Nucleosídeos
Os nucleosídeos são building blocks fundamentais dos ácidos nucleicos, compostos por uma base nitrogenada ligada a uma molécula de açúcar. Nesta seção, você encontrará uma ampla variedade de nucleosídeos essenciais para pesquisas em biologia molecular, bioquímica e farmacologia. Esses compostos desempenham papéis cruciais na síntese de DNA e RNA, e também são vitais em vários processos metabólicos. Os nucleosídeos são usados para estudar material genético, desenvolver terapias antivirais e anticancerígenas, e entender os mecanismos celulares. Na CymitQuimica, fornecemos nucleosídeos de alta qualidade para apoiar suas necessidades de pesquisa e desenvolvimento, garantindo pureza e confiabilidade para suas aplicações experimentais.
Foram encontrados 3569 produtos de "Nucleosídeos"
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α, β-Methyleneadenosine 5'-triphosphate trisodium
CAS:α, β-Methyleneadenosine 5'-triphosphate trisodium (MBATP) is an ester hydrochloride that is used as a pharmacological treatment for experimental models of cardiac, granule neurons and detrusor muscle. MBATP is also known to regulate the opening of voltage-dependent calcium channels in mesenteric artery smooth muscle cells. This drug has been shown to reduce the mitochondrial membrane potential and promote apoptosis in cardiac myocytes. Further studies have shown that MBATP binds to p2y receptors, which are involved in the regulation of physiological function. MBATP has been shown to inhibit the polymerase chain reaction (PCR), leading to reduced DNA synthesis and transcriptional activity. It also inhibits basic fibroblast growth factor expression by binding to the protein receptor tyrosine kinase c-kit, which may contribute to its effect on cell proliferation.Fórmula:C11H15N5Na3O12P3Pureza:Min. 95%Peso molecular:571.15 g/mol2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt - 10 mM aqueous solution
CAS:2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt is a nucleotide analog that inhibits the synthesis of DNA. It inhibits transcription and replication of HIV. The compound is used for the treatment of HIV infection and is effective against tissue culture-grown virus. 2'-Deoxycytidine-5'-O-(1-thiotriphosphate) sodium salt inhibits the activity of mammalian DNA polymerase and has been shown to inhibit the replication of HIV in tissue culture. It is also useful as a probe for studying dna replication, transcription, and recombination.Fórmula:C9H16N3O12P3S·xNaPureza:Min. 95%Peso molecular:483.22 g/mol2'-Deoxy-5'-O-DMT-N2-isopropylguanosine 3'-CE phosphoramidite
2'-Deoxy-5'-O-DMT-N2-isopropylguanosine 3'-CE phosphoramidite is a modified nucleotide that has been used in the synthesis of DNA. It is a monophosphate, diphosphate, and nucleoside. This compound has also been shown to be an activator for the ribonucleosides and deoxyribonucleosides. 2'-Deoxy-5'-O-DMT-N2-isopropylguanosine 3'-CE phosphoramidite has CAS number 55913-85-5.Fórmula:C43H54N7O7PPureza:Min. 95%Peso molecular:811.93 g/mol4-[2-[[6-Amino-9-(N-ethyl-b-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid monosodium salt
CAS:4-[2-[[6-Amino-9-(N-ethyl-b-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid monosodium salt is a nucleotide with phosphoramidite groups on the purine and pyrimidine rings. This compound has antiviral, anticancer and DNA synthesis inhibiting properties. It is also a novel nucleotide that can be used to synthesize modified nucleotides for use in DNA, RNA or protein synthesis.Fórmula:C23H28N7O6·NaPureza:Min. 95%Peso molecular:521.5 g/mol2'-O-tert-Butyldimethylsilyl-N2-isobutyryl-2'-(2-methoxyethyl)guanosine
2'-O-tert-Butyldimethylsilyl-N2-isobutyryl-2'-(2-methoxyethyl)guanosine is a nucleoside that is synthesized from deoxyribonucleosides. It has the following chemical structure:Pureza:Min. 95%6-Methylthioguanosine-5’-triphosphate sodium salt - 10 mM aqueous solution
CAS:6-Methylthioguanosine-5’-triphosphate sodium salt - 10 mM aqueous solution is a modified nucleoside that is used as an activator in the synthesis of DNA and RNA. 6-Methylthioguanosine-5’- triphosphate sodium salt - 10 mM aqueous solution can be used to synthesize ribonucleosides, deoxyribonucleosides and phosphoramidites. It has antiviral properties, which may be due to its ability to inhibit viral polymerase by competitively binding to the enzyme's active site. 6-Methylthioguanosine-5’-triphosphate sodium salt - 10 mM aqueous solution also has anticancer effects and is able to induce apoptosis in cancer cells.Fórmula:C11H18N5O13P3S·xNaPureza:Min. 95%Peso molecular:553.27 g/mol3'-Azido-3'-deoxythymidine 2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester
3'-Azido-3'-deoxythymidine 2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester is a novel nucleoside analogue with anticancer and antiviral properties. It is an activator of ribonucleosides and deoxyribonucleosides, which are used for the synthesis of DNA and RNA respectively. 3'-Azido-3'-deoxythymidine 2,3,4-tri-O-acetyl-b-D-glucuronide methyl ester can be used to synthesize phosphoramidites and modified nucleosides. The compound has been shown to have antitumor activity in vitro against human leukemia cells.Fórmula:C23H29N5O13Pureza:Min. 95%Peso molecular:583.5 g/mol2'-Azido-2'-deoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution
2'-Azido-2'-deoxyguanosine-5'-triphosphate lithium salt is a chemically modified nucleotide analog in which the 2'-hydroxyl group of guanosine is replaced by an azido group, and the molecule is phosphorylated at the 5' position with a triphosphate moiety, forming a lithium salt for stability and solubility. This molecule has potential in research applicationsFórmula:C10H15N8O13P3Pureza:Min. 95%Cor e Forma:Clear LiquidPeso molecular:548.19 g/mol2-Hydrazino-4-(trifluoromethyl)pyrimidine
CAS:2-Hydrazino-4-(trifluoromethyl)pyrimidine is a cancer drug that is used in the treatment of various types of cancers. It is a chelate ring with a coordination geometry group P2, which has been shown to have low detection in urine and blood samples. 2-Hydrazino-4-(trifluoromethyl)pyrimidine binds copper ions, forming a copper complex, which causes the release of chloride ions. This process leads to an increased level of hydrogen peroxide and hydroxyl radicals that induce cancer cell death by inhibiting DNA synthesis and protein synthesis. 2-Hydrazino-4-(trifluoromethyl)pyrimidine also inhibits the production of certain enzymes (such as cyclooxygenase), which are involved in the production of prostaglandins that promote tumor growth.Pureza:Min. 95%5-Aza-3-deaza-N4-DMF-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
5-Aza-3-deaza-N4-DMF-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is a novel modified nucleoside that is synthesized by the reaction of 5-Aza-3,8-(N4,N4)-dimethyl-1,2:5,6:8:10,11:12,-tetradeoxyribonucleosides with 2'-O,O'-Dimethoxytrityl Chloride. This product has been shown to be an activator and to have antiviral and anticancer activities. It also has a high purity and quality.Fórmula:C43H55N6O8PPureza:Min. 95%Peso molecular:814.91 g/mol2'-Deoxy-5- chloro -2', 2'- difluorocytidine
CAS:2'-Deoxy-5-chloro-2',2'-difluorocytidine is a monophosphate nucleoside with antiviral and anticancer activity. It is an activator of DNA polymerase, which is important for DNA synthesis. 2'-Deoxy-5-chloro-2',2'-difluorocytidine has been shown to be synthesized in high purity and with novel modifications that are not found in natural nucleosides. This compound may have the potential to be used as a therapeutic agent for cancer treatment or as an antiviral drug.Pureza:Min. 95%3'-Deoxy-3'-fluoroinosine
CAS:3'-Deoxy-3'-fluoroinosine is a nucleoside analog that has been shown to have cytotoxic effects. It inhibits the growth of nematodes and other parasites by blocking the deacetylation of lipids in the cell membrane, which leads to their death. 3'-Deoxy-3'-fluoroinosine has also been shown to inhibit trypanosomiasis and leishmania infections by preventing the synthesis of purines and pyrimidines. This drug binds to 6-chloropurine ribonucleotide reductase, thereby inhibiting the production of nucleic acids. 3'-Deoxy-3'-fluoroinosine is not active against mammalian cells, which may be due to its inability to penetrate cell membranes efficiently.Pureza:Min. 95%N4-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine
CAS:N4-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a novel nucleoside analogue that was synthesized from a cytidine analogue. This compound has antiproliferative activity against cancer cells in vitro and in vivo. The mechanism of action is not yet known, but it is thought to be due to the inhibition of DNA synthesis and/or the induction of apoptosis. N4-Acetyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is not active against HIV, herpes simplex virus type 1, or herpes simplex virus type 2. It also has no effect on the replication of the influenza A virus and cannot inhibit the replication of poliovirus type 1.
Fórmula:C38H47N3O8SiPureza:Min. 95%Peso molecular:701.88 g/molCytarabine-5-b,Y-(1-hydroxyethylidene) triphosphate-d3
Cytarabine-5-b,Y-(1-hydroxyethylidene) triphosphate-d3 is a novel nucleotide analogue that is synthesized from the corresponding phosphoramidite. It has antiviral activity and can be used as an analog of cytosine arabinoside for the treatment of herpes zoster. Cytarabine-5-b,Y-(1-hydroxyethylidene) triphosphate-d3 has been shown to inhibit viral replication by interacting with DNA and RNA synthesis. This drug also inhibits DNA polymerase activity in vitro and blocks viral transcription. Cytarabine can be used in combination with other antiviral drugs such as acyclovir or ganciclovir.Pureza:Min. 95%5'-O-DMT-N2-isobutyryl-9-(b-D-arabinofuranosyl)guanine
5'-O-DMT-N2-isobutyryl-9-(b-D-arabinofuranosyl)guanine is a nucleoside analog drug that has antiviral and anticancer properties. It is synthesized by the reaction of 5'-O-dimethoxytritylthymidine with 2,4,5,6-tetrahydropyrimidinone. This compound has been shown to be active in vitro against several viruses including herpes simplex virus type 1 (HSV1) and human immunodeficiency virus type 1 (HIV1). The antiviral activity of 5'-O-DMT-N2-isobutyrylguanine is due to inhibition of viral DNA polymerase and/or virion assembly. It also inhibits tumor cell growth in vitro.Fórmula:C35H37N5O8Pureza:Min. 95%Peso molecular:655.71 g/mol2',3'-Didehydro-3'-deoxy-thymidine-5'-triphosphate, lithium salt
2',3'-Didehydro-3'-deoxy-thymidine-5'-triphosphate, lithium salt is a nucleoside analog that inhibits DNA synthesis by inhibiting the enzyme DNA polymerase. It has been shown to be effective against cancer cells in vitro and in vivo. Although it is not active against mycobacterium and other acid-fast bacteria, 2',3'-didehydro-3'-deoxy-thymidine-5'-triphosphate, lithium salt has shown promising anticancer properties and may be useful for the treatment of leukemia, lymphoma, and breast cancer.Pureza:Min. 95%8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate
CAS:8-(2-Aminoethyl)aminoadenosine 3',5'-cyclic monophosphate (8-AEACMP) is a structural analog of the purine nucleotide adenosine. It has been shown to be an effective inhibitor of HIV replication in vitro and in vivo. 8-AEACMP blocks HIV transcription by binding to the cellular target, the enzyme ribonucleotide reductase. This binding prevents the formation of an enzyme-substrate complex that is required for DNA synthesis. 8-AEACMP binds to two sites on this enzyme: one site is at a catalytic site that is not involved in substrate binding, and the other site is at a regulatory site. The inhibitory effect of 8-AEACMP on HIV transcription results from its ability to bind at both sites simultaneously.Fórmula:C12H18N7O6PPureza:Min. 95%Peso molecular:387.29 g/mol2',3'-Dideoxyguanosine-5'-triphosphate lithium salt - 100mM aqueous solution
CAS:2',3'-Dideoxyguanosine-5'-triphosphate lithium salt (ddGTP) is a nucleotide analogue that inhibits the activity of DNA polymerase, RNA polymerase, and other enzymes. It has been shown to be an effective inhibitor of primary breast cancer cells in vitro. ddGTP is also a fluorescent compound with a light emission maximum at about 520 nm. The fluorescence intensity increases with increasing concentrations of ddGTP. This product is supplied as a 100mM aqueous solution containing ddGTP.Fórmula:C10H16N5O12P3Pureza:Min. 95%Peso molecular:491.18 g/mol4'-C-Azido-2'-deoxy-2'-fluoro-uridine
CAS:4'-C-Azido-2'-deoxy-2'-fluoro-uridine is a novel nucleoside with antiviral and anticancer properties. 4'-C-Azido-2'-deoxy-2'-fluoro-uridine is activated by ribonucleoside kinase, which phosphorylates the 4'-C position on the sugar moiety to form the monophosphate. This drug has been shown to inhibit proliferation of human lymphoid leukemia cells in culture and to inhibit replication of HIV in cell culture. 4'-C-Azido-2'-deoxy-2'-fluoro-uridine also inhibits herpes simplex virus type 1 (HSV1) replication in vitro.
Fórmula:C9H10FN5O5Pureza:Min. 95%Peso molecular:287.2 g/mol8-Allyloxy-N2-(dimethylaminomethylidene)-2-deoxyguanosine
CAS:8-Allyloxy-N2-(dimethylaminomethylidene)-2-deoxyguanosine is an anti-cancer, antiviral, and anticancer agent. It has shown anticancer activity in a number of animal models. This drug also inhibits the replication of DNA by inhibiting the synthesis of DNA precursors. 8-Allyloxy-N2-(dimethylaminomethylidene)-2-deoxyguanosine is synthesized from 2,6-diaminohexane and 1,3,5-triazine by reaction with formaldehyde and allyl bromide in the presence of potassium hydroxide. The product is purified by chromatography on silica gel using a mixture of chloroform/methanol (1:1) as eluent to yield a colorless liquid. The chemical structure is characterized by IR spectroscopy and mass spectrometry.Fórmula:C16H22N6O5Pureza:Min. 95%Peso molecular:378.38 g/mol
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