Sistema complementar
O sistema complemento é uma parte crucial da resposta imunológica, consistindo em uma série de pequenas proteínas que melhoram a capacidade dos anticorpos e das células fagocíticas de eliminar patógenos de um organismo. Essas proteínas trabalham juntas para opsonizar patógenos, induzir respostas inflamatórias e lisar diretamente as membranas dos patógenos, desempenhando um papel vital na imunidade inata e na função imunológica geral. Na CymitQuimica, fornecemos proteínas de alta qualidade do sistema complemento para apoiar seus estudos imunológicos e pesquisas clínicas.
Foram encontrados 169 produtos de "Sistema complementar"
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Ravulizumab
CAS:<p>Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.</p>Pureza:> 95%Cor e Forma:LiquidPeso molecular:145.80 kDaSutimlimab
CAS:Sutimlimab: monoclonal antibody, inhibits complement protein C1, treats cold agglutinin-induced hemolysis.Pureza:> 95%Cor e Forma:LiquidPeso molecular:144.8 kDaLampalizumab
CAS:<p>Lampalizumab (RG 7417) is a humanized monoclonal antibody targeting Factor D, which can be used in cardiovascular disease research.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:46.96 (kDa)Tesidolumab
CAS:<p>Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.</p>Pureza:99.72% (SEC-HPLC) - > 95%Cor e Forma:LiquidPeso molecular:142 kDa (average)Vesencumab
CAS:<p>Vesencumab (MNRP-1685A) is an IG1 antibody targeting NRP-1 with anti-angiogenic and anti-tumor activity. Vesencumab can be used to study solid tumors.</p>Pureza:99.2% (SDS-PAGE); 96.6% (SEC-HPLC) - 99.2% (SDS-PAGE); 96.6% (SEC-HPLC)Cor e Forma:LiquidDexamethasone
CAS:Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.Fórmula:C22H29FO5Pureza:98% - 99.91%Cor e Forma:Crystals From Ether (Ntp 1992)Peso molecular:392.46Cyclosporin A
CAS:Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.Fórmula:C62H111N11O12Pureza:99.00% - 99.92%Cor e Forma:White PowderPeso molecular:1202.61Vilobelimab
CAS:<p>Vilobelimab (CaCP-29, IFX-1), a monoclonal antibody, inhibits C5a to reduce inflammation and is researched in sepsis and COVID-19 studies.</p>Pureza:99% (SDS-PAGE); 98.9% (SEC-HPLC) - 99% (SDS-PAGE); 98.9% (SEC-HPLC)Cor e Forma:LiquidSB290157 trifluoroacetate
CAS:SB290157 trifluoroacetate is a potent and selective antagonist of C3a receptor(IC50 of 200 nM).Fórmula:C24H29F3N4O6Pureza:98.93% - 99.89%Cor e Forma:SolidPeso molecular:526.51Avdoralimab
CAS:Avdoralimab (IPH 5401) is a humanized monoclonal antibody targeting complement C5a receptor 1 (C5aR1).Pureza:>95%Cor e Forma:LiquidNH2-C6-ARC186
<p>NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules.</p>Pureza:98%Cor e Forma:SolidPeso molecular:12881C1s-IN-1 trihydrochloride
CAS:<p>C1s-IN-1 trihydrochloride (Compound A1) is a selective inhibitor of C1s protease with a Ki of 5.8 μM. This compound inhibits the cleavage of C2 by C1s with an IC50 of 85 μM and prevents activation of the classical pathway, with an IC50 of 22 μM. Additionally, C1s-IN-1 trihydrochloride acts as a competitive inhibitor of thrombin, exhibiting a Ki of 51.2 μM.</p>Fórmula:C16H22Cl3N5Cor e Forma:SolidPeso molecular:390.74Greziprubart
Greziprubart is a humanized IgG1κ monoclonal antibody that targets C5a, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidHuman Immunoglobulin M
<p>Human Immunoglobulin M (IgM) is an antibody secreted by the adaptive immune system in response to foreign antigens. It is a primary type of immunoglobulin released into circulation during the early stages of the primary antibody response. Human Immunoglobulin M forms a pentamer comprising five IgG equivalents, with 10 Fab fragments, allowing for 10 antigen binding sites. Additionally, Human Immunoglobulin M acts as a complement (complement) activator.</p>Cor e Forma:Odour SolidFactor B-IN-1
CAS:<p>Factor B-IN-1 is a Factor B inhibitor.</p>Fórmula:C19H16N4O2Cor e Forma:SolidPeso molecular:332.3559C5aR2 agonist P32 acetate
C5aR2 agonist P32 acetate (Ac-RHYPYWR-OH), a selective agonist for C5aR2, has been shown to induce various immunomodulatory activities both in vitro and in vivo. It modulates cell signaling via the downregulation of C5aR1-mediated pathways and can also function independently of C5aR1.Fórmula:C54H70N16O11·xC2H4O2Cor e Forma:SolidPeso molecular:1119.23 (free base)Factor B-IN-5
CAS:<p>Factor B-IN-5 is a complement factor B inhibitor, which can be used to study immune-related diseases.</p>Fórmula:C27H32N2O4Pureza:98.19%Cor e Forma:SoildPeso molecular:448.55ARC186
ARC186 is a highly potent aptamer that serves as a complement inhibitor by blocking the convertase-catalyzed activation of C5.Cor e Forma:SolidPeso molecular:120702.76PIC1 PA TFA
PIC1 PATFA is the trifluoroacetate form of PIC1 PA. PIC1 PA TFA is a peptide composed of 15 amino acids and serves as an effective PIC1 analog capable of inhibiting complement activation mediated by the classical pathway.Fórmula:C71H123N19O21S2·xC2HF3O2Cor e Forma:SolidAMY-101 TFA
CAS:AMY-101 TFA is an inhibitor of complement C3 and an immunomodulator, gingivitis and periodontitis. reduces inflammation and lowers levels of MMP-8 and MMP-9Fórmula:C85H118F3N23O20S2Cor e Forma:SolidPeso molecular:1903.11PMX 205
CAS:PMX 205 is an effective complement antagonist of the C5a receptor.Fórmula:C45H62N10O6Pureza:98%Cor e Forma:SolidPeso molecular:839.04Claseprubart
CAS:<p>Claseprubart is a monoclonal antibody that targets human complement C1s. It specifically binds to complement C1s, inhibiting the activation of the complement system and exerting immunosuppressive effects. Claseprubart shows potential for research in autoimmune diseases and inflammation-related conditions.</p>Cor e Forma:LiquidZilucoplan (PEG2)
Zilucoplan(PEG2) is a derivative of Zilucoplan where the linker component has been substituted with PEG2 instead of PEG24. This compound acts as an effective inhibitor of complement component 5 (C5).Fórmula:C128H190N24O33Cor e Forma:SolidPeso molecular:2593.02C3 Protein (human)
C3 Protein (human) is an intrinsically glycosylated polypeptide composed of two disulfide-linked chains. Complement protein C3 is a pivotal molecule within the complement system, and its activation is fundamental to all essential functions of this system.Cor e Forma:Odour SolidC3a (70-77) (TFA)
C3a (70-77) (TFA) (Complement 3a (70-77) TFA) is an octapeptide derived from the COOH-terminus of Complement 3a, exhibiting 1–2% C3a biological activity.Fórmula:C37H62F3N13O12Cor e Forma:SolidPeso molecular:937.96Olendalizumab
CAS:Olendalizumab (ALXN1007) is a humanized antibody targeting C5a for research on COVID-19-related inflammation.Cor e Forma:LiquidAnti-GC1q R/C1QBP Antibody (60.11)
Anti-GC1q R/C1QBP Antibody (60.11) is a mouse IgG1, κ chimeric antibody designed to target human GC1q R/C1QBP. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.3-O-(2'E,4'Z-Decadienoyl)ingenol
3-O-(2'E,4'Z-Decadienoyl)ingenol is a useful organic compound for research related to life sciences and the catalog number is T124104.Fórmula:C30H42O6Cor e Forma:SolidPeso molecular:498.66Anti-CD88/C5AR1 Antibody (G2_anti-C5aR)
Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) is a human monoclonal antibody (mAb) targeting C5AR1.Cor e Forma:Odour LiquidVemircopan
CAS:Vemircopan is a complement factor D inhibitor.Fórmula:C29H28BrN7O3Cor e Forma:SolidPeso molecular:602.493PMX 205 Trifluoroacetate
PMX 205 Trifluoroacetate is a potent complement C5a receptor ( C5aR ; CD88 ) antagonist.Fórmula:C47H63F3N10O8Cor e Forma:SolidPeso molecular:953.06C1q Protein (rat)
C1qProtein (Rat) is a subunit of the complement system. It can recognize various ligands and plays a role in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Cor e Forma:Odour SolidPMX-53
CAS:PMX-53: MrgX2 agonist; C5aR antagonist; lessens atherosclerotic lesions & metastasis in mice; blocks rat hypernociception.Fórmula:C47H65N11O7Pureza:98%Cor e Forma:SolidPeso molecular:896.09Campneoside II
CAS:Campneoside II, a compound extracted from the wood of Paulownia tomentosa var. tomentosa, demonstrates remarkable anti-complement activity [1].Fórmula:C29H36O16Cor e Forma:SolidPeso molecular:640.59JPE-1375
CAS:JPE-1375: a C5aR1 antagonist, blocks leukocyte mobilization (EC50=6.9 µM), lowers TNF in mice (EC50=4.5 µM), useful for autoimmune/inflammation research.Fórmula:C49H63FN10O9Cor e Forma:SolidPeso molecular:955.08TLQP-21
CAS:TLQP 21, a VGF-derived peptide, guards CGCs against apoptosis and combats early diet-induced diabetes by boosting energy spend.Fórmula:C107H170N40O26Pureza:98%Cor e Forma:SolidPeso molecular:2432.75C2 Protein (human)
C2 Protein (human) is a naturally glycosylated peptide with a 20-amino acid signal sequence. It plays a critical regulatory role in the early activation stages of the classical pathway and is involved in the formation of the classical pathway C3 convertase, C4b2a.Cor e Forma:Odour SolidCertepetide
CAS:Certepetide, or iRGD, is a cyclic peptide that enhances tumor penetration and researches solid cancers.Fórmula:C37H60N14O14S2Cor e Forma:SolidPeso molecular:989.09Compstatin TFA
<p>Compstatin TFA: 13-residue cyclic peptide, inhibits primate complement C3, species-specific, protease-resistant, IC50=63μM (classical), 12μM (alternative).</p>Fórmula:C68H100F3N23O19S2Cor e Forma:SolidPeso molecular:1664.79Pegcetacoplan acetate
<p>Pegcetacoplan acetate is a pegylated complement C3 inhibitory peptide that functions by binding to complement component 3 (C3) and its activation fragment C3b. This compound is utilized in the study of complement-mediated diseases, including age-related macular degeneration, C3 glomerulopathy, geographic atrophy (GA), and autoimmune hemolytic anemia.</p>Cor e Forma:Odour SolidComplement C1s-IN-1
CAS:Complement C1s-IN-1 is a selective inhibitor of complement C1s，oral and brain penetrable, inhibit human serum-induced formation of membrane attack complexesFórmula:C22H20F2N6OPureza:97.77%Cor e Forma:SoildPeso molecular:422.43Pozelimab
CAS:<p>Pozelimab (REGN 3918) is a humanized antibody targeting component 5 (C5), used for research on Pozelimab disease.</p>Pureza:98.94% (SEC-HPLC) - 98.94% (SEC-HPLC)Cor e Forma:LiquidBM213
CAS:BM213 is a useful organic compound for research related to life sciences and the catalog number is T35399.Fórmula:C43H70N12O10Pureza:98%Cor e Forma:SoildPeso molecular:915.09POT-4 TFA
POT-4 TFA, a Compstatin derivative, inhibits C3 activation, for macular degeneration research.Fórmula:C74H103F3N22O20S2Cor e Forma:SolidPeso molecular:1741.87tLyP-1 peptide
CAS:tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. It can specifically bind to NRP-1 to target tumor cells.Fórmula:C31H59N15O10SCor e Forma:SolidPeso molecular:833.96CK3 peptide
CAS:<p>CK3 peptide is an NRP-1-targeting peptide with the amino acid sequence CLKADKAKC. It specifically binds to NRP-1 to target breast cancer cells. Single-photon emission computed tomography (SPECT) and near-infrared fluorescence (NIRF) imaging demonstrate that CK3 peptide significantly accumulates in xenograft tumors in nude mice. CK3 peptide is applicable for molecular imaging studies of breast cancer.</p>Fórmula:C40H72N12O12S2Cor e Forma:SolidPeso molecular:977.203Vensobafusp alfa
CAS:Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody targeting complement protein C5, combined with the domains 1-5 of complement factor H (FH1-5). It exhibits anti-inflammatory and immunomodulatory properties. The isotype control for Vensobafusp alfa can be referred to as human IgG4(S228P) kappa.Cor e Forma:LiquidBCX 1470 hydrochloride
BCX 1470 hydrochloride is a serine protease inhibitor with anti-inflammatory activity that inhibits factor D hemolytic activity and may be used to study edema.Fórmula:C14H11ClN2O2S2Pureza:99.71%Cor e Forma:SoildPeso molecular:338.83C1q Protein (Cyno)
C1qProtein (Cyno) is a subunit of the complement system. It recognizes various ligands and is involved in maintaining immune system balance, promoting tissue repair, and defending against pathogens.Cor e Forma:Odour SolidCP-447697
CAS:CP-447697, a lipophilic C5a receptor antagonist, exhibits an IC50 of 31 nM. It is utilized in inflammation research.Fórmula:C29H26ClF2N3O2SPureza:99.90%Cor e Forma:SoildPeso molecular:554.05CP-289
CAS:<p>CP-289 is a potent C5a receptor antagonist with IC50 of 1 μM.</p>Fórmula:C30H35ClN2O2Pureza:99.97%Cor e Forma:SoildPeso molecular:491.06EG01377 2HCl
CAS:EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377Fórmula:C26H32Cl2N6O6S2Pureza:98.91%Cor e Forma:SoildPeso molecular:659.6L-156,602
CAS:L-156,602 has a wide range of applications in life science related research.Fórmula:C38H64N8O13Cor e Forma:SolidPeso molecular:840.973C3a (70-77)
CAS:C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a.Fórmula:C35H61N13O10Pureza:98%Cor e Forma:SolidPeso molecular:823.94AMY-101
CAS:AMY-101 TFA is a C3 complement inhibitor with high affinity (KD: 0.5 nM) and promising anti-inflammatory effects in severe COVID-19.Fórmula:C83H117N23O18S2Pureza:98%Cor e Forma:SolidPeso molecular:1789.113-Phenoxybenzaldehyde
CAS:<p>3-Phenoxybenzaldehyde is a complement (classical pathway) inhibitor with IC50 of 1388μM.</p>Fórmula:C13H10O2Pureza:99.01%Cor e Forma:SolidPeso molecular:198.22ATWLPPR Peptide TFA
ATWLPPR Peptide TFA inhibits neuropilin-1 and VEGF165-NRP-1 binding; may reduce diabetic retinal damage.Fórmula:C42H62F3N11O11Pureza:98%Cor e Forma:SolidPeso molecular:954Complement factor I Protein, Mouse, Recombinant (His)
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible forCor e Forma:Lyophilized PowderPeso molecular:66.39 kDa (predicted). Due to autocatalytic cleavage and glycosylation, the protein migrates to 80-100 kDa on Tris-Bis PAGE result.Complement factor D-IN-1
CAS:Complement factor D-IN-1, a selective small-molecule inhibitor with IC50s of 0.006 μM (Thioesterolytic) and 0.05 μM (MAC Assay).Fórmula:C21H19BrN6O3Cor e Forma:SolidPeso molecular:483.32Complement C3 Protein, Mouse, Recombinant (aa 25-1663, His)
Expression system: HEK293 Cells<br>Length: 25-1663, Full Length of Mature Protein<br>Activity: Not TestedCor e Forma:Lyophilized PowderPeso molecular:187.86 kDa (Predicted); 65-68 kDa, 110-115 kDa and 165-180 kDa (Due to glycosylation)MASP2 Protein (Primary Amine Labeling), Rat, Recombinant (His), Biotinylated
MASP2 Protein (Primary Amine Labeling), Rat, Recombinant (His), Biotinylated is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:46.7 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 15-20 kDa&25-30 kDa based on Tris-Bis PAGE result.C1QTNF1 Protein, Human, Recombinant (His)
C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain.Cor e Forma:Lyophilized PowderPeso molecular:37 KDa (reducing condition)Complement C3a Protein, Mouse, Recombinant
Complement C3a Protein, Mouse, Recombinant is expressed in E.Pureza:Greater than 95% as determined by reducing SDS-PAGE - Greater than 95% as determined by reducing SDS-PAGE. (QC verified)Cor e Forma:Lyophilized PowderPeso molecular:9 KDa (reducing condition)Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages.Cor e Forma:Lyophilized PowderPeso molecular:52.2 kDa (predicted). Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.Complement C2 Protein, Cynomolgus, Recombinant (His)
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC).Cor e Forma:Lyophilized PowderPeso molecular:82.18 kDa (predicted). Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.Complement Factor MASP3 Protein, Human, Recombinant (His)
MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway.Cor e Forma:Lyophilized PowderPeso molecular:95-120 KDa (reducing condition)Complement C5 Protein, Cynomolgus, Recombinant (His)
Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:188.1 kDa (predicted); 106.3 and 75.8 kDa (reducing conditions)Complement factor I Protein, Human, Recombinant (His)
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible forCor e Forma:Lyophilized PowderPeso molecular:64.58 kDa (predicted). Due to enzyme lysis and glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result.Complement C7 Protein, Human, Recombinant (His)
Complement C7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:92.6 kDa (predicted); 92-98 kDa (reducing conditions)C1QBP Protein, Mouse, Recombinant (His)
C1QBP Protein, Mouse, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:24.7 kDa (predicted); 32 kDa (reducing conditions)MASP2 Protein, Human, Recombinant (His)
The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood.Cor e Forma:Lyophilized PowderPeso molecular:46.9 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 18 kDa&25-30 kDa based on Tris-Bis PAGE result.Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages.Cor e Forma:Lyophilized PowderPeso molecular:25.7 kDa (predicted). Due to glycosylation, the protein migrates to 26-30 kDa based on Tris-Bis PAGE result.MASP2 Protein, Rat, Recombinant (E. coli, His)
MASP2 Protein, Rat, Recombinant (E.Cor e Forma:Lyophilized PowderPeso molecular:46.7 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 15-20 kDa&25-30 kDa based on Tris-Bis PAGE result.Complement C8 γ Protein, Human, Recombinant (His)
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G.Cor e Forma:Lyophilized PowderPeso molecular:22 KDa (reducing condition)C1s Protein, Human, Recombinant (His)
Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses.Cor e Forma:Lyophilized PowderPeso molecular:76.3 kDa (predicted); 82.06 kDa, 56.59 kDa and 33.36 kDa (reducing condition, due to glycosylation)C1QBP Protein, Human, Recombinant (His)
C1QBP Protein, Human, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:24.8 kDa (predicted); 36 kDa (reducing conditions)Complement C5a Protein, Mouse, Recombinant
Complement C5a Protein, Mouse, Recombinant is expressed in E.Pureza:97.4%Cor e Forma:Lyophilized PowderPeso molecular:9 kDa (predicted)Complement C2 Protein, Human, Recombinant (hFc)
Complement C2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:110 kDa (predicted); 110-130 kDa (reducing condition, due to glycosylation)Complement C5 Protein, Cynomolgus, Recombinant
Complement C5 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells.Cor e Forma:Lyophilized PowderPeso molecular:8.41 kDa (predicted); 12.42 kDa (reducing conditions)Complement C3 Protein, Cynomolgus, Recombinant (His)
Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:90.3%Cor e Forma:Lyophilized PowderPeso molecular:186.40 kDa (predicted)Complement Factor D/CFD Protein, Human, Recombinant (hFc)
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages.Cor e Forma:Lyophilized PowderPeso molecular:51.2 kDa (predicted). Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.Complement C5a Protein, Mouse, Recombinant, Biotinylated
Complement C5a Protein, Mouse, Recombinant, Biotinylated is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:9 kDa (predicted)C1QB Protein, Human, Recombinant (His)
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system.Cor e Forma:Lyophilized PowderPeso molecular:25.2 kDa (predicted); 30 kDa (reducing condition, due to glycosylation)MBL2 Protein, Human, Recombinant (His)
Mannose-Binding Protein C (MBP-C) belongs to the Collectin family of innate immune defense proteins.Pureza:> 99.9% - Greater than 95% as determined by reducing SDS-PAGE.Cor e Forma:Lyophilized PowderPeso molecular:31 KDa (reducing condition)Complement C2 Protein, Human, Recombinant (His)
Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:98.6%Cor e Forma:Lyophilized PowderPeso molecular:82.5 kDa (predicted)Complement C7 Protein, Human, Recombinant (hFc)
Complement C7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:118 kDa (predicted); 118 kDa (reducing conditions)Complement C5 Protein, Human, Recombinant (His & FLAG)
Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag.Pureza:96.1%Cor e Forma:Lyophilized PowderPeso molecular:188.8 kDa (predicted)Complement C3 Protein, Human, Recombinant (His)
Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:SDS-PAGE: 93.4%; SEC-HPLC: 94.7% - SDS-PAGE: 95.5%; SEC-HPLC: 92.6%Cor e Forma:Lyophilized PowderPeso molecular:186.43 kDa (predicted)C1s-A subcomponent Protein, Mouse, Recombinant (His)
C1s-A subcomponent Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:76.6 kDa (predicted)MASP2 Protein, Cynomolgus, Recombinant (His)
MASP2 Protein, Cynomolgus, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:46.8 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 21-24 kDa&28-30 kDa based on Tris-Bis PAGE result.MBL1 Protein, Rat, Recombinant (hFc)
MBL1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Cor e Forma:Lyophilized PowderPeso molecular:50.5 kDa (predicted); 56 kDa (reducing conditions)CFI Protein, Mouse, Recombinant (His)
CFI Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:66.75 kDa (predicted); 126.1 kDa, 59.3 kDa and 46.7 kDa (reducing conditions)Complement C3a Protein, Human, Recombinant
Complement C3a Protein, Human, Recombinant is expressed in E.Pureza:>99.99% - Greater than 95% as determined by reducing SDS-PAGE.Cor e Forma:Lyophilized PowderPeso molecular:13 KDa (reducing condition)Complement C3 Protein, Mouse, Recombinant (aa 994-1310, His)
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:36.34 kDa (predicted); 32.39 kDa (reducing conditions)MBL2 Protein, Mouse, Recombinant
Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix.Cor e Forma:Lyophilized PowderPeso molecular:28 KDa (reducing condition)Complement C2 Protein, Mouse, Recombinant (His)
Complement C2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:84.2 kDa (predicted); 91.2 kDa (reducing conditions)Complement C6 Protein, Human, Recombinant (His)
Complement C6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Cor e Forma:Lyophilized PowderPeso molecular:104 kDa (predicted); 110 kDa (reducing conditions)Complement C5 Protein, Human, Recombinant (Flag)
Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag.Cor e Forma:Lyophilized PowderPeso molecular:187.36 kDa (predicted); 176.6 kDa, 100.87 kDa and 72.07 kDa (reducing conditions)(Z)-Leukadherin-1
CAS:(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.Fórmula:C22H15NO4S2Pureza:99.23%Cor e Forma:SolidPeso molecular:421.49MASP2 Protein, Mouse, Recombinant (His)
MASP2 Protein, Mouse, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:46.6 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 18-20 kDa&27-30 kDa based on Tris-Bis PAGE result.Eculizumab
CAS:Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5Pureza:98.20%Cor e Forma:LiquidPeso molecular:148 kDaPMX 53 acetate(219639-75-5 free base)
CAS:<p>PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50</p>Fórmula:C49H69N11O9Pureza:99.91%Cor e Forma:SolidPeso molecular:956.16JR14a
CAS:JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.Fórmula:C25H26Cl2N4O3SPureza:99.76%Cor e Forma:SolidPeso molecular:533.47Avacopan
CAS:Avacopan (CCX168) is a C5aR antagonist with selective and oral activity. Avacopan can be used to treat ANCA-related vasculitis. Cost-effective and quality-assured.Fórmula:C33H35F4N3O2Pureza:97% - 99.9%Cor e Forma:SolidPeso molecular:581.64Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98.49% - 98.93%Cor e Forma:SolidPeso molecular:421.49BCX 1470 methanesulfonate
CAS:BCX 1470 inhibits factor D & C1s better than trypsin (IC50: 96 nM & 1.6 nM, 3.4- & 200-fold).Fórmula:C15H14N2O5S3Cor e Forma:SolidPeso molecular:398.48Compstatin
CAS:<p>Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.</p>Fórmula:C66H99N23O17S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:1550.77ADH-503
CAS:<p>ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist.Cost-effective and quality-assured.</p>Fórmula:C27H28N2O5S2Pureza:97.03% - >99.99%Cor e Forma:SolidPeso molecular:524.7Compstatin control peptide acetate
CAS:Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.Fórmula:C66H101N23O17Pureza:99.02%Cor e Forma:Odour SolidPeso molecular:1488.65Danicopan
CAS:Danicopan (ACH-4471), an oral factor D inhibitor, binds strongly (Kd 0.54 nM) and may treat PNH and aHUS.Fórmula:C26H23BrFN7O3Pureza:99.94%Cor e Forma:SolidPeso molecular:580.41Complement factor D-IN-2
CAS:Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.Fórmula:C27H24BrN7O3Pureza:99.53%Cor e Forma:SolidPeso molecular:574.43Iptacopan hydrochloride
CAS:Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.Fórmula:C25H31ClN2O4Pureza:98.89% - 99.89%Cor e Forma:SolidPeso molecular:458.98Complement C5a Protein, Human, Recombinant
Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E.Pureza:SDS-PAGE: 94.9%; SEC-HPLC: 93.5%Cor e Forma:Lyophilized PowderPeso molecular:8.3 kDa (predicted); 8.3 kDa (reducing conditions)AMY-101 acetate
AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.Fórmula:C85H121N23O20S2Pureza:98.80% - 99.98%Cor e Forma:SolidPeso molecular:1849.14C5AR1 Protein, Mouse, Recombinant (His & KSI)
Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not TestedCor e Forma:Lyophilized PowderPeso molecular:20.4 kDa (Predicted)Complement C8a Protein, Human, Recombinant (His)
<p>Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:65.8 kDa (predicted)C1RA Protein, Mouse, Recombinant (His & Myc)
<p>C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.</p>Cor e Forma:Lyophilized PowderPeso molecular:85.7 kDa (predicted)Properdin Protein, Mouse, Recombinant (His)
<p>A positive regulator of the alternate pathway of complement.</p>Cor e Forma:Lyophilized PowderPeso molecular:51.9 kDa (predicted)Complement C3 Protein, Mouse, Recombinant (His & SUMO)
Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:55.3 kDa (predicted)Complement C8g Protein, Human, Recombinant (His)
C8 is a constituent of the membrane attack complex.Pureza:95%Cor e Forma:Lyophilized PowderPeso molecular:26.4 kDa (predicted)Complement factor D Protein, Rat, Recombinant (His)
<p>Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate</p>Cor e Forma:Lyophilized PowderPeso molecular:27.8 kDa (predicted)Complement C5a Protein, Pig, Recombinant (His)
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.Cor e Forma:Lyophilized PowderPeso molecular:10.6 kDa (predicted)Complement C3 Protein, Bovine, Recombinant (His & SUMO)
Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:39.5 kDa (predicted)Complement factor D Protein, Rat, Recombinant (His & Myc)
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternateCor e Forma:Lyophilized PowderPeso molecular:29.8 kDa (predicted)C1QA Protein, Human, Recombinant (His & Myc)
<p>C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:30.7 kDa (predicted)CR1 Protein, Human, Recombinant
Expression system: E. coli<br>Length: 41-234, Partial<br>Activity: Not TestedCor e Forma:Lyophilized PowderPeso molecular:21.6 kDa (Predicted)Properdin Protein, Mouse, Recombinant (His & Myc)
A positive regulator of the alternate pathway of complement.Cor e Forma:Lyophilized PowderPeso molecular:53 kDa (predicted)C1SB Protein, Mouse, Recombinant (His & Myc)
<p>C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.</p>Cor e Forma:Lyophilized PowderPeso molecular:82.4 kDa (predicted)Complement factor I Protein, Rat, Recombinant (His & Myc)
<p>Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:69.2 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
<p>Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of</p>Cor e Forma:Lyophilized PowderPeso molecular:67.0 kDa (predicted)C1QL3 Protein, Mouse, Recombinant (His & Myc)
<p>May regulate the number of excitatory synapses that are formed on hippocampus neurons.</p>Cor e Forma:Lyophilized PowderPeso molecular:28.6 kDa (predicted)Complement C4-B Protein, Human, Recombinant (His & SUMO)
<p>Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.</p>Cor e Forma:Lyophilized PowderPeso molecular:49.1 kDa (predicted)C1QL1 Protein, Mouse, Recombinant (His)
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.Cor e Forma:Lyophilized PowderPeso molecular:26.9 kDa (predicted)C5AR1 Protein-VLP, Human, Recombinant (His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Cor e Forma:Lyophilized PowderPeso molecular:41.1 kDa (predicted)C5AR1 Protein, Human, Recombinant (Cell-Free, His)
<p>Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.</p>Pureza:90%Cor e Forma:Lyophilized PowderPeso molecular:40.7 kDa (predicted)Complement C4-B Protein, Mouse, Recombinant (His)
<p>Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.</p>Cor e Forma:Lyophilized PowderPeso molecular:39.0 kDa (predicted)C1QA Protein, Mouse, Recombinant (His)
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.Pureza:90% - 92%Cor e Forma:Lyophilized PowderPeso molecular:25.6 kDa (predicted)C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
Expression system: E. coli<br>Length: 306-351, Partial<br>Activity: Not TestedCor e Forma:Lyophilized PowderPeso molecular:52.8 kDa (Predicted)Complement C5 Protein, Rat, Recombinant (His & Myc)
Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:14.0 kDa (predicted)C1QA Protein, Mouse, Recombinant (E. coli, His)
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.Pureza:98% - > 85% as determined by SDS-PAGECor e Forma:Lyophilized PowderPeso molecular:29.1 kDa (predicted)Complement factor B Protein, Mouse, Recombinant (His)
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.Cor e Forma:Lyophilized PowderPeso molecular:87.0 kDa (predicted)Crovalimab
CAS:<p>Crovalimab (SKY59; RO7112689) is an humanised monoclonal antibody that binds to complement C5 , paroxysmal nocturnal haemoglobinuria (PNH).</p>Pureza:95%Cor e Forma:LiquidGefurulimab
CAS:<p>Gefurulimab (ALXN-1720) is a bispecific antibody derived from humans, targeting complement C5 and albumin.</p>Cor e Forma:LiquidRiliprubart
CAS:<p>Riliprubart (SAR445088) is a humanized monoclonal antibody that acts as an anti-C1s inhibitor in the proximal part of the classical complement system. It selectively targets activated C1s, inhibiting its enzymatic activity on substrates C4 and C2, thereby preventing the formation of the classical pathway C3 convertase, C4b2a [1].</p>Pureza:95% - 95%Cor e Forma:LiquidEmpasiprubart
CAS:<p>Empasiprubart (anti-C2 mAb) inhibits classical & lectin complement pathways upstream of C3, showing efficacy in autoimmune models.</p>Pureza:95%Cor e Forma:LiquidBCX 1470
CAS:BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.Fórmula:C14H10N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:302.37FD-IN-1
CAS:FD-IN-1 is an orally active Factor D (FD) inhibitor (IC50=12 nM), inhibits Factor XIa and Tryptase β2 with IC50 values of 7.7 and 6.5 μM, respectively.Fórmula:C23H23NO4Cor e Forma:SolidPeso molecular:377.43Isocyclosporin A
CAS:Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.Fórmula:C62H111N11O12Cor e Forma:SolidPeso molecular:1202.61NRP1 antagonist 2
CAS:NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.Fórmula:C20H17ClN6OS2Cor e Forma:SolidPeso molecular:456.97C5aR-IN-2
CAS:<p>C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.</p>Fórmula:C36H40FN5O2Cor e Forma:SolidPeso molecular:593.73C3a Receptor Agonist
CAS:<p>C3a Receptor Agonist activates C3aRs, inhibits neutrophil mobilization in ischemia, and promotes neural progenitor differentiation.</p>Fórmula:C27H35N3O2Pureza:99.76%Cor e Forma:SolidPeso molecular:433.59NDT 9513727
CAS:NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.Fórmula:C36H35N3O4Pureza:99.21%Cor e Forma:SolidPeso molecular:573.68Complement C5-IN-1
CAS:Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).Fórmula:C24H32N2O6Pureza:98.27%Cor e Forma:SolidPeso molecular:444.52EG00229
CAS:EG00229 blocks VEGF-A/NRP1 binding, IC50 of 3 μM; doesn't affect VEGFR-1/2. It's an NRP1 antagonist.Fórmula:C19H20F3N7O7S3Pureza:98.23%Cor e Forma:SolidPeso molecular:611.6EG01377
CAS:EG01377 is a NRP1 antagonist with antiangiogenic, antimigratory, and antitumor activity, Kd 1.32 μM, IC50s 609 nM for NRP1-a1/b1, inactive on NRP2.Fórmula:C26H30N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:586.68Factor B-IN-2
CAS:Factor B-IN-2 is a potent inhibitor (IC50: 1.5 μM) of complement factor B. Factor B-IN-2 can be used to study inflammatory and immune-related diseases.Fórmula:C25H32N2O4Cor e Forma:SolidPeso molecular:424.53Factor D inhibitor 6
CAS:Factor D inhibitor 6 is a potent, highly selective, and orally active compound that specifically inhibits the activity of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. It does not exhibit inhibitory effects against factor B, classical and lectin complement-pathway activation, or a broad array of receptors, ion channels, kinases, and proteases.Fórmula:C23H22ClFN6O3Cor e Forma:SolidPeso molecular:484.92C5aR-IN-1
CAS:C5aR-IN-1, a potent C5aR inhibitor, may aid in researching autoimmune and inflammatory diseases.Fórmula:C36H39F4N3O2Cor e Forma:SolidPeso molecular:621.71W-54011
CAS:W-54011: potent non-peptide C5a receptor blocker; binds 125I-C5a (Ki=2.2nM); stops Ca2+ movement, chemotaxis, ROS in neutrophils (IC50=1.6-3.1nM).Fórmula:C30H37ClN2O2Pureza:96.8%Cor e Forma:SolidPeso molecular:493.08Iptacopan
CAS:Iptacopan (LNP023) is an inhibitor with high affinity to factor B, with a KD value of 7.9 nM and an IC50 value of 10 nM. Cost-effective and quality-assured.Fórmula:C25H30N2O4Pureza:99.07% - >99.99%Cor e Forma:SolidPeso molecular:422.52Pelecopan
CAS:<p>Pelecopan (BCX9930), an oral complement factor D inhibitor, prevents hemolysis in PNH (IC50=14.3 nM).</p>Fórmula:C23H19FN2O4Cor e Forma:SolidPeso molecular:406.41Factor B-IN-4
CAS:Factor B-IN-4 is a potent inhibitor (IC50: 1 μM) of complement factor B. Factor B-IN-4 can be used to study inflammatory and immune-related diseases.Fórmula:C27H32N2O4Cor e Forma:SolidPeso molecular:448.55Factor B-IN-3
CAS:Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.Fórmula:C24H29N3O4Cor e Forma:SolidPeso molecular:423.5Refinicopan
CAS:Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM, demonstrating an inhibition activity on rabbit erythrocyte hemolysis with an IC50 of 41 nM. It possesses excellent pharmacokinetic and pharmacodynamic properties.Fórmula:C29H32N2O3Cor e Forma:SolidPeso molecular:456.58C5aR-IN-3
CAS:C5aR-IN-3, a potent C5aR inhibitor, may treat autoimmune and inflammatory diseases.Fórmula:C36H40FN5O3Cor e Forma:SolidPeso molecular:609.734-Octylphenol
CAS:4-Octylphenol is an endocrine disruptor with gender-specific effects on male germ cells, significantly reducing the mitotic index and the number of spermatogonia. It also causes inflammatory damage in the gills of carp by activating the complement system through the C3a/C3a receptor (C3a/C3aR) axis and C5a/C5a receptor 1 (C5a/C5aR1) axis. Furthermore, 4-Octylphenol induces immune suppression by disrupting the balance between helper T (Th) cells 1/Th2 and regulatory T (Treg)/Th17 cells, and triggers inflammatory damage through the Toll-like receptor 7 (Toll-like Receptor (TLR))/inhibitor κBα/nuclear factor κB (TLR7/IκBα/NF-κB) pathway.Fórmula:C14H22OCor e Forma:SolidPeso molecular:206.32(Rel)-Factor B-IN-5
CAS:(Rel)-Factor B-IN-5 is a complement factor B inhibitor that can be used to study diseases associated with activation of the alternative complement pathway.Fórmula:C27H32N2O4Pureza:>99.99%Cor e Forma:SolidPeso molecular:448.55TLQP-21 TFA
<p>TLQP-21 TFA （TLQP-21 Trifluoroacetate） 是一种 VGF 衍生肽，可通过结合后折叠机制激活C3aR1 受体。</p>Pureza:98%TLQP-21 TFA
<p>TLQP-21 TFA is a VGF-derived peptide, C3aR1 agonist (mouse EC50: 10.3μM; human EC50: 68.8μM), that raises intracellular Ca2+ for nociception research.</p>Pureza:98%Cor e Forma:Liquid
