Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8892 produtos de "Derivados de Purinas e Pirimidinas"
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Sumatriptan Hydroxy-Oxindole Impurity (Sumatriptan Impurity 1)
CAS:Produto Controlado<p>Applications Sumatriptan Impurity 1, is an impurity of Sumatriptan (S810000), which is a serotonin 5HT1-receptor agonist, used for the treatment of migraine headaches.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Fórmula:C14H21N3O4SCor e Forma:NeatPeso molecular:327.4Caffeine Citrate
CAS:<p>Applications Caffeine citrate (Cafcit) is a citrate salt of Caffeine, sometimes used in medical treatment, including short-term treatment of apnea of prematurity (lack of breathing in premature infants). Caffeine citrate functions in much the same capacity as does caffeine, but takes effect more quickly; its speed of dissociation is faster than that of Caffeine. Caffeine citrate is typically only used to treat severe migraines.<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988); Grillon, C., et al.: Clin. Neurophysiol., 114, 1557 (2003); Duangdao, D., et al.: Behav. Brain Res., 205, 1 (2009);<br></p>Fórmula:C8H10N4O2·C6H8O7Cor e Forma:WhitePeso molecular:386.312,4-Diamino-6-(hydroxymethyl)pteridine Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Methotrexate intermediate.<br>References Feng, Y., et al.: J. Med. Chem., 49, 770 (2006),<br></p>Fórmula:C7H8N6O·ClHCor e Forma:YellowPeso molecular:228.641-(3-(2-(Dimethylamino)ethyl)-1-((5-((N-methylsulfamoyl)methyl)-1H-indol-3-yl)methyl)-1H-indol-5-yl)-N-methylmethanesulfonamide Formate Salt
CAS:Produto ControladoFórmula:C25H33N5O4S2·CH2O2Cor e Forma:NeatPeso molecular:531.694603nPOC-POC Tenofovir Fumarate(Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Fórmula:C19H30N5O10P·C4H4O4Cor e Forma:White To Off-WhitePeso molecular:635.51Hydroxy Urea-15N
CAS:Produto Controlado<p>Applications Labelled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide.<br>References Ratcliffe, W., et al.: Lancet, 339, 164 (1992), Roodman, G., et al.: Cancer, 80, 1557 (1997), Horwitz, M., et al.: J. Clin. Endocrinol. Metab., 2003, 88, 1603 (2003),<br></p>Fórmula:CH415NNO2Cor e Forma:NeatPeso molecular:77.05Methotrexate-d3 Pentaglutamate Trifluoroacetate (>90%)
CAS:Produto Controlado<p>Applications Methotrexate-d3 Pentaglutamate is the isotope labelled analog of Methotrexate Pentaglutamate (M260735); a metabolite of Methotrexate (M260675) which is a folic acid antagonist, antineoplastic, and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958); Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985)<br></p>Fórmula:C40H47D3N12O17(C2HF3O2)xCor e Forma:NeatPeso molecular:973.913-Descyano Febuxostat Ethyl Ester
CAS:Produto Controlado<p>Applications 3-Descyano Febuxostat Ethyl Ester is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>Fórmula:C17H21NO3SCor e Forma:NeatPeso molecular:319.42(R)-Methotrexate-d3 (Technincal Grade)
CAS:Produto ControladoFórmula:C20H19D3N8O5Cor e Forma:NeatPeso molecular:457.46N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid
CAS:Produto Controlado<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>Fórmula:C20H21N5O6Cor e Forma:NeatPeso molecular:427.41rac-Clopidogrel Carboxylic Acid Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications rac-Clopidogrel Carboxylic Acid Hydrochloride is a salt metabolite of rac-Clopidogrel.<br></p>Fórmula:C15H15Cl2NO2SCor e Forma:NeatPeso molecular:344.26Caffeidine Acid
CAS:Produto Controlado<p>Applications Caffeidine Acid is a degradation compound of Caffeine (C080100), which is a central nervous system stimulant.<br>References Kigasawa, K., et al.: Chem. Pharm. Bull., 22, 2448 (1974); Peinhardt, G.: Pharmazie, 46, 812 (1991); Kumar, R., et al.: Carcinogenesis, 13, 2179 (1992);<br></p>Fórmula:C8H12N4O3Cor e Forma:NeatPeso molecular:212.218-13C-Uric Acid (contains ~1.5% unlabelled)
CAS:Produto Controlado<p>Applications 8-13C-Uric Acid is the labeled analogue of Uric Acid (U829200), a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006)<br></p>Fórmula:C413CH4N4O3Cor e Forma:NeatPeso molecular:169.14-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium chloride
CAS:<p>Please enquire for more information about 4-[1,5-Bis-(2-methylsulfamoylethyl)-1H-indol-3-yl]-1-methylpyridinium chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>Fórmula:C20H27N4O4S2•ClPureza:Min. 95%Peso molecular:487.04 g/mol3,4-Dihydro naratriptan
CAS:<p>3,4-Dihydro naratriptan is a medicinal compound that is used as an anti-migraine drug. It is a hydrogenated form of the parent molecule naratriptan and has been shown to have a reaction time of about 30 minutes when catalyzed by palladium. The impurity, 3,4-dihydro naratriptan sulfonamide, has been found to be less potent than the target compound and can be eliminated from the synthesis by using catalytic hydrogenation. 3,4-Dihydro naratriptan sulfonamide can also be reduced by catalytic hydrogenation to yield 3,4-dihydro naratriptan.</p>Fórmula:C17H23N3O2SPureza:Min. 95%Peso molecular:333.45 g/molPemetrexed impurity C
CAS:<p>Pemetrexed is a drug product that belongs to the group of drugs called antifolate agents. It is used in the treatment of cancer and is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. The impurity C is a natural metabolite that can be found in urine as well as in plasma. This impurity has not been identified as a major metabolite of pemetrexed.</p>Fórmula:C40H40N10O13Pureza:Min. 95%Peso molecular:868.81 g/molAllopurinol impurity A
CAS:<p>Allopurinol is an anticancer drug that is used to treat leukemia and other cancers. Allopurinol impurity A is a byproduct of the production of allopurinol, which has been shown to have anticancer properties. It has been shown to suppress the expression of suppressor genes and up-regulated genes in pancreatic cancer cells. This compound also induces apoptosis in orthotopic liver cells in a process involving activation of caspase 3 and suppression of Akt signaling.</p>Pureza:Min. 95%3-(Formylamino)-1H-pyrazole-4-carboxamide
CAS:<p>This product is an organic compound that has a molecular formula of C6H7N3O2. It is a white solid with a melting point of 76.5 °C and an elution time of 7 minutes (range, 1-10 minutes). The detection method is based on the color change from yellow to blue in the presence of dimethylformamide (DMF). This product is used as a solvent for various chemical reactions and can be used in the synthesis of other products. 3-(Formylamino)-1H-pyrazole-4-carboxamide is used in analytical chemistry to determine substances such as pH, ionic strength, and concentration. In addition, this product can be used to quantify substances such as drugs or pharmaceuticals.</p>Fórmula:C5H6N4O2Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:154.13 g/mol1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol
CAS:<p>1,3-Dihydro-6-methylfuro[3,4-c]pyridin-7-ol is a compound that contains impurities such as fatty acids and uridine. It has been found to be an inhibitor of α-mangostin adduct formation with fatty acids. Additionally, it has been shown to inhibit the activity of GSK-3β, an enzyme involved in various cellular processes. This compound also exhibits inhibitory effects on monascus and safranal, two enzymes involved in the production of certain compounds. Furthermore, it has been found to inhibit calpain, an enzyme responsible for protein degradation. The compound can be used in various research applications involving electrode modification and polylysine immobilization. It may also have potential interactions with other drugs such as cefdinir.</p>Fórmula:C8H9NO2Pureza:Min. 95%Peso molecular:151.16 g/molLysine-methotrexate
CAS:<p>Lysine-methotrexate is a monoclonal antibody that binds to the DNA template of Leishmania. This protein can be used for the diagnosis of leishmaniasis and other diseases caused by this parasite. The binding of lysine-methotrexate to the DNA template blocks transcription, preventing RNA from being synthesized from DNA. Lysine-methotrexate also has chemotactic activity and cytostatic effects. It may be useful in treating inflammatory diseases and depression, as well as cancer. Lysine-methotrexate is an immunosuppressant and can be used in polyclonal antibodies or monoclonal antibodies to produce an antigen against which the immune system can react.</p>Fórmula:C21H27N9O3Pureza:Min. 95%Peso molecular:453.5 g/mol
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