Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65580 produtos de "Derivados de Quinazolina e Quinolina"
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8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
CAS:Produto Controlado<p>Impurity Loratadine EP Impurity B; Loratadine USP Related Compound C<br>Applications 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine EP Impurity B; Loratadine USP Related Compound C) is a Loratadine intermediate. Loratidine impurity C.<br>References Cox, A., et al.: Drugs, 61, 723 (2001), Caponigro, F., et al.: Anti-Cancer Drugs, 13, 891 (2002), , Haluska, P., et al.: Eur. J. Cancer, 38, 1685 (2002),<br></p>Fórmula:C14H10ClNOCor e Forma:Light YellowPeso molecular:243.69Ofloxacin-d8
CAS:Produto Controlado<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Monk, J.P., et al.: Drugs, 33, 346 (1987), Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>Fórmula:C182H8H12FN3O4Cor e Forma:NeatPeso molecular:369.42Stiripentol
CAS:Produto Controlado<p>Applications An epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Fórmula:C14H18O3Cor e Forma:Light Yellow SolidPeso molecular:234.29Hydroxythiovardenafil
CAS:Produto Controlado<p>Applications Hydroxythiovardenafil is a hydroxylated thiol analogue of the PDE 5 inhibitor Vardenafil (H995300).<br></p>Fórmula:C23H32N6O4S2Cor e Forma:Light Yellow SolidPeso molecular:520.67Cilostazol
CAS:Produto Controlado<p>Applications A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo. Neuroprotective & Neuroresearch product.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Fórmula:C20H27N5O2Cor e Forma:NeatPeso molecular:369.462-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE
CAS:Pureza:95.0%Peso molecular:337.37899780273442-(2-Chlorophenyl)-2-(methylamino)-6-(thiophen-2-ylmethylidene)cyclohexan-1-one
CAS:Pureza:98%Peso molecular:331.86Tianeptine Metabolite MC5 Sodium Salt
CAS:Produto Controlado<p>Applications Primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Fórmula:C19H20ClN2O4S·NaCor e Forma:NeatPeso molecular:430.884-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
CAS:Produto Controlado<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>Fórmula:C11H8F3N3O2Cor e Forma:Light YellowPeso molecular:271.20Bisdionin C
CAS:Produto Controlado<p>Applications Bisdionin C is the derivative of Theobromine (T343800), which is a metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004)<br></p>Fórmula:C17H20N8O4Cor e Forma:NeatPeso molecular:400.39N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications N-tert-Butyl-3-(2-hydroxypropan-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide is a metabolite of Amicarbazone (A605040); a triazolinone herbicide with a broad spectrum of weed control.<br>References Dayan, F., et al.: Weed Science, 57, 579 (2009); Elmore, M., et al.: Weed Technol., 27, 596 (2013); Dong, M., et al.: J. Sep. Sci., 38, 2245 (2015)<br></p>Fórmula:C10H18N4O3Cor e Forma:NeatPeso molecular:242.27Fluconazole-d4
CAS:Produto Controlado<p>Applications Labelled Fluconazole (F421000). Used as an antifungal.<br>References Richardson, K., et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),<br></p>Fórmula:C132H4H8F2N6OCor e Forma:White To Off-WhitePeso molecular:310.30Methyl Ethanesulfonate
CAS:<p>Applications Methyl Ethanesulfonate is a sulfonic acid ester that is transparent at around 157 nm region, and is used in DFT calculations of vacuum-UV spectra in order to design the vinyl alkylsulfonate polymers for vacuum-UV photoresist applications.<br>References Fujigaya, T., et al.: J. Photopolym. Sci. Tec., 15, 643 (2002);<br></p>Fórmula:C3H8O3SCor e Forma:NeatPeso molecular:124.16N-(4-Hydroxybenzyl)-3,4-dimethoxybenzamide
CAS:Produto Controlado<p>Applications N-(4-Hydroxybenzyl)-3,4-dimethoxybenzamide is an intermediate in the synthesis of Itopride (I931500, HCl); a dopamine D2-receptor antagonist with anticholinesterase activity. Also gastroprokinetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwanaga, Y., et al; Jpn. J. Pharmacol., 56, 261 (1991); Mushiroda, T., et al.: Drug Metab. Dispos., 28, 1231 (2000); Khamar, B.M., et al.: PCT Int. Appl. WO 2007074386 A2 20070705. Jul 5, 2007<br></p>Fórmula:C16H17NO4Cor e Forma:NeatPeso molecular:287.31Chlorpromazine Sulfoxide
CAS:<p>Impurity Chlorpromazine EP Impurity A<br>Applications Chlorpromazine Sulfoxide is a derivative of Chlorpromazine Hydrochloride (C424750), which is a dopamine antagonist of the typical antipsychotic class of medications possessing additional antiadrenergic, antiserotonergic, anticholinergic and antihistaminergic properties used for schizophrenia treatment.<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990), Yuhas, D., Svi. Smer. Mind, (March 2003),<br></p>Fórmula:C17H19ClN2OSCor e Forma:Light YellowPeso molecular:334.86Vemurafenib
CAS:Produto Controlado<p>Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor<br>References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);<br></p>Fórmula:C23H18ClF2N3O3SCor e Forma:NeatPeso molecular:489.92Dibenzyloxy Tezacaftor-D4
Produto ControladoFórmula:C40H35D4F3N2O6Cor e Forma:NeatPeso molecular:704.78Loratadine N-Oxide
CAS:Produto Controlado<p>Applications Loratadine N-oxide nonsedating-type histamine.<br></p>Fórmula:C22H23ClN2O3Cor e Forma:NeatPeso molecular:398.88Dothiepin
CAS:Produto Controlado<p>Applications A tricyclic antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Metysova, J., et al.: Arzneim.-Forsch., 13, 1039 (1963), Maguire, K.P., et al.: Br. J. Clin. Pharmacol., 12, 405 (1981), Donovan, S., et al.: Prog. Neuro-Psychopharmacol. Biol. Psychiatry, 18, 1143 (1994),<br></p>Fórmula:C19H21NSCor e Forma:Light Yellow Solid With A Low Melting PointPeso molecular:295.44[2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone
CAS:<p>Impurity Clozapine EP Impurity D<br>Applications [2-[(2-Amino-4-chlorophenyl)amino]phenyl](4-methyl-1-piperazinyl)methanone (Clozapine EP Impurity D) is used in the synthesis of substituted dibenzodiazepines. Also an impurity in the synthesis of Clozepine (C587500), an antipsychotic.<br>References Stille, et al: Farnaco, Ed. Prat., 26, 603 (1971), Hane, J.M., et al.: Psychopharmacol. Bull., 24, 62 (1988), Meltzer, H.Y.: J. Clin. Psychiatry, 55, Suppl. B, 47 (1994)<br></p>Fórmula:C18H21ClN4OCor e Forma:Light Red To RedPeso molecular:344.84Gabapentin Related Compound B
CAS:<p>Impurity Gabapentin EP Impurity B; Gabapentin USP Related Compound B<br>Applications Gabapentin Related Compound B (Gabapentin EP Impurity B; Gabapentin USP Related Compound B) is a Gabapentin analogue for treatment of neurological disorders.<br>References Sit, S., et al.: J. Med. Chem., 33, 2982 (1990), O'Brien, P., et al.: J. Med. Chem., 37, 1810 (1994), Bryans, J., et al.: Med. Res. Rev., 19, 149 (1999),<br></p>Fórmula:C9H13NO2Cor e Forma:NeatPeso molecular:167.204-(3-Aminophenyl)-3-morpholinone
CAS:Produto Controlado<p>Applications 4-(3-Aminophenyl)-3-morpholinone is an intermediate during the preparation of imidazothiazoles as protein kinase inhibitors for treating cancers.<br>References Bamaung, N., et al.: PCT Int. Appl. (2009), WO 2009070516 A1 20090604.<br></p>Fórmula:C10H12N2O2Cor e Forma:NeatPeso molecular:192.214Adrafinil
CAS:Produto ControladoFórmula:C15H15NO3SCor e Forma:Off-White Light Orange ColourPeso molecular:289.35Prochlorperazine Sulfoxide-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Prochlorperazine.<br>References Finn, A., et al.: J. Clin. Pharmacol., 45, 1383 (2005),<br></p>Fórmula:C202H3H21ClN3OSCor e Forma:Off WhitePeso molecular:392.96N”Nitrosoketamine
CAS:Produto ControladoFórmula:C13H15ClN2O2Cor e Forma:White To Light YellowPeso molecular:266.7233-(4-Fluorophenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde
CAS:Pureza:95.0%Peso molecular:266.2749938964844Teneligliptin Sulfoxide (Mixture of Diastereomers)
Produto Controlado<p>Applications Teneligliptin Sulfoxide, is an impurity of Teneligliptin (T018300) which is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. Tenegliptin is eliminated from the via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. & Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>Fórmula:C22H30N6O2SCor e Forma:NeatPeso molecular:442.58(E/Z)-Tamoxifen-d5
CAS:Produto Controlado<p>Applications Mixture of labelled Tamoxifen and its (E)-isomer.<br></p>Fórmula:C26H24D5NOCor e Forma:Off White SolidPeso molecular:376.55N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine Impurity)
CAS:Produto Controlado<p>Impurity Cimetidine EP Impurity H<br>Applications N-Cyano-3-(cyanoamino)-N'-methyl-7,8-dithia-2,4,11-triazadodec-2-en-12-imidamide (Cimetidine EP Impurity H) is an impurity of Cimetidine (C441650), an H2-receptor antagonist that is used for the treatment and prevention of stress-induced gastroduodenal lesions.<br>References Burland, W., et al.: Brit. J. Clin. Pharm., 2, 481 (1975); Kauffman, G. & Morton, I.: Gastroenterology, 75, 1099 (1978); Peura, D. & Johnson, L.: Ann. Int. Med., 103, 173 (1985)<br></p>Fórmula:C10H18N8S2Cor e Forma:Off-WhitePeso molecular:314.434-Dehydroxy-5-hydroxy Ritonavir
CAS:Produto Controlado<p>Impurity Ritonavir EP Impurity N<br>Applications 4-Dehydroxy-5-Hydroxy Ritonavir (Ritonavir EP Impurity N) is an impurity of the selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Kempf, D.J. et al.: J. Med. Chem., 41, 602 (1998); Mekapati, S.B. et al.: J. Enzyme Inhib., 16, 185 (2001);<br></p>Fórmula:C37H48N6O5S2Cor e Forma:NeatPeso molecular:720.942-(Methoxymethyl)-5-(phenylthio)-1H-benzimidazole
CAS:Produto Controlado<p>Applications Febantel (F227000) impurity. Anthelmintic.<br>References Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>Fórmula:C15H14N2OSCor e Forma:NeatPeso molecular:270.35Omeprazole Sulfone N-Oxide
CAS:<p>Impurity Omeprazole EP Impurity I<br>Applications Omeprazole Sulfone N-Oxide (Omeprazole EP Impurity I) is a metabolite of Omeprazole. Impurity I.<br>References Stevens, C.M., et al.: J. Biol. Chem., 75, 182 (1950), Okamoto, S., et al.: Biochem. Biophys. Res. Commun., 101, 440 (1981)<br></p>Fórmula:C17H19N3O5SCor e Forma:NeatPeso molecular:377.41trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol(Ambroxol Impurity C)
CAS:Produto Controlado<p>Impurity Ambroxol EP Impurity C Hydrochloride<br>Stability Light Sensitive<br>Applications trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol is an impurity of Ambroxol (A575900), a bronchosecretolytic drug and the metabolite of Bromhexine (B678600). Ambroxol EP Impurity C<br>References Jauch, R., et al.: Arzneim-Forsch., 13, 474 (1963)<br></p>Fórmula:C13H16Br2N2OCor e Forma:NeatPeso molecular:376.09(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
CAS:Produto Controlado<p>Applications (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine is an intermediate used to prepare trans-2-arylcyclopropylamines as potent and selective dipeptidyl peptidase IV inhibitors.<br>References Tsai, T., et al.: Bioorg. Med. Chem., 17, 2388 (2009)<br></p>Fórmula:C9H9F2N·HClCor e Forma:Off White SolidPeso molecular:205.632Ethosuximide-d3
CAS:Produto ControladoFórmula:C7H8D3NO2Cor e Forma:White To Light YellowPeso molecular:144.19Celecoxib-d4
CAS:Produto Controlado<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C17H10D4F3N3O2SCor e Forma:White To Light YellowPeso molecular:385.4Valsartan-d9 (Major)
CAS:Produto Controlado<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Fórmula:C24H20D9N5O3Cor e Forma:Off WhitePeso molecular:444.57N-Nitrosodiethylamine (1 mg/mL in Methanol)
CAS:Fórmula:C4H10N2OCor e Forma:Single SolutionPeso molecular:102.14Captopril
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Orally active angiotensin-converting enzyme (ACE) inhibitor. Neuroprotective & Neuroresearch Product.<br>References Rubin, B., et al.: Eur. J Pharmacol., 51, 377 (1978),<br></p>Fórmula:C9H15NO3SCor e Forma:NeatPeso molecular:217.29rac-Monepantel Sulfone
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications rac-Monepantel Sulfone is a derivative of Monepantel (M515800), a recently discovered anthelmitic used in the treatment of parasitic nematodes via stun or kill without damaging the host entity.<br>References Baur, R. et al.: Mol. Pharm., 87, 96 (2015); Stuchlikova, L. et al.: Chemico. Biol. Interact., 227, 63 (2015);<br></p>Fórmula:C20H13F6N3O4SCor e Forma:NeatPeso molecular:505.39(AlphaR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride
CAS:Produto Controlado<p>Applications (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet (C441800), which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels).<br>References Franceschini N., et al.: Expert Opin. Invest. Drugs, 12, 1413 (2003), Block, G.A., et al.: N. Engl. J. Med. 350, 1516 (2004),<br></p>Fórmula:C22H25NCor e Forma:NeatPeso molecular:303.443-Bromo-5-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-pyridine
Pureza:95.0%Peso molecular:266.0979919433594Olanzapine N-Oxide
CAS:<p>Impurity Olanzapine EP Impurity D/ Olanzepine USP Related Compound C<br>Applications A metabolite of Olanzapine (Olanzapine EP Impurity D).<br>References Jacobsen, E., et al.: Acta Pharmacol. Toxacol., 11, 135 (1955), Chakrabarti, J.K., et al.: J. Med. Chem., 23, 878 (1980), Luo, H., et al.: J. Pharm. Sci., 11, 1079 (1992), Moore, N.A., et al.: Curr. Opin. Invest. Drugs, 2, 281 (1993),<br></p>Fórmula:C17H20N4OSCor e Forma:YellowPeso molecular:328.43N-Deshydroxyethyl Dasatinib
CAS:Produto ControladoFórmula:C20H22ClN7OSCor e Forma:Off-WhitePeso molecular:443.95MDV 3100-d6 (Enzalutamide-d6)
CAS:Produto Controlado<p>Applications Isotope labelled MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br></p>Fórmula:C21H10D6F4N4O2SCor e Forma:NeatPeso molecular:470.48Glycopyrrolate Bromide-d3 (Mixture of Diastereomers)
CAS:Produto Controlado<p>Applications Labelled analogue of Glycopyrrolate Bromide, a novel pharmaceutical compound based on PDE IV inhibitors. Glycopyrrolate Bromide is used in the treatment of respiratory complaints.<br>References Gomez, et al.: Br. J. Anaesth., 74, 549 (1995);<br></p>Fórmula:C19H25D3NO3·BrCor e Forma:NeatPeso molecular:401.35DL-threo-Ritalinic Acid-d10 (Major)
CAS:Produto ControladoFórmula:C13H7D10NO2Cor e Forma:NeatPeso molecular:229.347-chloro-4-methoxy-N-(pyridin-2-ylmethyl)benzo[d]thiazol-2-amine
CAS:Pureza:95.0%Peso molecular:305.77999877929694-Phenyl-2-(4-pyridyl)thiazole-5-carboxylic acid
CAS:Cor e Forma:SolidPeso molecular:282.320007324218754-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide
CAS:<p>Applications 4-[2-[1-(4-Methylphenyl)ethylidene]hydrazinyl]benzenesulfonamide is an impurity of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis. Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>Fórmula:C15H17N3O2SCor e Forma:White To Light YellowPeso molecular:303.38Sibutramine, Hydrochloride Monohydrate
CAS:Produto ControladoFórmula:C17H26ClN·ClH·H2OCor e Forma:Off White SolidPeso molecular:334.32Hydroxy Flutamide
CAS:Produto Controlado<p>Applications The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.<br>References Katchen, B., et al.: J. Clin. Endocrinol. Metab., 41, 373 (1975), Fau, D., et al.: J. Pharmacol. Exp. Ther., 269, 954 (1994), Anzenbacher, P., et al.: Drug Metab. Dispos., 30, 100 (2002), Norlin, M., et al.: J. Lipid Res., 43, 721 (2002),<br></p>Fórmula:C11H11F3N2O4Cor e Forma:Off White SolidPeso molecular:292.211,1’-N-[Methylenebis(sulphanediylethylene)]bis(N’-methyl-2-nitroethene-1,1-diamine
CAS:Produto Controlado<p>Impurity Ranitidine EP Impurity J<br>Applications 1,1’-N-[Methylenebis(sulphanediylethylene)]bis(N’-methyl-2-nitroethene-1,1-diamine (Ranitidine EP Impurity J) is a Ranitidine (R120000) impurity.<br></p>Fórmula:C11H22N6O4S2Cor e Forma:Off-White To BeigePeso molecular:366.463-[[[2-[(Diaminomethylene]amino-4-thiazolyl]thio]propionitrile
CAS:Produto ControladoFórmula:C8H11N5S2Cor e Forma:NeatPeso molecular:241.34Nadifloxacin
CAS:<p>Applications Fluorinated quinolone antibacterial (topical).<br>References Kurokawa, I., et al.: J. Am. Acad. Dermatol., 25, 674 (1991),<br></p>Fórmula:C19H21FN2O4Cor e Forma:White To Off-WhitePeso molecular:360.38Afatinib-d6
CAS:Produto ControladoFórmula:C24H19D6ClFN5O3Cor e Forma:Light Yellow SolidPeso molecular:491.98MDV 3100 (Enzalutamide)
CAS:Produto Controlado<p>Applications MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>Fórmula:C21H16F4N4O2SCor e Forma:WhitePeso molecular:464.44Trimetazidine Dihydrochloride
CAS:Produto Controlado<p>Applications Coronary vasodilator. Antianginal.<br>References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),<br></p>Fórmula:C14H22N2O3·2ClHCor e Forma:Off WhitePeso molecular:339.26Tilidine Impurity D Hydrochloride
CAS:Produto Controlado<p>Applications Tilidine Impurity D Hydrochloride is an imourity of Tilidine, which is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970), Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983), Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),<br></p>Fórmula:C13H19NO2·ClHCor e Forma:NeatPeso molecular:257.762-(4-Benzyl-morpholin-2-ylmethyl)-isoindole-1,3-dione
CAS:Pureza:95.0%Peso molecular:336.3909912109375(S)-Lansoprazole
CAS:Produto Controlado<p>Applications The S-enantiomer of Lansoprazole; a gastric proton pump inhibitor. An antiulcerative.<br>References Figgitt, D., et al.: Drugs, 60, 925 (2000), Katsuki, H., et al.: Eur. J. Clin. Pharmacol., 57, 709 (2001), Barradell, L.B., et al.: Drugs, 44, 225 (1992), Kim, K., et al.: Clin. Pharmacol. Ther., 72, 90 (2002), Niioka, T., et al.: Ther. Drug Monit., 28, 321 (2006),<br></p>Fórmula:C16H14F3N3O2SCor e Forma:NeatPeso molecular:369.36Retigabine N-β-D-Glucuronide Sodium Salt
CAS:Produto Controlado<p>Applications Sodium salt of Retigabine N-β-D-Glucuronide is the major metabolite of the antiepileptic drug Retigabine (R189050) that is produced via N-glucuronidation in humans.<br>References Hiller, A. et al.: Drug Metab. Dispos., 27, 605 (1999); Borlak, J. et al.: Metab. Clin. Exp., 55, 711 (2006); McNeilly, P.P. et al.: Zenobiotica, 27, 431 (1997);<br></p>Fórmula:C22H25FN3NaO8Cor e Forma:NeatPeso molecular:501.445-Hydroxy Omeprazole (~5% Triethylamine as stabilizer)
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications 5-Hydroxy Omeprazole is the main metabolite of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Fórmula:C17H19N3O4SCor e Forma:NeatPeso molecular:361.42Risperidone N-Oxide
CAS:Produto Controlado<p>Applications Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References El-Sherif, Z., et al.: J. Pharm. Biomed. Anal., 36, 975 (2005), Sattanathan, P., et al.: J. Pharm. Biomed. Anal., 40, 598 (2006),<br></p>Fórmula:C23H27FN4O3Cor e Forma:WhitePeso molecular:426.485’-Hydroxymethyl 5’-Desmethyl Meloxicam
CAS:Fórmula:C14H13N3O5S2Cor e Forma:NeatPeso molecular:367.407-(Diethylamino)-3-(thiophen-2-yl)-2H-chromen-2-one
CAS:Pureza:98% HPLC,TPeso molecular:299.39001464843754-(4-Phenylbutoxy)benzoic Acid
CAS:Produto Controlado<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>Fórmula:C17H18O3Cor e Forma:NeatPeso molecular:270.32Hydroxy Dehydro Nifedipine Lactone
CAS:Produto ControladoFórmula:C16H12N2O6Cor e Forma:NeatPeso molecular:328.28TEMPO
CAS:Produto Controlado<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>Fórmula:C9H18NOCor e Forma:NeatPeso molecular:156.256-Methyl Risperidone
CAS:Produto Controlado<p>Impurity Risperidone EP Impurity E<br>Applications 6-Methyl Risperidone (Risperidone EP Impurity E) is a Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C24H29FN4O2Cor e Forma:Light YellowPeso molecular:424.51Valsartan
CAS:<p>Stability Hygroscopic<br>Applications A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>Fórmula:C24H29N5O3Cor e Forma:NeatPeso molecular:435.52Palbociclib-d4
CAS:Produto Controlado<p>Applications Palbociclib-d4 is an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)<br></p>Fórmula:C24H25D4N7O2Cor e Forma:Light YellowPeso molecular:451.56(R)-Rabeprazole Sodium Salt
CAS:Produto Controlado<p>Applications A partially reversible gastric proton pump inhibitor.<br>References Moda, T., et al.: Lett. Drug Des. Discov., 4, 502 (2007), Belaz, K., et al.: J. Pharm. Biomed. Anal., 47, 81 (2008),<br></p>Fórmula:C18H20N3NaO3SCor e Forma:NeatPeso molecular:381.423-(1-Benzyl-4-hydroxypiperidin-4-yl)-2-chloroquinoline
CAS:Pureza:98%Peso molecular:352.8599853515625(S) FTY720 Phosphate
CAS:<p>Applications FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. FTY720 Phosphate is the active metabolite of FTY720-phosphate.<br>References Chiba, K., et al.: J. Immunol., 160, 5037 (1998), Brinkmann, V., et al.: J. Biol. Chem., 277, 21453 (2002), Kiuchi, M., et al.: Bioorganic & Medicinal Chemistry, 13, 425 (2005<br></p>Fórmula:C19H34NO5PCor e Forma:WhitePeso molecular:387.45Ethyl 2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
CAS:Produto Controlado<p>Applications Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (cas# 27143-07-3) is a useful research chemical.<br></p>Fórmula:C11H13N2O3ClCor e Forma:NeatPeso molecular:256.68Valsartan Benzyl Ester
CAS:<p>Impurity Valsartan USP Related Compound C<br>Applications Valsartan (V095750) intermediate. Valsartan USP Related Compound C.<br>References Cramer., et al.: J. Med. Chem., 42, 3919 (1999),<br></p>Fórmula:C31H35N5O3Cor e Forma:NeatPeso molecular:525.644-(4-Nitrophenyl)-3-morpholinone
CAS:Produto ControladoFórmula:C10H10N2O4Cor e Forma:NeatPeso molecular:222.20Pseudo Vardenafil
CAS:<p>Applications Vardenafil analog.<br>References Blok-Tip, L., et al.: Food Addit. Contam., 21, 737 (2004), Reffelmann, T., et al.: Curr. Pharm. Des., 12, 3485 (2006), Reepmeyer, J., et al.: J. Pharm. Biomed. Anal., 43, 1615 (2007),<br></p>Fórmula:C22H29N5O4SCor e Forma:NeatPeso molecular:459.566-CHLORO-N-((1-(2-METHYLPYRIDIN-4-YL)PIPERIDIN-4-YL)METHYL)-2,7-NAPHTHYRIDIN-1-AMINE
Pureza:95.0%Peso molecular:367.8800048828125α-(4-Chlorophenyl)-α-propionylacetonitrile
CAS:Produto Controlado<p>Applications Pyrimethamine intermediate.<br>References Takayama, K., et al.: Antimicrob. Agents Chemother., 33, 1493 (1989), Robson, C., et al.: J. Med. Chem., 40, 3040 (1997), Horton, J., et al.: J. Mol. Biol., 353, 334 (2005), Horton, J., et al.: J. Mol. Biol., 353, 334 (2005), Janin, Y., et al.: Bioorg. Med. Chem., 15, 2479 (2007),<br></p>Fórmula:C11H10ClNOCor e Forma:White To BrownPeso molecular:207.66Ipragliflozin
CAS:Produto Controlado<p>Applications Ipragliflozin is a potent and selective inhibitor of sodium-glucose cotransporter-2 (SGLT2) and can serve as a potential agent for the treatment of type 1 and type 2 diabetes.<br>References Kadokura, T., et al.: Clin. Pharmacokinet., 53, 975 (2014); Kashiwagi, A., et al.: J. Diabetes Investig., 5, 382 (2014); Tahara, A., et al.: J. Pharm. Pharmacol., 66, 975 (2014); Zhang, W., et al.: Clin. Drug Invest., 33, 489 (2013)<br></p>Fórmula:C21H21FO5SCor e Forma:WhitePeso molecular:404.45Marbofloxacin-d8
CAS:Produto Controlado<p>Applications Labelled fluorinated quinolone antibacterial.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977), Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998),<br></p>Fórmula:C172H8H11FN4O4Cor e Forma:NeatPeso molecular:370.402,5-Dimethyl Celecoxib
CAS:Produto Controlado<p>Applications A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.<br>References Deckmann, K. et al.: Biochem. Pharmacol., 80, 1365 (2010); Virrey, J.J. et al.: Mol. Cancer. Therap., 9, 631 (2010); Chen, S. et al.: Leukemia Res., 34, 250 (2010);<br></p>Fórmula:C18H16F3N3O2SCor e Forma:NeatPeso molecular:395.39872-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:245.28599548339844Gabapentin Related Compound D
CAS:<p>Impurity Gabapentin EP Impurity D; Gabapentin USP Related Compound D<br>Applications Gabapentin Related Compound D (Gabapentin EP Impurity D; Gabapentin USP Related Compound D) is a Gabapentin analogue.<br></p>Fórmula:C18H29NO3Cor e Forma:White To Off-WhitePeso molecular:307.43(E)-2-Chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride
CAS:Produto Controlado<p>Applications (E)-2-chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride is an impurity of Etoricoxib (E934100), a selective cyclo-oxygenase-2 (COX-2) inhibitor that is used to improve the signs and symptoms of osteoarthritis and rheumatoid arthritis.<br>References Hunt, R., et al.: Am. J. Gastroenterol., 98, 1725 (2003); Schumacher Jr., H., et al.: Bmj, 324, 1488 (2002)<br></p>Fórmula:C5H9ClN2·HClCor e Forma:Light YellowPeso molecular:169.05R 84852
CAS:<p>Applications R 84852 is an impurity of paliperidone (P141000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.<br>References Solanki, P.V., et. al.: ACS Sustainable Chem. Eng., 1, 243 (2013)<br></p>Fórmula:C23H28FN3O4Cor e Forma:NeatPeso molecular:429.486'-Methoxy-2'-acetonaphthone (Naproxen Impurity L)
CAS:Produto Controlado<p>Impurity Naproxen USP Related Compound L<br>Applications Naproxen impurity L. Naproxen USP Related Compound L<br>References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Li, J., et al.: J. Med. Chem., 39, 1846 (1996), Monser, L., et al.: J. Pharm. Biomed. Anal., 27, 851 (2002),<br></p>Fórmula:C13H12O2Cor e Forma:BeigePeso molecular:200.233
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