52, 766 (2013);

Applications 3-(Triisopropylsilyl)oxy-isourolithin A is an intermediate for the synthesis of Isourolithin A 9-Glucuronide (I917525), which is a metabolite of ellagitannins and ellagic acid in different mammals.
References Gonzalez-Barrio, R., et al.: J. Agric. Food Chem., 59, 1152 (2011)

Applications (3,4-Dinitrophenyl)(phenyl-d5)methanone is an intermediate for the synthesis of Mebendazole-d8 (M200502), which is labelled Mebendazole (M200500). Anthelmintic (Nematodes).
References Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 16, 291 (1987)

Applications Lactosyl-C18-sphingosine has been found to have a strong interaction with HIV-1 Gp120.
References McReynolds, K.D., et. al.: Bioconjugate Chem., 10, 1021 (1999)

Applications 2-Amino-3-chlorobenzoic Acid is a plant growth regulator.
References James, C. S., et a.: Ann. Appl. Biol., 61, 295 (1968)

Applications 1-(2-Nitroethyl)-2-naphthol is an aromatic alcohol that is used in photoacid for extremely long lived and reversible pH jumps.
References Nunes, R.M.D., et al.: J. Am. Chem. Soc., 131, 26 (2009);

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxycytidine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Applications 4-Chlorosulfonylcinnamic Acid (cas# 17641-30-4) is a compound useful in organic synthesis.

Applications (+)-Carotol is an essential oil extracted from Seseli libanotis plant. A natural product.
References Chizzola, R.: Chem. Biodivers., 16, 6 (2019), El O., et al.: Res. J. Pharm. Biol. Chem. Sci., 9, 1524 (2018)

Applications 2-[2-(4’-Chloro-biphenyl-4-yl)-2-oxo-ethyl]acrylic Acid (cas# 58211-82-8) is a compound useful in organic synthesis.

Applications 1-(3-Bromophenyl)thiourea
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications METHYL 2-METHYL-1-OXO-1,2,3,4-TETRAHYDRONAPHTHALENE-2-CARBOXYLATE (cas# 54125-61-0) is a useful research chemical.

Applications A 9-substituted derivative of the polycyclic aromatic hydrocarbon (PAH) Anthracene (A678400).

Applications 1,2,3,4-Tetrahydro-1,2,8-naphthalenetriol is a reagent is used in the preparation of pharmaceuticals and in organic synthesis.

Applications Benzyl 4-Nitrophenyl Carbonate is used as a reagent in the synthesis of Janus PEG-based dendrimers for use in combination therapy by controlled multi-drug loading and sequential release. Benzyl 4-Nitrophenyl Carbonate is also used as a reagent in the synthesis of Norfloxacin analogs which can exhibit antibacterial and antifungal activities under visible and UV light.
References Acton, A.L., et al.: Biomacromolecules, 14, 564 (2013); Bakhotmah, D.A., et al.: ISRN Org. Chem., 184754, 11 (2011)

Applications BIS(4-NITROPHENYL) SULFONE (cas# 1156-50-9) is a useful research chemical.

Applications Isotope labelled δ-Valerolactone used in the synthesis of various antibiotics including the ionophore antibiotic X-14547A. Also used in the preparation of polyesters via copolymerization.
References Nicolaou, K. et al.: J. Org. Chem., 50, 1440 (1985); Parrish, B. et al.: J. Polym. Sci. Polym, Chem., 40, 1983 (2002);