Derivados de Purinas e Pirimidinas
As purinas possuem uma estrutura bicíclica, formada por um anel de seis membros fundido a um anel de cinco membros, ambos contendo átomos de nitrogênio em posições-chave. Os derivados das purinas, como a adenina e a guanina, são essenciais para a formação do DNA e RNA. Estes compostos possuem aplicações terapêuticas no tratamento do câncer e de doenças virais, pois inibem a replicação celular. As pirimidinas, por outro lado, possuem uma estrutura monocíclica de seis membros com dois átomos de nitrogênio. Seus derivados, como citosina, timina e uracila, também são componentes essenciais do DNA e RNA e são utilizados na quimioterapia e em tratamentos antivirais.
Na CymitQuimica, oferecemos derivados de purinas e pirimidinas para pesquisa em biologia molecular, genômica e desenvolvimento de terapias inovadoras.
Foram encontrados 8902 produtos de "Derivados de Purinas e Pirimidinas"
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2-Chloro-N-piperidin-4-ylpyrimidin-4-amine hydrochloride
CAS:Pureza:97.0%Peso molecular:249.13999938964844Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)
CAS:Fórmula:C20H22N8O5Cor e Forma:Single SolutionPeso molecular:454.44Ondansetron Hydrochloride Dihydrate
CAS:Fórmula:C18H19N3O·ClH·2H2OCor e Forma:Off-WhitePeso molecular:365.85(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride
CAS:Fórmula:C13H20ClN5O2Pureza:95.0%Cor e Forma:SolidPeso molecular:313.792-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Produto Controlado<p>Applications 2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid is an impurity of Febuxostat (F229000), an xanthine oxidase/xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H., et al.: J. Pharma. Biomed. Anal., 56, 749 (2011);<br></p>Fórmula:C16H18N2O4SCor e Forma:White To Off-WhitePeso molecular:334.39N-(9-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
CAS:Pureza:98%Peso molecular:373.3439941406254-(3-Ethylureido)-2-methylbenzenesulfonyl chloride
CAS:Fórmula:C10H13ClN2O3SCor e Forma:SolidPeso molecular:276.743,4-Dihydro Naratriptan Oxalate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 3,4-Dihydro Naratriptan Oxalate is the basic form of 3,4-Dihydro Naratriptan(D449205); it is an impurity of Naratriptan (N378730), It is a triptan drug and is used for the treatment of migraine headaches.<br>References Dulery, B.D., et al.: J. Pharm. Biomed. Anal., 15, 1009 (1997), Havanka, H., et al.: Clin. Ther., 22, 970 (2000),<br></p>Fórmula:C17H23N3O2S·C2H2O4Cor e Forma:White To Light YellowPeso molecular:333.45 + 90.03Ref: 10-F527886
1gA consultar5gA consultar10gA consultar25gA consultar100mgA consultar250mgA consultarMethotrexate a-tert-Butyl Ester
CAS:Produto Controlado<p>Applications Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.<br>References Yoshii, T., et al.: J. Am. Chem. Soc., 136, 16635 (2014);<br></p>Fórmula:C24H30N8O5Cor e Forma:NeatPeso molecular:510.5465-Chloro-2-((4-fluorobenzyl)sulfonyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide
CAS:Pureza:98.0%Peso molecular:427.85000610351564-(2H-1,3-benzodioxol-5-yl)-6-(thiophen-2-yl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:297.32998657226562-Chloro Adenosine
CAS:<p>Applications A selective A1-adenosine receptor agonist. Induces apoptosis.<br>References Evans, et al.: Neurosci. Lett., 83, 287 (1987), Szondy, Z.: Biochem. J., 304, 877 (1994)<br></p>Fórmula:C10H12ClN5O4Cor e Forma:Off-WhitePeso molecular:301.69(R)-Methotrexate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications R-Methotrexate is an enantiomer of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H22N8O5Cor e Forma:Dark YellowPeso molecular:454.543-Descyano-3-((hydroxyimino)methyl) Febuxostat
CAS:Produto ControladoFórmula:C16H18N2O4SCor e Forma:NeatPeso molecular:334.393-Chlorodiphenylamine
CAS:Produto Controlado<p>Applications 3-Chlorodiphenylamine (cas# 101-17-7) is a compound useful in organic synthesis.<br></p>Fórmula:C12H10ClNCor e Forma:NeatPeso molecular:203.675-METHOXY-4-((4-(1-METHYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-NITROPHENOL
Pureza:95.0%Peso molecular:391.3869934082031L-Phenylalanine-d8
CAS:Produto Controlado<p>Applications Labelled analogue of L-Phenylalanine, an essential amino acid.<br>References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>Fórmula:C9D8H3NO2Cor e Forma:NeatPeso molecular:173.246-Methyl-2-methylsulfanyl-3H-pyrimidin-4-one
CAS:Pureza:98.0%Cor e Forma:Solid, CrystallinePeso molecular:156.1999969482422Formaldehyde 2,4-Dinitrophenylhydrazone
CAS:<p>Stability Shock Sensitive<br>Applications Formaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Fórmula:C7H6N4O4Cor e Forma:NeatPeso molecular:210.15Tri-POC Tenofovir Dimer (>90%)
CAS:Produto Controlado<p>Stability Very Hygroscopic<br>Applications Tri-POC Tenofovir Dimer is a dimer of Tenofovir Disoproxil (T018505), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. It is also used in the preparation of phosphocitrate for the treatment of rheumatoid and osteoarthritis in the elderly.<br>References Turhanen, P. et al.: J. Org. Chem., 72, 1468 (2007);<br></p>Fórmula:C34H52N10O17P2Pureza:>90%Cor e Forma:White To Light BeigePeso molecular:934.78Purine
CAS:Produto Controlado<p>Applications Purine (cas# 120-73-0) is a useful research chemical.<br></p>Fórmula:C5H4N4Cor e Forma:NeatPeso molecular:120.11Guanidinoacetic Acid
CAS:<p>Applications Guanidinoacetic Acid is an important marker for renal failure, in kidney transplantation, and for the renal metabolic activity.<br>References Zugno, A., et al.: Neurochem. Res., 33, 1804 (2008), Debray, F., et al.: Neurol., 71, 44 (2008), da Silva, R., et al.: Am. J. Physiol., 296, E256 (2009),<br></p>Fórmula:C3H7N3O2Cor e Forma:WhitePeso molecular:117.119-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one
CAS:Pureza:97%Peso molecular:270.22000122070317-Hydroxy Methotrexate Ammonium
CAS:Produto Controlado<p>Applications 7-Hydroxy Methotrexate Ammonium Salt is a metabolite of Methotrexate (M260675), which is used as an antineoplastic and antirheumatic.<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H22N8O6·NH3Cor e Forma:Yellow To BrownPeso molecular:487.475-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
CAS:Produto Controlado<p>Applications 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide is a metabolite of Temozolomide (T017775); an imidazotetrazine alkylating agent and antineoplastic.<br>References Newlands, E.S., et al.: Cancer Treat. Rev., 23, 35 (1997); Kim, C., et al.: J. Biol. Chem., 274, 1233 (1999); Hait, W., et al.: Cancer Res., 69, 1263 (2009); Wang, Y., et al.: J. Org. Chem., 62, 7288 (1997)<br></p>Fórmula:C6H9N5O2Cor e Forma:Off-WhitePeso molecular:183.17N-Butyldeoxynojirimycin Hydrochloride
CAS:Produto Controlado<p>Applications An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal model of Tay-Sachs disease.1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.<br>References Hettkamp, H., et al.: Eur. J. Biochem., 142, 85 (1984), Szumilo, T., et al.: Arch. Biochem. Biophys., 247, 261 (1986), Fleet, G.W.J., et al.: FEBS Letters, 237, Number 1,2, 128 (1988), Kolter, T., et al.: Angew. Chem. Int. Ed. Engl., 36, 1955 (1997),<br></p>Fórmula:C10H21NO4·ClHCor e Forma:NeatPeso molecular:255.741,3,7-Trimethyluric Acid
CAS:<p>Applications 1,3,7-Trimethyluric Acid is a caffeine derivative, and a methyl derivative of uric acid. Detected as a urine marker of caffeine consumption.<br>References Rothwell, J. et al.: PLoS One, 9, e93474 (2014); Silva, C. et al.: Sci. Trans. Med., 5, 197ra04 (2013);<br></p>Fórmula:C8H10N4O3Cor e Forma:Light Beige SolidPeso molecular:210.19Paraxanthine
CAS:<p>Stability Store tightly sealed at RT<br>Applications Paraxanthine is an adenosine receptor ligand and a major metabolite of caffeine.This compound is a contaminant of emerging concern (CECs).<br>References Proc. Natl. Acad. Sci. USA 78, 3260 (1981); Cell Mol. Neurobiol., 3, 69 (1983); Eur. J. Pharmacol., 179, 295 (1990)<br></p>Fórmula:C7H8N4O2Cor e Forma:White To Light YellowPeso molecular:180.163-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Fórmula:C6H6N6OCor e Forma:Off-WhitePeso molecular:178.15Tenofovir Alafenamide Fumarate
CAS:Produto Controlado<p>Applications Tenofovir Alafenamide Fumarate is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Fórmula:C21H29N6O5P·C4H4O4Cor e Forma:NeatPeso molecular:592.53814-Hydroxy-3,5-diiodobenzyl Alcohol
CAS:Produto Controlado<p>Applications Intermediate in the production of Thyroxine<br></p>Fórmula:C7H6I2O2Cor e Forma:NeatPeso molecular:375.93N4-BENZYL-N2-(4-BROMOPHENYL)-5-FLUOROPYRIMIDINE-2,4-DIAMINE
Pureza:95.0%Peso molecular:373.22900390625Methyl Acetoacetate
CAS:Produto Controlado<p>Applications 3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Ranu, B. et al.: J. Org. Chem. 65, 6270 (2000); Lu, J. et al.: Tetrahedron Lett., 41, 9075 (2000); Lu, J. et al.: Synlett., 1, 63 (2000);<br></p>Fórmula:C5H8O3Cor e Forma:NeatPeso molecular:116.122-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
CAS:Pureza:98.0%Cor e Forma:SolidPeso molecular:349.31698608398444,6-Dihydroxypyrazolo[3,4-d]pyrimidine
CAS:Produto Controlado<p>Stability Hygroscoipic<br>Applications 4,6-Dihydroxypyrazolo[3,4-d]pyrimidine is a major metabolite of Allopurinol (A547300). It is a xanthine oxidase inhibitor.<br>References Pacher, P., et al.: Pharmacol. Rev., 58, 87 (2006); Marro, P., et al.: Brain Res., 650, 9 (1994); Abramov, A., et al.: J. Neurosci., 27, 1129 (2007); Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007);<br></p>Fórmula:C5H4N4O2Cor e Forma:Off White SolidPeso molecular:152.114-[2’-(7’’-Deazaguanine)ethyl]benzoic Acid N-Hydroxysuccinimide Ester
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Pemetrexed.<br></p>Fórmula:C19H17N5O5Cor e Forma:WhitePeso molecular:395.37Nicotinic Acid-d3 (major)
CAS:Produto Controlado<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).A representative lot contains >20% d4.<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>Fórmula:C6H2D3NO2Cor e Forma:NeatPeso molecular:126.13Ethyl 2-(2-(methylamino)pyrimidin-4-yl)-1H-indole-5-carboxylate
CAS:Pureza:95.0%Cor e Forma:Liquid, No data available.Peso molecular:296.3299865722656Tenofovir Alafenamide
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Tenofovir Alafenamide is a prodrug of Tenofovir (T018500), which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral.<br>References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),<br></p>Fórmula:C21H29N6O5PCor e Forma:NeatPeso molecular:476.47D-Neopterin-13C5
CAS:<p>Applications Labelled precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.<br>References Kobashi, I., et al.: Agric. Biol. Chem., 35, 47 (1971), Fukushima, S., et al.: J. Biol. Chem., 247, 4549 (1972),<br></p>Fórmula:C413C5H11N5O4Cor e Forma:Light Beige To BrownPeso molecular:258.183-Nitro-L-tyrosine-d3
CAS:Produto Controlado<p>Applications A labelled marker for peroxynitrite. Oxidant and cytotoxic agent.<br>References Sekiguchi, M., et al.: Brain Res., 978, 228 (2003), van den Tweel, E., et al.: J. Neurobiol., 167, 64 (2005), Shirakura, T., et al.: Biol. Pharm. Bull., 28, 1658 (2005),<br></p>Fórmula:C9D3H7N2O5Cor e Forma:NeatPeso molecular:229.21,7-Dimethyluric Acid-d3
CAS:Produto ControladoFórmula:C7H5D3N4O3Cor e Forma:Off-White To Light GreyPeso molecular:199.18(S)-Tenofovir Disoproxil Fumarate
CAS:Produto Controlado<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Fórmula:C19H30N5O10P·C4H4O4Cor e Forma:White SolidPeso molecular:635.524-[6-(4-Methoxy-phenyl)-pyridin-3-yl]-pyrimidin-2-ylamine
Pureza:95.0%Peso molecular:278.315002441406255-Azido Oseltamivir
CAS:Produto Controlado<p>Applications Intermediate in the production of Oseltamivir. It is a COVID19-related research product.<br>References Kim, C., et al.: J. Med. Chem., 41, 2451 (1998), Carbain, B., et al.: Chem. Med. Chem., 4, 335 (2009),<br></p>Fórmula:C16H26N4O4Cor e Forma:NeatPeso molecular:338.40
![2-[3-(Aminocarbonyl)-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FA603115.webp&w=3840&q=75)
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