Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8902 produtos de "Derivados de Purinas e Pirimidinas"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
4-(3,4-dimethylphenyl)-6-(3-methylphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:289.3819885253906trans (2,3)-Dihydro Tetrabenazine
CAS:Produto Controlado<p>Applications A metabolite of Tetrabenazine in vivo. The trans izomer of Dihydrotetrabenazine is used for the treatment of hyperkinetic movement disorders.<br>References Kilbourn, M., et al.: Eur. J. Pharmacol., 278, 249 (1995), Perera, R., et al.: J. Med. Chem., 46, 2599 (2003), Mager, D., et al.: J. Pharm. Sci., 94, 2475 (2005), Zheng, G., et al.: Bioorg. Med. Chem., 16, 5018 (2006),<br></p>Fórmula:C19H29NO3Cor e Forma:NeatPeso molecular:319.443-[(4,6-Dimethylpyrimidin-2-yl)amino]benzoic acid
CAS:Fórmula:C13H13N3O2Pureza:95.0%Cor e Forma:SolidPeso molecular:243.266Thyroxine
CAS:Produto Controlado<p>Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.<br>References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);<br></p>Fórmula:C15H11I4NO4Cor e Forma:Off-WhitePeso molecular:776.87Tenofovir Disoproxil Isopropoxycarbonyl
CAS:<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Fórmula:C23H36N5O12PCor e Forma:White SolidPeso molecular:605.535-Azido Oseltamivir
CAS:Produto Controlado<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Kim, C., et al.: J. Med. Chem., 41, 2451 (1998), Carbain, B., et al.: Chem. Med. Chem., 4, 335 (2009),<br></p>Fórmula:C16H26N4O4Cor e Forma:NeatPeso molecular:338.401-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:375.4070129394531Thyroxine Ethyl Ester
CAS:Produto Controlado<p>Applications An analog of Thyroxine (L425600) with stimulatory effects on human red blood cell membrane Ca2+-activated ATPase. It is a potential inactivator of iodothyronine deiodinase type II.<br>References Davis, F.B. et al.: J. Biol. Chem., 258, 12373 (1983); Safran, M. et al.: J. Biol. Chem., 268, 14224 (1993);<br></p>Fórmula:C17H15I4NO4Cor e Forma:NeatPeso molecular:804.92Ondansetron-d3
CAS:Produto Controlado<p>Applications Ondansetron-d3 is a labeled specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Fórmula:C18H16D3N3OCor e Forma:NeatPeso molecular:296.381-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine 1-oxide (Imatinib Impurity)
CAS:Pureza:98%Peso molecular:509.614(E)-3-(2-chlorophenyl)-N-(4-(N-(pyrimidin-2-yl)sulfamoyl)phenyl)acrylamide
CAS:Pureza:98%Peso molecular:414.85998535156254-Chloro Kynurenine-13C2,15N
CAS:Produto Controlado<p>Applications 7-Cl-kynurenic acid (7-Cl-KYNA) is a potent, selective antagonist of the NMDA/glycine receptor but penetrates poorly through the blood-brain barrier. Its prodrug, L-4-Cl-kynurenine (4-Cl-KYN), readily enters the brain from the circulation and provides antiexcitotoxic neuroprotection after systemic application.<br>References Leeson, P., et al.: J. Med. Chem., 37, 4053 (1994), Hilmas, C., et al.: J. Neurosci., 2001, 21, 7463 (2001), Palmer, G., et al.: Curr. Drug Targets, 2, 241 (2001), Wu, H., et al.: Exp. Neurol., 177, 222 (2002),<br></p>Fórmula:C813C2H11ClN15NO3Cor e Forma:NeatPeso molecular:245.64N-Hydroxymethyl Sumatriptan
CAS:Produto Controlado<p>Applications Hydroxymethyl Sumatriptan is an analog of Sumatriptan (S810000), a serotonin 5HT1-receptor agonist.<br>References Humphrey, P.P.A., et al.: Brit. J. Pharmacol., 94, 1123 (1988), Doenicke, A., et al.: Lancet 1, 1309 (1988),<br></p>Fórmula:C15H23N3O3SCor e Forma:NeatPeso molecular:325.433-Nitro-L-tyrosine-d3
CAS:Produto Controlado<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Fórmula:C9D3H7N2O5Cor e Forma:NeatPeso molecular:229.23-Des[2-(Dimethylamino)ethyl] Zolmitriptan 3-Acetic Acid
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The indole acetic acid metabolite of Zolmitriptan (Z639000) formed by human hepatocytes.<br>References Wild, M.J. et al.: Xenobiotica, 29, 847 (1999);<br></p>Fórmula:C14H14N2O4Cor e Forma:NeatPeso molecular:274.27Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Fórmula:C17H20ClNO6S2Cor e Forma:White To Off-WhitePeso molecular:433.933-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride
CAS:Produto Controlado<p>Impurity Ondansetron EP Impurity A/ Ondansetron USP Related Compound A<br>Applications 3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one (Ondansetron EP Impurity A) is an impurity of Ondansetron (O655000), an antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mackinnon, J.W.M., et al.: Eur. J. Cancer Clin. Oncol., 25, 61 (1989);<br></p>Fórmula:C16H20N2O·ClHCor e Forma:NeatPeso molecular:292.804-(4,6-Dimethoxypyrimidin-2-yl)benzoic acid
CAS:Fórmula:C13H12N2O4Pureza:95.0%Cor e Forma:SolidPeso molecular:260.2496-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-9H-purine
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:277.260009765625trans-Zeatin
CAS:Produto Controlado<p>Applications Zeatin, purified from Zea mays, is a member of the cytokinin group of plant growth factors, the activity of which is attributed to its more stable trans form. Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts. Trans-Zeatin is a potential agent for the management of skin photoaging.<br>References Murashige, T., et al.: Physiol. Plant, 15, 473 (1962), Brenneisen, P., et al.: J. Biol. Chem., 273, 5279 (1998), Choi, M., et al.: J. Dermatol. Sci., 46, 127 (2007), Bae, J., et al.: Food Chem. Toxicol., 46, 1298 (2008),<br></p>Fórmula:C10H13N5OCor e Forma:NeatPeso molecular:219.24Urea-15N2
CAS:Produto Controlado<p>Applications Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.<br>References Demetriou, A., et al.: Science, 233, 1190 (1986), Aebischer, P., et al.: Nat. Med., 2, 696 (1996), Prakash, S., et al.: Biotechnol. Bioeng., 46, 621 (1995),<br></p>Fórmula:CH415N2OCor e Forma:Off White SolidPeso molecular:62.04(S)-Tenofovir Disoproxil Fumarate
CAS:Produto Controlado<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Fórmula:C19H30N5O10P·C4H4O4Cor e Forma:White SolidPeso molecular:635.52Acetaldehyde 2,4-Dinitrophenylhydrazone
CAS:<p>Stability Hygroscopic<br>Applications Acetaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic alldehyde found in mainstream cigarette smoke. Dyes and metabolites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zwiener, C. et al.: Anal. Bioanal. Chem., 372, 615 (2002); Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Fórmula:C8H8N4O4Cor e Forma:YellowPeso molecular:224.17Phenylhydrazine
CAS:Produto Controlado<p>Applications An aryl hydrazine used in the preparation of various dyes and pharmaceutical compounds. It is used in the investigation of oligosaccharides as well as the structure of photosystem II.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lattova, E. et al.: Meth. Mol. Biol., 534, 65 (2009); Anderson, L.B. et al.: J. Biol. Chem., 275, 4920 (2000);<br></p>Fórmula:C6H8N2Cor e Forma:Yellowish LiquidPeso molecular:108.144-(2H-1,3-benzodioxol-5-yl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:319.3640136718754-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Pureza:95.0%Peso molecular:278.31500244140625Methotrexate-Cadaverine-Biotin Conjugate
Produto Controlado<p>Applications Methotrexate-Cadaverine-Biotin Conjugate is biotin labelled Methotrexate. Methotrexate (M260675) is a folic acid antagonist and it is used as a antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C35H48N12O6SPureza:>85%Cor e Forma:NeatPeso molecular:764.9Pirimiphos-methyl, 90%
CAS:Produto Controlado<p>Applications Pirimiphos-methyl is a phosphorothioate used as an insecticide. Pirimiphos-methyl is commonly used for mosquito control as well as control of greenhouse crop pests and stored-product insects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Deighton, J. et al.: Mosq. News, 34, 163 (1974); LaHue, D.W.: J. Econ. Entomol., 68, 236 (1975); Antonious, G.F. et al.: J. Entomol. Sci., 30, 191 (1995):<br></p>Fórmula:C11H20N3O3PSPureza:90%Cor e Forma:ColourlessPeso molecular:305.334-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester, 100 mg
CAS:<p>Impurity Oseltamivir EP Impurity D<br>Applications 4-Acetylamino-3-hydroxybenzoic Acid Ethyl Ester (Oseltamivir EP Impurity D) is an impurity in the antiviral drug Oseltamivir (O700100).<br></p>Fórmula:C11N13NO4Cor e Forma:NeatPeso molecular:223.23Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H22N8O5Cor e Forma:Yellow To Dark YellowPeso molecular:454.444-([1,1'-Biphenyl]-4-yl)-6-chloro-2-phenylpyrimidine
CAS:Pureza:95.0%Peso molecular:342.8299865722656Tenofovir
CAS:<p>Applications Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);<br></p>Fórmula:C9H14N5O4PCor e Forma:White To Off-WhitePeso molecular:287.21N-Desmethyl Zolmitriptan
CAS:<p>Impurity Zolmitriptan USP Related Compound A<br>Stability Hygroscopic<br>Applications A metabolite of Zolmitriptan (Z639000). Zolmitriptan USP Related Compound A.<br>References Chen, J., et al.: J. Pharm. Biomed. Anal., 35, 639 (2004), Srinivasu, M., et al.: J. Pharm. Biomed. Anal., 37, 453 (2005),<br></p>Fórmula:C15H19N3O2Cor e Forma:NeatPeso molecular:273.335-Nitro Nicotinic Acid
CAS:Produto Controlado<p>Applications An intermediate in the synthesis of nicotinamide with potential anticoccidial activity.<br>References Morisawa, Y. et al.: J. Med. Chem., 20, 129 (1977);<br></p>Fórmula:C6H4N2O4Cor e Forma:NeatPeso molecular:168.11Memantine Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>Fórmula:C12H21N·ClHCor e Forma:White To Off-WhitePeso molecular:215.766-Methyl Nicotinic Acid
CAS:Produto Controlado<p>Applications A degradation product of Nicotinic acid (N429250). An impurity of Nicotinic acid.<br>References Ensign, J., et al.: Biol. Chem., 239, 2285 (1964), Houghton, C., et al.: Biochem. J., 130, 879 (1972),<br></p>Fórmula:C7H7NO2Cor e Forma:NeatPeso molecular:137.141,3,7-Trimethyluric Acid-d3
CAS:Produto Controlado<p>Stability Store in freezer<br>Applications A caffeine metabolite.<br>References Regal, K.A., et al.: J. of Chromatography B, 708, 75 (1998)<br></p>Fórmula:C82H3H7N4O3Cor e Forma:NeatPeso molecular:213.21Tri-POC Tenofovir Dimer (>90%)
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Tri-POC Tenofovir Dimer is a dimer of Tenofovir Disoproxil (T018505), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. It is also used in the preparation of phosphocitrate for the treatment of rheumatoid and osteoarthritis in the elderly.<br>References Turhanen, P. et al.: J. Org. Chem., 72, 1468 (2007);<br></p>Fórmula:C34H52N10O17P2Pureza:>90%Cor e Forma:White To Light BeigePeso molecular:934.785-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
CAS:Pureza:95.0%Peso molecular:360.395996093756-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
CAS:Fórmula:C5H4N2O3SCor e Forma:No data available.Peso molecular:172.16Nicotinamide-d4 N-Oxide (d4 Major)
CAS:Produto Controlado<p>Applications A labelled metabolite of Nicotinamide.<br>References Musfeld, C., et al.: J. Pharm. Biomed. Anal., 24, 391 (2001), Sakakibara, Y., et al.: Brain Res., 931, 68 (2002), Zielonka, J., et al.: Chem. Res. Toxicol., 19, 668 (2006), Wieczorkowska, M., et al.: Pharmacol. Rep., 59, 216 (2007),<br></p>Fórmula:C6H2D4N2O2Cor e Forma:NeatPeso molecular:142.156-Mercaptopurine-13C2,15N (major)
CAS:Produto Controlado<p>Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Naguib, F., et al.: Biochem. Pharmacol., 50, 1685 (1995), Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004).<br></p>Fórmula:C313C2H4N315NSCor e Forma:NeatPeso molecular:155.16
![3-[(4,6-Dimethylpyrimidin-2-yl)amino]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF023725.webp&w=3840&q=75)
![3-Des[2-(Dimethylamino)ethyl] Zolmitriptan 3-Acetic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD288965.webp&w=3840&q=75)
![3-[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one Hydrochloride](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FD471400.webp&w=3840&q=75)
![4-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF511275.webp&w=3840&q=75)
![4-([1,1'-Biphenyl]-4-yl)-6-chloro-2-phenylpyrimidine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF053935.webp&w=3840&q=75)
![5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F10%2Fthumb-webp%2FF497507.webp&w=3840&q=75)
