Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8902 produtos de "Derivados de Purinas e Pirimidinas"
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3-(2-Amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile
CAS:Pureza:98.0%Peso molecular:426.48400878906255-BENZYLOXY-2-(5-CHLORO-PYRIDIN-3-YL)-4-METHOXY-PYRIMIDINE
CAS:Pureza:95.0%Peso molecular:327.7699890136719(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride
CAS:Fórmula:C13H20ClN5O2Pureza:95.0%Cor e Forma:SolidPeso molecular:313.794-[6-(3-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Pureza:95.0%Peso molecular:278.31500244140625Thyroxine
CAS:Produto Controlado<p>Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.<br>References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);<br></p>Fórmula:C15H11I4NO4Cor e Forma:Off-WhitePeso molecular:776.874-(3,3-Dipropyl-ureido)benzenesulfonyl chloride
CAS:Fórmula:C13H19ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:318.821-(4-tert-Butylphenyl)-2-pyrimidin-4-yl ethanol
CAS:Fórmula:C16H20N2OPureza:≥95%Cor e Forma:SolidPeso molecular:256.3495-Ethyl-2-methylpyridine(5-Ethyl-2-picoline)
CAS:<p>Applications Perfume composition.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999),<br></p>Fórmula:C8H11NCor e Forma:ColourlessPeso molecular:121.184-(3,4-dimethylphenyl)-6-(3-methylphenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:289.38198852539063-Methyluric Acid
CAS:<p>Applications 3-Methyluric Acid is a methylated derivative of uric acid that inhibits peroxynitrite-mediated oxidation, which has potential therapeutic application in the treatment of multiple sclerosis. 3-Methyluric Acid is also a known metabolite of Caffeine (C080100).<br>References Kean, R.B. et al.: J. Immunol., 165, 6511 (2000); Caubet, M.-S. et al.: J. Pharm. Biomed. Anal., 27, 261 (2002);<br></p>Fórmula:C6H6N4O3Cor e Forma:Light YellowPeso molecular:182.142,5-Ethyl Acetate Febuxostat
CAS:Produto Controlado<p>Applications Febuxostat (F229000) is the parent compound for 2,5-Ethyl Acetate Febuxostat. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Fórmula:C20H25NO5SCor e Forma:NeatPeso molecular:391.48Methyl 4-((6-(3,5-dimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)oxy)benzoate
CAS:Pureza:97.0%Peso molecular:324.3399963378906Hypoxanthine-13C2,15N (Mixture)
CAS:<p>Applications A metabolite of Purine in cocaine addiction.<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),<br></p>Fórmula:C3C2H4N3NOCor e Forma:NeatPeso molecular:139.091-Methyl-nicotinamide Iodide
CAS:Produto Controlado<p>Applications A nicotinic acid derivative which shows a dopaminergic neurotoxicity.<br>References Rollema, H., et al.: J. Med. Chem., 33, 2221 (1990),<br></p>Fórmula:C7H9IN2OCor e Forma:NeatPeso molecular:264.061,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
CAS:Produto Controlado<p>Impurity Ondansetron EP Impurity D; Ondansetron USP Related Compound D<br>Applications 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one (Ondansetron EP Impurity D; Ondansetron USP Related Compound D) is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011); Zizkovsky, V. et al.: J. Pharm. Biomed. Anal., 44, 1048 (2007)<br></p>Fórmula:C14H13NOCor e Forma:WhitePeso molecular:211.26(R)-9-[2-(Hydroxypropyl] Adenine(Desphosphoryl Tenofovir)
CAS:Produto Controlado<p>Applications (R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir) (cas# 14047-28-0) is a useful reagent for preparing the antiviral drug tenofovir.<br>References Dietz, J.-P., et al.: ChemRxiv, 1 (2020)<br></p>Fórmula:C8H11N5OCor e Forma:NeatPeso molecular:193.21Mono-POC Isopropyl Tenofovir(Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir (T018500) impurity.<br></p>Fórmula:C17H28N5O7PCor e Forma:White SolidPeso molecular:445.414-[(4,6-Dimethylpyrimidin-2-yl)thio]aniline
CAS:Fórmula:C12H13N3SPureza:95.0%Cor e Forma:SolidPeso molecular:231.32Theophylline-7-acetic Acid
CAS:Produto Controlado<p>Applications A xanthine derivative with bronchodilator activity. Typically combined as salt component with other medications such as Ambroxol to treat bronchial and pulmonary diseases.<br>References Kim, S., et al.: J. Med. Chem., 45, 2131 (2002), Bruno-Blanch, L., et al.: Bioorg. Med. Chem. Lett., 13, 2749 (2003), Foppoli, A., et al.: J. Pharm. Sci., 96, 1139(2007),<br></p>Fórmula:C9H10N4O4Cor e Forma:NeatPeso molecular:238.204-(4-Oxobutyl)benzoic Acid Methyl Ester
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 4-(4-Oxobutyl)benzoic Acid Methyl Ester is used as a reagent in the preparation of Pemetrexed (P219500) and furoxanoxyalkyl esters of Pemetrexed as antifolates and nitric oxide donors for use as anticancer agents.<br>References Zhao, D., et al.: Zhongguo Yaowu Huaxue Zazhi, 18, 445 (2008); Yi, B., et al.: Zhongguo Yiyao Gongye Zazhi, 37, 798 (2006); Min, T., et al.: Med. Chem. Res., 18, 495 (2009)<br></p>Fórmula:C12H14O3Cor e Forma:NeatPeso molecular:206.24Tenofovir Disoproxil Dimer
CAS:Produto Controlado<p>Stability Very Hygroscopic and Temperature Sensitive<br>Applications Tenofovir Disoproxil impurity.<br>References Cheng, G., et al.: Chem. Res. Toxicol., 16, 145 (2003),<br></p>Fórmula:C39H60N10O20P2Cor e Forma:White SolidPeso molecular:1050.903,5-Dinitropyridine
CAS:Produto Controlado<p>Applications 3,5-Dinitropyridine is used as an azabenzyne pyrolytic precursor. The anion radical of 3,5-dinitropyridine aundergoes reversible dimerization reactions.<br>References Winkler, M., et al.: J. Am. Chem. Soc., 126, 6135 (2004); Macias-Ruvalcaba, N., et al.: J. Electroanal. Chem., 600, 294 (2007)<br></p>Fórmula:C5H3N3O4Cor e Forma:NeatPeso molecular:169.10N-Methyl Pemetrexed
CAS:Produto Controlado<p>Impurity Pemetrexed EP Impurity A<br>Applications N-Methyl Pemetrexed (Pemetrexed EP Impurity A) is an impurity of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.<br>References Kjell, D.P., et al.: Org. Proc. Res. Develop., 9, 738 (2005);<br></p>Fórmula:C21H23N5O6Cor e Forma:NeatPeso molecular:441.444-(3,4-dimethylphenyl)-6-(3-fluorophenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:293.3450012207031N6-(2-Isopentenyl)adenine
CAS:Produto Controlado<p>Applications N6-(2-Isopentenyl)adenine can be used in biological study for cytokinins stimulated expression of stress-related proteins and transcripts in Arabidopsis thaliana with isopentenyltransferase overexpression.<br>References Skalak, J., et al.: J. Exp. Bot., 67, 2861-2873 (2016)<br></p>Fórmula:C10H13N5Cor e Forma:White To Off-WhitePeso molecular:203.24Didesmethyl Zolmitriptan (90%)
CAS:Produto Controlado<p>Applications A metabolite of Zolmitriptan (Z639000).<br>References Buckingham, J., et al.: J. Med. Chem., 38, 3566 (1995),<br></p>Fórmula:C14H17N3O2Pureza:90%Cor e Forma:NeatPeso molecular:259.30[1-(2-Chloro-pyrimidin-4-yl)-piperidin-3-yl]-methyl-amine hydrochloride
CAS:Pureza:95.0%Peso molecular:263.1700134277344Telbivudine
CAS:Produto Controlado<p>Applications Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.<br>References Standring, D.N., et al.: Antiviral. Chem. Chemother., 12, 119 (2001), Hernandez-Santiago, B., et al.: Antimicrob. Agents Chemother., 46, 1728 (2002), Lai, C.-L., et al.: Hepatology, 40, 719 (2004), Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005),<br></p>Fórmula:C10H14N2O5Cor e Forma:White To Off-WhitePeso molecular:242.232,4-Bis(dimethylamino)pyrimidine-6-carboxylic acid, hydrate
CAS:Fórmula:C9H16N4O3Pureza:95.0%Peso molecular:228.2524,6-Dihydroxypyrazolo[3,4-d]pyrimidine
CAS:Produto Controlado<p>Stability Hygroscoipic<br>Applications 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine is a major metabolite of Allopurinol (A547300). It is a xanthine oxidase inhibitor.<br>References Pacher, P., et al.: Pharmacol. Rev., 58, 87 (2006); Marro, P., et al.: Brain Res., 650, 9 (1994); Abramov, A., et al.: J. Neurosci., 27, 1129 (2007); Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007);<br></p>Fórmula:C5H4N4O2Cor e Forma:Off White SolidPeso molecular:152.11Nicotinic Acid-d3 (major)
CAS:Produto Controlado<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).A representative lot contains >20% d4.<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Fórmula:C6H2D3NO2Cor e Forma:NeatPeso molecular:126.13Theophylline-d6
CAS:Produto Controlado<p>Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>Fórmula:C72H6H2N4O2Cor e Forma:White To Off-WhitePeso molecular:186.20(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
CAS:Pureza:95.0%Peso molecular:320.3599853515625S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride
CAS:Produto Controlado<p>Applications S(+)-N-(2-(2-Thienyl)ethyl)-2-chlorophenyl Glycine Methyl Ester Hydrochloride is an impurity from Clopidogrel (C587250) which acts as an anti-platelet agent.<br>References Zhu, Y. et al.: ACS. Med. Chem. Lett., 4, 349 (2013); Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Fórmula:C15H16ClNO2S·ClHCor e Forma:NeatPeso molecular:346.27N-Nitroso Desmethyl Rizatriptan
Produto ControladoFórmula:C14H16N6OCor e Forma:NeatPeso molecular:284.316(E/Z)-3-[(2-Cyano-3-ethoxy-3-oxo-1-propenyl)amino]-1H-Pyrazole-4-carboxylic Acid Ethyl Ester
CAS:<p>Applications Impurity of Allopurinol (A547300), an xanthine oxidase inhibitor used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Fórmula:C12H14N4O4Cor e Forma:NeatPeso molecular:278.271-(4-Methoxyphenyl)-2-pyrimidin-4-ylethanone
CAS:Fórmula:C13H12N2O2Pureza:95.0%Cor e Forma:SolidPeso molecular:228.251
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