Protacs e Impurezas

PROTAC AR Degrader-4: IAP ligand, linker, AR binder; it's a SNIPER that degrades AR non-genetically.

PROTAC PIN1 degrader-1, a targeted PROTAC for PIN1, effectively degrades PIN1 protein in MDA-MB-468 triple-negative …

DZ-837 is a PROTAC that targets the BCL6 protein. The composition of DZ-837 includes the …

PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target …

Compound 6C, a PROTAC degrader, targets CYP1B1 with IC50s (95.1 nM CYP1B1, 9838.6 nM CYP1A2) …

ACBI2: potent, oral VHL PROTAC, EC50=7nM; degrades SMARCA2, DC50=1nM in RKO cells; for lung cancer …

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.

SHP2-D26: potent SHP2 degrader binding VHL-1/SHP2, neddylation & proteasome-dependent.

CMP98, a PROTAC, fails to degrade VHL; useful as CM11 negative control; contains two active …

MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations …

U7D-1: First-class USP7 PROTAC degrader, DC50 33 nM, anticancer, induces apoptosis in Jeko-1.

Potent cereblon degrader with a DC50 of 1.5 nM, fully degrades cereblon in MM1S cells; …

MD-222: a first-in-class, highly potent PROTAC that degrades MDM2, activates p53, and exhibits anticancer properties.

PROTAC STING Degrader-1 (Compound SP23) is a STING-targeted PROTAC degrader exhibiting a DC50 of 3.2 …

INY-03-041 trihydrochloride: potent, selective PROTAC AKT degrader; combines Ipatasertib and Lenalidomide; IC50s: AKT1 (2.0 nM), …

PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon …

PP-C8: PROTAC CDK12-Cyclin K degrader with DC50s 416/412 nM; synergizes with PARP inhibitor against TNBC.

PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP …

Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM …

MS170, specific PROTAC AKT degrader, potent with DC 50 of 32 nM, binds AKT1/2/3 with …