Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65576 produtos de "Derivados de Quinazolina e Quinolina"
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3-[2-[4-[4-Fluoro-2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]benzolyl]piperidin-1-yl]ethyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
CAS:Produto Controlado<p>Impurity Risperidone EP Impurity I<br>Applications 3-[2-[4-[4-Fluoro-2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]benzolyl]piperidin-1-yl]ethyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (Risperidone EP Impurity I) is a Risperidone (R525000) impurity.<br></p>Fórmula:C35H39F2N5O3Cor e Forma:NeatPeso molecular:615.713-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib
CAS:Produto Controlado<p>Applications 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib is an impurity of Gefitinib (G304000); a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR).<br>References Lynch, T.J., et al.: N. Engl. J. Med., 350, 2129 (2004); Engelman, J.A., et al.: Science, 316, 1039 (2007); Kris, M.G., et al.: J. Am. Med. Assoc., 290, 2149 (2003)<br></p>Fórmula:C22H24ClFN4O3Cor e Forma:NeatPeso molecular:446.904,6-Dimethyl-2-(methylsulfonyl)pyrimidine
CAS:Produto Controlado<p>Applications 4,6-Dimethyl-2-(methylsulfonyl)pyrimidine is a reactant used in the preparation of [(dimethylpyrimidinyl)oxy]diphenyl butyric acid derivatives as endothelin receptor antagonists.<br>References Xia, J., et. al.: Bioorg. Med. Chem. Lett., 21, 3894 (2011)<br></p>Fórmula:C7H10N2O2SCor e Forma:Off WhitePeso molecular:186.23α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
CAS:Produto Controlado<p>Impurity Anastrozole EP Impurity C / Anastrozole USP Related Compound D<br>Applications α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity C) is an impurity of Anastrozole (A637425) (impurity D).<br>References Ge, Z., et al.: J. Med. Chem., 13, 146 (2003),<br></p>Fórmula:C15H17BrN2Cor e Forma:NeatPeso molecular:305.215-(Pyridin-2-yl)thiophene-2-carbaldehyde
CAS:Fórmula:C10H7NOSPureza:97.0%Cor e Forma:SolidPeso molecular:189.23trans-Amorolfine
CAS:Produto Controlado<p>Applications trans-Amorolfine is an analog / impurity of Amorolfine (A634170, HCl); a morpholine antifungal drug and topical solution for the treatment of toenail infections.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Fórmula:C21H35NOCor e Forma:NeatPeso molecular:317.51Brivaracetam
CAS:Produto Controlado<p>Applications Brivaracetam, is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Fórmula:C11H20N2O2Cor e Forma:Off-WhitePeso molecular:212.296,7-Dimethoxy-N2,N2-dimethylquinazoline-2,4-diamine
CAS:Produto ControladoFórmula:C12H16N4O2Cor e Forma:NeatPeso molecular:248.2814,8-Dichloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine Impurity)
CAS:Produto Controlado<p>Impurity Loratadine USP Related Compound E<br>Applications Loratadine impurity. Loratidine impurity E. Loratadine USP Related Compound E.<br>References Villani, et al.: J. Med. Chem., 15, 750 (1972), Zhong, D., et al.: Pharmazie, 49, 736 (1994), Ruperez, F., et al.: J. Pharm. Biomed. Anal., 29, 35 (2002),<br></p>Fórmula:C14H9Cl2NOCor e Forma:NeatPeso molecular:278.132-Methyl-6-(trifluoromethyl)nicotinonitrile
CAS:Pureza:95%Cor e Forma:Solid, Off white solidPeso molecular:186.13699340820312Ivacaftor
CAS:<p>Applications Ivacaftor is used in the treatment of cystic fibrosis.<br>References Clancy, J. et al.: Am. J. Resp. Crit. Care. Med., 186, 593 (2012);<br></p>Fórmula:C24H28N2O3Cor e Forma:Off-WhitePeso molecular:392.492-Methoxy-4-amino-5-ethylsulfonylbenzoic Acid
CAS:Produto Controlado<p>Impurity Amisulpride EP Impurity E<br>Applications An impurity found in amisulpride (A633250). Amisulpride EP Impurity E<br></p>Fórmula:C10H13NO5SCor e Forma:WhitePeso molecular:259.282-Thiopheneethanol Tosylate
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Rotigotine<br>References Janssens, F., et al.: J. Med. Chem., 29, 2290 (1986),<br></p>Fórmula:C13H14O3S2Cor e Forma:NeatPeso molecular:282.386-Benzyloxy-7-methoxy-2-methyl-quinoline-3-carboxylic acid
Pureza:95.0%Peso molecular:323.34799194335945-Hydroxyhydantoin
CAS:Produto Controlado<p>Applications 5-Hydroxyhydantoin (cas# 29410-13-7) is a compound useful in organic synthesis.<br></p>Fórmula:C3H4N2O3Cor e Forma:WhitePeso molecular:116.08(R)-O-Desmethyl Naproxen
CAS:Produto Controlado<p>Applications A metabolite of Naproxen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),<br></p>Fórmula:C13H12O3Cor e Forma:NeatPeso molecular:216.23Bisdionin C
CAS:Produto Controlado<p>Applications Bisdionin C is the derivative of Theobromine (T343800), which is a metabolite of Caffeine.<br>References Suto, M., et al.: Anticancer Drug Des., 6, 107 (1991), Burkart, V., et al.: Nat. Med., 5, 314 (1999), Hassa, P., et al.: J. Biol. Chem., 278, 45145 2003), Veres, B., et al.: J. Pharmacol. Exp. Ther., 310, 247(2004)<br></p>Fórmula:C17H20N8O4Cor e Forma:NeatPeso molecular:400.394-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole
CAS:Produto Controlado<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>Fórmula:C11H8F3N3O2Cor e Forma:Light YellowPeso molecular:271.20[1-(2-Chloro-pyridine-3-carbonyl)-piperidin-3-ylmethyl]-carbamic acid tert-butyl ester
CAS:Pureza:95.0%Peso molecular:353.8500061035156Tianeptine Metabolite MC5 Sodium Salt
CAS:Produto Controlado<p>Applications Primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>Fórmula:C19H20ClN2O4S·NaCor e Forma:NeatPeso molecular:430.882-(3-hydroxyphenyl)-6-methylquinoline-4-carboxylic acid
CAS:Pureza:95.0%Peso molecular:279.29501342773443-(4-Fluoro-phenyl)-1-methyl-1H-pyrazole-4-carbaldehyde
CAS:Fórmula:C11H9FN2OPureza:95.0%Cor e Forma:Solid, Light yellow powderPeso molecular:204.204Ethyl 5-{[1,1'-biphenyl]-4-yl}-1H-pyrazole-3-carboxylate
CAS:Pureza:95.0%Peso molecular:292.33801269531252-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
CAS:Pureza:97.0%Cor e Forma:LiquidPeso molecular:370.82998657226563-(1-METHYL-1H-PYRAZOL-4-YL)QUINOLINE-6-CARBOXYLIC ACID
CAS:Pureza:95.0%Peso molecular:253.26100158691406[2-(1H-indol-3-yl)ethyl][(pyridin-4-yl)methyl]amine hydrochloride
CAS:Pureza:95.0%Peso molecular:287.79000854492192-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE
CAS:Pureza:95.0%Peso molecular:337.3789978027344Cilostazol
CAS:Produto Controlado<p>Applications A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogenic, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo. Neuroprotective & Neuroresearch product.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Fórmula:C20H27N5O2Cor e Forma:NeatPeso molecular:369.46Hydroxythiovardenafil
CAS:Produto Controlado<p>Applications Hydroxythiovardenafil is a hydroxylated thiol analogue of the PDE 5 inhibitor Vardenafil (H995300).<br></p>Fórmula:C23H32N6O4S2Cor e Forma:Light Yellow SolidPeso molecular:520.677-Nitro-4-(pyridin-2-ylmethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS:Pureza:95+%Peso molecular:285.2590026855469Ref: 10-F608382
1gA consultar2gA consultar5gA consultar10gA consultar100mgA consultar250mgA consultar500mgA consultar6-chloro-2-(2-methylphenyl)quinoline-4-carboxylic acid
CAS:Pureza:95.0%Peso molecular:297.7399902343753-Methyl-1-{4-[4-(propan-2-yl)benzenesulfonyl]phenyl}-1H-pyrazol-5-amine
CAS:Pureza:97%Peso molecular:355.4599914550781(6-Trifluoromethyl-pyridin-3-yl)-carbamic acid tert-butyl ester
CAS:Pureza:95.0%Peso molecular:262.231994628906254-Morpholin-4-ylmethyl-1H-quinolin-2-one
CAS:Pureza:97.0%Cor e Forma:SolidPeso molecular:244.2940063476562510-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinolin-11(5H)-one
CAS:Pureza:98%Peso molecular:318.37600708007817-Hydroxy Ondansetron
CAS:<p>Applications A metabolite of Ondansetron.<br>References Colthup, P., et al.: J. Pharm. Sci., 80, 868 (1991), Miyauchi, S., et al.: Pharm. Res.,10, 434 (1993), Ekins, S., et al.: Drug Metab. Dispos., 23, 1274 (1995), Worboys, P., et al.: Xenobiotica, 26, 897 (1996),<br></p>Fórmula:C18H19N3O2Cor e Forma:NeatPeso molecular:309.3624-Chloro-7-(3,5-dimethylisoxazol-4-yl)-6-methoxyquinoline-3-carboxamide
CAS:Pureza:97%Peso molecular:331.760009765625Ref: 10-F987646
1gA consultar5gA consultar5mg80,00€10mg102,00€25mg211,00€50mg362,00€100mgA consultar250mgA consultar4,6-Diphenyl-1-[(E)-(phenylmethylidene)amino]-1,2-dihydropyridin-2-one
CAS:Peso molecular:350.4209899902344Stiripentol
CAS:Produto Controlado<p>Applications An epilepsy drug. It has been used as co-therapy for treatment of epilepsy. It inhibits the enzymes responsible for metabolism of other anti-convulsant agents.<br>References Laurie, D., et al.: J. Neurosci., 12, 4151 (1992), Smith, A., et al.: J. Pharmacol. Exp. Therap., 311, 601 (2004), Trojnar, M., et al.: Pharm. Rep., 57, 154 (2005), Drafts, B., et al.: J. Pharm. Exp. Ther., 318, 1094 (2006), Picton, A., et al.: Brain Res., 1165, 40 (2007),<br></p>Fórmula:C14H18O3Cor e Forma:Light Yellow SolidPeso molecular:234.295-Bromo-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde
CAS:Pureza:95+%Peso molecular:357.2070007324219Sodium (S)-6-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide
CAS:Pureza:97%Peso molecular:405.35000610351562-(5-amino-3-methyl-1H-pyrazol-1-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:245.285995483398441,1'-Bis(2,4-dinitrophenyl)-4,4'-bipyridinium dichloride
CAS:Pureza:98%Peso molecular:561.28997802734382-(2,5-Dichlorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Pureza:97.0%Peso molecular:329.19000244140625Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
CAS:Produto Controlado<p>Applications Ethyl 6-(4-Aminophenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate is an impurity of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Nevuluri, N. et al.: Monat. fuer Chem., 148, 1477 (2017);<br></p>Fórmula:C22H22N4O4Cor e Forma:NeatPeso molecular:406.435-bromo-2-pyridin-3-yl-1,3-benzoxazole
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:275.1050109863281Oxaprozin-d10
CAS:Produto Controlado<p>Applications Oxaprozin-d10 is the labeled analogue of Oxaprozin (O845400), an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).<br>References Whitehouse, M.W., et al.: Biochem. Pharmacol., 20, 2309 (1971); Janssen, F.W., et al.: Drug Metab. Dispos., 6, 465 (1978); Shriver, D.A., et al.: Toxicol. Appl. Pharmacol., 42, 75 (1977)<br></p>Fórmula:C18H5D10NO3Cor e Forma:NeatPeso molecular:303.382-(Chloromethyl)-4-methylquinazoline
CAS:Produto Controlado<p>Impurity Linagliptin 2-Chloromethyl Impurity<br>Applications 2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>Fórmula:C10H9ClN2Cor e Forma:NeatPeso molecular:192.64N-Demethyl Ondansetron
CAS:<p>Applications A metabolite of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bayliss, M., et al: Xenobiotica, 24, 231 (1994), Atkins, W., et al.: J. Biol. Chem., 277, 33258 (2002), De Graaf, I., et al.: Drug Metab. Dispos., 30, 1129 (2002),<br></p>Fórmula:C17H17N3OCor e Forma:White To BrownPeso molecular:279.34(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:327.7699890136719Irbesartan-d6
CAS:Produto Controlado<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>Fórmula:C25D6H22N6OCor e Forma:White SolidPeso molecular:434.572-(2,3-Dimethylbenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Pureza:97.0%Peso molecular:288.3599853515625Butoxy Olopatadine Hydrochloride
CAS:Produto ControladoFórmula:C25H31NO3•HClCor e Forma:NeatPeso molecular:429.98Netupitant
CAS:Produto Controlado<p>Applications Netupitant is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active.<br>References Hoffmann, T., et al.: Bioorg. Med. Chem. Lett., 16, 1362 (2006); Di Fabio, R., et al.: Bioorg. Med. Chem., 21, 6264 (2013)<br></p>Fórmula:C30H32F6N4OCor e Forma:NeatPeso molecular:578.592-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine
CAS:Pureza:99.0%Cor e Forma:SolidPeso molecular:321.3760070800781Riociguat-13C-d3
CAS:Produto Controlado<p>Applications Riociguat-13C-d3 is the labelled analogue of Riociguat (R520000), which is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Fórmula:C1913CH16D3FN8O2Cor e Forma:NeatPeso molecular:426.431-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine
CAS:Pureza:95.0%Cor e Forma:SolidPeso molecular:242.3260040283203O3-Desethyl Apremilast
CAS:Produto ControladoFórmula:C20H20N2O7SCor e Forma:NeatPeso molecular:432.452-Hydroxymethyl Olanzapine-d3 (Major)
CAS:Produto Controlado<p>Applications A minor labelled metabolite of Olanzapine.<br>References Moore, N., et al.: J. Pharmacol. Exper. Ther., 262, 545 (1992), Chiu, J., et al.: J. Pharmaceut. Biomed. Anal., 14, 609 (1996), Kassahun, K., et al.: Drug Metab. Dispos., 25, 81 (1997),<br></p>Fórmula:C17H17D3N4OSCor e Forma:NeatPeso molecular:331.45
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