Inibidores
Os inibidores são moléculas que se ligam a enzimas, receptores ou outras proteínas para reduzir ou bloquear sua atividade biológica. Esses compostos são amplamente utilizados em pesquisas para estudar vias biológicas, entender mecanismos de doenças e desenvolver medicamentos terapêuticos. Os inibidores desempenham um papel crucial no tratamento de várias doenças, incluindo câncer, doenças cardiovasculares e infecções. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade para apoiar sua pesquisa em bioquímica, biologia celular e desenvolvimento farmacêutico.
Subcategorias de "Inibidores"
- Angiogénese(2.687 produtos)
- Apoptose(6.097 produtos)
- Ciclo celular/Ponto de verificação(4.691 produtos)
- Cromatina/Epigenética(2.376 produtos)
- Sinalização Citoesquelética(1.472 produtos)
- Dano de DNA/Reparo de DNA(2.921 produtos)
- Endocrinologia/Hormónios(3.611 produtos)
- Enzima(3.655 produtos)
- GPCR/Proteína-G(8.755 produtos)
- Imunologia e Inflamação(3.765 produtos)
- Vírus da Influenza(298 produtos)
- Sinalização JAK/STAT(407 produtos)
- Sinalização MAPK(1.230 produtos)
- Transportador de Membranas/Canal Iónico(2.947 produtos)
- Metabolismo(9.940 produtos)
- Microbiologia/Virologia(7.347 produtos)
- Neurociência(10.240 produtos)
- Outros inibidores(36.533 produtos)
- Oxidação-Redução(43 produtos)
- Sinalização PI3K/Akt/mTOR(1.437 produtos)
- Proteases/Proteassoma(1.675 produtos)
- Células - tronco e Derivados(830 produtos)
- Tirosina Quinase/Adaptador(2.028 produtos)
- Ubiquitinação(1.682 produtos)
Exibir 16 mais subcategorias
Foram encontrados 66582 produtos de "Inibidores"
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CDK8-IN-11 hydrochloride
CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.Fórmula:C19H16ClF3N4O2Cor e Forma:SolidPeso molecular:424.8Tubulin inhibitor 14
Tubulin inhibitor 14 blocks NQO2 and microtubule formation, disrupts blood vessels, and may target tumors; IC50 of 1.0 μM.Fórmula:C15H9F2NOCor e Forma:SolidPeso molecular:257.23FW 34569
CAS:FW 34569, an enkephalin analog, boosts growth hormones and prolactin, reduces cortisol and LH; FSH stable.Fórmula:C30H43N5O7SPureza:98%Cor e Forma:SolidPeso molecular:617.76Antifungal agent 42
Antifungal 42 blocks biofilm formation and inhibits C.albicans' CYP51.Fórmula:C22H20Cl2N4Se2Cor e Forma:SolidPeso molecular:569.25Tilpisertib fosmecarbil
CAS:Tilpisertib fosmecarbil is a potent inhibitor of serine/threonine kinases with anti-inflammatory properties.Fórmula:C35H36ClN8O7PCor e Forma:SolidPeso molecular:747.14Quinagolide Free Base
CAS:Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Fórmula:C20H33N3O3SCor e Forma:SolidPeso molecular:395.56MDK6465
CAS:MDK6465 (PCSK9-IN-8b), CAS#1900686-46-5, is a liver-targeted PCSK9 synthesis inhibitor.Fórmula:C27H29ClFN9O4Cor e Forma:SolidPeso molecular:598.03LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Fórmula:C29H26N10O3SCor e Forma:SolidPeso molecular:594.65Pibrozelesin
CAS:Pibrozelesin, a water-soluble duocarmycin B2 derivative, binds AT-rich DNA, blocking replication and inducing cell death.Fórmula:C32H36BrN5O8Cor e Forma:SolidPeso molecular:698.56Ivaltinostat formic
Ivaltinostat (CG-200745) is an oral panHDAC inhibitor, inducing apoptosis and enhancing cancer drug sensitivity.Fórmula:C25H35N3O6Cor e Forma:SolidPeso molecular:473.56DSP-1053 benzenesulfonate
CAS:DSP-1053: Benzylpiperidine-based, potent SERT inhibitor (Ki=1.02nM), partial 5-HT1A receptor agonist (Ki=5.05nM), antidepressant.Fórmula:C32H38BrNO7SCor e Forma:SolidPeso molecular:660.62EBOV-GP-IN-1
EBOV-GP-IN-1 (Compound 28) is a potent inhibitor of Ebola entry, acting on the Ebola virus envelope glycoprotein (EBOV-GP) (IC50: 0.05 μM).Fórmula:C25H40ClN3O2Cor e Forma:SolidPeso molecular:450.06Ambelline
CAS:Ambelline has antitumor activity.Fórmula:C18H21NO5Pureza:98%Cor e Forma:SolidPeso molecular:331.36AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Fórmula:C25H33NO3Cor e Forma:SolidPeso molecular:395.53RAD51-IN-6
CAS:RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)Fórmula:C27H40N3O5PSCor e Forma:SolidPeso molecular:549.66Tonapofylline
CAS:Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.Fórmula:C22H32N4O4Pureza:98.57%Cor e Forma:SolidPeso molecular:416.51CD73-IN-13
CD73-IN-13, a potent CD73 inhibitor, may be developed for tumor-related disease treatment.Fórmula:C13H11F3N4O2Cor e Forma:SolidPeso molecular:312.25SPR7
SPR7 is a potent and selective rhodesain inhibitor (Ki: 0.51 nM). SPR7 exhibited antiparasitic effects against T. b. brucei (EC50: 1.65 μM).Fórmula:C30H32ClN3O3Cor e Forma:SolidPeso molecular:518.05Bometolol Hydrochloride
CAS:<p>Bometolol Hydrochloride is a beta-adrenergic blocking compound used for the treatment of cardiovascular disease.</p>Fórmula:C25H33ClN2O7Pureza:98%Cor e Forma:SolidPeso molecular:508.99OXS007417
OXS007417 induces AML cell differentiation at 48 nM EC50 and shows potent in vivo antitumor effects.Fórmula:C20H14F3N3OCor e Forma:SolidPeso molecular:369.34BRD7929
CAS:BRD7929 is a multistage antimalarial inhibitor for single-dose treatment of malaria in mouse models.Fórmula:C33H38N4O2Cor e Forma:SolidPeso molecular:522.68Antifungal agent 13
CAS:Antifungal agent 13 demonstrates significant antifungal activity against Sclerotinia sclerotiorum, achieving an EC50 of 1.25 mg/L.Fórmula:C21H16ClF3N4OCor e Forma:SolidPeso molecular:432.83MAP3K14-IN-173
CAS:MAP3K14-IN-173 is a potent MAP3K14 kinase inhibitor.Fórmula:C29H31N7O2Cor e Forma:SolidPeso molecular:509.60SGE-516
CAS:<p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>Fórmula:C23H35N3O2Pureza:98%Cor e Forma:SolidPeso molecular:385.54Thalicarpine
CAS:<p>Thalicarpine, a natural anticancer alkaloid, inhibits p-glycoprotein and induces DNA damage, arresting cell cycle.</p>Fórmula:C41H48N2O8Cor e Forma:SolidPeso molecular:696.83Tubulin polymerization-IN-4
CAS:Tubulin polymerization-IN-4: inhibits tubulin (IC50=4.6 μM), blocks G2/M phase, induces apoptosis, hinders cell cloning/migration, damages vasculature.Fórmula:C21H21ClN2O4Cor e Forma:SolidPeso molecular:400.86URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Fórmula:C14H8Cl2N2O2Cor e Forma:SolidPeso molecular:307.13MS117
MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38Keap1-Nrf2-IN-1 TFA
Keap1-Nrf2-IN-1 TFA (compound35) is a potent inhibitor (IC50: 43 nM) protecting against acetaminophen liver damage.Fórmula:C26H25F3N2O9SCor e Forma:SolidPeso molecular:598.5417β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Fórmula:C21H21NO3Cor e Forma:SolidPeso molecular:335.4MAP855
CAS:MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Fórmula:C28H23ClF2N6O3Cor e Forma:SolidPeso molecular:564.97Macitentan (n-butyl analogue)
CAS:Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Fórmula:C20H21Br2N5O4SPureza:98%Cor e Forma:SolidPeso molecular:587.29GNE-886
CAS:<p>GNE-886 has a wide range of applications in life science related research.</p>Fórmula:C28H30N6O3Pureza:98%Cor e Forma:SolidPeso molecular:498.59EFdA-TP tetrasodium
CAS:EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.Fórmula:C12H11FN5Na4O12P3Pureza:98%Cor e Forma:SolidPeso molecular:621.12CYP2C9/CYP2C19-IN-1
CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.Fórmula:C27H28N2O6SCor e Forma:SolidPeso molecular:508.59Merigolix
CAS:Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .Fórmula:C36H35F7N4O6Cor e Forma:SolidPeso molecular:752.68DNA crosslinker 4 dihydrochloride
CAS:<p>DNA Crosslinker 4 binds DNA's minor groove, inhibits NCI-H460, A2780, MCF-7 cancer cells, and is used in cancer research.</p>Fórmula:C16H24Cl2N8OCor e Forma:SolidPeso molecular:415.32Macropa-NCS
CAS:Macropa-NCS is a macropa bifunctional analog with antitumor activity and can be used to study prostate cancer.Fórmula:C27H35N5O8SPureza:98%Cor e Forma:SolidPeso molecular:589.66SphK2-IN-1
CAS:<p>SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.</p>Fórmula:C23H22ClF3N8OCor e Forma:SolidPeso molecular:518.928-Deazafolic acid
CAS:8-Deazafolic acid inhibits folate-dependent bacteria S. faecium & L. casei, and fights lymphoid leukemia L1210 in mice.Fórmula:C20H20N6O6Pureza:98%Cor e Forma:SolidPeso molecular:440.41RET-IN-7
CAS:RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice throughFórmula:C22H24ClFN6O2Cor e Forma:SolidPeso molecular:458.92CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride blocks SDF-1 and I-TAC from CXCR7; may prevent cancer and inflammation.Fórmula:C21H20ClFN6OCor e Forma:SolidPeso molecular:426.87CVS-1578
CAS:CVS-1578 is a potent serine protease inhibitor, targeting the S2S3 thrombin and FXa subsites.Fórmula:C20H30N6O5SCor e Forma:SolidPeso molecular:466.55XPO1-IN-1
XPO1-IN-1: an oral MM.1S cell inhibitor (IC50: 24 nM), induces apoptosis, stable metabolism, good pharmacokinetics.Fórmula:C20H15F6N5O3SCor e Forma:SolidPeso molecular:519.42AChE/GSK-3β-IN-1
CAS:AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-Fórmula:C31H35N7O3SCor e Forma:SolidPeso molecular:585.72(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Fórmula:C15H38N2O9SCor e Forma:SolidPeso molecular:422.54iMDK quarterhydrate
iMDK quarterhydrate, PI3K inhibitor, blocks MDK growth; suppresses NSCLC safely with MEK inhibitor.Fórmula:C21H15FN2O3SCor e Forma:SolidPeso molecular:380.91VEGFR-2-IN-17
VEGFR-2-IN-17 (15a) is a potent VEGFR-2 inhibitor with an IC50 of 67.25 nM, showing significant antitumor effects.Fórmula:C21H14ClN3O2Cor e Forma:SolidPeso molecular:375.81A-9758
CAS:A-9758: RORγt selective inverse agonist, IC50 5nM, inhibits IL-17A, Th17, and treats psoriasis.Fórmula:C25H23Cl2F3N2O3Pureza:98%Cor e Forma:SolidPeso molecular:527.36Antibacterial agent 63
CAS:Aztreonam-siderophore conjugate 63 is an antibacterial agent that exhibits efficacy against Gram-negative bacteria through the linkage of aztreonam to aFórmula:C35H43N9O14S2Cor e Forma:SolidPeso molecular:877.9DNA-PK-IN-8
CAS:<p>DNA-PK-IN-8: Potent, selective oral DNA-PK inhibitor, IC50 = 0.8 nM, boosts anti-cancer effects with Doxorubicin.</p>Fórmula:C19H22N8O2Cor e Forma:SolidPeso molecular:394.43Antibacterial agent 118
Antibacterial agent 118, potent against various mycobacteria, has MIC values ranging from 10.2 to 163.0 μM. Useful in TB research.Fórmula:C19H21N5O2SCor e Forma:SolidPeso molecular:383.47NLRP3-IN-7
<p>NLRP3-IN-7 (Compound 36) is a selective inhibitor of the NLRP3 inflammasome and is able to assemble the NLRP3 inflammasome.</p>Fórmula:C18H15ClN2O4S3Cor e Forma:SolidPeso molecular:454.97P-gp modulator 3
<p>P-gp modulator 3 (Compound 37) is a potent, competitive, metabotropic P-glycoprotein (P-gp) modulator.</p>Fórmula:C31H37N3O5Cor e Forma:SolidPeso molecular:531.64ORP-101
CAS:ORP-101: large, stable molecule with partial μ agonist, full κ antagonist properties.Fórmula:C60H84N2O8Cor e Forma:SolidPeso molecular:961.32Ciprokiren
CAS:Ciprokiren, a renin inhibitor by Roche, halts human renin; IC50: 0.07/0.65 nmol/L. Lowers blood pressure in animals. Preclinical development ceased.Fórmula:C37H55N5O8SCor e Forma:SolidPeso molecular:729.93PTP1B-IN-17
PTP1B-IN-17, a benzimidazole derivative, inhibits PTP1B (Ki: 30.2 μM) and may help study type 2 diabetes.Fórmula:C26H19N3O4SCor e Forma:SolidPeso molecular:469.51Trichostatin A S-isomer
CAS:<p>Trichostatin A S-isomer, a HDAC 1, 3, 4, 6, 10 inhibitor with IC50 ~20 nM, has wide-ranging epigenetic effects.</p>Fórmula:C17H22N2O3Pureza:98%Cor e Forma:SolidPeso molecular:302.37CH-38083
CAS:CH-38083 is a selective and effective alpha-2 adrenoceptors antagonist.Fórmula:C18H24ClNO3Pureza:98%Cor e Forma:SolidPeso molecular:337.84Gamendazole
CAS:Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.Fórmula:C18H11Cl2F3N2O2Pureza:98%Cor e Forma:SolidPeso molecular:415.19P053
CAS:<p>P053: potent, selective CerS1 inhibitor, IC50 = 0.5µM, curbs muscle fat oxidation, affects body fat.</p>Fórmula:C18H21Cl2NO2Pureza:98%Cor e Forma:SolidPeso molecular:354.27Antimalarial agent 3
Antimalarial agent 3 has a potent IC50 of 0.035 μM against Plasmodium and high selectivity for mammalian cells.Fórmula:C15H16BrN3O2Cor e Forma:SolidPeso molecular:350.21U75302
CAS:U75302 is an antagonist of thymosin beta-4 (TB4) receptor with a Ki value of 159 nM on guinea pig lung membranes.Fórmula:C22H35NO3Pureza:98%Cor e Forma:Light Yellow OilPeso molecular:361.52HBV-IN-18
HBV-IN-18 (Compound 3) is an HBV capsid assembly modulator (CpAM) (EC50: 2790 nM).Fórmula:C17H15F6N5O2Cor e Forma:SolidPeso molecular:435.32AChE-IN-10
<p>AChE-IN-10 (24r) inhibits AChE (IC50=2.4 nM), reducing amyloid buildup, tau phosphorylation, and promotes neuron health.</p>Fórmula:C23H27F2NO4SCor e Forma:SolidPeso molecular:451.53Disulergine
CAS:Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Fórmula:C17H24N4O2SPureza:98%Cor e Forma:SolidPeso molecular:348.46Tubulin polymerization-IN-6
Compound 5f, a potent tubulin polymerization inhibitor (IC50 = 1.09 μM), blocks cell migration, tube formation, and has anti-angiogenic effects.Fórmula:C19H21NO7Cor e Forma:SolidPeso molecular:375.37Namitecan
CAS:Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Fórmula:C23H22N4O5Pureza:98%Cor e Forma:SolidPeso molecular:434.44Hcyb1
Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.Fórmula:C24H20N4OCor e Forma:SolidPeso molecular:380.44CEP-14083
CAS:<p>CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.</p>Fórmula:C31H30N6O2Cor e Forma:SolidPeso molecular:518.616-trans-12-epi-Leukotriene B4
CAS:<p>6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47DX-9065A HCl hydrate
CAS:<p>DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.</p>Fórmula:C26H39ClN4O8Pureza:98%Cor e Forma:SolidPeso molecular:571.06Abarelix acetate
CAS:Abarelix acetate: synthetic GnRHR antagonist, spikes histamine, lowers LH and testosterone temporarily, used in advanced prostate cancer.Fórmula:C72H95ClN14O14·xC2H4O2Cor e Forma:SolidPeso molecular:1476.14HIV-1 protease-IN-6
HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.Fórmula:C27H31FN2O6SCor e Forma:SolidPeso molecular:530.61SCP1-IN-2
<p>SCP1-IN-2: potent, selective SCP1 inhibitor; induces REST degradation, hinders its activity, may study REST-driven glioblastoma growth.</p>Fórmula:C19H17F3N2O6S2Cor e Forma:SolidPeso molecular:490.47Antibacterial agent 87
Antibacterial agent 87 is an effective antibacterial agent that acts on MRSA (MIC: 0.125 μg/ml), MRSE (MIC: 0.0625 μg/ml) and S. aureus (MIC: 0.0625 μg/ml).Fórmula:C31H46N2O6SCor e Forma:SolidPeso molecular:574.77Leukotriene F-4 sulfone
CAS:Leukotriene F-4 sulfone induces vascular permeability changes.Fórmula:C28H44N2O10SCor e Forma:SolidPeso molecular:600.72Anti-ToCV agent 1
Anti-ToCV agent 1 can be used as a potential anti-ToCV drug.Fórmula:C22H19FN2O5SCor e Forma:SolidPeso molecular:442.46PRMT5-IN-3
CAS:<p>PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.</p>Fórmula:C22H23F3N4O3Cor e Forma:SolidPeso molecular:448.44AY 17,605
CAS:AY 17,605 is an inhibitor of bovine heart and rat brain nucleoside-3',5'- monophosphate phosphodiesterase.Fórmula:C25H36O5Cor e Forma:SolidPeso molecular:416.55Antibacterial agent 75
Antibacterial agent 75 re-sensitizes VRSA to vancomycin.Fórmula:C22H28N6OCor e Forma:SolidPeso molecular:392.5GPR81 agonist 2
CAS:GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.Fórmula:C26H27ClN6O5S2Cor e Forma:SolidPeso molecular:603.11ONO-8809
CAS:ONO-8809: Thromboxane A2 antagonist, reduces airway hyperresponse, macrophage accumulation, and MMP-9 in SHRSP brains.Fórmula:C30H46BrNO4SPureza:98%Cor e Forma:SolidPeso molecular:596.66BMS-681
CAS:BMS-681 is a CCR2 antagonist blocking chemokine binding, aiding control of inflammatory and neurodegenerative diseases.Fórmula:C26H36F3N5OCor e Forma:SolidPeso molecular:491.59CM-414
CAS:<p>CM-414: HDAC/PDE5 inhibitor, targeting Alzheimer’s, IC50s: PDE5 (60 nM), HDAC1/2/3/6. Reduces Aβ, pTau in mice, boosts cognition.</p>Fórmula:C23H29N5O4Pureza:98%Cor e Forma:SolidPeso molecular:439.51YEATS4 binder-1
YEATS4 binder-1(4e) is an effective and selective compound that targets the KAc recognition site within the YEATS structural domain, exhibiting a bindingFórmula:C23H34N4O3Cor e Forma:SolidPeso molecular:414.54IAA65
CAS:<p>IAA65 is a potent inhibitor of T-type calcium channels, exhibiting an IC50 value of 18.9 μM, and holds potential for use in epilepsy research [1].</p>Fórmula:C16H13F6NO2Cor e Forma:SolidPeso molecular:365.27DN-F01
<p>DN-F01 exhibits a potent calcium-dependent inhibitory effect on cardiac myofibrillar ATPase activity, with an IC50 of 11 ± 4 nmol/L.</p>Fórmula:C22H16N2O2Cor e Forma:SolidPeso molecular:340.37Cap-dependent endonuclease-IN-10
CAS:Cap-dependent endonuclease-IN-10, with low toxicity & good stability, effectively inhibits flu viruses and shows promise against A, B, C types.Fórmula:C25H18F2N4O5SCor e Forma:SolidPeso molecular:524.50BRD2879
CAS:BRD2879 is a potent and cell-active inhibitor of IDH1-R132H (IC50 = 50 nM).Fórmula:C30H38FN3O5SPureza:98%Cor e Forma:SolidPeso molecular:571.70Nrf2 activator-2
Compound O15, an Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM; it inhibits Keap1-Nrf2 binding and Nrf2 ubiquitination.Fórmula:C20H17BrO3Cor e Forma:SolidPeso molecular:385.25iNOs-IN-1
iNOs-IN-1 (YPW) is a strong iNOS inhibitor with dose-dependent anti-inflammatory properties, reducing IL-6, iNOS, and NO levels.Fórmula:C25H30N4O5Cor e Forma:SolidPeso molecular:466.53METTL3-IN-3
CAS:METTL3-IN-3 is a polyheterocyclic compound, acts as METTL3 inhibitor .Fórmula:C26H28BrFN6O2Cor e Forma:SolidPeso molecular:555.44RF9 hydrochloride
<p>RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).</p>Fórmula:C26H39ClN6O3Cor e Forma:SolidPeso molecular:519.08Riminkefon
CAS:<p>Riminkefon is a kappa opioid receptor agonist .</p>Fórmula:C38H57N7O6Cor e Forma:SolidPeso molecular:707.9SZ1676
CAS:SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.Fórmula:C37H59BrN2O6Pureza:98%Cor e Forma:SolidPeso molecular:707.78MT-134
MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.Fórmula:C19H16N4O3Cor e Forma:SolidPeso molecular:348.36Gallinamide A
CAS:Gallinamide A is a potent inhibitor of cathepsin L with an IC 50 value of 17.6 pM.Fórmula:C31H52N4O7Cor e Forma:SolidPeso molecular:592.77L-697639
CAS:L-697639 inhibits of HIV-1 reverse transcriptase and HIV-1 replication.Fórmula:C18H21N3O2Cor e Forma:SolidPeso molecular:311.38LJ-4517
LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.Fórmula:C19H21N5O3SCor e Forma:SolidPeso molecular:399.47L-Sepiapterin
CAS:L-Sepiapterin aids in making BH4, a coenzyme essential for eNOS, enhancing artery function and angiogenesis, while suppressing ovarian cancer cell growth.Fórmula:C9H11N5O3Cor e Forma:SolidPeso molecular:237.22Antitrypanosomal agent 5
Antitrypanosal agent 5 is a selective anti-trypanosomal agent that acts on T. brucei (IC50: 1 nM) and HEK293 cells (IC50: 483.3 μM).Fórmula:C30H30N6O4SCor e Forma:SolidPeso molecular:570.66Neuraminidase-IN-7
Neuraminidase-IN-7, a thiophene, inhibits neuraminidase (IC50 0.03 μM), showing promise for flu research.Fórmula:C21H20N2O6SCor e Forma:SolidPeso molecular:428.46STAT3-IN-8
CAS:<p>"STAT3-IN-8 (compound H172) is a potent inhibitor of STAT3 with potential applications in cancer research [1]."</p>Fórmula:C19H7F7N2O3Pureza:98%Cor e Forma:SolidPeso molecular:444.26FAK-IN-6
<p>FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.</p>Fórmula:C25H31ClN5O6PSCor e Forma:SolidPeso molecular:596.04CDK4/6-IN-3
CAS:<p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>Fórmula:C25H31FN8Pureza:98%Cor e Forma:SolidPeso molecular:462.57AS-1940477 hydrobromide
CAS:AS-1940477 hydrobromide is a p38 mitogen-activated protein kinase (MAPK) inhibitor.Fórmula:C24H23BrFN5O2Cor e Forma:SolidPeso molecular:512.38Anti-inflammatory agent 23
Anti-inflammatory agent 23 blocks LPS-induced NO (IC50: 0.449 μM) and binds p65 well.Fórmula:C34H49NO6Cor e Forma:SolidPeso molecular:567.76Metocurine chloride
CAS:Metocurine: a muscle relaxant, not for kidney failure patients as it's kidney-excreted.Fórmula:C40H48Cl2N2O6Cor e Forma:SolidPeso molecular:723.72Saussureamine C
CAS:Saussureamine C is an inhibitor of H274Y and N294S mutants.Fórmula:C19H26N2O5Cor e Forma:SolidPeso molecular:362.42PF-446687
CAS:PF-446687 is a highly selective MC4 receptor (MC4R) agonist.Fórmula:C28H37ClF2N2O2Cor e Forma:SolidPeso molecular:507.06RET-IN-14
CAS:RET-IN-14 inhibits RET (IC50: <0.51-9.3 nM) & BTK (C481S) (IC50: 9.2-15 nM), promising for tumor research.Fórmula:C24H23FN8O4Cor e Forma:SolidPeso molecular:506.49CLR01 sodium
CAS:CLR01 is a tweezer reducing α-synuclein in MSA, inhibits SOD1 in ALS, blocks Ebola/Zika, stabilizes proteins, and lessens mutant p53 toxicity.Fórmula:C42H30Na2O8P2Cor e Forma:SolidPeso molecular:770.6211Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 is a potent inhibitor of the Cav3.2 T-type Ca2+channel (IC50: 0.1534 μM) and has a low binding affinity for D2 receptors.Fórmula:C32H37N3O2Cor e Forma:SolidPeso molecular:495.66Anti-inflammatory agent 13
Pentacyclic triterpene, Anti-inflammatory 13 inhibits DAMP/PAMP inflammation models.Fórmula:C30H48O4Cor e Forma:SolidPeso molecular:472.7Ganoderic acid R
CAS:<p>Ganoderic acid R: potent anticancer, induces apoptosis, cytotoxic to MDR and sensitive tumor cells.</p>Fórmula:C34H50O6Cor e Forma:SolidPeso molecular:554.76Antiangiogenic agent 3
Antiangiogenic agent 3 blocks HUVEC cell migration, chemotaxis, and lowers Src, cdc42, MAPK gene expression.Fórmula:C19H20O7Cor e Forma:SolidPeso molecular:360.36CPPG
CAS:CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.Fórmula:C11H14NO5PCor e Forma:SolidPeso molecular:271.21MSX-3
CAS:MSX-3 is an antagonist of the A2A adenosine receptor and a prodrug of MSX-2.Fórmula:C21H23N4Na2O7PPureza:98%Cor e Forma:SolidPeso molecular:520.389Anti-inflammatory agent 6
<p>Anti-inflammatory agent 6 blocks IKKα/β, IκBα, and NF-κB p65 phosphorylation, key to controlling inflammation.</p>Fórmula:C22H20O12Cor e Forma:SolidPeso molecular:476.39FXIa-6f
CAS:<p>FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species</p>Fórmula:C31H29ClF2N4O4Cor e Forma:SolidPeso molecular:595.04E6201
CAS:E6201, a dual kinase inhibitor, blocks MEK1/FLT3 and has anti-tumor/psoriasis effects with low IC50s: ERK2 (5.2 nM), JNK (91 nM), p38 MAPK (19 nM).Fórmula:C21H27NO6Cor e Forma:SolidPeso molecular:389.44Tofacitinib Prodrug-1
Tofacitinib Prodrug-1: an oral prodrug reducing Tofacitinib's side effects, treats ulcerative colitis in mice effectively with low toxicity.Fórmula:C36H39ClN10O7Cor e Forma:SolidPeso molecular:759.21Steroid sulfatase/17β-HSD1-IN-4
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a potent dual inhibitor of steroid sulfatase ( STS ) and 17β-hydroxysteroid dehydrogenase type 1 ( 17β HSD1 ).Fórmula:C18H17N3O4S2Cor e Forma:SolidPeso molecular:403.4811-trans Leukotriene E4
CAS:Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.Fórmula:C23H37NO5SCor e Forma:SolidPeso molecular:439.61LXR antagonist 2
<p>LXR antagonist 2 inhibits adipogenesis, downregulates LXR genes, and reduces lipids in hyperlipidemic mice (LXRβ IC50: 0.36μM, LXRα IC50: 2.25μM).</p>Fórmula:C34H40N2O5SCor e Forma:SolidPeso molecular:588.76c-Met-IN-2
CAS:c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.Fórmula:C24H21FN10OPureza:98%Cor e Forma:SolidPeso molecular:484.49NK1 receptor antagonist 2
CAS:NK1 Receptor Antagonist 2, a compound targeting the NK1 receptor, holds potential for tinnitus and hearing loss research.Fórmula:C31H35F7N4O2Cor e Forma:SolidPeso molecular:628.62CDK8-IN-5
CAS:CDK8-IN-5: potent CDK8 inhibitor, IC50=72 nM, boosts IL-10 by 43%, may aid inflammatory bowel disease research.Fórmula:C26H22N2O4Cor e Forma:SolidPeso molecular:426.46CDK9-IN-11
CAS:CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].Fórmula:C20H25N3O4Pureza:98%Cor e Forma:SolidPeso molecular:371.43Prohibitin ligand 1
Compound 22i, a prohibitin ligand, protects the heart at nanomolar levels by inducing STAT3 phosphorylation.Fórmula:C20H22N2OCor e Forma:SolidPeso molecular:306.4FGFR4-IN-4
CAS:FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.Fórmula:C28H32Cl2N6O5Pureza:98%Cor e Forma:SolidPeso molecular:603.5Ibafloxacine
CAS:Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect againstFórmula:C15H14FNO3Pureza:97.67%Cor e Forma:SolidPeso molecular:275.27Ac-ATS010-KE
CAS:Ac-ATS010-KE is a novel Selective, irreversible, and Rapid Cell-Permeable Inhibitor of Human Caspase-3.Fórmula:C43H41F5N6O12SCor e Forma:SolidPeso molecular:960.88ChE/Aβ1-42-IN-1
<p>ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.</p>Fórmula:C19H24N2O3Cor e Forma:SolidPeso molecular:328.41AR antagonist 4
<p>AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).</p>Fórmula:C29H36N4OCor e Forma:SolidPeso molecular:456.62Tesirine
CAS:<p>MP-PEG8-VA-PABC-PBD Dimer: ADC drug-linker for various cancers; DNA alkylating agent that blocks DNA replication.</p>Fórmula:C75H101N9O23Pureza:98%Cor e Forma:SolidPeso molecular:1496.65PDE4-IN-5
PDE4-IN-5: potent PDE4 inhibitor, IC50 = 3.1 nM, superb skin penetration, anti-psoriasis effect.Fórmula:C21H28N2O3Cor e Forma:SolidPeso molecular:356.46(S)-Purvalanol B
CAS:<p>(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .</p>Fórmula:C20H25ClN6O3Pureza:98%Cor e Forma:SolidPeso molecular:432.9ZLWT-37
ZLWT-37: Oral CDK inhibitor, CDK9 IC50=0.002 µM, CDK2 IC50=0.054 µM; halts HCT116 cells at G2/M, induces apoptosis.Fórmula:C26H30ClN5OCor e Forma:SolidPeso molecular:464ONO-9780307
CAS:ONO-9780307 is a specific antagonist of LPA1 (lysophosphatidic acid receptor 1) (IC50: 2.7 nM).Fórmula:C30H35NO7Cor e Forma:SolidPeso molecular:521.6SX 3202
CAS:<p>SX 3202 is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy.</p>Fórmula:C17H11BrFN3O4Cor e Forma:SolidPeso molecular:420.19BM635 hydrochloride
<p>BM635 hydrochloride, an MmpL3 inhibitor, strongly blocks Divergent bacteriophage H37Rv (MIC50: 0.08 μM), with doubled in vivo potency.</p>Fórmula:C25H30ClFN2OCor e Forma:SolidPeso molecular:428.97Adafosbuvir
CAS:<p>Adafosbuvir has antiviral activity.</p>Fórmula:C22H29FN3O10PCor e Forma:SolidPeso molecular:545.457Zaragozic acid C
CAS:Zaragozic acid C is an effective inhibitor of squalene synthase.Fórmula:C40H50O14Pureza:98%Cor e Forma:SolidPeso molecular:754.82RORγt inverse agonist 29
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM.Fórmula:C25H24N2O5SCor e Forma:SolidPeso molecular:464.53MRS4738
MRS4738 is a potent antagonist with high affinity for the P2Y14R receptor. It demonstrates in vivo anti-hyperallodynic and antiasthmatic activity [1].Fórmula:C30H24F3NO2Cor e Forma:SolidPeso molecular:487.51EGFR/HER2-IN-5
<p>EGFR/HER2-IN-5: Irreversible, oral dual EGFR inhibitor, IC50 0.6 nM, targets L858R/T790M mutations, anti-tumor in vivo for lung cancer study.</p>Cor e Forma:SolidTribenuron
CAS:<p>Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed.</p>Fórmula:C14H15N5O6SCor e Forma:SolidPeso molecular:381.36ERGi-USU-6 mesylate
<p>ERGi-USU-6 (mesylate) is a new selective ERG positive prostate cancer inhibitor with an IC50 value of 0.089 μM that is an ERGi-USU-6 salt derivative.</p>Fórmula:C14H18N4O4SCor e Forma:SolidPeso molecular:338.38SB 243213 hydrochloride
CAS:SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).ItFórmula:C22H20ClF3N4O2Pureza:98%Cor e Forma:SolidPeso molecular:464.87Antibiotic MA 144M1
CAS:Antibiotic MA 144M1, an anthracycline, targets gram-positive bacteria and animal tumors; derived from Streptomyces fermentation or aclacinomycin A conversion.Fórmula:C42H55NO15Cor e Forma:SolidPeso molecular:813.88Antitumor agent-42
Antitumor agent-42 inhibits microtubule multimerisation and NO release, exhibiting anti-angiogenic, colony-forming and apoptosis-inducing effects.Fórmula:C24H19BrN2O8SCor e Forma:SolidPeso molecular:575.39DNA crosslinker 2 dihydrochloride
CAS:Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.Fórmula:C15H22Cl2N8OCor e Forma:SolidPeso molecular:401.29PAT-347
CAS:PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.Fórmula:C28H21ClF2N2O3SCor e Forma:SolidPeso molecular:538.99KT5926
CAS:KT5926 selectively inhibits myosin light chain kinase and NGF-dependent neurite growth; it's a K-252a analogue.Fórmula:C30H27N3O6Pureza:98%Cor e Forma:SolidPeso molecular:525.55Oxythiamine diphosphate ammonium
<p>Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).</p>Cor e Forma:SolidPamiparib maleate
CAS:Pamiparib (BGB-290) is a selective PARP inhibitor that blocks DNA repair and promotes apoptosis.Fórmula:C44H42F2N8O14Pureza:98%Cor e Forma:SolidPeso molecular:944.859DWN-12088 HCl
CAS:DWN-12088 HCl is the salt form of DWN-12088 Free Base, an orally administered small molecule prolyl-tRNA synthetase (PRS) inhibitorFórmula:C15H21Cl4N3OCor e Forma:SolidPeso molecular:401.15GSD-11
GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.Fórmula:C20H28O2Cor e Forma:SolidPeso molecular:300.44Pparδ agonist 5
Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.Fórmula:C23H21F3N2O2SCor e Forma:SolidPeso molecular:446.49Rafutrombopag
CAS:Rafutrombopag is a thrombopoietin (TPO) agonist.Fórmula:C25H22N4O5Cor e Forma:SolidPeso molecular:458.47SHR902275
CAS:<p>SHR902275: potent RAF inhibitor, hits RAS mutations, oral use. cRAF IC50=1.6 nM, bRAFwt IC50=10 nM, bRAFV600E IC50=5.7 nM, hinders cell growth.</p>Fórmula:C26H23F3N4O4Cor e Forma:SolidPeso molecular:512.48LY 292728
CAS:LY 292728 is a highly potent antagonist of leukotriene B4 receptor.Fórmula:C34H29FO9Pureza:98%Cor e Forma:SolidPeso molecular:600.59Antifungal agent 27
<p>Antifungal agent 27 shows moderate action against MRSA, weak against C. albicans, with MICs of 8 μg/mL and 32 μg/mL, respectively.</p>Fórmula:C18H23N5OSCor e Forma:SolidPeso molecular:357.47UB 165
CAS:Subtype-selective nicotinic agonistFórmula:C13H15ClN2Pureza:98%Cor e Forma:SolidPeso molecular:234.72AZD-4121
CAS:<p>AZD-4121 is an oral cholesterol absorption inhibitor targeting NPC1L1 for the treatment of dyslipidaemia.</p>Fórmula:C36H39F2N3O7SCor e Forma:SolidPeso molecular:695.77PROTAC FKBP Degrader-3
CAS:PROTAC FKBP Degrader-3, with FKBP and VHL binding groups linked, is a potent FKBP degrader.Fórmula:C68H90N6O17SPureza:98%Cor e Forma:SolidPeso molecular:1295.54GSK-1264
CAS:<p>GSK-1264: allosteric HIV integrase inhibitor, halts viral replication & abnormal protein multimerization.</p>Fórmula:C26H28FNO5Cor e Forma:SolidPeso molecular:453.5Squalestatin 3
CAS:Squalestatin 3 is an inhibitor of squalene synthase.Fórmula:C25H30O13Pureza:98%Cor e Forma:SolidPeso molecular:538.5Bizelesin
CAS:Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.Fórmula:C43H36Cl2N8O5Cor e Forma:SolidPeso molecular:815.7Topo I/COX-2-IN-1
Topo I/COX-2-IN-1: potent dual inhibitor; IC50 0.24μM (COX-2), 4.42μM (Topo I); anti-cancer; induces apoptosis, halts migration.Fórmula:C21H18ClFN2O3Cor e Forma:SolidPeso molecular:400.83PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) selectively degrades CDK12/13 at nanomolar potency, targeting breast cancer.Cor e Forma:SolidCREB-IN-1 TFA
<p>CREB-IN-1 TFA: Potent oral CREB inhibitor, IC50 of 0.18 μM, suppresses breast cancer cell growth.</p>Cor e Forma:SolidNLRP3-IN-4
NLRP3-IN-4 is an effective, oral NLRP3 inflammasome inhibitor with potent anti-inflammatory effects on colitis.Fórmula:C22H22N2O5Cor e Forma:SolidPeso molecular:394.42Cap-dependent endonuclease-IN-7
CAS:Cap-dependent endonuclease-IN-7, a potent CEN inhibitor, blocks viral mRNA synthesis and virus spread, with research use for influenza A, B, C.Fórmula:C36H28FN3O7SCor e Forma:SolidPeso molecular:665.69WF-47-JS03
<p>WF-47-JS03: RET kinase inhibitor, crosses blood-brain barrier, 500x more selective for KDR, IC50: 1.7 nM in Ba/F3 cells, 5.3 nM in LC-2/ad lung cancer cells.</p>Fórmula:C30H38N6O2Cor e Forma:SolidPeso molecular:514.66BMS-961955
CAS:BMS-961955 is an allosteric inhibitor of the hepatitis C virus NS5B polymerase.Fórmula:C37H43FN4O4SCor e Forma:SolidPeso molecular:658.83Pan-Trk-IN-3
<p>Pan-Trk-IN-3: potent Trk inhibitor (IC50: 2-26 nM), effective against drug-resistant mutants, induces apoptosis, anti-tumor effects.</p>Fórmula:C29H31ClN8O3Cor e Forma:SolidPeso molecular:575.06BET-IN-8
BET-IN-8 (Compound 27) is a potent inhibitor of BET (Ki: 0.83 μM, Kd: 0.571 μM), which ameliorates LPS-induced sepsis in vivo.BET-IN-8 has shown potential inFórmula:C22H21N3O4SCor e Forma:SolidPeso molecular:423.48hCAIX/XII-IN-5
<p>Coumarin 9a: Selective inhibitor of hCA IX/XII (Ki 93.3/85.7 nM), blocks cancer cell growth, and induces apoptosis.</p>Fórmula:C18H13NO3Cor e Forma:SolidPeso molecular:291.3DGY-08-097
CAS:<p>DGY-08-097: potent HCV NS3 degrader, low resistance risk, strong inhibition in cells, DC50 of 50nM at 4h.</p>Fórmula:C60H76N10O14Cor e Forma:SolidPeso molecular:1161.3L-threo-Sphingosine C-18
CAS:L-threo-Sphingosine C-18 is a protein kinase C inhibitor.Fórmula:C18H37NO2Pureza:98%Cor e Forma:SolidPeso molecular:299.49M-525
CAS:M-525, a potent first-in-class menin-MLL inhibitor, binds at 3 nM IC50 and curbs MLL leukemia cell growth & gene expression.Fórmula:C39H51FN6O5SPureza:98%Cor e Forma:SolidPeso molecular:734.92KDM1/CDK1-IN-1
KDM1/CDK1-IN-1 inhibits KDM1 (IC50: 0.096 μM) & CDK1 (IC50: 0.078 μM), blocks HOP-92 G2/M phase, induces apoptosis, toxic to cancer cells.Fórmula:C22H17N5O3SCor e Forma:SolidPeso molecular:431.47microRNA-21-IN-1
CAS:microRNA-21-IN-1: microRNA inhibitor, curbs HeLa/HCT-116 growth (IC50: 5.5/2.8 μM), induces HeLa apoptosis, elevates PTEN/EGR1/SLIT2, for cancer research.Fórmula:C30H37FN6O3Cor e Forma:SolidPeso molecular:548.65hMAO-B/MB-COMT-IN-1
Dual hMAO-B/MB-COMT inhibitor, IC50: 2.5 μΜ (hMAO-B), 3.84 μΜ (MB-COMT); potential in Parkinson's research.Fórmula:C16H19NO3Cor e Forma:SolidPeso molecular:273.33Protease-Activated Receptor-1 antagonist 2
Selective, orally active PAR-1 antagonist with an IC50 of 7 nM, potential for cardiovascular disease studies.Cor e Forma:SolidRetezorogant
CAS:Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.Fórmula:C23H33ClN2O3Cor e Forma:SolidPeso molecular:420.97JAK3-IN-13
JAK3-IN-13: Oral JAK3 inhibitor, selective & potent. Acts on NK1, JNK2, JNK3, Tyk2. Anti-tumor. IC50: JNK3, 8 nM; Tyk2, 365 nM; JNK2, 2039 nM; NK1, 4728 nM.Fórmula:C25H33ClN6O5Cor e Forma:SolidPeso molecular:533.02DENV-IN-6
CAS:<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Fórmula:C23H26ClFN4OSCor e Forma:SolidPeso molecular:461TCMDC-135051 TFA (2413716-15-9 free base)
TCMDC-135051 TFA is a highly selective and potent inhibitor of protein kinase PfCLK3.Fórmula:C31H34F3N3O5Pureza:98%Cor e Forma:SolidPeso molecular:585.61Inupadenant HCl
CAS:<p>Inupadenant (EOS-850) is a selective A2a receptor antagonist, targeting immunosuppression in tumors.</p>Fórmula:C25H27ClF2N8O4S2Cor e Forma:SolidPeso molecular:641.11COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Fórmula:C31H32FN5O2SCor e Forma:SolidPeso molecular:557.68Plagiochilin A
CAS:Plagiochilin A Inhibits Cytokinetic Abscission and Induces Cell DeathFórmula:C15H14O7Cor e Forma:SolidPeso molecular:306.27CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Fórmula:C26H22BrN5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:516.3911-Oxahomoaminopterin
CAS:11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.Fórmula:C20H21N7O6Pureza:98%Cor e Forma:SolidPeso molecular:455.42HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Fórmula:C16H12N2O3Cor e Forma:SolidPeso molecular:280.28SHR0687
CAS:<p>SHR0687: potent KOR agonist, selective, favorable PK, effective in rat pain model, minimal BBB penetration, less CNS side effects.</p>Fórmula:C39H60N8O5Cor e Forma:SolidPeso molecular:720.94Naltalimide
CAS:Naltalimide: µ-opioid receptor partial agonist, improves bladder storage by affecting spinal cord reflex.Fórmula:C28H28N2O5Pureza:98%Cor e Forma:SolidPeso molecular:472.53
