Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65578 produtos de "Derivados de Quinazolina e Quinolina"
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3-(Aminomethyl)-2-tert-butoxypyridine
CAS:Fórmula:C10H16N2OPureza:95.0%Cor e Forma:SolidPeso molecular:180.2511-[3-(chloromethyl)phenyl]-3,5-dimethyl-1H-pyrazole hydrochloride
CAS:Fórmula:C12H14Cl2N2Pureza:95.0%Cor e Forma:No data available.Peso molecular:257.16N-(3-Thienylmethyl)-2-butanamine hydrochloride
CAS:Fórmula:C9H16ClNSPureza:95.0%Peso molecular:205.744-[1,5-Dicyano-3-(2-cyanoethyl)pentan-3-yl]-1-[2-(pyridin-2-yl)ethyl]pyridinium chloride
CAS:Fórmula:C22H24ClN5Peso molecular:393.925-Bromo-2-chloro-4-methylpyridine
CAS:Fórmula:C6H5BrClNPureza:95%Cor e Forma:SolidPeso molecular:206.472-(5-Amino-3-methyl-pyrazol-1-yl)-ethanol
CAS:Fórmula:C6H11N3OPureza:95%Cor e Forma:SolidPeso molecular:141.1745-Bromo-4-methoxy-thiophene-3-carbonyl chloride
CAS:Fórmula:C6H4BrClO2SPureza:95.0%Peso molecular:255.51N-(2-Amino-4-trifluoromethylphenyl)morpholine
CAS:Fórmula:C11H13F3N2OPureza:97%Cor e Forma:SolidPeso molecular:246.2335-Aminoisoquinoline
CAS:Fórmula:C9H8N2Pureza:97%Cor e Forma:Solid, White to yellow or brown solidPeso molecular:144.177N-Methyl-N-(3-pyridylmethyl)amine
CAS:Fórmula:C7H10N2Pureza:98%Cor e Forma:Liquid, ClearPeso molecular:122.171(6-(Pyrrolidin-1-yl)pyridin-3-yl)methanamine
CAS:Fórmula:C10H15N3Pureza:95.0%Cor e Forma:Solid, No data available.Peso molecular:177.251(5-Bromo-6-chloropyridin-2-yl)methanamine hydrochloride
CAS:Fórmula:C6H7BrCl2N2Pureza:98%Peso molecular:257.942-(6-(Cyclopentyloxy)pyridin-3-yl)ethan-1-amine dihydrochloride
CAS:Pureza:95+%Peso molecular:279.20999151-(2-Chloropyridine-3-carbonyl)-4-piperidinone
CAS:Fórmula:C11H11ClN2O2Pureza:97.0%Peso molecular:238.672-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine 4-nitrobenzoate
CAS:Pureza:97%Peso molecular:469.9200134(butan-2-yl)[(pyridin-4-yl)methyl]amine dihydrochloride
CAS:Fórmula:C10H18Cl2N2Pureza:95.0%Peso molecular:237.171-(3-Chloro-5-trifluoromethyl-pyridin-2-ylmethyl)-piperidine-4-carboxylic acid ethyl ester
Fórmula:C15H18ClF3N2O2Pureza:95.0%Peso molecular:350.77tert-Butyl 4-(2-bromopyridin-4-yl)piperazine-1-carboxylate
CAS:Fórmula:C14H20BrN3O2Pureza:95.0%Peso molecular:342.2372,3-Dibromopyridine-4-carboxylic acid
CAS:Fórmula:C6H3Br2NO2Pureza:98%+(HPLC);RGCor e Forma:SolidPeso molecular:280.9036-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-OL
CAS:Fórmula:C10H9N3OPureza:95.0%Cor e Forma:SolidPeso molecular:187.2023-(3-methyl-5-oxo-2,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonamide
CAS:Pureza:95%+(HPLC);RGPeso molecular:253.27999883-(2-Methyl-pyridin-4-yl)-propan-1-ol
CAS:Fórmula:C9H13NOPureza:98%Cor e Forma:ClearPeso molecular:151.2092-Pyridinesulfonyl chloride
CAS:Fórmula:C5H4ClNO2SPureza:95%Cor e Forma:Liquid, ClearPeso molecular:177.61-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophen-3-yl)ethanone
CAS:Fórmula:C12H17BO3SPureza:95.0%Peso molecular:252.141-(4-Chloro-phenyl)-3-methyl-1H-pyrazole-5-carboxylic acid
CAS:Fórmula:C11H9ClN2O2Pureza:99.0%Cor e Forma:SolidPeso molecular:236.661-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
CAS:Fórmula:C7H8N2O2Pureza:95%Cor e Forma:SolidPeso molecular:152.1532-Amino-4-(4-fluorophenyl)thiophene-3-carboxylic acid methyl ester
CAS:Fórmula:C12H10FNO2SPureza:96.0%Cor e Forma:Orange powderPeso molecular:251.285-amino-1H-pyrazole-3-carboxamide hydrochloride
CAS:Fórmula:C4H7ClN4OPureza:95.0%Peso molecular:162.585-amino-4-methylnicotinonitrile
CAS:Fórmula:C7H7N3Pureza:95.0%Cor e Forma:SolidPeso molecular:133.154N-methyl-N-{[1-(2-methylpropyl)-1H-pyrazol-4-yl]methyl}piperidin-4-amine
CAS:Fórmula:C14H26N4Pureza:95.0%Peso molecular:250.39Thiophene-3-carboxamidine hydrochloride
CAS:Fórmula:C5H7ClN2SPureza:95.0%Cor e Forma:SolidPeso molecular:162.646-Methoxy-5-methylnicotinic acid
CAS:Fórmula:C8H9NO3Pureza:95%Cor e Forma:SolidPeso molecular:167.1642-[3-(6-Chloro-4-trifluoromethyl-pyridin-2-yl)-phenoxy]-propionic acid
Fórmula:C15H11ClF3NO3Pureza:95.0%Peso molecular:345.73,5-Difluoro-2-(trifluoromethyl)pyridine
CAS:Fórmula:C6H2F5NPureza:97.0%Cor e Forma:Liquid, ClearPeso molecular:183.0811-(2-amino-4-(thiophen-2-yl)thiazol-5-yl)-2,2,2-trifluoroethan-1-one
CAS:Fórmula:C9H5F3N2OS2Pureza:95.0%Peso molecular:278.271-(3-Methoxyphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid
CAS:Fórmula:C13H14N2O3Peso molecular:246.2666-Methoxyquinoline-4-carboxylic acid
CAS:Fórmula:C11H9NO3Pureza:95%Cor e Forma:SolidPeso molecular:203.1976-Bromo-4-hydroxy-2-(trifluoromethyl)quinoline
CAS:Fórmula:C10H5BrF3NOPureza:96%Cor e Forma:SolidPeso molecular:292.055Tert-butyl4-[5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
CAS:Pureza:97%Peso molecular:391.3200073(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(pyridin-4-yl)propanoic acid
CAS:Pureza:98%Peso molecular:402.4500122Ticlopidine
CAS:<p>Ticlopidine (PCR 5332) is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor.</p>Fórmula:C14H14ClNSPureza:99.67%Cor e Forma:SolidPeso molecular:263.79Meclofenamic acid
CAS:<p>Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.</p>Fórmula:C14H11Cl2NO2Pureza:98%Cor e Forma:SolidPeso molecular:296.15Icotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Fórmula:C22H21N3O4Pureza:99.76% - 99.94%Cor e Forma:SolidPeso molecular:391.42Betrixaban
CAS:<p>Betrixaban is a non-VKORC1 anticoagulant targeting factor Xa, with low hERG affinity, used to prevent VTE in adults with mobility issues.</p>Fórmula:C23H22ClN5O3Pureza:99.33%Cor e Forma:SolidPeso molecular:451.91Esmolol hydrochloride
CAS:Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Fórmula:C16H25NO4·HClPureza:98.72% - 99.48%Cor e Forma:White SolidPeso molecular:331.15Mephenoxalone
CAS:<p>Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc.</p>Fórmula:C11H13NO4Pureza:98%Cor e Forma:SolidPeso molecular:223.23Penbutolol sulfate
CAS:<p>Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.</p>Fórmula:C18H29NO2H2O4SPureza:98.55%Cor e Forma:SolidPeso molecular:340.47Diphenidol
CAS:<p>Diphenidol, a muscarinic antagonist, is employed as an antivertigo and antiemetic agent.</p>Fórmula:C21H27NOCor e Forma:Needles From Petroleum Ether SolidPeso molecular:309.45Amfenac
CAS:<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Itopride free base
CAS:<p>Itopride HCl combats dyspepsia and GERD, inhibiting AChE and blocking D2 receptors.</p>Fórmula:C20H26N2O4Cor e Forma:WhitePeso molecular:358.43(3S,4S)-Tofacitinib
CAS:<p>(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.</p>Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37Procymidone
CAS:<p>Procymidone is a broad-spectrum fungicide that inhibits fungal glycerol triester synthesis, thereby disrupting hyphal growth. androgen receptor (AR) antagonist</p>Fórmula:C13H11Cl2NO2Pureza:99.86%Cor e Forma:Colorless SolidPeso molecular:284.14Pardoprunox
CAS:<p>Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties.</p>Fórmula:C12H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:233.27Prothioconazole
CAS:<p>Prothioconazole (Proline 480 SC Fungicide) is a chiral triazole fungicide in plant pathogen control.</p>Fórmula:C14H15Cl2N3OSPureza:99.77%Cor e Forma:Un3077 9/Pg 3Peso molecular:344.26Hydroxynorketamine Hydrochloride
CAS:Produto Controlado<p>Applications Hydroxynorketamine is a metabolite of Ketamine (K165300, HCl salt) which is a medication used mainly for starting and maintaining anesthesia.<br>References Adams, J., et al.: Biomed. Mass Spec., 11, 527 (1981); Sass, W.C., et al.: Anal. Profiles Drug Subs., 6, 297 (1977); Reich, D.L., et al.: Can. J. Anaesth., 36, 186 (1989)<br></p>Fórmula:C12H15Cl2NO2Cor e Forma:White To Off-WhitePeso molecular:276.16Montelukast Cyclized Ether impurity
CAS:Produto Controlado<p>Applications A cyclic ether impurity of antiasthmatic Montelukast (M568000).<br>References Egekeze, J.O. et al.: Anal. Chem., 67, 2292 (1995);<br></p>Fórmula:C29H26ClNOCor e Forma:NeatPeso molecular:439.98Palbociclib
CAS:<p>Applications Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.<br>References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009);<br></p>Fórmula:C24H29N7O2Cor e Forma:NeatPeso molecular:447.534-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]-triazin-2-yl)benzene-sulfonyl Chloride
CAS:Produto Controlado<p>Applications Vardenafil Intermediate.<br>References Terrett, N.K., et al.: Bioorg. Med. Chem. Lett., 6, 1819, (1996)<br></p>Fórmula:C17H19ClN4O4SCor e Forma:NeatPeso molecular:410.88Haloperidol Octanoate
CAS:Produto ControladoFórmula:C29H37ClFNO3Cor e Forma:NeatPeso molecular:502.064'-Nitro-3'-(trifluoromethyl)acetanilide
CAS:<p>Applications 4’-Nitro-3’-(trifluoromethyl)acetanilide is a metabolite of the nonsteroidal antiandrogen drug, Flutamide (F598850).<br>References Kang, P. et al.: Drug Metab. Dispos., 36, 1425 (2008); Takashima, E. et al.: Biol. Pharmac. Bull., 26, 1455 (2003); Katchen, B. et al.: J. Invest. Dermatol., 66, 379 (1976);<br></p>Fórmula:C9H7F3N2O3Cor e Forma:NeatPeso molecular:248.16Repirinast (>80%)
CAS:Produto ControladoFórmula:C20H21NO5Pureza:>80%Cor e Forma:NeatPeso molecular:355.38Bis(3-methylthien-2-yl)methanone
CAS:Produto Controlado<p>Applications Bis(3-methylthien-2-yl)methanone is an impurity of Tiagabine (T436400), a GABA uptake inhibitor and nticonvulsant agent.<br>References Zhang, J.G., et al.: Chem. Res. Chin. Uni., 22, 351 (2006); Callen, G., et al.: Heterocycles., 39, 293 (1994);<br></p>Fórmula:C11H10OS2Cor e Forma:NeatPeso molecular:222.33N-Desmethyl N-Nitroso Olopatadine-d3
Produto ControladoFórmula:C20D3H17N2O4Cor e Forma:NeatPeso molecular:355.402Thioridazine 2-Sulfone
CAS:Produto Controlado<p>Impurity Thioridazine EP Impurity E<br>Applications Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).<br>References Niedzwiecki, D., et al.: J. Pharmacol. Exp. Ther., 250, 126 (1989), Eap, C., et al.: Ther. Drug Monit., 13, 356 (1991), Shah, P., et al.: J. Pharm. Sci., 81, 309 (1992), Eap, C., et al.: J. Pharm. Biomed. Anal., 11, 451 (1993), Blake, B., et al.: Xenobiotica, 25, 337 (1995),<br></p>Fórmula:C21H26N2O2S2Cor e Forma:NeatPeso molecular:402.57(2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride
CAS:<p>Impurity Amorolfine EP Impurity C<br>Stability Hygroscopic<br>Applications (2R,6S)-rel-2,6-Dimethyl-4-(2-methyl-3-phenylpropyl)morpholine Hydrochloride (1:1), is used in the preparation of Amorolfine (A634170), a morpholine antifungal drug.<br>References Rotta, I., et al.: JAMA Dermatol., 149, 341 (2013); Espinel-Ingroff, A., et al.: Antimicrob. Agents Ch., 26, 5 (1984)<br></p>Fórmula:C16H26ClNOCor e Forma:NeatPeso molecular:283.844’-Bromomethylbiphenyl-2-carboxylic Acid, Methyl Ester
CAS:Produto ControladoFórmula:C15H13BrO2Cor e Forma:NeatPeso molecular:305.171-(6-Methylpyridin-3-yl)-2-((4-(2-(6-methylpyridin-3-yl)-2-oxoethyl)phenyl)sulfonyl)ethanone
CAS:Produto ControladoFórmula:C22H20N2O4SCor e Forma:NeatPeso molecular:408.47Zomepirac Sodium Salt
CAS:Produto Controlado<p>Applications Zomepirac is an analgesic, anti-inflammatory drug.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sofia, R., et al.: Pharmacol. Res. Commun., 11, 179 (1979), Grindel, J.M., et al.: Drug Metab. Dispos., 8, 343 (1980), Steele, C.E., et al.: Curr. Med. Res. Opin., 8, 382 (1983),<br></p>Fórmula:C15H13ClNO3·NaCor e Forma:Off White SolidPeso molecular:313.71N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid
CAS:Produto Controlado<p>Impurity Ritonavir EP Impurity A<br>Applications N-[[N-Methyl-N-[(2-isopropyl]-4-thiazolyl)methyl)amino]carbonyl-L-valine Carboxylic Acid (Ritonavir EP Impurity A) is an intermediate in the synthesis of Ritonavir.<br>References Hamada, Y., et al.: Bioorg. Med. Chem., 10, 4155 (2002),<br></p>Fórmula:C14H23N3O3SCor e Forma:NeatPeso molecular:313.42Desacetyl Diltiazem-d3
CAS:Produto Controlado<p>Applications A labelled metabolite of Diltiazem (D460620).<br>References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),<br></p>Fórmula:C20H21D3N2O3SCor e Forma:NeatPeso molecular:375.53-Isoniazid
CAS:Produto Controlado<p>Applications An impurity of Isoniazid (I821450), potent antitubercular agent against M. tuberculosis.<br>References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Andrade, C., et al.: Lett. Drug. Des. Discov., 5, 377 (2008)<br></p>Fórmula:C6H7N3OCor e Forma:Off White PowderPeso molecular:137.144-Hydroxy Phenylbutazone
CAS:<p>Applications Impurity in the production of Phenylbutazone (P319570)<br>References Fricoteaux, R., et al.: J. Pharm. Biomed. Anal., 7, 1585 (1989), Segrestaa, J., et al.: Chem. Pharm. Bull., 50, 744 (2002),<br></p>Fórmula:C19H20N2O3Cor e Forma:White To Off-WhitePeso molecular:324.374,5-Dehydro Apixaban
CAS:Produto Controlado<p>Applications 4,5-Dehydro Apixaban is an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011)<br></p>Fórmula:C25H23N5O4Cor e Forma:NeatPeso molecular:457.484-Desisopropyl-4-ethyl Nateglinide
CAS:Produto Controlado<p>Applications D-phenylanaline derivative and an analog Nateglinide (N379375) with similar hypoglycemic activity.<br>References Shinkai, H. et al.: J. Med. Chem., 32, 1436 (1989);<br></p>Fórmula:C18H25NO3Cor e Forma:NeatPeso molecular:303.40Ofloxacin Isopropyl Ester
CAS:Produto ControladoFórmula:C21H26FN3O4Cor e Forma:NeatPeso molecular:403.45Methylene-Bis Paroxetine Dihydrochloride
CAS:Produto Controlado<p>Impurity Paroxetine EP Impurity F<br>Applications Methylene-Bis Paroxetine Dihydrochloride (Paroxetine EP Impurity F) is used in the chiral HPLC method for chiral purity determination of Paroxetine drug substance.<br>References Zukowski, J., et al.: Chirality, 15, 600 (2003),<br></p>Fórmula:C39H42Cl2F2N2O6Cor e Forma:NeatPeso molecular:743.66Chlorpromazine-d6 Hydrochloride
CAS:Produto Controlado<p>Applications Labelled Chlorpromazine (C424750). Used as an antiemetic; antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anden, N.-E., et al.: Eur. J. Pharmacol., 11, 303 (1970), Curzon, G., et al.: Trends Pharmacol. Sci., 11, 61 (1990),<br></p>Fórmula:C172H6H13ClN2S·ClHCor e Forma:White To Light YellowPeso molecular:361.36Carboxyamidotriazole
CAS:Produto Controlado<p>Applications Carboxyamidotriazole is an orally active calcium channel blocker. Carboxyamidotriazole also exhibits inhibition of pro-inflammatory cytokines in tumor associated macrophages as potential anti-cancer mechanism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ju, R., et al.: Euro. J. Cancer., 48, 1085 (2012); Corrado, C., et al.: Cancer. lett., 300, 205 (2011);<br></p>Fórmula:C17H12Cl3N5O2Cor e Forma:NeatPeso molecular:424.672-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid
CAS:Produto Controlado<p>Impurity Ambrisentan Impurity E<br>Applications 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid is an acrylic acid derivative that can be used as an endothelin receptor antagonist useful for treating hypertension or pulmonary artery hypertension. Ambrisentan Impurity E<br>References Zhang, D., et al.: Faming Zhuanli Shenqing. CN 102093286 A 20110615. Jun 15, 2011<br></p>Fórmula:C21H18N2O3Cor e Forma:White To Off-WhitePeso molecular:346.384'-(Bromomethyl)-[1,1'-biphenyl]-2-carboxamide
CAS:Produto Controlado<p>Impurity Telmisartan Bromo Amide Impurity<br>Applications An impurity in the preparation of the angiotensin II receptor antagonist Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Fórmula:C14H12BrNOCor e Forma:WhitePeso molecular:290.16Aprepitant-13C2,d2 (Major)
CAS:Produto Controlado<p>Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),<br></p>Fórmula:C2113C2H19D2F7N4O3Cor e Forma:Off White SolidPeso molecular:538.42(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one
CAS:Produto Controlado<p>Applications (S)-4-(4-(5-(AMINOMETHYL)-2-OXOOXAZOLIDIN-3-YL)PHENYL)MORPHOLIN-3-ONE (cas# 446292-10-0) is a useful research chemical.<br></p>Fórmula:C14H17N3O4Cor e Forma:White To Off-WhitePeso molecular:291.302-Nitrodeamino Fingolimod
CAS:Produto Controlado<p>Applications An impurity of Fingolimod (F805000, HCl salt), a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs.<br>References Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),<br></p>Fórmula:C19H31NO4Cor e Forma:NeatPeso molecular:337.45N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe
CAS:Produto ControladoFórmula:C24H21ClFNO3Cor e Forma:NeatPeso molecular:425.88Cinitapride
CAS:<p>Applications A novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors (1,2,3).<br>References (1) Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997)(2) Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007)(3) Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Fórmula:C21H30N4O4Cor e Forma:NeatPeso molecular:402.49Asenapine-d7 (Major)
CAS:Produto Controlado<p>Applications Labelled Asenapine. Asenapine is a combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to Mianserin. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Meltzer, H. et al.: J. Pharmacol. Exp. Ther., 251, 238 (1989); Schotte, A. et al.: Brain Res., 631, 191 (1993); Andree, B. et al.: Psychopharmacology, 131, 339 (1997); Richelson, E. et al.: Life Sci., 68, 29 (2000);<br></p>Fórmula:C17D7H9ClNOCor e Forma:NeatPeso molecular:292.812-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol
CAS:Produto Controlado<p>Applications 2-[[(3aR,4S,6R,6aS)-6-[[5-Amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol is used as a reagent in the synthesis of Ticagrelor (T437700) derivatives as antiplatelet agents.<br>References Zhang, H., et al.: Bioorg. Med. Chem. Lett., 22, 3598 (2012)<br></p>Fórmula:C17H27ClN4O4SCor e Forma:NeatPeso molecular:418.94Perphenazine-d8 Dihydrochloride Salt (1.0 mg/mL in Methanol)
CAS:Fórmula:C21H18D8ClN3OS·2HClCor e Forma:ColourlessPeso molecular:484.93N-De[2-(methylsulfonyl)ethyl] Lapatinib
CAS:Produto Controlado<p>Applications A reactive metabolite of Lapatinib (L175800) which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites.<br>References He, K., et al.: Chem. Res. Toxicol., 11, 252 (1998), Rusnuk, D., et al.: Cancer Res., 61, 7196 (2001), Li, X., et al.: Drug Metab. Dispos., 37, 1242 (2009),<br></p>Fórmula:C26H20ClFN4O2Cor e Forma:NeatPeso molecular:474.91Brivaracetam-d7 (Mixture of Diastereomers)
Produto Controlado<p>Applications Brivaracetam-d7 (Mixture of Diastereomers), is a mixture of 2 diastereomers of Brivaracetam-d7 (B677647), and a labeled analogue of Brivaracetam (B677645), 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Fórmula:C11H13D7N2O2Cor e Forma:NeatPeso molecular:219.33Hydroxy Saxagliptin
CAS:Produto Controlado<p>Applications Hydroxy Saxagliptin is a metabolite of Saxagliptin (S143500).<br>References Patel, C. et al.: J. Clinic. Pharmacol., 50, 1211 (2010); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007),:Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008);<br></p>Fórmula:C18H25N3O3Cor e Forma:NeatPeso molecular:331.416,8-Dioxo Apalutamide
CAS:Produto Controlado<p>Applications 6,8-Dioxo Apalutamide is an impurity of Apalutamide (A726120). Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Fórmula:C21H15F4N5O3Cor e Forma:NeatPeso molecular:461.38R-Amisulpride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications R-Amisulpride is an isomer of the antipsychotic Amisulpride (A633250). R-Amisulprideis a potential antidiabetic agent.<br>References Roix, J.J., et. al.: Diabetes Obesity Metab., 14, 329 (2012)<br></p>Fórmula:C17H27N3O4SCor e Forma:NeatPeso molecular:369.48Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride
CAS:Produto Controlado<p>Applications Thiazol-5-ylmethyl ((2R,5R)-5-Amino-1,6-diphenylhexan-2-yl)carbamate Hydrochloride is an impurity of Cobicistat (C633150), a HIV protease inhibitor that has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012)<br></p>Fórmula:C23H27N3O2S·HClCor e Forma:NeatPeso molecular:446.0Solifenacin EP Impurity A Nitroso Impurity
Produto ControladoFórmula:C15H14N2OCor e Forma:NeatPeso molecular:238.29Efavirenz Penteneyne
Produto Controlado<p>Applications Efavirenz penteneyne is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>Fórmula:C14H9ClF3NO2Cor e Forma:NeatPeso molecular:315.67Apatinib-d8 25-N-Oxide Dihydrochloride
CAS:Produto Controlado<p>Applications Labelled Apatinib 25-N-Oxide (A726160). Apatinib 25-N-Oxide is a metabolite of the antiangiogenic agent and selective VEGFR2 inhibitor Apatinib (A726150).<br>References Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>Fórmula:C24H15D8N5O2•2HClCor e Forma:NeatPeso molecular:421.52236465-(4'-Methyl-2-biphenyl)tetrazole-d4
CAS:Produto Controlado<p>Applications Labelled Valsartan (V095750) impurity.<br>References Thai, H., et al.: J. Cardiovasc. Pharmacol., 50, 703 (2007), Lukas, J., et al.: Science, 313, 662 (2006),<br></p>Fórmula:C14H8D4N4Cor e Forma:Off-WhitePeso molecular:240.301Plerixafor Hydrochloride (1:8)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Plerixafor Hydrochloride (1:8), is an immunostimulant used to mobilize hematopoietic stem cells in cancer patients. It is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α).<br>References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),<br></p>Fórmula:C28H54N8·8ClHCor e Forma:NeatPeso molecular:794.47Vortioxetine Hydrobromide (1 mg/mL in Methanol)
CAS:Fórmula:C18H22N2S·BrHCor e Forma:Single SolutionPeso molecular:379.3587,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone
CAS:<p>Applications 7,7’-[(1,4-Butanediyl)bis(oxy)]bis-2(1H)quinolinone is an impurity of Brexpiprazole (B677385), which is a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006)<br></p>Fórmula:C22H20N2O4Cor e Forma:NeatPeso molecular:376.405(1S,2R)-2-(2-Benzylamino-1-hydroxyethyl)-6-fluorochromane
CAS:Produto Controlado<p>Applications (-)-Nebivolol intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C18H20FNO2Cor e Forma:WhitePeso molecular:301.364-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
CAS:Produto ControladoFórmula:C21H21N3O5Cor e Forma:NeatPeso molecular:395.414-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one-d4
CAS:Produto Controlado<p>Applications Isotope labelled Sitagliptin (S491000) intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.<br>References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Fórmula:C16H8D4F6N4O2Cor e Forma:NeatPeso molecular:410.31N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide
CAS:Produto Controlado<p>Applications N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide is derived from Diethyl 2-Acetamidomalonate (D443130), which is a versatile building block used for the synthesis of various pharmaceutical and biologically active compounds. It is an intermediate for the preparation of Novobiocin (N888500) analogues as potential heat shock protein 90 inhibitors.<br>References Gunaherath, G. M., et al.: Bioorg. Med. Chem., 21, 5118 (2013);<br></p>Fórmula:C25H39NO5Cor e Forma:NeatPeso molecular:433.58Sitagliptin N-Sulfate Sodium Salt
CAS:Produto Controlado<p>Applications A metabolite of Sitagliptin.<br>References Beconi, M.G. , et al.: Drug Metab. Dispos., 35, 525 (2007),<br></p>Fórmula:C16H15F6NaN5O4SCor e Forma:NeatPeso molecular:509.36N-Nitroso-desethyl-Hydroxychloroquine
Produto ControladoFórmula:C16H21ClN4O3Cor e Forma:NeatPeso molecular:336.817Iguratimod
CAS:Produto Controlado<p>Applications Iguratimod acts as an anti-inflammatory agent, used primarily in the treatment of rheumatoid arthritis.<br>References Estellat, C. et al.: Arch. Int. Med., 172, 237 (2012); Du, F. et al.: Arth. Res. Ther., 10 (2008); Tanaka, K. et al.: Rheumatol. Rep., 1, 11 (2009);<br></p>Fórmula:C17H14N2O6SCor e Forma:NeatPeso molecular:374.37
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