Antraciclinas
As antraciclinas são uma classe de potentes antibióticos antitumorais amplamente utilizados na quimioterapia do câncer. Esses compostos funcionam intercalando-se no DNA, interrompendo a função da topoisomerase II e impedindo a replicação das células cancerosas. As antraciclinas são particularmente eficazes contra uma ampla gama de cânceres, incluindo leucemias, linfomas e câncer de mama. No entanto, seu uso é muitas vezes limitado pela cardiotoxicidade, tornando a pesquisa de formulações mais seguras e eficazes uma área de foco importante. Na CymitQuimica, oferecemos uma seleção de antraciclinas para apoiar sua pesquisa em oncologia, desenvolvimento de fármacos e terapia do câncer.
Foram encontrados 173 produtos de "Antraciclinas"
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Epirubicin hydrochloride
CAS:<p>Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C27H30ClNO11Pureza:98.13% - 99.79%Cor e Forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.98Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Fórmula:C27H29NO11·HClPureza:98% - 99.52%Cor e Forma:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.99Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Fórmula:C22H30Cl2N4O6Pureza:97.05% - >99.99%Cor e Forma:Blue-Black Solid From Water Ethanol SolidPeso molecular:517.4Idarubicin Lactose Adduct Trifluoroacetate (Amadori Rearrangement Product)
Fórmula:C38H47NO19·C2HF3O2Peso molecular:821.78 114.02Pantoprazole Sodium Hydrate
CAS:Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagusFórmula:C16H14F2N3NaO4SH2OPureza:98.32%Cor e Forma:SolidPeso molecular:432.37Mitoxantrone EP Impurity C Ditrifluoroacetate
CAS:Fórmula:C22H27ClN4O6·2C2HF3O2Peso molecular:478.93 2*114.02Doxorubicin Impurity 15 HBr
CAS:Fórmula:C31H38BrNO11·HBrCor e Forma:Dark Red SolidPeso molecular:680.55 80.91Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS:Fórmula:C27H29NO11·HClCor e Forma:Red SolidPeso molecular:543.53 36.46Doxorubicin EP Impurity B HBr
CAS:Fórmula:C29H34BrNO11·HBrCor e Forma:Red SolidPeso molecular:652.50 80.91Mitoxantrone EP Impurity D HCl
CAS:Fórmula:C22H26N4O6·HClCor e Forma:Dark Blue SolidPeso molecular:442.47 36.46Epirubicin EP Impurity B (Daunorubicin EP Impurity A, Daunomycinone)
CAS:Fórmula:C21H18O8Peso molecular:398.37Doxorubicinone (Doxorubicin EP Impurity D, Epirubicin EP Impurity A)
CAS:Fórmula:C21H18O9Cor e Forma:Red SolidPeso molecular:414.37Epirubicin (epi-Doxorubicin)-13C-d3 Trifluoroacetate
Fórmula:C2613CH26D3NO11·C2HF3O2Peso molecular:547.54 114.02Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Fórmula:C26H27NO9·HClPureza:98.91% - 99.96%Cor e Forma:SolidPeso molecular:533.95Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Fórmula:C13C22H26D3NO11·HClPeso molecular:547.56 36.45NSC348884
CAS:NSC348884, a nucleophosmin inhibitor, disrupts oligomers, induces apoptosis, and inhibits cancer cell growth (IC50: 1.7-4.0 μM).Fórmula:C38H40N10Pureza:98.69% - 99.91%Cor e Forma:SolidPeso molecular:636.79Pantoprazole sodium
CAS:<p>Pantoprazole sodium is a proton pump inhibitor that irreversibly blocks gastric acid secretion by bonding with H+/K+-ATPase.</p>Fórmula:C16H14F2N3NaO4SPureza:96.92% - 99.81%Cor e Forma:White To Off-White SolidPeso molecular:405.35Doxorubicinol-13C-d3 HCl (Mixture of Diasteromers)
CAS:Fórmula:CC26H28NO11D3Peso molecular:549.58 36.46Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Fórmula:C22H28N4O6Pureza:96.29% - 98.74%Cor e Forma:Blue PowderPeso molecular:444.48Pantoprazole
CAS:Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal refluxFórmula:C16H15F2N3O4SPureza:97.16% - 99.63%Cor e Forma:Almost White SolidPeso molecular:383.37Idarubicin
CAS:Idarubicin, a potent oral anthracycline, halts DNA/RNA replication and synthesis, damages DNA, and inhibits microbial growth.Fórmula:C26H27NO9Cor e Forma:SolidPeso molecular:497.499,10-Anhydro-8-desacetyl-8-carboxy Daunorubicin Hydrochloride
Produto Controlado<p>Applications 9,10-Anhydro-8-desacetyl-8-carboxy Daunorubicin is an impurity of Doxorubicin (D558000), an antineoplastic agent.<br></p>Fórmula:C26H26ClNO10Pureza:>85%Cor e Forma:NeatPeso molecular:547.94Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Fórmula:C27H29NO11Pureza:99.31%Cor e Forma:Red Crystalline Solid SolidPeso molecular:543.52Idarubicinol (Mixture of Diastereomers)
CAS:<p>Stability Hygroscopic<br>Applications Idarubicinol is the alcohol analog of Idrabucin (I167000), an orally active anthracycline; analog of Daunorubicin. Antineoplastic.<br>References Arcamone, F., et al.: Caner Treat. Rep., 60, 829 (1976), Zini, G., et al.: Cancer Chemother. Pharmacol., 16, 107 (1986), Gillies, H.C., et al.: Br.J. Clin. Pharmacol., 23, 303 (1987), Villani, F., et al.: Eur. J. Cancer Clin. Oncol., 25, 13 (1989),<br></p>Fórmula:C26H29NO9Cor e Forma:NeatPeso molecular:499.51Doxorubicin impurity
CAS:<p>Doxorubicin is an organic compound that belongs to the class of polycyclic aromatic hydrocarbons. It is used as a cancer therapy, primarily in the treatment of breast cancer. The chemical sensing of impurities in doxorubicin can be done using phase transfer methods. The quantification of these impurities can be done using high-performance liquid chromatography (HPLC) or gas chromatography (GC).</p>Fórmula:C26H27NO11Pureza:Min. 90 Area-%Cor e Forma:Red PowderPeso molecular:529.49 g/molKarminomycin Hydrochloride
CAS:<p>Applications Karminomycin Hydrochloride is an antibiotic that potently kills human tumor cells and their multidrug resistant variants. Highly active quinone-containing anticancer drugs. A new anthracycline antineoplastic antibiotic.<br>References Tevyashova, A. N., et al.: J. Antibiot., 57, 143 (2004); Bachur, N. R., et al.: Cancer Res., 38, 1745 (1978); Brazhnikova, M. G., et al.: J. Antibiot., 27, 254 (1974)<br></p>Fórmula:C26H27NO10·HClCor e Forma:NeatPeso molecular:549.95414-Bromo, 13-Deoxo, 13,13-Dimethoxy Daunorubicin Hydrobromide (>85%)
CAS:Produto Controlado<p>Applications (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-(2-bromo-1,1-dimethoxyethyl)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione, is the metabolite of Doxorubicin (D558000), which is a neoplasm inhibitor,and an antineoplastic.<br>References Smith, T.H., et al.: J. Med. Chem., 22, 40 (1979); Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969), Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984),<br></p>Fórmula:C29H34BrNO11·BrHPureza:>85%Cor e Forma:NeatPeso molecular:733.407,8,9,10-Dehydro Doxorubicinone (~70%)
CAS:Produto ControladoFórmula:C21H14O8Pureza:~70%Cor e Forma:NeatPeso molecular:394.33Doxorubicin Imp B HBr salt
CAS:<p>Doxorubicin Imp B HBr salt is a drug product that is custom synthesized for research and development. It's high purity, analytical, and natural are well suited for pharmacopoeia, drug development, and niche. Doxorubicin Imp B HBr salt has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The CAS No. 148218-14-8 is an impurity standard that can be used in HPLC analysis to determine the purity of Doxorubicin Imp B HBr salt.</p>Fórmula:C29H34BrNO11BrHPureza:Min. 95%Peso molecular:733.4 g/molDoxorubicin Impurity 15
CAS:<p>Doxorubicin impurity 15 is a natural product that is used as an analytical reference standard in pharmacopoeia. It has been synthesized for use in drug development and research and development, and is available as a high-purity HPLC standard. Doxorubicin impurity 15 has a CAS number of 131086-18-5.</p>Fórmula:C31H38BrNO11Pureza:Min. 95%Peso molecular:680.54 g/molDes[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone
CAS:<p>Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone is a research and development impurity standard for synthesis. It is a synthetic, high purity compound with a CAS number of 89991-52-6. The chemical is not found in nature and does not have any natural metabolites. Des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone has been shown to be metabolized by the liver into various metabolites that have been identified through analysis of urine samples. The metabolite of des[2-[(2-hydroxyethyl)amino]ethyl] mitoxantrone may be used as an analytical standard for HPLC methods.</p>Fórmula:C18H19N3O5Pureza:Min. 95%Peso molecular:357.36 g/molEpirubicin
CAS:Epirubicin, a doxorubicin derivative, is an antineoplastic, inhibits topoisomerase, DNA/RNA synthesis, and Foxp3, reducing T cell activity.Fórmula:C27H29NO11Cor e Forma:SolidPeso molecular:543.52Mitoxantrone (2-hydroxyethyl)piperazine impurity
CAS:<p>Mitoxantrone is an anticancer drug that is used to treat various types of cancer. Mitoxantrone is a prodrug, which means it needs to be metabolized by the body to become active. The main metabolic pathway for mitoxantrone involves hydrolysis of the 2-hydroxyethyl piperazine impurity and formation of N-desmethylmitoxantrone, which is a metabolite that has been found to be more potent than the parent compound in inhibiting DNA synthesis. This impurity standard is used as a reference substance for quality control purposes during drug development. Mitoxantrone can also be synthesized with high purity and custom synthesis services are available upon request.</p>Fórmula:C22H26N4O6Pureza:Min. 95%Cor e Forma:Brown PowderPeso molecular:442.47 g/molDoxorubicin Dimer Impurity-1
Doxorubicin Dimer Impurity-1 is a drug product that is used as an HPLC standard. It is a metabolite of doxorubicin and has been shown to inhibit DNA synthesis in vitro. This impurity has been detected in the drug product using HPLC, and the purity of this impurity is greater than 98%. Doxorubicin Dimer Impurity-1 is a synthetic compound that has not been found in natural sources. It has been shown to be metabolized by human enzymes, such as esterases, glucuronidases, glutathione reductase, cytochrome P450 enzymes, and glucuronic acid conjugates. Doxorubicin Dimer Impurity-1 may also have anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.Fórmula:C54H56N2O21Pureza:Min. 95%Peso molecular:1,069.02 g/molRef: 4Z-D-3456
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