Padrões Farmacêuticas

Homogentisic acid gamma-lactone is a synthetic compound that is an inhibitor of the enzyme cytochrome P450. It binds to cytochrome P450 in a competitive manner and inhibits the oxidation of other molecules, such as steroids and fatty acids. Homogentisic acid gamma-lactone has been shown to have an inhibitory effect on the growth of Pseudomonas aeruginosa in vitro. This compound is able to suppress the formation of reactive oxygen species by inhibiting the activity of cytochrome P450. Homogentisic acid gamma-lactone also possesses antifungal properties that may be due to its ability to inhibit the synthesis of ergosterol, which is an important component for fungal cell membranes.

5,6,7,8-Tetrahydro-[1,8]naphthyridine-2-carboxylic acid is a chemical compound with CAS No. 885278-22-8. It is a high quality reagent that can be used as a building block for the synthesis of complex compounds. 5,6,7,8-Tetrahydro-[1,8]naphthyridine-2-carboxylic acid can also be used as a reaction component in chemical synthesis and as an intermediate in the production of various fine chemicals and speciality chemicals.

S-Methylisovalerate is a branched fatty acid that is an intermediate in the biosynthesis of valine. It has been isolated from Corynebacterium glutamicum and Brevibacterium sp. S-Methylisovalerate has been identified by gas chromatography/mass spectrometry (GC/MS) as a major component of the volatile organic compounds produced by strains of Corynebacterium glutamicum and Brevibacterium sp. The GC/MS profile of these strains consists mainly of ester compounds, such as methyl ethyl acetate and butyric acid.

Methyl 4-chlorocinnamate is an aryl chloride that is synthesized by the reaction of methoxyethyl chloride with cinnamic acid derivatives. It has bacteriostatic activity against a variety of bacteria species, including staphylococcus and candida glabrata. Methyl 4-chlorocinnamate reacts with amine groups in proteins to form amides, which are strong inhibitors of protein synthesis. This compound also inhibits the growth of Candida glabrata by inhibiting phosphonates, which are essential for cell division.

Applications Guanosine-5'-triphosphate disodium salt (CAS# 56001-37-7) is a nucleotide used in the preparation of photoreactive GTP affinity probes, and in inhibitors of eukaryotic initiation factor eIF-4E.
References George Cisar, E. A.; J. Am. Chem. Soc., 135, 4676 (2013); Ghosh, P.; et al.: Bioorg. Med. Chem. Lett., 16, 750 (2006).

Applications N-Acetylethylene Urea-d4 (cas# 1189701-94-7) is a compound useful in organic synthesis.

2',4-Dihydroxy-3-methoxychalcone is a chalcone that has been shown to have reactive properties. The compound was found to be cytotoxic to cancer cells in the presence of neutrophils, and it has been shown to inhibit the growth of t47d cells in culture. There is also evidence that 2',4-Dihydroxy-3-methoxychalcone may help regulate the microflora in the gut, which may help prevent obesity and diabetes. In epidemiological studies, 2',4-Dihydroxy-3-methoxychalcone was found to be protective against cancer, but more research is required.

2'-Fluoro-4'-hydroxyacetophenone is a glycosylated molecule that is used in phase transfer catalysis. It is a glycoside that can undergo the glycosylation reaction and can be used as a phase transfer reagent. 2'-Fluoro-4'-hydroxyacetophenone has been studied for its potential use in the synthesis of xylosides and selenadiazoles. In addition, it has shown anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

6-Methyl-4-hydroxycoumarin is a coumarin derivative that has been shown to have potent inhibitory activity against both Gram-positive and Gram-negative bacteria. It also inhibits the growth of leukemia cells and shows anti-inflammatory properties. The photophysical studies of this molecule show that it has absorption bands in the visible region, which may be attributed to its hydroxyl group. 6-Methyl-4-hydroxycoumarin has also been shown to be an effective inhibitor of LPS (lipopolysaccharide)-stimulated RAW 264.7 cells, as well as benzofuran derivatives that have been shown to have inflammatory propertys.

N-a-t-Boc-N-g-trityl-L-asparagine is a recombinant human protein that has been synthesized in E. coli. It is a peptide with 17β-estradiol at its C terminus, and it binds to the oestrogen receptor α (ERα) via hydrogen bonding interactions. The linker between the asparagine and estradiol is a Boc group that can be removed by protease activity, revealing the active form of 17β-estradiol. ERα ligates to N-a-t-Boc-N-g-trityl L asparagine with high affinity, and this interaction is reversible. The linker also contains a functional group for surface attachment, which may be used to attach this peptide to a solid support or tissue culture substrate for use in cell cultures.
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7-Nitrocoumarin is an agent that inhibits the growth of protozoa by inhibiting enzyme activities, specifically those involved in glycolysis. It has been shown to be a potent inhibitor of surface proteins and functional assays. 7-Nitrocoumarin is also active against trophozoites in vitro. The compound has been shown to be nontoxic to mammalian cells, with a constant of 0.3 μM for inhibition of resazurin reduction. The mechanism of action for 7-nitrocoumarin is not well understood, but it may involve oxidation products such as nitro groups, which are indicated by the prefix '7-'.

3,4'-Dimethoxy-2'-hydroxychalcone is a reaction component and useful scaffold for the synthesis of complex compounds. This chemical is an intermediate in the synthesis of various pharmaceuticals, such as anti-tuberculosis drugs, cancer chemotherapeutics and antibiotics. 3,4'-Dimethoxy-2'-hydroxychalcone has been shown to be a versatile building block that can be used to synthesize both natural products and pharmaceuticals. This compound also has a wide range of applications in the production of fine chemicals.

Applications The formation of p-Cresol-(methyl-13C) via phenol methylation at higher temperature from the deactivation of basic catalyst.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Borodina, I. B., et al.: Russ. J. Phys. Chem., 80, 892-898 (2006)

Applications Triethylborane reacted with 8-hydroxyquinoline to synthesize three 8--​hydroxyquinolato (q) boron compounds B(C2H5)​2q (1)​, BPh2q (2)​, and B(2-​naph)​2q (3).
References Wu, Q., et al.: Chem. Mater., 12, 79 (2000).

3-Chloro-4-nitropyridine 1-oxide is the condensation product of 2-chloro-3-nitropyridine and nitric acid. 3-Chloro-4-nitropyridine 1-oxide has an isomeric nature and can be purified by recrystallization from water. The compound has a molecular weight of 286.1 g/mol and a monoclinic crystal structure. It has two n-oxides, which are isomers of each other, with nmr spectra that differ by the shift in the chemical shifts of the protons on the aromatic ring. 3-Chloro-4-nitropyridine 1-oxide condenses with lanthanides to form lanthanide complexes, such as Eu(III)(3,5'-ClO 4 ) 2 . This compound is also used in the synthesis of phenoxathiine derivatives that have antihypertensive activity.

Naphthalene is a chemical that is used for wastewater treatment and as a pesticide. It is also used in the manufacturing of polymers, resins, and plastics. Naphthalene has antimicrobial properties due to its hydrophobic effect. Naphthalene's antimicrobial activity is based on its ability to react with the skeleton of bacterial cells and disrupt the integrity of their outer membrane. Naphthalene also interacts with proteins and DNA, causing cell death. The molecular mechanisms of naphthalene's antibacterial activity are not well understood but have been studied using Hl-60 cells, which are immortalized human monocytic leukemia cells. This study showed that naphthalene affects the cell cycle by inhibiting protein synthesis in bacteria through binding to ribosomes or by disrupting the dna replication process.

(S)-3',5'-Bis(trifluoromethyl)-1-phenethanol is a choline derivative that is used in the treatment of liver cancer. It has been shown to increase the permeability of cell membranes and to suppress the growth of tumor cells by inhibiting protein synthesis. (S)-3',5'-Bis(trifluoromethyl)-1-phenethanol can be used as a surfactant and a hydrophobic solvent for optimization of reaction parameters. This chemical also has been shown to be active against Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis, but not against Gram-negative bacteria such as Escherichia coli or Pseudomonas aeruginosa. The mechanism of this effect is mediated by chloride ions that act as bioreductive agents on cellular membranes, leading to increased permeability and cell death.

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Valeric acid is a fatty acid that is used in the manufacture of polymers. Valeric acid can be synthesized from caproic acid, which is found in palm oil and coconut oil. Valeric acid has been shown to inhibit the activity of nicotinic acetylcholine receptors at low concentrations and to have an inhibitory effect on the ryanodine receptor at high concentrations. Valeric acid also has a matrix effect on analytical methods such as gas-liquid chromatography, which has been modeled using polymer compositions.

Please enquire for more information about Vitamin B12 c-lactone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Codeine Impurity F is a biochemical that is an impurity of codeine. Codeine Impurity F is a byproduct of the enzymatic reaction with morphine and the bacterial strain Pseudomonas putida. Codeine Impurity F has been shown to inhibit the growth of gram-negative bacteria, including Escherichia coli and Salmonella enterica, by binding to cellular membranes and inhibiting their function. It also binds to RNA in vitro and prevents translation of mRNA from its ribosome complex. The hydroxyl group on Codeine Impurity F binds to aluminium ions, which may interfere with the absorption of other drugs such as ampicillin or tetracycline. This impurity has been shown to have an effect on biological products such as immunoglobulins and albumin.

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Cinnamtannin B-1 is a cytosolic Ca2+ modulator that binds to and inhibits the activity of ATPases, which are enzymes that hydrolyze ATP. This causes an increase in intracellular Ca2+ levels, which leads to altered cell physiology. Cinnamtannin B-1 also inhibits mitochondrial membrane potential and enzyme activities. Cinnamtannin B-1 is a bioactive phytochemical found in cinnamon extract, which has been shown to have anti-obesity effects due to its ability to reduce the number of fat cells. Cinnamtannin B-1 has been shown to inhibit 3T3-L1 preadipocyte differentiation by targeting proteins such as procyanidins.

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Ropivacaine Related Compound A is a chemical compound that has not been fully characterized. It is an inhibitor of the enzyme P-hydroxybenzoic acid, which is involved in the synthesis of tyrosine and phenylalanine. Ropivacaine Related Compound A has shown to be potent inducers of the enzyme polymerase chain reaction (PCR) when combined with other chemicals such as potassium peroxydisulfate. The optimum concentration for this chemical compound to inhibit PCR reactions is 50 mM. Ropivacaine Related Compound A may have carcinogenic potential due to its ability to form p-hydroxybenzoic acid and other carcinogenic compounds. This chemical compound has been found to be a good candidate for wastewater treatment due to its low potency and high solubility in water.

5-Deazariboflavin is a proton carrier that is found in the mitochondrial cytochrome b. It has been shown to bind covalently to the protein, forming 5-deazariboflavin-protein adducts. These adducts are formed by reacting with amines and other amino acids present in the protein. In vitro studies have shown that 5-deazariboflavin inhibits Mycobacterium avium growth and acid production by binding to the enzyme pyruvate kinase, which is involved in glycolysis. 5-Deazariboflavin can also be used as an indicator of pH because it is reduced at low pH levels and oxidized at high pH levels. The second order rate constant for this reaction can be determined using kinetic data, such as absorbance or fluorescence properties.

3-Hydroxy-3-methylglutaric acid is an organic acid that is a valuable intermediate in the chemical production of epidermal growth factor. 3-Hydroxy-3-methylglutaric acid also has been shown to be useful as a reagent for the detection of bacterial strains, including E. coli, Salmonella enterica, and Pseudomonas aeruginosa. The enzyme activities of 3-hydroxy-3-methylglutaric acid are not well understood, but it has been shown to have effects on congestive heart failure and bowel disease. 3-Hydroxy-3-methylglutaric acid may be used in the treatment of inflammatory bowel disease due to its ability to inhibit certain enzymes responsible for inflammation and pain. The long term toxicity and symptoms associated with 3-hydroxy-3-methylglutaric acid have not yet been studied, but it has been shown to have no effect on cardiac function

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L-Tyrosine dipotassium salt is a high quality, reagent, complex compound, useful intermediate and fine chemical. It is a useful scaffold that can be used in the synthesis of various important natural products. L-Tyrosine dipotassium salt is a versatile building block that has been widely applied in research on the development of new drugs, such as antiviral agents and antibiotics. L-Tyrosine dipotassium salt can act as a reaction component for many organic reactions. It also has applications in many areas such as medicine, food production, and environmental protection.

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