Açúcares e Nucleobases da Espinha Dorsal
Os açúcares da espinha dorsal e as bases nitrogenadas são componentes essenciais dos ácidos nucleicos, como o DNA e o RNA. A espinha dorsal é composta por grupos de açúcar e fosfato, enquanto as bases nitrogenadas formam o código genético por meio do pareamento de bases. Esses compostos são cruciais no estudo da genética e da biologia molecular. Na CymitQuimica, você encontrará uma variedade de açúcares da espinha dorsal e bases nitrogenadas para pesquisa e uso laboratorial.
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1,3-Dipropylxanthine
CAS:Produto Controlado1,3-Dipropylxanthine is a congener of caffeine. It is a nonselective adenosine receptor antagonist that binds to the adenosine receptors in the kidney. 1,3-Dipropylxanthine has been shown to increase renal blood flow and increase urine output. This drug may be used as a mobilisation agent for patients who are bedridden or have limited mobility. It should not be given to patients with heart disease or high blood pressure. 1,3-Dipropylxanthine has also been shown to inhibit the binding of pyrimido [1,2-a]benzimidazole (PPIM) and furyl derivatives to the adenosine receptor.Fórmula:C11H16N4O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:236.27 g/mol5-Iodocytosine
CAS:5-Iodocytosine (5-IC) is an analog of cytosine that can be used as a precursor for the synthesis of thymine. 5-IC has been shown to cross-couple with DNA, which may contribute to its antiviral potency. 5-IC is also a potent inhibitor of dna replication and herpes simplex virus. The biochemical properties of 5-IC have been extensively studied, including its ability to react with hydrochloric acid to form the corresponding tautomers. The hydrolysis rate increases at higher pH values and decreases at lower pH values. Bioconjugate chemistry has been applied to synthesize a bioconjugated prodrug of 5-IC for cancer treatment.
Fórmula:C4H4IN3OPureza:Min. 95%Cor e Forma:PowderPeso molecular:237 g/mol(R)-(+)-9-(2-Hydroxypropyl)adenine
CAS:(R)-(+)-9-(2-Hydroxypropyl)adenine (HPA) is a carbocyclic nucleoside that has been shown to be effective against the human immunodeficiency virus (HIV). HPA inhibits the reverse transcriptase and integrase enzymes, which are necessary for HIV replication. It also inhibits phosphorylation of host cell proteins, leading to decreased viral protein synthesis. The reaction yield of this compound is high and it can be industrially produced with a synthetic process. HPA is synthesized from adenosine by the addition of two hydroxyl groups on the adjacent carbon atoms. HPA has a low energy ring-opening reaction with hydrogen chloride, which leads to its potent inhibition of HIV infection.Fórmula:C8H11N5OPureza:Min. 95%Cor e Forma:PowderPeso molecular:193.21 g/mol5-Bromo-6-azauracil
CAS:5-Bromo-6-azauracil is a nucleophilic compound that can be used to treat wastewater. It is also able to lyse cells and has been used as an immobilizing agent. The reactive nature of 5-Bromo-6-azauracil enables it to undergo nucleophilic substitutions with amines, which are present in the cell wall and other biomolecules. This process results in the formation of amide bonds, which leads to the inhibition of protein synthesis. 5-Bromo-6-azauracil has shown inhibitory effects on glucans, which may be due to its ability to form covalent bonds with glucose molecules.Fórmula:C3H2BrN3O2Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:191.97 g/molFmoc-PNA-C(Bhoc)-OH
CAS:Fórmula:C39H35N5O8Pureza:>95.0%(qNMR)Cor e Forma:White to Light yellow powder to crystalPeso molecular:701.748-Azaadenine
CAS:8-Azaadenine is an analog of adenine that binds to the purine receptor in the cell membrane. It has been shown to inhibit the growth of bacterial strains, such as Klebsiella pneumoniae and Staphylococcus aureus, by targeting their DNA gyrase and topoisomerase IV. 8-Azaadenine has also been shown to have a high resistance to bacterial mutants resistant to other antibiotics. It has been found that the nitrogen atoms in 8-azaadenine are important for its biological properties. The optimum pH for this antibiotic is 7.4.Fórmula:C4H4N6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:136.12 g/mol8-Nitroguanine
CAS:8-Nitroguanine is a reactive cell factor that can be found in the skin and other tissues. It is an endogenous product of nitric oxide, which can be formed by the reaction of nitric oxide with superoxide in the presence of peroxynitrite. 8-Nitroguanine has been shown to inhibit matrix metalloproteinase-9 activity and to have a protective effect on cells from UV radiation. 8-Nitroguanine also has been shown to be a potential biomarker for bowel disease and damage. The levels of 8-nitroguanine increase in chronic viral hepatitis and cancer tissues. This compound can also be used as an analytical method for detection of inflammation, oxidative stress, or DNA damage.Fórmula:C5H4N6O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:196.13 g/mol7-Methylguanine
CAS:Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, topFórmula:C6H7N5OPureza:Min. 95 Area-%Cor e Forma:Slightly Brown PowderPeso molecular:165.15 g/molEritadenine
CAS:Eritadenine is a glycoside that has been found in the edible roots of plants belonging to the family Euphorbiaceae. Eritadenine is an inhibitor of malonic acid, which is a precursor for fatty acid synthesis. It has also been shown to have biological properties, such as inhibiting fat cell growth and reducing cholesterol levels in rats. Eritadenine can be detected with an analytical method that uses high-performance liquid chromatography coupled with a photodiode array detector. This method separates and identifies eritadenine from other compounds using polymerase chain reaction amplification on camp levels and sodium salts. Eritadenine can also be found in samples of liver cells or ethanolamine.Fórmula:C9H11N5O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:253.21 g/molAzathioprine
CAS:Fórmula:C9H7N7O2SPureza:>98.0%(T)(HPLC)Cor e Forma:Light yellow to Yellow to Green powder to crystalPeso molecular:277.265-Trifluorothymine
CAS:Intermediate in the synthesis of tipiracil + trifluridineFórmula:C5H3F3N2O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:180.08 g/mol6-Ethoxypurine
CAS:6-Ethoxypurine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. It is used in cell culture to measure the effects of radiation and hydrochloric acid on the production of ATP. 6-Ethoxypurine has been shown to inhibit influenza virus replication with an IC50 of 10 μM. This compound has reactive hydroxyl groups that allow it to participate in hydrogen bonding, which can be beneficial for interactions with other molecules. 6-Ethoxypurine also exhibits nucleophilic properties, which allows it to react with other chemical species and can be useful for generating new chemical compounds.Fórmula:C7H8N4OPureza:Min. 95%Cor e Forma:PowderPeso molecular:164.16 g/molN9-Methyladenine
CAS:N9-Methyladenine is a purine derivative that has been shown to be an antagonist at the adenosine receptor. It can be synthesized by reacting N6-benzoyladenine with methanol, followed by treatment with aqueous sodium hydroxide and hydrogen peroxide. The molecule is planar, with a neutral pKa of 7.4. Proton and nitrogen NMR spectra were obtained for this compound, which showed it to have two hydrogen bonds and one intermolecular hydrogen bond. The proton resonances are observed at 2.97 ppm (H1) and 3.27 ppm (H2).Fórmula:C6H7N5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:149.15 g/mol6-Chloro-1,3-dimethyluracil
CAS:6-Chloro-1,3-dimethyluracil is a nucleoside analog that has been shown to be cytotoxic in vitro. This compound can be synthesized by reacting naphthalene with a nucleophilic nitrogen source, such as sodium carbonate and chlorinating the resulting product with trifluoroacetic acid. 6-Chloro-1,3-dimethyluracil can also be synthesized by reacting malonic acid with cyclen and uridine in the presence of copper metal. The reaction mechanism is believed to involve photoelectron transfer from the copper metal to the uridine ring.
Fórmula:C6H7ClN2O2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:174.58 g/mol6-Methyl-5-nitrouracil
CAS:Fórmula:C5H5N3O4Pureza:>95.0%(T)(HPLC)Cor e Forma:Light orange to Yellow to Green powder to crystalPeso molecular:171.117-Methyladenine
CAS:7-Methyladenine is a nitrogen-containing compound that has been shown to cause an increase in renal blood flow. It is also a synthetic estrogen. 7-Methyladenine is mainly metabolized by methylation, and it can be detected in urine samples. This substance has been shown to have a direct effect on cardiac contractility and blood pressure. 7-Methyladenine also has the ability to stimulate the growth of cells and tissues, as well as being able to inhibit the synthesis of certain proteins.Fórmula:C6H7N5Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:149.15 g/mol2-Thiothymine
CAS:2-Thiothymine is a nucleotide that can be synthesized by the polymerase chain reaction. It is used as a probe for determining the sequence of DNA duplexes. 2-Thiothymine binds to dna and forms hydrogen bonds with the nitrogen atoms in dna bases, which prevents them from being able to bind with other dna bases, thereby disrupting the binding of dna strands. This leads to chain reactions that result in high temperatures and could cause damage to the cells. 2-Thiothymine has been shown to be toxic to both bacteria and human cells. It was found to inhibit HIV infection by binding to viral RNA and preventing it from being translated into protein, leading to cell death.
Fórmula:C5H6N2OSPureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:142.18 g/mol8-Hydroxyguanine hydrochloride
CAS:8-Hydroxyguanine hydrochloride is a fine chemical that is used as a building block in the synthesis of pharmaceuticals, agrochemicals and other organic compounds. It is also used as a reagent for research into the mechanisms of DNA damage. CAS No. 1246818-54-1 8-Hydroxyguanine hydrochloride is a complex compound that can be used as a versatile building block for the synthesis of many different types of molecules, including valuable intermediates and scaffolds for drug discovery.
Fórmula:C5H5N5O2•HClPureza:Min. 90 Area-%Cor e Forma:White PowderPeso molecular:203.59 g/mol3’-O-t-Bulyldimethylsilyl thymidine
CAS:3’-O-t-Bulyldimethylsilyl thymidine is a nucleoside analog that is chemically stable and has been shown to be a potential biomarker for the diagnosis of fetal bovine spongiform encephalopathy (BSE). 3’-O-t-Bulyldimethylsilyl thymidine binds to basic proteins in the cell nucleus, which can be detected by immunoassay. It also has been shown to inhibit protein synthesis in tubule cells of the kidney and skin cancer cells. The drug is metabolized by dephosphorylation to t-butyldeoxyuridine, which is then converted into thymidine.Fórmula:C16H28N2O5SiPureza:Min. 95%Cor e Forma:White PowderPeso molecular:356.49 g/molAutoinduction Medium (AIM) Solution
Autoinduction Medium (AIM) Solution for protein expression that needs little user intervention after inoculation of the culture. The principle of AIM media is based on carbon sources in the medium that are metabolized differentially to promote high density cell growth and automatically induce protein expression from lac promoters. This solution constitutes a unique combination of carbon source concentrations. AIM with pH 7.2 provides an efficient way to produce recombinant proteins for functional characterizations. This solution is useful in the study of intensity of induction, expression at different cell densities, or investigation of induction in early-, mid-, or late-log conditions of proteins of focused interest.Cor e Forma:Liquid, Dark Yellow to Brown, Clear
