Antifúngicos

Applications Bisabolol Oxide B is a metabolite of (-)-α-Bisabolol. In the metabolic pathway was used Glomerella Cingulata, a pathogenic fungus. Bisabolol Oxide A and B are in the composition of chamomile flower.
References Hoelzl, J., et al.: J. Biosci., 30, 853 (1975); Gibson, S.E., et al.: Org. Biomol. Chem., 1, 676 (2003);

Applications Difluocortolone is used as a topical therapy in the treatment of pediatric tinea corporis; a common mycotic infection in children.
References Veraldi, S., et al.: J. Dermatol. Treat., 29, 200 (2018)

Applications Methyl 2-Cyano-2-oximinoacetate is an intermediate in synthesizing 2-Cyano-2-(methoxyimino)acetic Acid (C989423), which is a cyano-oxime derivative used as a fungicide.
References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)

Applications Used in the synthesis of new 5-nitroimidazoles as potential antibacterial drugs via VNS procedure.
References Cudmore, S., et al.: Clin. Microbiol. Rev., 17, 783 (2004), Upcroft, J., et al.: Antimicrob. Agents Chemother., 50, 344 (2006),

Applications Potassium Pentathionate Sesquihydrate is potassium salt of Pentathionic acid which is the fungicidal factor of sulfur..
References Young, H., et al.: Science, 67, 19 (1928)

Applications Rhein 8-Glucoside has been seen to exhibit cytotoxic and DNA-damaging properties towards tumor and normal human cells. In addition it has been shown to be an inhibitor of PTP1B (Human Protein Tyrosine Kinase 1B) in vitro. It is an analog of Rhein (R318500) which is found in the free state and as glucoside in Rheum spp, Polygonaceae (rhubarb) and in Senna leaves. It is a potential antioxidant resource: endophytic fungi from medicinal plants.
References Wanitschke, Pharmacology, 20, Suppl. 1, 21 (1980); Raimondi, L., et al.: Pharmacol. Res. Commun., 14, 103 (1982); Franchi-Micheli, S., et al.: J. Pharm. Pharmacol., 35, 262 (1983); Li, S. et al.: J. Asian Nat. Prod. Res., 8, 281 (2006); Shi, Y.Q. et al.: Anticancer. Res., 21, 2847 (2001);

Applications R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).
References Borge, M. et al.: J. Immunol., 193, 3165 (2014); Kimura, Y. et al.: J. Biol. Chem., 289, 31565 (2014);

Applications Cyrene is a novel bio-based green solvent used in polymerization reactions. Byproduct in the synthesis of levoglucosenone fungicidal agent.
References Sharipov, B. et al.: Chem. Hetero. Comp., 55, 31 (2019); Marino, T. et al.: J. Membrane Sci., 580, 224 (2019);

Impurity Ipratropium EP Impurity C
Applications Tropic Acid (Ipratropium EP Impurity C) is a benzoic acid derivative and thus carries anti-fungal properties.
References Amborabe, B.E. et al.: Plant. Phys. Biochem., 40, 1051 (2002);

Applications (±)-α-Fenchol is found in essential oils from many plants. It has been studied for, insecticidal activity of essential oil from Helichrysum faradifani; antioxidant and antibacterial activity of essential oils from rhizome, leaf and stem of Etlingera sayapensis against growth of Bacillus subtilis, Escherichia coli and Candida albicans.
References Benelli G., et al., Nat. Prod. Res., 32, 690-1698 (2018); Mahdavi B., et al., Asian. Pac. J. Trop. Med., 10, 819-826 (2017)