Ligações cruzadas de DNA
Foram encontrados 617 produtos de "Ligações cruzadas de DNA"
Procarbazine hydrochloride
CAS:Fórmula:C12H19N3O·HClPureza:98.0 - 102.0 % (dried basis)Cor e Forma:White to off-white powderPeso molecular:257.76Bendamustine hydrochloride
CAS:Fórmula:C16H21Cl2N3O2·HCl·xH2OPureza:≥ 98.0%Cor e Forma:White to yellow crystalline powderPeso molecular:394.72 (anhydrous)cis-Dichlorodiamine platinum(II); 99.95% (metals basis)
CAS:Fórmula:Pt(NH3)2Cl2Pureza:≥ 99.95%Cor e Forma:Yellow to orange powder or crystalsPeso molecular:300.06Fluorescein 5-Maleimide (90%)
CAS:Produto ControladoApplications Fluorescent labeling reagent for proteins and peptides.
References Vives, E. and Lebleu, B. : Tetrahedron Letters, 44, 5389 (2003), Li, J., et al.: Bioorg. Med. Chem. Lett., 15, 5558 (2005), Oejmeyr, L., et al.: Biochemi., 48, 2173 (2009),Fórmula:C24H13NO7Pureza:90%Cor e Forma:NeatPeso molecular:427.362-(Triethylammonium)ethyl Methanethiosulfonate Bromide
CAS:Produto ControladoStability Water Sensitive
Applications A water soluble, bulkier analogue of the charged MTS reagent MTSET. Charged MTS reagents have been used successfully with SCAM (substituted cysteine accessibility method) to probe the topology and function of a number of ligand-gated ion channels and transporter proteins.Fórmula:C9H22BrNO2S2Cor e Forma:NeatPeso molecular:320.31(2S,2’S,5S)-5-Hydroxy Lysinonorleucine
CAS:Stability Hygroscopic
Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.
References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),Fórmula:C12H25N3O5Cor e Forma:Light Orange to Brown SolidPeso molecular:291.34S-[2-(4-Azidosalicylamido)ethylthio]-2-thiopyridine
CAS:Produto ControladoFórmula:C14H13N5O2S2Cor e Forma:NeatPeso molecular:347.424-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid Salt
CAS:Produto ControladoApplications A sulfhydryl and carbohydrate reactive, heterobifunctional crosslinking reagent. Glycoprotein reactive.
References Yoshitake, S., et al.: Eur. J. Biochem., 101, 395 (1979), Chamow, S.M., et al.: J. Biol. Chem., 267(22), 15916 (1992)Fórmula:C12H17N3O3·C2HF3O2Cor e Forma:NeatPeso molecular:365.3Deoxypyridinoline Chloride Trihydrochloride Salt
CAS:Produto ControladoStability Hygroscopic
Applications Deoxypyridinoline Chloride Trihydrochloride Salt a collagen cross-links agent. A primary reference material for the monitoring of bone metabolism.
References Heaney, R., et al.: J. Bone Miner. Res., 5, 1135 (1990), Hannon, R., et al.: J. Bone Miner. Res., 13, 1124 (1998), Coudray, C., et al.: Eur. J. Nutr., 42, 91 (2003), Abrams, S., et al.: Am. J. Clin. Nutr., 82, 471 (2005),Fórmula:C18H28N4O7·HClCor e Forma:NeatPeso molecular:448.899N-Biotinylcaproylaminocaproylaminoethyl Methanethiosulfonate
CAS:Produto ControladoStability Moisture Sensitive
Applications Reacts specifically and rapidly with thiols to form mixed disulfides. Used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease.
References Wagner, D.A.and Czajkowski, C.: J. Neurosci., 21, 67 (2001), Traebert, M.: J. Membr. Biol., 180, 83 (2001)Fórmula:C25H45N5O6S3Cor e Forma:NeatPeso molecular:607.85Benzophenone-4-carboxamidoethyl Methanethiosulfonate
CAS:Fórmula:C17H17NO4S2Cor e Forma:NeatPeso molecular:363.45Lomustine - Bio-X ™
CAS:Lomustine is an alkylating agent that is used as chemotherapy for treating metastatic brain tumors and relapsed Hodgkin’s disease in combination with radiation treatments. This drug causes alkylation and cross-linking of DNA, thus inducing cytotoxicity. Furthermore, this drug inhibits DNA synthesis.
Fórmula:C9H16ClN3O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:233.7 g/molProcarbazine HCl - Bio-X ™
CAS:Procarbazine is an alkylating agent used in chemotherapy to treat brain cancer and Hodgkin's lymphoma. It methylates guanine in DNA which causes the strands to become prone to breakage, thus inhibiting both DNA and RNA synthesis. The drug has been shown to be effective in vitro against a variety of human carcinoma cell lines.Fórmula:C12H20ClN3OPureza:Min. 95%Cor e Forma:PowderPeso molecular:257.76 g/molCarmustine - Bio-X ™
CAS:Carmustine is a DNA alkylating agent which also cross-links DNA. As a result, Carmustine disrupts the function of DNA, resulting in the arrest the cell cycle and apoptosis. Consequently these properties of Carmustine, in addition to its ability to easily transmit through the blood-brain barrier, means it can be used as a cancer treatment, treating cancers such as, breast, ovarian and pancreatic as well as lymphomas and leukemias. Furthermore Carmustine can contribute to cytotoxic effects through its ability to carbamoylate DNA repair enzymes and proteins.Fórmula:C5H9Cl2N3O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:214.05 g/molTemozolomide - Bio-X ™
CAS:Temozolomide is an imidazotetrazine alkylating agent. It has anti-tumor activity against a broad spectrum of tumors, such as leukemias, lymphomas and solid tumors. Temozolomide induces G2/M arrest, preventing cells from entering mitosis and, therefore, apoptosis. As a drug resistance-modifying agent it is used for studying drug resistance mechanisms in glioblastoma cell lines.
Fórmula:C6H6N6O2Pureza:Min. 98 Area-%Cor e Forma:White To Pale Pink SolidPeso molecular:194.15 g/molBendamustine HCl - Bio-X ™
CAS:Bendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite properties. An alkylating group, a benzimidazole ring that may function as a purine analog, and a butyric acid side chain are the three active moieties found in bendamustine. Through its function as an alkylating agent, Bendamustine causes intra and inter-strand crosslinks between DNA bases resulting in DNA, RNA synthesis inhibition and cell death.Fórmula:C16H21Cl2N3O2•HClPureza:Min. 95%Cor e Forma:PowderPeso molecular:394.72 g/molIfosfamide - Bio-X ™
CAS:Ifosfamide is an alkylating agent and immunosuppressive drug used in chemotherapy for the treatment of various cancers such as ovarian, testicular, cervical and bladder. This drug interferes with the normal process of DNA replication causing damage to the DNA in cancer cells hence preventing them from growing and dividing.Fórmula:C7H15Cl2N2O2PPureza:Min. 95%Cor e Forma:PowderPeso molecular:261.09 g/molMitomycin C - Bio-X ™
CAS:Mitomycin C is a cytotoxic agent that belongs to the class of mitomycins. It has been used for the treatment of a range of cancers and for ocular surface diseases, such as the glaucoma surgery trabeculectomy. In this case it is administered to reduce post-operative scarring which could otherwise lead to failure of the procedure. Mitomycin C is an alkylating antibiotic that inhibits DNA synthesis by cross-linking the DNA double helix. Mitomycin C also stimulates the production of transforming growth factor β1 (TGF-β1) and basic fibroblast growth factor (bFGF). Clinically, mitomycin can be used both intravenously and topically, and has been studied in a range of wound healing models.Fórmula:C15H18N4O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:334.33 g/molMelphalan hydrochloride
CAS:Nitrogen mustard derivative; DNA crosslinking agent; anti-cancer agentFórmula:C13H18Cl2N2O2·HClPureza:Min. 95%Cor e Forma:PowderPeso molecular:341.66 g/mol
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