Esteróides

Dihydroformononetin is an isoflavonoid phytoestrogen, which is a type of naturally occurring compound found primarily in leguminous plants. It is derived from plant sources such as red clover and soybeans, known for their rich isoflavone content. This compound undergoes metabolic conversion in plants and potentially in the human body, exerting effects through interactions with estrogen receptors.

<p>Phytosterol with anti-osteoarthritic activity; inhibits cholesterol biosynthesis</p>

<p>Hydrocortisone acetate is a synthetic corticosteroid, which is a product derived from the modification of natural adrenal cortex hormones. It functions as an anti-inflammatory and immunosuppressive agent through its interaction with glucocorticoid receptors, leading to the modulation of gene expression involved in immune and inflammatory responses. This interaction inhibits the release of pro-inflammatory mediators and reduces the permeability of capillaries, thereby diminishing inflammation and immune activity.</p>

<p>Periplogenin is a compound classified as a cardiac glycoside, which is typically derived from certain plant species such as those in the Apocynaceae family. These compounds are known for affecting the heart by influencing cellular ion transport mechanisms. The primary mode of action of periplogenin involves inhibition of the Na⁺/K⁺-ATPase pump. This inhibition leads to an increased intracellular concentration of sodium ions, which indirectly increases intracellular calcium levels via the sodium-calcium exchanger. The elevated calcium concentration enhances cardiac muscle contractility, a mechanism often leveraged in treating certain heart conditions.</p>

<p>Pseudoprotodioscin is a bioactive saponin compound, which is primarily derived from various plant sources, including members of the genus Tribulus. The compound is part of a larger family of steroidal saponins known for their diverse biological activities. Its mode of action includes influencing cellular pathways through modulation of enzyme activity and interaction with steroid hormone receptors, contributing to its bioactivity.</p>

<p>Beclomethasone dipropionate is a synthetic corticosteroid, which is derived from beclomethasone, a glucocorticoid steroid. Its mode of action involves binding to specific intracellular glucocorticoid receptors. This binding modulates the transcription of glucocorticoid-responsive genes, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory cytokine production. This reduces airway inflammation, edema, and mucus production, and enhances the responsiveness of beta-adrenergic receptors in the bronchial smooth muscle, facilitating bronchodilation.</p>

Betamethasone 21-phosphate disodium is a synthetic glucocorticoid, which is a man-made analog of naturally occurring steroid hormones produced in the adrenal cortex. Its molecular structure allows for enhanced potency and solubility, making it highly effective for use in various clinical settings. As a glucocorticoid, Betamethasone 21-phosphate disodium functions by binding to glucocorticoid receptors, regulating the expression of anti-inflammatory proteins, and inhibiting the production of pro-inflammatory cytokines. This mechanism of action reduces inflammation and suppresses the immune response, making it valuable in the treatment of conditions that involve excessive inflammation. It is commonly used in the management of conditions such as allergic reactions, certain types of arthritis, and skin diseases. Its ability to rapidly modulate inflammatory pathways also makes it useful in emergency settings for conditions like acute asthma exacerbations and severe allergic reactions. As a water-soluble ester, it allows for diverse administration routes, including oral, intravenous, and topical applications, depending on the clinical requirement.

<p>Prednisolone is a synthetic corticosteroid, which is a derivative of the natural hormone cortisol. It is derived from the modification of the corticosteroid structure to enhance its anti-inflammatory and immunosuppressive properties. The mode of action of prednisolone involves binding to glucocorticoid receptors, leading to the modulation of gene expression. This results in the suppression of pro-inflammatory cytokines and the inhibition of various immune responses.</p>

Gracillin is a steroidal saponin, which is a bioactive compound derived from the plant genus Dioscorea. This natural product is characterized by its complex glycoside structure, where a sugar moiety is attached to a steroid-like aglycone. The mode of action of Gracillin involves its interaction with cellular membranes, leading to increased cell membrane permeability. This action is thought to disrupt normal cellular functions, making it a compound of interest for studying membrane dynamics.

Bufalin is a bufadienolide compound, which is a type of steroid derived primarily from toad venom, specifically from the skin and parotid venom glands of the toad species Bufo gargarizans. Its mode of action involves the inhibition of Na+/K+-ATPase, an enzyme critical for maintaining the electrochemical gradient across cell membranes. By disrupting this gradient, Bufalin affects cellular ion homeostasis and induces apoptosis in various cancer cell lines.

<p>Equilenin is a steroidal estrogen, which is a type of naturally occurring hormone. It is derived primarily from the urine of pregnant mares and belongs to the class of conjugated equine estrogens. In terms of its mode of action, equilenin functions by binding to estrogen receptors in various tissues, thereby modulating gene expression and influencing cellular activity. This interaction supports the management of estrogen deficiencies in postmenopausal women and can influence the regulation of certain metabolic processes.</p>

Ent-Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-ent-fisetinidol is a complex flavan-3-ol oligomer, which is a type of polyphenolic compound commonly found in various plant species. This compound is derived primarily from plants such as those in the genus *Acacia* and other similar species rich in condensed tannins. The mode of action of this oligomer involves its ability to engage in antioxidant activities, which include scavenging free radicals and chelating metal ions that facilitate oxidative stress in biological systems.

<p>Please enquire for more information about Erizimoside including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Segesterone is a synthetic progestin, which is a chemically engineered hormone analogue. It is synthesized from steroid precursors, specifically designed to mimic the naturally occurring hormone progesterone. Segesterone acts primarily through binding to progesterone receptors, exerting its effects by modulating gene expression related to reproductive processes. This mechanism inhibits ovulation, alters cervical mucus to prevent sperm penetration, and modifies the endometrial lining to reduce the likelihood of implantation.

7-Dehydrostigmasterol is a phytosterol, which is a type of steroid alcohol derived from plant sources, particularly within the metabolic pathway of various sterols. This compound acts as an intermediate in the biosynthesis of other phytosterols, functioning within key enzymatic conversion processes that are part of the larger sterol metabolic network.

<p>Betamethasone enol aldehyde Z isomer is a synthetic corticosteroid, which is derived from modifications of the naturally occurring glucocorticoid, cortisol. Its structure has been altered to enhance anti-inflammatory and immunosuppressive potency. As a Z isomer, it exhibits specific stereochemistry, potentially affecting its pharmacokinetics and interactions at the molecular level.</p>

<p>Formononetin is a naturally occurring isoflavone, which is a type of phytoestrogen found predominantly in legumes like red clover and other related plant species. It is a secondary metabolite that influences various biological processes by interacting with estrogen receptors. Formononetin acts primarily by mimicking or modulating the activity of natural estrogens within the body, binding to estrogen receptors and influencing gene expression and cellular responses.</p>

Pabulenol is an innovative biopolymer, which is synthesized from renewable plant-based resources through advanced biotechnological methods involving enzymatic polymerization. With its unique molecular structure, Pabulenol exhibits specific mode of action by facilitating biodegradation under ambient conditions, catalyzed by naturally occurring microbes. The polymer’s intrinsic ability to break down into non-toxic byproducts makes it an exceptional choice for sustainable environmental applications.

<p>Phytoestrogen with anti-cancer properties</p>

<p>Brassicasterol is a phytosterol, which is synthesized by various plant sources, particularly found in the seeds of plants such as rapeseed, mustard, and some algae. As a sterol, it is structurally similar to cholesterol but differs by having a methyl group at C24. This characteristic structure plays a vital role in its mode of action, modulating membrane fluidity and cell signaling pathways in organisms. In mammalian systems, brassicasterol may contribute to the reduction of cholesterol absorption by competing for incorporation into micelles, thus influencing metabolic pathways related to lipid processing and absorption.</p>

<p>DHED is a neuroactive steroid precursor, specifically a bioprecursor prodrug of estradiol, which is derived from chemical synthesis pathways. It is unique in its targeted mode of action, as it selectively converts to the active hormone estradiol within the brain via enzymatic processes that occur in situ. This specificity is facilitated by 17β-hydroxysteroid dehydrogenase type 1, which catalyzes the conversion of DHED to estradiol exclusively in the brain, minimizing peripheral estrogenic effects.</p>

Cortisone acetate is a synthetic corticosteroid, which is a derivative of cortisone, a naturally occurring hormone produced by the adrenal cortex. As a pharmaceutical compound, cortisone acetate acts primarily as an anti-inflammatory and immunosuppressive agent. Its mode of action involves the conversion into cortisol, a glucocorticoid, which then interacts with glucocorticoid receptors to modulate the transcription of responsive genes. This process reduces the production of pro-inflammatory cytokines and inhibits the function of immune cells, thereby producing an anti-inflammatory effect.

<p>Composed of Lanosterol (~65%), dihydrolanosterol, agnosterol,dihydroagnosterol.Extracted from wool.</p>

<p>Pregnenolone acetate is a synthetic compound classified as a steroidal hormone precursor. It is derived from pregnenolone, which is a naturally occurring steroid hormone in the body. Pregnenolone is primarily synthesized from cholesterol, a fundamental component upon which steroidogenesis is based. The acetate form is an ester derivative, which can enhance stability and bioavailability.</p>

<p>9,10-Secocholesta-5,7,10(19)-trien-3beta-ol is a secosteroid compound, which is predominantly derived from the photochemical conversion of 7-dehydrocholesterol in the skin upon exposure to ultraviolet B radiation. This compound undergoes a series of hepatic and renal hydroxylations to form active vitamin D metabolites, such as calcitriol. These active forms modulate calcium and phosphate homeostasis through a nuclear receptor-mediated mechanism that governs gene expression relevant to mineral metabolism.</p>

Please enquire for more information about Teasterone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cholesterol is a complex lipid molecule, which is an essential component of cell membranes in animals. It is primarily synthesized in the liver, though it can also be obtained from dietary sources such as meat, dairy, and eggs. Cholesterol's mode of action involves its incorporation into the phospholipid bilayer of cell membranes, where it modulates fluidity and structural integrity, impacting membrane protein function and cellular signaling pathways.

<p>Saponins are naturally occurring glycosides, which are compounds sourced primarily from various plant species, including legumes, herbs, and certain vegetables. These compounds are characterized by their unique structure, comprising a hydrophobic aglycone linked to hydrophilic sugar moieties. This dual nature endows saponins with surfactant-like properties, allowing them to interact with both hydrophilic and hydrophobic molecules.</p>

<p>Uzarigenin is a steroidal sapogenin, which is a naturally derived chemical compound typically extracted from plants belonging to the Apocynaceae family. It is primarily sourced from species like *Cynanchum* and *Xysmalobium*, where it exists as part of glycosidic complexes. The mode of action of uzarigenin involves its interaction with cellular steroid pathways, providing insights into various biological processes involving steroidal regulation and interaction. Such properties make it valuable in the study of steroid biosynthesis and the pharmacodynamics of cardiotonic steroids.</p>

Promegestone is a synthetic progestogen, which is derived from progesterone. It functions by mimicking the effects of natural progesterone in the body, acting primarily on progesterone receptors to modulate reproductive processes. This progestogenic agent alters the lining of the uterus and inhibits gonadotropin production, thereby exerting its effects on ovulation and menstrual cycles.

<p>Zuclomiphene is a selective estrogen receptor modulator (SERM), which is derived from clomiphene citrate, a mixture containing two isomers, zuclomiphene and enclomiphene. Zuclomiphene acts by binding to estrogen receptors, exhibiting both estrogenic and anti-estrogenic effects depending on the target tissue. This dual action makes it a valuable tool in modulating estrogen receptor activity for scientific research.</p>

<p>Cholesterol 3-sulfate sodium salt is a fine chemical that is used as a versatile building block and reagent. It is a useful intermediate that can be used in the synthesis of complex compounds, speciality chemicals, and reaction components. Cholesterol 3-sulfate sodium salt can be used to synthesize cholesterol derivatives. This compound has been shown to have high reactivity with nucleophiles and can be used as a building block for other organic compounds. The CAS number for Cholesterol 3-sulfate sodium salt is 2864-50-8.</p>

<p>Epibrassinolide is a plant growth regulator, which is a synthetic analog of brassinosteroids derived from natural plant steroids. It exerts its effects through modulating gene expression and activating signaling pathways that enhance cell elongation, division, and differentiation. Additionally, Epibrassinolide plays a crucial role in improving a plant's tolerance to environmental stresses such as drought, salinity, and temperature extremes. It is widely used in agricultural research and practices to boost crop yield and quality. Researchers apply Epibrassinolide to study its potential in promoting growth, increasing resistance to pathogens, and enhancing overall plant vitality. Its applications extend to various plant species, where it is utilized to explore genetic expressions and physiological adaptations in response to its regulatory effects.</p>

Coumestrol-9-methyl ether is a synthetic estrogen analogue, which is derived from coumestrol, a naturally occurring phytoestrogen found in various plant sources such as soybeans and clover. This compound is synthesized through chemical modification to enhance its stability and bioactivity, differing from its naturally occurring counterpart by the addition of a methyl group.

<p>Protodioscin is a steroidal saponin, which is a naturally occurring glycoside. It is predominantly sourced from the plant Tribulus terrestris but can also be found in other medicinal plants such as Dioscorea species. The mode of action of protodioscin involves its ability to influence the levels of dehydroepiandrosterone (DHEA) and other hormones, potentially affecting physiological functions related to vitality and performance.</p>

Pregnenolone is a steroidal hormone precursor, which is synthesized from cholesterol in the mitochondria of adrenal glands and other tissues. Its mode of action involves serving as a precursor for other critical steroid hormones, including progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As a neurosteroid, it plays a significant role in modulating synaptic function and neurogenesis.

<p>Coumestrol is a phytoestrogen compound, which is a naturally occurring compound found in a variety of plants, such as soybeans, clover, and alfalfa. It is derived from the metabolic processes within these plants. Coumestrol exhibits estrogenic activity, acting as an agonist for estrogen receptors. This biological activity enables coumestrol to mimic the action of endogenous estrogens, thereby influencing estrogen-responsive pathways.</p>

<p>Betamethasone is a synthetic corticosteroid, which is an analogue of a glucocorticoid sourced from adrenal cortex hormones. Its mode of action involves modulating the immune response by inhibiting the release of substances in the body that cause inflammation. This is achieved through its binding affinity to glucocorticoid receptors, leading to transcriptional changes that suppress pro-inflammatory cytokine production and other mediators of inflammation.</p>

<p>Polyphyllin B (Formosanin C) is a natural saponin compound, which is derived from the rhizomes of plants in the genus Paris, particularly Paris polyphylla. Known for its biological activity, Polyphyllin B functions primarily by disrupting cellular membranes and inducing apoptosis in cancer cells through various signaling pathways, including the mitochondrial pathway. This mechanism is attributed to its ability to interfere with cancer cell proliferation and promote cell death, making it a compound of interest in oncological research.</p>

<p>Applications 4,4,4-Trimethoxybutanoic Acid Methyl Ester is an substituent in the synthesis of Methyl Prednisolone (M325934).<br>References Ueno, H., et al.: J. Med. Chem., 34, 2468 (1991);<br></p>

<p>Impurity Ethinylestradiol EP Impurity H<br>Applications A degradation product of Ethynyl Estradiol (EE), (E685100).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Halcinonide is a potent topical corticosteroid, which is a synthetically derived compound from hydrocortisone. It operates by penetrating the cell membranes and binding to cytoplasmic receptors, leading to a subsequent translocation to the nucleus where it modulates genetic expression. This action results in diminished synthesis of pro-inflammatory cytokines, thereby exerting strong anti-inflammatory, antipruritic, and vasoconstrictive effects.</p>

Lanosterol - 90% is a sterol compound, which is a biochemical precursor to steroids. It is derived from various animal and plant sources, typically synthesized through the enzymatic conversion of squalene. Lanosterol functions through a significant role in the biosynthetic pathway of cholesterol and other essential sterols. This involves the cyclization process, where lanosterol is metabolized into cholesterol through a series of reactions catalyzed by specific enzymes.

<p>8'-Hydroxyformononetin is a phytoestrogen compound, which is derived from plant sources, particularly from legumes, including red clover and soy. As a naturally occurring isoflavone, it falls within the class of flavonoids, a group of polyphenolic compounds with varied biological activities. Its mode of action primarily involves binding to estrogen receptors, where it can mimic or modulate the action of estrogen in the body. This interaction can result in either estrogenic or anti-estrogenic effects, depending on the presence of endogenous estrogen and other factors within the target tissues.</p>

<p>Plant hormone</p>

<p>24-epi-Castasterone is a brassinosteroid, which is a class of plant steroids, often extracted from various plant tissues synthesized in small quantities. This compound is primarily derived from plant sources such as seeds, pollen, and young vegetative tissues. It functions by binding to specific receptor kinases on plant cell membranes, thereby initiating a cascade of intracellular signaling that regulates gene expression. These pathways are crucial for the modulation of plant growth and development processes.</p>

<p>Stability Hygroscopic<br>Applications Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling.<br>References Torossian, D.R., et al.: Arzneim.-Forsch., 31, 453 (1981),<br></p>

<p>Applications 4-Methoxy-17beta-estradiol-1,2,16,16,17-d5 is a useful isotopically labeled compound of 4-Methoxy 17β-Estradiol (M262630)<br></p>

<p>Applications 10β-Hydroperoxy Norethindrone Acetate is a derivative of Norethindrone (N676000), a progesterone in combination with acetate used as an oral contraceptive (1,2). It is reasonably anticipated to be a human carcinogen.<br>References 1. Shroff, A. et al.: Anal. Profiles Drug Subst. 1975 ; 4;268-293;<br></p>

<p>Applications 3β-Hydroxy Progesterone is a biotransformation product of Progesterone (P755900), by Chlorella spp. Progesterone is a steroid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer<br>References Pollio, A., et al.: Phytochem., 42, 685 (1996); Anderson, E., et al.: Breast Cancer Res., 4, 197 (2002); Lanari, C., et al.: Breast Cancer Res., 4, 240 (2002); Albrecht, E.D., et al.: Front. Biosci., 8, 416 (2003); Qiu, M., et al.: J. Steroid Biochem. Mol. Biol., 85, 147 (2003);<br></p>

<p>Applications 11,12-Dehydroxy-Betamethasone is an impurity of the steroid Betamethasone (B327000) which is a glucocorticoid used as an anti-inflammatory agent.<br>References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),<br></p>

<p>Applications The minor metabolite of Deflazacort.<br>References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),<br></p>

<p>Impurity Fulvestrant Impurity E;<br>Applications Fulvestrant (F862500) impurity E.<br></p>

<p>Stability Hygroscopic<br>Applications A degradation product of Betamethasone (B327000).<br>References Andersson, P., et al.: J. Pharm. Pharmacol., 36, 763 (1984), Wurthwein, G., et al.: Biopharm. Drug Dispos., 11, 381 (1990), Samtani, M., et al.: J. Pharm. Sci., 93, 726 (2004), Samtani, M., et al.: Drug Metab. Dispos., 33, 1124 (2005),<br></p>

<p>Applications Progesterone (P755900) impurity.<br>References Liang, T., et al.: Biol. Chem., 256, 7998 (1981), Bratoeff, E., et al.: J. Steroid Biochem. Mol. Biol., 111, 275 (2008),<br></p>

<p>Impurity Fluocinolone Acetonide EP Impurity I<br>Applications 14,15-Dehydro Fluocinolone Acetonide is an impurity of Fluocinolone Acetonide (F455800); a glucocorticoid and anti-inflammatory agent.<br>References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964); Emerson, M.V., et al.: BioDrugs, 21, 245 (2007)<br></p>

<p>Applications Sitostanol-d7 is a compound useful in organic synthesis.<br></p>

<p>Impurity Beclometasone Dipropionate EP Impurity C<br>Applications An impurity of Beclomethasone Dipropionate (B131030).<br></p>

<p>Applications 17beta-Dihydroequilin-2,4,16,16,17-d5 is a useful isotopically labeled compound of 17β-Dihydro Equilin (D449130)<br></p>

<p>Applications Tauro-d4-cholic Acid Sodium Salt is a useful isotopically labeled compound of Sodium Taurocholate (S080848)<br></p>

<p>Applications 3β-Dihydroxy-19-norandrost-5(10)-ene is an intermediate in the synthesis of 3β,17β-Dihydroxy-19-norandrost-5(10)-ene (D453800), which is a metabolite of Androstenedione. A novel 19-norsteroid, from androstenedione and 19-hydroxyandrostenedione by cultured porcine granulosa cells is reported for the first time.<br>References Haarbo, J., et al.: Clin. Physiol., 11, 331 (1991), Krebs-Smith, S., et al.: Eur. J. Clin. Nutr., 54, 281(2000), Rasmussen, B., et al.: J. Clin. Endocrinol. Metab., 85, 55 (2000),<br></p>

<p>Applications 7,7-Azo-3-α,12-α-dihydroxycholanic Acid (cas# 86992-52-1) is a compound useful in organic synthesis.<br></p>