Outros

<p>M04074 - 5-Bromo-6-chloro-3-indolyl beta-D-glucuronide cyclohexylammonium salt</p>

<p>Applications 3-Phenoxy-1,2-propanediol (cas# 538-43-2) is a useful research chemical.<br></p>

<p>Applications 2-CHLOROTOLUENE (cas# 95-49-8) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications As a dye for wool and silks; as colorant in food, drugs, and cosmetics. In biochemistry as an adsorption-elution indicator for chloride estimations. Tartrazine (otherwise known as E number E102, C.I. 19140, or FD&amp;C Yellow 5) is a synthetic lemon yellow azo dye used as a food coloring. Tartrazine appears to cause the most allergic and intolerance reactions of all the azo dyes, particularly among asthmatics and those with an aspirin intolerance. Dyes and metabolites, Environmental Testing.A recent report has shown that Tartrazine may be useful in 3D bio-printing of organ-like architectures.<br>References Rowe, K.S., et al.: J. Pedriatics, 125, 691 (1994), Tanaka, T., et al.: Food Chem. Toxicol., 44, 179 (2006); Chem. and Eng News Page 4 May 6, 2019<br></p>

<p>Applications Furfural is a compound mainly found in agricultural byproducts, and is produced from the hydrolysis and dehydration of xylan contained in lignocellulose using solid acid catalysts. Furfural is also a potential platform for biofuels and inhibits fermentation in yeast.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lange, J., et al.: ChemSusChem, 5, 150 (2012); Mamman, A., et al.: Biofuels, Bioprod. Biorefin., 2, 438 (2008); Navarro, A.: Curr. Microbiol., 29, 87 (1994)<br></p>

<p>Applications Lindane is an insecticide that is used as a treatment for scabies and lice. Lindane has been used as a broad-spectrum insecticide for seed and soil treatment, foliar applications, tree and wood treatment and against ectoparasites in both veterinary and human applications. Lindane is persistent, bioaccumulates easily in the food chain and bioconcentrates rapidly. There is evidence for long-range transport and toxic effects (immunotoxic, reproductive and developmental effects) in laboratory animals and aquatic organisms. One of the new POPs under the Stockholm Convention.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bist, R., et al.: Int. J. Pharm. Pharma. Sci., 4, 117 (2012); Heinz, M., et al.: Human. Health. Handbook., 1, 355 (2012); Bay, S.M., et al.: Enviro. Toxciol. Chem., 31, 2711 (2012);<br></p>

<p>Applications 5-Methylfurfural is a common chemical reagent used in a wide variety of chemical reactions and organic synthesis. Polycyclic pyridazine based derivatives are synthesized with this compound to form antimicrobial agents. Also used in the preparation of antiinflammatory diarylpentanoid analogues.<br>References Deeb, A. et al.: Eur. Chem. Bull., 3, 897 (2014); Leong, S. et al.: Molecules, 19, 16058 (2014);<br></p>

<p>Applications N-Acetyl Memantine is an intermediate used for preparation of Memantine (M218000).<br>References Gerzon, K., et al.: J. Med. Chem., 6, 760 (1963), Reddy, J., et al.: Org. Process Res. Dev., 11, 268 (2007),<br></p>

<p>Applications Bimatoprost 13,14-Epoxide is the impurity of Bimatoprost (B386800), which is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004)<br></p>

<p>Applications Ethyl Ethanesulfonate is used as a reactant in stereoselective Friedel-Crafts alkylation reactions. Also used in the preparation of 1-alkyl-3-methylimidazolium alkanesulfonate ionic liquids.<br>References Stadler, D., Bach, T.: Chem. Asian J., 3, 272 (2008); Blesic, M., et al.: Phys. Chem. Chem. Phys., 11, 8939 (2009);<br></p>

<p>Applications A labelled metabolite of Zopiclone.<br></p>

<p>Impurity Diazepam EP Impurity E<br>Applications 6-Chloro-1-methyl-4-phenyl-2(1H)-quinazolinone (Diazepam EP Impurity E) is an impurity of Temazepam (T017200), which is a pharmacologically active metabolite. It is used as a sedative and hypnotic drug.<br>References Sarteschi, P., et al.: Arzneim.-Forsch., 22, 93 (1972), Schwandt, H.J., et al.: Xenobiotica, 4, 733 (1974), Curry, S.H., et al.: Br. J. Pharmacol., 57, 427 (1976), Heel, R.C., et al.: Drugs, 21, 321 (1981)<br></p>

<p>Applications Diazepam is an anxiolytic; muscle relaxant (skeletal); anticonvulsant.Diazepam is a controlled substance (depressant).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 79 (1972); Mandelli, M., et al.: Clin. Pharmacokinet., 3, 72 (1978); Bertilsson, L., et al.: Pharmacol. Ther., 45, 85 (1990); Murray, J.B., et al.: J. Psychol., 124, 655 (1990); Pellock, J.M., et al.: Drug Saf., 27, 383 (2004);<br></p>

<p>Impurity Abiraterone Impurity 5<br>Applications 17-Iodo-androsta-5,16-diene-3β-ol is an analog of Abiraterone (A108490) and is used as a reagent in the synthesis of C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens which exhibit antitumor activity. Abiraterone Impurity 5<br>References Handratta, V.D., et al.: J. Med. Chem., 48, 2972 (2005)<br></p>

<p>Impurity Fulvestrant EP Impurity A<br>Applications Fulvestrant (F862500) impurity A. The S-isomer of Fulvestrant.<br>References Sharman, G.J., et al.: Mag. Resonance Chem., 39, 549 (2001),<br></p>

<p>Applications (15R)-Bimatoprost Acid is an impurity of the antiglaucoma agent Bimatoprost (B386820). (15R)-Bimatoprost Acid is a metabolically stable analog of PGF2α (P838625) and is a potent agonist for the FP receptor.<br>References Balapure, A.K. et al.: Biochem. Pharmacol., 38, 2375 (1989); Hellberg, M.R. et al.: J. Ocular Pharmacol. Ther., 19, 97 (2003); Krishna, P.M. et al.: J. Pharm. res., 4, 2381 (2011); Resul, B., et al.: J. Med. Chem., 36, 243 (1993)<br></p>

<p>Impurity Memantine Related Compound A (1,3-Dimethyladamantane)<br>Applications 1,3-Dimethyladamantane is a dimethylated adamantane derivative. Memantine impurity A. Memantine Related Compound A (1,3-Dimethyladamantane).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>