Nucleotídeos

2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a nucleoside that is used as an antiviral agent in the treatment of herpes zoster and varicella zoster. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis. 2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a novel nucleotide analogue that has been modified to improve its stability, solubility and bioavailability. It can be used as a starting material for the synthesis of phosphoramidites by reacting with phosphorous pentoxide at elevated temperatures and pH. CAS No. 151151-32-5

<p>Each dNTP supplied in a separate vial</p>

<p>3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt is an antiviral and anticancer agent that inhibits the synthesis of DNA, RNA, and protein. It has shown to be effective against a variety of viruses including HIV-1, herpes simplex virus type 1, influenza A virus, vaccinia virus, and vesicular stomatitis virus. 3'-Azido-3'-deoxythymidine-b-D-glucuronide sodium salt also inhibits the growth of cancer cells in vitro. This drug is a modified nucleoside with a phosphoramidite backbone and a 3'-azido group at one end. The other end contains a beta D glucuronic acid moiety. The modifications allow for the inhibition of DNA synthesis by blocking the incorporation of deoxyribonucleotides into DNA chains.</p>

<p>Polycytidylic acid is a single stranded RNA analog which is combined with Polyinosinic acid to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&amp;D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.<br>For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'</p>

<p>4-Bromo-3,5-dichloropyridine is a reactive intermediate that is used as a reagent in organic synthesis. It has low basicity and reacts with lithium to form the lithium salt. The salt can be deprotonated to form the bromide anion, which is more reactive than the chloride anion. 4-Bromo-3,5-dichloropyridine can also be used for the selective isomerization of ketones and related compounds. Bromine is added to prevent side reactions with oxygen. The intermediates are generated at the site of reaction by using an excess of diisopropylamide over bromination agent.</p>

<p>Regulates gene transcription; inhibits the synthesis of tRNA and rRNA</p>

Guanosine 5'-monophosphate disodium salt (GMPDS) is an antiviral agent that inhibits the synthesis of viral nucleic acids by competitive inhibition of the enzyme ribonucleotide reductase. GMPDS has been shown to inhibit the replication of a number of RNA viruses, including influenza A and B, herpes simplex virus type 1, and human immunodeficiency virus type 1. This drug also has been shown to decrease cyclic adenosine monophosphate (cAMP) levels in cells by inhibiting phosphodiesterase activity. GMPDS is used for treatment of infectious diseases such as influenza A, herpes, and HIV-1.

2'-Deoxy-a-guanosine is a nucleoside that is modified by the substitution of its ribose sugar with deoxyribose. It is used in anticancer and antiviral research. This chemical has been shown to inhibit DNA synthesis and RNA polymerase activity. 2'-Deoxy-a-guanosine has also been shown to have an anti-inflammatory effect, which may be due to its inhibition of prostaglandin synthesis.

<p>5'-O-DMT-N2-isobutyrylguanosine is a novel phosphoramidite monophosphate, which has been modified with an isobutyryl group. This compound was synthesized in order to be used as a nucleoside analogue and antimetabolite for the treatment of cancer. It also has antiviral properties and inhibits the replication of DNA by inhibiting transcription. 5'-O-DMT-N2-isobutyrylguanosine is an anticancer agent that can be used to treat tumors that are resistant to other chemotherapy drugs. It also inhibits the growth of cells by preventing the synthesis of proteins needed for cell division.</p>

<p>2'-O-Methylinosine is a nucleoside that is structurally related to inosine. It has been shown to induce apoptotic cell death in HIV-infected cells by inhibiting the synthesis of rRNA and by inhibiting the activity of the transcriptase enzyme. 2'-O-Methylinosine has also been shown to inhibit the replication of RNA viruses, such as herpes simplex virus and cytomegalovirus, and it can be used as an experimental model for studying apoptosis. 2'-O-Methylinosine can be synthesized from inosine using a chromatographic method that utilizes hydroxylamine. The chemical structure of this nucleoside is amphipathic, which allows it to bind both DNA and RNA strands.</p>

<p>Cytidine 5'-triphosphate (CTP) disodium dihydrate prevents the action of aspartate carbamoyltransferase, an enzyme involved in pyrimidine biosynthesis. CTP serves as a molecule of high energy and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.</p>

<p>7-Methyl-6-thioguanosine inner salt is a compound that inhibits the activity of creatine kinase and phosphatase, which are enzymes involved in energy metabolism. It also binds to actin filaments and prevents their depolymerization. The binding mechanism of 7-methyl-6-thioguanosine inner salt is believed to be due to its ability to form disulfide bonds with cysteine residues on the surface of the enzyme. This inhibition has been shown to reduce the ATP production in mammalian cells and has been used as a model system for studying cellular processes.</p>

<p>9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine is a nucleoside phosphorylase inhibitor that is used to treat inflammatory bowel disease. It has been shown to be effective in treating women with inflammatory bowel disease, and has no significant side effects. 9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine inhibits the bacterial enzyme nucleoside phosphorylase, which is responsible for the conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP). This inhibition prevents the synthesis of DNA and RNA by blocking the conversion of GTP and GDP into AMP and GMP. The drug binds to the active site of nucleoside phosphorylase, which is located in the bacterial cytoplasmic membrane. 9-(2'-Deoxy-2'-fluoro</p>

<p>5-Fluorouridine-5'-triphosphate sodium salt is an analog of uridine that has been used in the treatment of metastatic colorectal cancer. It is a prodrug that is metabolized to 5-fluorouracil, its active form. 5-Fluorouridine-5'-triphosphate sodium salt inhibits the synthesis of thymidylate, one of the precursors to DNA, and blocks the production of nucleotides. This results in cell lysis and death by apoptosis. The drug also inhibits epidermal growth factor receptor (EGFR), which may contribute to its antitumor effects.</p>

<p>Cytidine-5-carboxylic acid sodium salt is a nucleoside that is used as an activator for the synthesis of phosphoramidites. It is also used in anticancer and antiviral research as a component of DNA. Cytidine-5-carboxylic acid sodium salt is available in high purity, with a monophosphate form and diphosphate forms available.</p>

<p>2'-O-Methyluridine is a chemical compound that is used in the synthesis of RNA. It is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. 2'-O-Methyluridine has been shown to inhibit growth in some types of cancer cells, including colorectal adenocarcinoma cells. It may also be useful as a chemotherapeutic agent against HIV, as it inhibits virus replication by inhibiting reverse transcription and DNA synthesis.</p>

<p>4-Amino-2,6-dihydroxy-5-nitrosopyrimidine is a molecule that has been shown to be an effective inhibitor of the enzyme tyrosinase in the oxidation of tyrosine to DOPA, which is a precursor of melanin. It is believed that vibrational and structural changes during these reactions are responsible for the inhibitory effects. 4-Amino-2,6-dihydroxy-5-nitrosopyrimidine has also been shown to have anti cancer effects on glioma cells. This molecule binds to copper ions, forming a chelate ring that can stabilize reactive intermediates and terminate free radicals. The chlorine atom on this molecule may be responsible for its cytotoxic effects by reacting with nucleophilic sites on proteins. The functional groups on this molecule react with acid catalysts, such as protonation or dehydration reactions.</p>

<p>Ribonucleosides, Deoxyribonucleosides and Activator are a group of synthetic compounds that are used in the synthesis of DNA. Ribonucleosides and Deoxyribonucleosides are nucleotides that contain ribose or deoxyribose as the sugar moiety. Activator is an activator for DNA polymerase, which catalyses the formation of a phosphodiester bond between two adjacent 3'-5' phosphate groups on a single strand of DNA. Ribonuclesides, Deoxyribonucleosides and Activator are used in recombinant DNA technology to synthesize DNA molecules containing modified bases. The CAS number for Ribonuclesides, Deoxyribonucleosides and Activator is 59892-40-9.</p>

<p>8-Chloro-2'-deoxyadenosine is a nucleoside analogue and a disinfectant that inhibits the synthesis of DNA. It has been used to control active viruses and to induce apoptotic cell death in cancer cells. 8-Chloro-2'-deoxyadenosine binds to viral RNA and DNA, preventing viral replication by inhibiting the activity of reverse transcriptase, which is an enzyme that copies the virus's genetic information from RNA into DNA. This drug has also been shown to be effective for the treatment of HIV infection. 8-Chloro-2'-deoxyadenosine disrupts DNA synthesis and cellular metabolism by blocking transcription and protein synthesis.</p>

<p>N4-Etheno 2'-deoxycytidine is an aromatic hydrocarbon that has been shown to be a potent inhibitor of DNA synthesis. It binds covalently with the N4 position of deoxycytidine in DNA, thereby inhibiting transcription and replication. This drug has been shown to be a potent inhibitor of DNA synthesis in human cells when it is added to the culture medium, but it does not inhibit protein synthesis. N4-Etheno 2'-deoxycytidine can also react with hydrogen bonds in cellular proteins and nucleosides that are involved in DNA repair mechanisms. This drug is reactive and may cause oxidative damage to cellular components, which may lead to carcinogenesis.</p>