Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65615 produtos de "Derivados de Quinazolina e Quinolina"
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Methyl-1-naphthalenemethylamine
CAS:<p>Impurity Terbinafine EP Impurity A; Terbinafine BP Impurity A; Terbinafine USP Related Compound A<br>Applications Terbinafine EP Impurity A. Terbinafine BP Impurity A. Terbinafine USP Related Compound A<br></p>Fórmula:C12H13NCor e Forma:OrangePeso molecular:171.24Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone
CAS:Produto Controlado<p>Applications Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.<br>References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)<br></p>Fórmula:C31H28N2OCor e Forma:NeatPeso molecular:444.5710,11-Dihydro-11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepin-11-ol
CAS:Produto Controlado<p>Applications Quetol is an impurity of Quetiapine(Q509900) a dibenzothiazepine antipsychotic commonly used as monotherapy for patients with major depressive disorder and schizophrenia.<br>References Cutler, A., et al.: J. Clin. Psych., 70, 526 (2009); Kapur, S., et al.: Arch. Gen. Psych., 57, 553 (2000); Peuskens, J. & Link, C.: Acta. Psych. Scand., 96, 265 (1997)<br></p>Fórmula:C21H27N3O3SCor e Forma:YellowPeso molecular:401.5224-(2-Chloropyrimidin-4-yl)morpholine
CAS:Fórmula:C8H10ClN3OPureza:98%Cor e Forma:SolidPeso molecular:199.64Sitagliptin
CAS:Produto Controlado<p>Applications Sitagliptin (cas# 486460-32-6) is a useful research chemical.<br></p>Fórmula:C16H15F6N5OCor e Forma:Off-WhitePeso molecular:407.31Propiconazole
CAS:<p>Propiconazole (PRO) is an orally active brassinosteroid biosynthesis inhibitor and a triazole fungicide with antifungal activity.</p>Fórmula:C15H17Cl2N3O2Pureza:95.93%Cor e Forma:Yellowish Viscous Liquid Yellowish Odorless Liquid Non Corrosive Used As A FungicidePeso molecular:342.22(E)-Chlorprothixene-d6 Hydrochloride
CAS:Produto Controlado<p>Applications Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Fórmula:C18H13D6Cl2NSCor e Forma:NeatPeso molecular:358.36rac Penbutolol-d9
CAS:Produto Controlado<p>Applications Labelled Penbutolol (P220500). A β-adrenoceptor antagonist. Antihypertensive.<br>References Armstrong, D., et al.: Anal. Chem., 66, 1473 (1994), Kato, M., et al.: J. Pharm. Biomed. Anal., 30, 1845 (2003),<br></p>Fórmula:C18H20D9NO2Cor e Forma:White To Off-WhitePeso molecular:300.48(S)-9-Hydroxy Risperidone
CAS:Produto Controlado<p>Applications The S-enantiomer metabolite of Risperidone, a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tiberghien, F., et al.: Anticancer Drugs, 7, 568 (1996), Kansy, M., et al.: J. Med. Chem., 41, 1007 (1998), Kerns, E., et al.: J. Pharm. Sci., 90, 1838 (2001), Kerr, K., et al.: J. Biol. Chem., 276, 8657 (2001), Doran, A., et al.: Drug Metab. Dispos., 33, 165 (2005),<br></p>Fórmula:C23H27FN4O3Cor e Forma:NeatPeso molecular:426.483,4-Dihydroagomelatine
CAS:Produto Controlado<p>Impurity Agomelatine Impurity 1<br>Applications 3,4-Dihydroagomelatine is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 1<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),<br></p>Fórmula:C15H19NO2Cor e Forma:NeatPeso molecular:245.32N-Methyl β-Hydroxyl Phentermine
CAS:<p>Applications N-Methyl β-Hydroxyl Phentermine is derived from 2-Nitropropane (N519600), which is an oxidative stress-inducing agent and also a carcinogen. It is used in the induction of DNA polymerase β-dependent base excision repair in response to oxidative stress in the liver.<br>References Cabelof, D.C., et al.: Carcinogenesis,23, 1419 (2002); Kreis, P., et al.: Carcinogenesis, 21, 295 (2000)<br></p>Fórmula:C11H17NOCor e Forma:Off-WhitePeso molecular:179.262-(4-Benzyl-morpholin-2-ylmethyl)-isoindole-1,3-dione
CAS:Pureza:95.0%Peso molecular:336.39099121093756-fluoro-2-methylquinoline-4-carboxylic acid
CAS:Fórmula:C11H8FNO2Pureza:95.0%Cor e Forma:Yellow powderPeso molecular:205.188Ioversol
CAS:Produto Controlado<p>Applications Nonionic, low osmolality, radiographic contrast agent. Diagnostic aid (radiopaque medium).<br>References Wilkins, R.A., et al.: Invest. Radiol., 24, 781 (1989), Kaufman, A.J., et al.: Urol. Radiol., 12, 56 (1990),<br></p>Fórmula:C18H24I3N3O9Cor e Forma:Off-WhitePeso molecular:807.11(S)-4-(Dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)morpholine
CAS:Pureza:98.0%Peso molecular:421.274580777-chloro-8-methyl-2-pyridin-4-ylquinoline-4-carboxylic acid
CAS:Pureza:95.0%Peso molecular:298.7300109863281Spirodiclofen
CAS:Produto Controlado<p>Applications Spirodiclofen is a tetronic acid acaricide fungicide used in controlling red mites. Spirodiclofen is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Kramer, T., et al.: Pest. Manage. Sci., 67, 1285 (2011); Ilias, A., et al.: Crop. Protect., 42, 305 (2012); Bretschneider, T., et al.: Modern. Crop. Protect. Compounds., 3, 1108 (2012)<br></p>Fórmula:C21H24Cl2O4Cor e Forma:White To Off-WhitePeso molecular:411.32(R)-Lercanidipine-d3 Hydrochloride
CAS:Produto ControladoFórmula:C36H39D3ClN3O6Cor e Forma:NeatPeso molecular:651.215-Chloro-2-thiophenecarboxylic Acid
CAS:Produto Controlado<p>Applications 5-Chloro-2-thiophenecarboxylic Acid is a metabolite of Rivaroxaban (R538000).<br>References Brickner, S., et al.: J. Med. Chem., 39, 673 (1996), Sato, K., et al.: Eur. J. Pharmacol., 347, 231 (1998), Chang, P., et al.: IDrugs, 7, 50 (2004), Weinz, C., et al.: Drug Metab. Dispos., 37, 1056 (2009)<br></p>Fórmula:C5H3ClO2SCor e Forma:NeatPeso molecular:162.5911-Morpholino-dibenzo[b,f][1,4]thiazepine
CAS:Produto Controlado<p>Applications 11-Morpholino-dibenzo[b,f][1,4]thiazepine is part of a group of 11-(substituted-amino)dibenzo[b,f][1,4]thiazepine compounds that have analgesic and sedative properties.<br>References Schmutz, J. & Hunziker, F.: Patentschrift (Switz.), 7pp. (1969)<br></p>Fórmula:C17H16N2OSCor e Forma:NeatPeso molecular:296.392,3:4,5-Di-O-isopropylidene-β-D-fructopyranose
CAS:Produto Controlado<p>Applications 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose (cas# 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II (CA-II).<br>References Maryanoff, B. E., et al.: J. Med. Chem., 48, 1941 (2005)<br></p>Fórmula:C12H20O6Cor e Forma:White To Off-WhitePeso molecular:260.284'-(4-(1H-Tetrazol-5-yl)phenyl)-2,2':6',2''-terpyridine
CAS:Pureza:98%Peso molecular:377.4110107421875Methyl 2-methoxy-5-(methylsulfonyl)benzoate
CAS:<p>Impurity Tiapride EP Impurity A<br>Applications Methyl 2-methoxy-5-(methylsulfonyl)benzoate is an impurity of Tiapride (T437050), a D2 and D3 dopamine receptor antagonist and a antipsychotic drug predominately used in the pharmacotherapy of patients with dementia.<br>References Huber, M., et al.: Pharmacopsy., 45, 182 (2012); Mediavilla, C., et al.: Brain. Res. Bull., 87, 346 (2012);<br></p>Fórmula:C10H12O5SCor e Forma:White To Off-WhitePeso molecular:244.26Northiaden
CAS:Produto Controlado<p>Applications A metabolite of Dothiepin.<br>References Atkinson, H., et al.: Clin. Pharmacokin., 18, 151 (1990), Hagg, S., et al.: Br. J. Clin. Pharmacol., 49, 286 (2000), Fleishaker, J., et al.: Adv. Drug Deliv. Rev., 55, 643 (2003), Katritzky, A., et al.: Bioorg. Med. Chem., 12, 3027 (2004),<br></p>Fórmula:C18H19NSCor e Forma:NeatPeso molecular:281.42OSI-420, Free Base (Desmethyl Erlotinib)
CAS:Produto ControladoFórmula:C21H21N3O4Cor e Forma:NeatPeso molecular:379.41Ofloxacin
CAS:<p>Applications Ofloxacin is a fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>Fórmula:C18H20FN3O4Cor e Forma:Off-WhitePeso molecular:361.371-(3-Carboxypropyl)-3,7-dimethylxanthine
CAS:Produto Controlado<p>Applications A metabolite of Pentoxifylline (P276500).<br>References Yamaoka, K., et al.: J. Pharmacokin. Biopharm., 6, 165 (1978), Cottam, H.B., et al.: J. Med. Chem., 39, 2 (1996), Janvilisri, T., et al.: J. Biol. Chem., 278, 20645 (2003),<br></p>Fórmula:C11H14N4O4Cor e Forma:NeatPeso molecular:266.25Ivacaftor Carboxylic Acid
CAS:<p>Applications Ivacaftor Carboxylic Acid is an impurity of Ivacaftor (I940600); a drug used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012)<br></p>Fórmula:C24H26N2O5Cor e Forma:NeatPeso molecular:422.477-(Benzyloxy)quinolin-4-ol
CAS:Pureza:95.0%Cor e Forma:Liquid, No data available.Peso molecular:251.28500366210938rac-Mephenytoin
CAS:Produto Controlado<p>Applications rac-Mephenytoin is an anticonvulsant agent.<br>References Shimada, et al.: Anal. Biochem., 147, 174 (1975), Dzhagatspanyan. IA., et al.: Pharm. Chem. J., 25, 181 (1991),<br></p>Fórmula:C12H14N2O2Cor e Forma:White SolidPeso molecular:218.25Despiperazine Amino Norfloxacin
CAS:Produto ControladoFórmula:C12H11FN2O3Cor e Forma:NeatPeso molecular:250.22Tofacitinib impurity N
CAS:Produto Controlado<p>Impurity Tofacitinib Impurity (T528000)<br>Applications Tofacitinib impurity N is an impurity of Tofacitinib (T528000), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.<br>References Jiang, J., et. al.: J. med. Chem., 51, 8012 (2008)<br></p>Fórmula:C13H19N5Cor e Forma:NeatPeso molecular:245.324-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
CAS:Pureza:99.0%Cor e Forma:SolidPeso molecular:482.82000732421875Ref: 10-F361865
1gA consultar5gA consultar10gA consultar25gA consultar10mgA consultar50mgA consultar100mgA consultar250mgA consultar500mgA consultarCimetidine Amide Dihydrochloride
CAS:Produto Controlado<p>Impurity Cimetidine EP Impurity C<br>Applications Cimetidine Amide Dihydrochloride (Cimetidine EP Impurity C) is an impurity of Cimetidine.<br>References Durant, G.J., et al.: J. Med. Chem., 18, 830 (1975), Pounder, R.E., et al.: Br. Med. J., 2, 307 (1975),<br></p>Fórmula:C10H18N6OS·2ClHCor e Forma:White To Off-WhitePeso molecular:343.28Astemizole-d3
CAS:Produto Controlado<p>Applications Labelled Astemizole. Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>Fórmula:C28H28D3FN4OCor e Forma:NeatPeso molecular:461.592,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride
CAS:Pureza:98%Peso molecular:286.67001342773448-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione
CAS:<p>Applications 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an intermediate used to prepare selective inhibitors of dipeptidyl peptidase 4 (DPP4) for potential use in the treatment of type 2 diabetes.<br>References Sutton, J., et al.: Bioorg. Med. Chem. Lett., 22, 1464 (2012); Lai, Z., et al.: Eur. J. Med. Chem., 83, 547 (2014)<br></p>Fórmula:C20H17BrN6O2Cor e Forma:NeatPeso molecular:453.293-Chloro Cathinone Hydrochloride
CAS:Produto Controlado<p>Applications A metabolite of Bupropion (B689625).<br>References Milena, P., et al.: Eur. Congr. Biopharm. Pharmacokinet., 3rd, 2, 313 (1987),<br></p>Fórmula:C9H11Cl2NOCor e Forma:NeatPeso molecular:220.1Epinephrine 4-O-Sulfate Ester
CAS:Produto Controlado<p>Applications Epinephrine (E588585) derivative.<br>References Imai, K., et al.: Chem. Pharm. Bull., 16, 1854 (1968),<br></p>Fórmula:C9H13NO6SCor e Forma:NeatPeso molecular:263.27(±)-Mianserin-d3 Hydrochloride (methyl-d3)
CAS:Produto Controlado<p>Applications (±)-Mianserin-d3 HCl (methyl-d3) (CAS# 1219804-97-3) is a useful isotopically labeled research compound.<br></p>Fórmula:C18D3H17N2·ClHCor e Forma:NeatPeso molecular:303.8442rac-Vigabatrin-13C,d2 (Major)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled Vigabatrin. A novel antiepileptic drug. Antidepressant; antipsychotic; anxiolytic.<br>References Vajda, F., et al.: Clin. Neurosci., 7, 88 (2000), Beghi, E., et al.: Lancet. Neurol., 3, 618 (2004), Sagirli, O., et al.: J. Pharmaceut. Biomed., 42, 618 (2006),<br></p>Fórmula:C513CH9D2NO2Cor e Forma:White To Dark YellowPeso molecular:132.161,4-Dibromobenzene
CAS:<p>Applications 1,4-Dibromobenzene is used in the synthesis of triarylamines as well as trans-stilbenes. Also used in the synthesis of calcium channel blockers for inhibition of TRPV6-mediated calcium transport.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Corriu, R. et al.: J. Chem. Soc. Chem. Comm., 3, 144 (1972); Lambert, C. et al.: J. Am. Chem. Soc., 121, 8434 (1999); Hofer, A. et al.: Bioorg. Med. Chem., 21, 3202 (2013);<br></p>Fórmula:C6H4Br2Cor e Forma:Light YellowPeso molecular:235.903,4-Dimethoxybenzoic Acid (Veratric Acid)
CAS:Produto Controlado<p>Applications Veratric Acid is a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E., et al.: Eur. Food Res. Technol., 229, 365 (2009), Spaccini, R., et al.: Soil Biol. Biochem., 41, 1164 (2009), Narasimhan, B., et al.: Eur. J. Med. Chem., 44, 689 (2009), Pereira, L., et al.: J. Biotechnol., 139, 68 (2009),<br></p>Fórmula:C9H10O4Cor e Forma:NeatPeso molecular:182.17Tolvaptan
CAS:Produto Controlado<p>Applications Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006);<br></p>Fórmula:C26H25ClN2O3Cor e Forma:White To Off-WhitePeso molecular:448.94Lisinopril Cyclohexyl Analogue
CAS:Produto Controlado<p>Impurity Lisinopril EP Impurity F<br>Applications Lisinopril Cyclohexyl Analogue (Lisinopril EP Impurity F) is a Lisinopril (L468985) impurity.<br>References Paraskevas, G., et al.: J. Pharm. Biomed. Anal., 29, 865 (2002),<br></p>Fórmula:C21H37N3O5Cor e Forma:NeatPeso molecular:411.54Tolcapone-d4
CAS:Produto Controlado<p>Applications Orally active inhibitor of central and peripheral catechol-O-methyltransferase (COMT). Antiparkinsonian.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dingemanse, J., et al.: Clin. Pharmacol. Ther., 57, 508 (1995), Keating, K.A., Drugs, 19, 165 (2005),<br></p>Fórmula:C14H7D4NO5Cor e Forma:NeatPeso molecular:277.272-Methylpyrazine
CAS:Produto Controlado<p>Applications 2-Methyl-pyrazine is an intermediate used to synthesize 5-Methyl-2(1H)-pyrazinone (M324900) which is a derivative of 2-Hydroxypyrazine (H952710). 2-Hydroxypyrazine (H952710) is used in the synthesis of potential antioxidants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shi, J. et al.: J. Phys. Org. Chem., 22, 1038 (2009); Bonde, C. et al.: Ind. J. Hetero. Chem., 10, 271 (2001);<br></p>Fórmula:C5H6N2Cor e Forma:NeatPeso molecular:94.11(+/-)-4-Hydroxy Mephenytoin-d3
CAS:Produto Controlado<p>Applications A deuterated CYP2C19 metabolite of Mephenytoin.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980)<br></p>Fórmula:C12H11D3N2O3Cor e Forma:White To Off-WhitePeso molecular:237.27Perampanel
CAS:Produto Controlado<p>Applications Perampanel is a novel, noncompetitive AMPA receptor antagonist for the treatment of epilepsy. Also in the treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy. Perampanel is a selective non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor antagonist that reduces neuronal excitation (1,2,3,4).<br>References (1) Shih, J., et al.: Therap. Clinical Risk Management, 9, 285 (2013)(2) Rogawski, M. A., et al.: Epilepsy Curr., 11, 56 (2011)(3) Franco, V., et al.: Ther Drug Monit. 38, 744 (2016) (4) Rudzinski, L. A., et al.: J Investig Med. 64, 1087 (2016)<br></p>Fórmula:C23H15N3OCor e Forma:Light YellowPeso molecular:349.38(S)-Penbutolol Sulfate
CAS:<p>Stability Hygroscopic<br>Applications (S)-Penbutolol Sulfate is an isomer of Penbutolol (P220500), a β-adrenoceptor antagonist. Antihypertensive.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>Fórmula:C18H29NO2·H2O4SCor e Forma:NeatPeso molecular:680.941,2-Diphenyl Hydrazine
CAS:Produto Controlado<p>Stability Air Sensitive (Oxidize)<br>Applications Impurity in the production of Phenylbutazone (P319570). Hydrazobenzene is a metabolic intermediate of Azobenzene.Carcinogenic.<br>References Chung, K., et al.: Mutation Res., 114, 269 (1983), Kawanishi, S., et al.: J. Biol. Chem., 261, 5952 (1986), Floyd, R., et al.: Carcinogenesis, 11, 1447 (1990), Shibutani, S., et al.: Nature, 349, 431 (1991),<br></p>Fórmula:C12H12N2Cor e Forma:OrangePeso molecular:184.24Des(oxopentyl) Valsartan
CAS:Produto Controlado<p>Impurity Valsartan Desvaleryl Impurity<br>Applications An impurity in the synthesis of Valsartan (V095750).<br>References Carini, D., et al.: J. Med. Chem., 34, 2525 (1991), Buhlmayer, P., et al.: Bioorg. Med. Chem. Lett., 4, 29 (1994),<br></p>Fórmula:C19H21N5O2Cor e Forma:WhitePeso molecular:351.40Diclazuril 6-Carboxylic Acid
CAS:Produto Controlado<p>Applications Diclazuril 6-Carboxylic Acid is an impurity of Diclazuril (D436200), a nucleotide analog with broad-spectrum anticoccidial activity.<br>References Fodey, T.L., et al.: J. Immunol. Meth., 323, 31 (2007);<br></p>Fórmula:C18H9Cl3N4O4Cor e Forma:NeatPeso molecular:451.65Dehydro Amlodipine Oxalate
CAS:Produto ControladoFórmula:C20H23ClN2O5·C2H2O4Cor e Forma:White To Off-WhitePeso molecular:496.89Lansoprazole Sulfide
CAS:Produto Controlado<p>Impurity Lansoprazole EP Impurity C; USP Impurity B<br>Applications Lansoprazole Sulfide (Lansoprazole EP Impurity C; USP Impurity B) is a metabolite of Lansoprazole, as gastric pump inhibitor.<br>References Oie, et al.: J. Pharm. Sci., 68, 1203 (1979), Naesdal, J., et al.: Clin. Pharmacol. Ther., 40, 344 (1986), Dube, L., et al.: Biopharm. Drug Dispos., 10, 55 (1989), Barradell, L., et al.: Drugs, 44, 225 (1992),<br></p>Fórmula:C16H14F3N3OSCor e Forma:WhitePeso molecular:353.36Nateglinide
CAS:Produto Controlado<p>Applications An amino-acid derivative that stimulates insulin secretion. Used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>Fórmula:C19H27NO3Cor e Forma:White To Off-WhitePeso molecular:317.424-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS:Produto Controlado<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C13H17ClN2O3Cor e Forma:NeatPeso molecular:284.74Lansoprazole Sulfide N-Oxide
CAS:<p>Applications Used in the preparation of Lansoprazole and its metabolite and impurities.<br>References Reddy, G. et al.; Synthetic Commun. 38, 3477 (2008)<br></p>Fórmula:C16H14F3N3O2SCor e Forma:Off White SolidPeso molecular:369.36N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamide
CAS:Produto ControladoFórmula:C19H21N5OCor e Forma:WhitePeso molecular:335.40Propylthiouracil-d5
CAS:Produto Controlado<p>Applications Labelled antihyperthyroid. Has been used to promote fattening. This substance is reasonably anticipated to be a human carcinogen.<br>References Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 6, 457 (1977), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984),<br></p>Fórmula:C7H5D5N2OSCor e Forma:Off-WhitePeso molecular:175.26Phenylephrone Hydrochloride
CAS:<p>Impurity Phenylephrine EP Impurity C; Phenylephrine USP Related Compound C (1-(3-Hydroxyphenyl)-2-(methylamin<br>Applications Phenylephrine Hydrochloride (Phenylephrine EP Impurity C; Phenylephrine USP Related Compound C (1-(3-Hydroxyphenyl)-2-(methylamino)ethan-1-one Hydrochloride)) is an impurity C of Phenylephrine.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988), Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999),<br></p>Fórmula:C9H11NO2·ClHCor e Forma:Off-White To BeigePeso molecular:201.65(S)-1-Boc-3-hydroxypiperidine
CAS:Produto Controlado<p>Applications (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chen, L., et al.: Tetrahedron Lett., 58, 1644 (2017); Ju, X., et al.: Org. Process Res. Dev., 18, 827 (2014)<br></p>Fórmula:C10H19NO3Cor e Forma:NeatPeso molecular:201.264’-(Bromomethyl)biphenyl-2-carboxylic Acid tert-Butyl Ester
CAS:Produto Controlado<p>Impurity Telmisartan EP Impurity H<br>Applications 4’-(Bromomethyl)biphenyl-2-carboxylic Acid tert-Butyl Ester (Telmisartan EP Impurity H) is a biphenyl derivative used in the preparation of angiotensin II receptor antagonists. T017000<br>References Wahhab, A. et al.: Arzneim.-Forsch., 43, 1157 (1993); Yanagisawa, H. et al.: J. Med. Chem., 39, 323 (1996);<br></p>Fórmula:C18H19BrO2Cor e Forma:NeatPeso molecular:347.25N-Formyl Trimetazidine
CAS:<p>Stability Hygroscopic<br>Applications N-Formyl Trimetazidine is an impurity of Trimetazidine (T795610).<br>References Szwed, H., et al.: Clin. Drug Invest., 19, 1 (2000), Thoppil, S., et al.: J. Pharm. Biomed. Anal., 25, 15 (2001), Wang, Z., et al.: Pharmazie, 62, 27 (2007),<br></p>Fórmula:C15H22N2O4Cor e Forma:NeatPeso molecular:294.35Gabapentin Related Compound A
CAS:Produto Controlado<p>Impurity Gabapentin EP Impurity A; Gabapentin USP Related Compound A<br>Applications Gabapentin Lactam (Gabapentin EP Impurity A; Gabapentin USP Related Compound A) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.<br>References Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)<br></p>Fórmula:C9H15NOCor e Forma:WhitePeso molecular:153.22N-Desmethyl Regorafenib (Pyridine)-N-oxide
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>Fórmula:C20H13ClF4N4O4Cor e Forma:NeatPeso molecular:484.79Phenformin Hydrochloride
CAS:<p>Applications It is an anti-diabetic drug from the biguanide class.<br>References Moody, J.E., Anal. Profiles Drug Subs., 4, 319 (1975),<br></p>Fórmula:C10H15N5·ClHCor e Forma:NeatPeso molecular:241.724-Hydroxy Benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester
CAS:Produto Controlado<p>Applications Impurity of Camostat (C150300).<br>References Bodor, N., et al.: Pharm. Res., 3, 120 (1984), Han, L., et al.: Biochem., 46, 1432 (2007),<br></p>Fórmula:C12H15NO4Cor e Forma:NeatPeso molecular:237.25Triallate
CAS:Produto Controlado<p>Applications Triallate is a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schneider, M., et al.: J. Environ. Qual., 42, 844 (2013); Busi, R., et al.: Pest Manag. Sci., 69, 1379 (2013)<br></p>Fórmula:C10H16Cl3NOSCor e Forma:Light Brown To BrownPeso molecular:304.661-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications 1-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one is an impurity of the local anesthetic Levobupivacaine (B689546).<br></p>Fórmula:C14H17NOCor e Forma:NeatPeso molecular:215.29(3R,4S)-3-[(3S)-3-(4-Fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-1-(2,3,5,6-tetradeuterio-4-fluorophenyl)azetidin-2-one
CAS:Produto Controlado<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C242H4H17F2NO3Cor e Forma:NeatPeso molecular:413.452,2,2-Trifluoroethyl 2,5-Bis(2,2,2-trifluoroethoxy)benzoate
CAS:Produto Controlado<p>Applications Intermediate in the production of antiarrhythmic N-(Piperidylalkyl)trifluoroethoxybenzamides. Possible Flecainide impurity.<br>References Banitt, E., et al.: J. Med. Chem., 20, 821 (1977),<br></p>Fórmula:C13H9F9O4Cor e Forma:NeatPeso molecular:400.19Thioridazine Hydrochloride
CAS:Produto Controlado<p>Applications Thioridazine HCl is a dopamine receptor blocker and antipsychotic. It is the parent compound of sulforidazine and mesoridazine. This compound has been reported to bind strongly to dopamine receptors on cancer stem cells and cause differentiation leaving normal cells alone (see Can. Chem. News 12 July/August 2012).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, E.I., Toxicol. Appl. Pharmacol., 18, 185 (1971), Abdel-Moety, E.M., et al.: Anal. Profile Drug Subs., 18, 459 (1989),<br></p>Fórmula:C21H26N2S2·ClHCor e Forma:Light YellowPeso molecular:407.04Regorafenib
CAS:Produto Controlado<p>Applications It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Dual action VEGFR & Raf inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000),<br></p>Fórmula:C21H15ClF4N4O3Cor e Forma:Off White PowderPeso molecular:482.82(±)-Albuterol-d3 (3-hydroxymethyl-d2; α-d1)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (±)-Albuterol-d3 (3-hydroxymethyl-d2; alpha-d1) (CAS# 1219798-60-3) is a useful isotopically labeled research compound.<br></p>Fórmula:C132H3H18NO3Cor e Forma:Off-WhitePeso molecular:242.3317α-Dutasteride
CAS:Produto Controlado<p>Impurity Dutateride EP Impurity E<br>Applications 17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).<br></p>Fórmula:C27H30F6N2O2Cor e Forma:Dark Orange Colour SolidPeso molecular:528.53Gimeracil-13C3
CAS:Produto Controlado<p>Applications Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD).<br>References Shirasaka, T., et al.: Cancer Res., 56, 2602 (1996), Patt, Y., et al.: J. Clin. Oncol., 22, 271 (2004), Shirao, K., et al.: Cancer, 100, 2355 (2004), Kelly, H., et al.: J. Clin. Oncol., 23, 4553 (2005),<br></p>Fórmula:C213C3H4ClNO2Cor e Forma:NeatPeso molecular:148.52N-nitroso-Ritalinic Acid
CAS:Produto ControladoFórmula:C13H16N2O3Cor e Forma:NeatPeso molecular:248.28N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib
CAS:Produto Controlado<p>Impurity Celecoxib EP Impurity B<br>Applications N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib (Celecoxib EP Impurity B) is an isomeric impurity of Celecoxib (C251000) with selective inhibitory activity against human cyclooxygenase-2. USP Celecoxib Related Compound B<br>References Talley, J.J. et al.: Actual. Chim. Therap., 25, 123 (1999); Rao, R. et al.: Anal. Sci., 22, 1257 (2006);<br></p>Fórmula:C17H14F3N3O2SCor e Forma:NeatPeso molecular:381.371,3,3-Trimethyl-6'-morpholinospiro[indoline-2,3'-naphtho[2,1-b][1,4]oxazine]
CAS:Pureza:97%Peso molecular:413.52099609375Ethyl 2-amino-2-(3-chloropyridin-4-yl)acetate hydrochloride
CAS:Pureza:97.0%Peso molecular:251.11000061035156
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