Derivados de Quinazolina e Quinolina
As quinazolinas e quinolinas são compostos heterocíclicos contendo nitrogénio, com estruturas aromáticas que desempenham um papel fundamental na síntese de fármacos com atividade anticancerígena, antimicrobiana e anti-inflamatória. Os seus derivados apresentam modificações estruturais que otimizam a biodisponibilidade e a seletividade, permitindo o desenvolvimento de novos princípios ativos para diversas aplicações terapêuticas. Estes compostos são utilizados na fabricação de APIs para o tratamento do câncer, infeções, doenças neurodegenerativas e cardiovasculares. Além disso, os derivados de quinazolina e quinolina são essenciais na investigação de inibidores enzimáticos e no desenvolvimento de moléculas bioativas inovadoras.
Na CymitQuimica, oferecemos derivados de quinazolina e quinolina de alta pureza para aplicações em síntese química, desenvolvimento farmacêutico e biotecnologia.
Foram encontrados 65630 produtos de "Derivados de Quinazolina e Quinolina"
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Ombitasvir
CAS:Produto Controlado<p>Applications Ombitasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.<br>References Feld, J.J., et al.: New Eng. J. Med., 370, 1594 (2014); Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)<br></p>Fórmula:C50H67N7O8Cor e Forma:NeatPeso molecular:894.11Dechloro-Rivaroxaban
CAS:Produto Controlado<p>Applications Dechloro-Rivaroxaban is an impurity of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H19N3O5SCor e Forma:NeatPeso molecular:401.44Droperidol N-Oxide
CAS:Produto Controlado<p>Applications Droperidol N-Oxide is a derivative of Droperidol (D679500), a D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.<br>References Yelnosky, J., et al.: Toxicol. Appl. Pharmacol., 6, 37 (1964), Janicki, C.A., et al.: Anal. Profiles Drug Subs., 7, 171 (1978), Hamik, et al.: Cancer Chemother. Pharmacol., 24, 307 (1989), Heyer, E.J., et al.: Brain Res., 863, 20 (2000),<br></p>Fórmula:C22H22FN3O3Cor e Forma:White To Off-WhitePeso molecular:395.43Des(methoxycarbonyl) Febantel
CAS:Produto Controlado<p>Applications Febantel (F227000) impurity. Anthelmintic.<br>References Wollweber, H., et al.: Arzneim.-Forsch., 34, 531 (1984),<br></p>Fórmula:C18H20N4O4SCor e Forma:NeatPeso molecular:388.44Asenapine N-β-D-Glucuronide Trifluoroacetic Acid Salt (Mixture of Diastereomers)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Asenapine N-β-D-Glucuronide is a metabolite of Asenapine (A788000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C23H25ClNO7·C2F3O2Cor e Forma:NeatPeso molecular:575.92Levomepromazine EP Impurity D
Produto ControladoFórmula:C32H33N3O2S2Cor e Forma:NeatPeso molecular:555.8(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor.<br>References Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010); Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005); Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Fórmula:C10H10F3NO2·ClHCor e Forma:White To Off-WhitePeso molecular:269.65Maraviroc-d6
CAS:Produto Controlado<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>Fórmula:C29D6H35F2N5OCor e Forma:NeatPeso molecular:519.707-Hydroxy Granisetron Hydrochloride
CAS:Produto Controlado<p>Applications Granisetron (G780000) metabolite.<br>References Bloomer, J., et al.: Brit. J. Clin. Pharmacol., 38, 557 (1994), Vernekar, S.,e t al.: J. Med. Chem., 53, 2324 (2010),<br></p>Fórmula:C18H24N4O2·ClHCor e Forma:NeatPeso molecular:364.878-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
CAS:Produto Controlado<p>Impurity Loratadine EP Impurity B; Loratadine USP Related Compound C<br>Applications 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (Loratadine EP Impurity B; Loratadine USP Related Compound C) is a Loratadine intermediate. Loratidine impurity C.<br>References Cox, A., et al.: Drugs, 61, 723 (2001), Caponigro, F., et al.: Anti-Cancer Drugs, 13, 891 (2002), , Haluska, P., et al.: Eur. J. Cancer, 38, 1685 (2002),<br></p>Fórmula:C14H10ClNOCor e Forma:Light YellowPeso molecular:243.69Etomidate-D5
CAS:Produto Controlado<p>Applications A labelled isotope of Etomidate (E933300) which is used in neuroprotective products.<br>References Goetz, E., et al.: Anaesthesist, 23, 331 (1974), Chang, Z. L., et al.: Anal. Profiles Drug Subs., 12, 191 (1983),<br></p>Fórmula:C14D5H11N2O2Cor e Forma:NeatPeso molecular:249.322-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine, Hydrochloride
CAS:Produto ControladoFórmula:C9H9ClF3NO·ClHCor e Forma:NeatPeso molecular:276.08(S)-Lisinopril Dimer
CAS:Produto Controlado<p>Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)<br></p>Fórmula:C42H60N6O9Cor e Forma:WhitePeso molecular:792.96N-Nitrosoatrazine
CAS:Produto Controlado<p>Applications N-Nitrosoatrazine is an Atrazine (A794600) nitrosation product. Exposing human lymphocyte cultures to N-Nitrosoatrazine resulted in elevated levels of chromosome breakage.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Janzowski, C. et al.: ARC Sci. Pub., 31, 329 (1980); Meisner, L.F. et al.: Arch. Environ. Cont. Toxicol., 24, 108 (1993):<br></p>Fórmula:C8H13ClN6OCor e Forma:NeatPeso molecular:244.6810α-Hydroxy Naloxone
CAS:Produto Controlado<p>Impurity Naloxone EP Impurity C<br>Applications 10α-Hydroxy Naloxone is a hydroxylated analog of the opioid antagonist Naloxone (N285000(P)), which is a specific opioid antagonist; narcotic antagonist.<br>References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967), McNicholas, L.F., et al.: Drugs, 27, 81 (1984), Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985), Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)<br></p>Fórmula:C19H21NO5Cor e Forma:NeatPeso molecular:343.371-(3-Hydroxypropyl)theobromine
CAS:Produto ControladoFórmula:C10H14N4O3Cor e Forma:White To Off-WhitePeso molecular:238.243(3S,4S,3’S)-Ezetimibe
CAS:<p>Applications (3S,4S,3’S)-Ezetimbe is a 3-epimer impurity of Ezetimibe (E975000), a cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Fórmula:C24H21F2NO3Cor e Forma:Off-WhitePeso molecular:409.43Nimodipine-d7
CAS:Produto Controlado<p>Applications A labelled dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral).<br>References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),<br></p>Fórmula:C21H19D7N2O7Cor e Forma:NeatPeso molecular:425.481,3,5-trimethyl-1H-pyrazole-4-carbonyl chloride
CAS:Fórmula:C7H9ClN2OPureza:95.0%Cor e Forma:SolidPeso molecular:172.612-Hydroxymethyl Loratadine
CAS:Produto Controlado<p>Impurity Loratadine 2-Hydroxymethyl Impurity (USP)<br>Applications A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor. Loratadine 2-Hydroxymethyl Impurity (USP).<br>References Okamoto, T., et al.: Chem. Pharm. Bull ., 7, 130 (1959), Eyjolfsson, R., et al.: Pharmazie, 58, 154 (2003),<br></p>Fórmula:C23H25ClN2O3Cor e Forma:NeatPeso molecular:412.91N-Nitroso-Atomoxetine
Produto ControladoFórmula:C17H20N2O2Cor e Forma:Off WhitePeso molecular:284.353N-(2-Amino-4-thiazolyl)acetyl Mirabegron
CAS:Fórmula:C26H28N6O3S2Cor e Forma:NeatPeso molecular:536.669N-(3-pyridinylmethyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrobromide
CAS:Pureza:95.0%Peso molecular:319.24600219726562-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid
CAS:<p>Applications 2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]benzoic Acid is a research reagent with antispasmodic<br>References Bal-Tembe, S., et al.: Bioorg. Med. Chem., 5, 1381(1997);Punekar, N., et al.: Biotech. App. Biochem, 14, 378 (1991);<br></p>Fórmula:C21H23NO4Cor e Forma:NeatPeso molecular:353.41N-(R)-Glycidyl Phthalimide
CAS:Produto Controlado<p>Applications Reagent used for the simultaneous preparation of amino alcohol solvating agents as well as preparation of orally available anticoagulants.<br>References Roehrig, S. et al: J. Med. Chem., 48, 5900 (2005); Bozkurt, S. et al: Tetra: Asymm., 22, 541 (2011);<br></p>Fórmula:C11H9NO3Cor e Forma:NeatPeso molecular:203.19Nuarimol
CAS:<p>Applications Nuarimol is used in the preparation of difluoroethyl-containing heterocyclic compounds useful as antiviral agents and fungicides. Also used as a substance in the modelling inhibition of avian aromatase by azole pesticides.<br>References Fan, Z., et al.: Faming Zhuanli Shenqing (2016), CN 105503708 A 20160420; Saxena, A. K., et al.: SAR and QSAR in Environmental Research, 26, 757 (2015)<br></p>Fórmula:C17H12ClFN2OCor e Forma:White To Light YellowPeso molecular:314.74rac Rivastigmine-d6
CAS:Produto Controlado<p>Applications Labelled rac Rivastigmine. A brain selective acetylcholinesterase inhibitor. Nootropic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Fórmula:C14H16D6N2O2Cor e Forma:NeatPeso molecular:256.373-methyl-1-(4-methyl-2-quinolinyl)-1H-pyrazol-5-amine
CAS:Pureza:95.0%Peso molecular:238.29400634765625ent-Tadalafil
CAS:Produto Controlado<p>Impurity Tadalafil EP Impurity B<br>Applications Tadalafil (T004500) analog. Tadalafil Impurity (6S,12aS)<br>References Daugan, A., et al.: J. Med. Chem., 46, 4533 (2003), Jiang, W., et al.: Bioorg. Med. Chem., 12, 1505 (2004),<br></p>Fórmula:C22H19N3O4Cor e Forma:NeatPeso molecular:389.40N-[2-(Diphenylmethoxy)ethyl]-N,N',N'-trimethyl-ethylenediamine Dimaleate
CAS:Produto Controlado<p>Impurity Dimenhydrinate Impurity D<br>Stability Hygroscopic<br>Applications N-[2-(Diphenylmethoxy)ethyl]-N,N',N'-trimethyl-ethylenediamine Dimaleate is an impurity of Dimenhydrinate (D460520). Dimenhydrinate is an antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).<br>References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);<br></p>Fórmula:C28H36N2O9Cor e Forma:NeatPeso molecular:544.59ent-Rivaroxaban
CAS:<p>Applications ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H18ClN3O5SCor e Forma:White To Off-WhitePeso molecular:435.884,5-O-(1-Methylethylidene)-β-D-fructopyranose
CAS:Produto Controlado<p>Applications Intermediate in the preparation of 2,3-Desisopropylidene Topiramate, a metabolite of Topiramate<br></p>Fórmula:C9H16O6Cor e Forma:NeatPeso molecular:220.222-Amino-4-(3-bromophenyl)thiophene-3-carboxylic acid methyl ester
CAS:Fórmula:C12H10BrNO2SPureza:98%Cor e Forma:SolidPeso molecular:312.18Isoniazid
CAS:Produto Controlado<p>Applications Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).<br>References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)<br></p>Fórmula:C6H7N3OCor e Forma:NeatPeso molecular:137.142-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole
CAS:Fórmula:C19H20N4Cor e Forma:WhitePeso molecular:304.39Deacetyl Ketoconazole
CAS:Produto Controlado<p>Impurity Ketoconazole EP Impurity D<br>Applications Deacetyl Ketoconazole (Ketoconazole EP Impurity D) is a Ketoconazole derivative.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C24H26Cl2N4O3Cor e Forma:Off-WhitePeso molecular:489.394-Phenyl-2-(2-pyridyl)thiazole-5-carboxylic acid
CAS:Cor e Forma:SolidPeso molecular:282.32000732421875N-Octyl Nortadalafil
CAS:Produto Controlado<p>Applications Tadalafil (T004500) analog which is a phosphodiesterase 5 inhibitor.<br>References Jiru, M., et al.: J. Pharm. Biomed. Anal., 164, 713-724 (2019)<br></p>Fórmula:C29H33N3O4Cor e Forma:White To Off-WhitePeso molecular:487.596'-Methoxy-2'-acetonaphthone (Naproxen Impurity L)
CAS:Produto Controlado<p>Impurity Naproxen USP Related Compound L<br>Applications Naproxen impurity L. Naproxen USP Related Compound L<br>References Boynton, C., et al.: J. Clin. Pharmacol., 28, 512 (1988), Li, J., et al.: J. Med. Chem., 39, 1846 (1996), Monser, L., et al.: J. Pharm. Biomed. Anal., 27, 851 (2002),<br></p>Fórmula:C13H12O2Cor e Forma:BeigePeso molecular:200.233Anastrozole Monoamide
CAS:<p>Impurity Anastrozole Monoamide Impurity<br>Applications Anastrozole Monoamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C17H21N5OCor e Forma:WhitePeso molecular:311.382-((2R,3R)-3-(tert-butyl)-4(2,6-dimethoxyphenyl)-2,3dihydrobenzo[d][1,3]oxaphosphol-2-yl)pyridine
CAS:Pureza:97%Peso molecular:407.45001220703125Saquinavir-d9
CAS:Produto Controlado<p>Applications Labelled Saquinavir (S135000). A selective HIV protease inhibitor. Antiviral.<br>References Roberts, N.A., et al.: Science, 248, 358 (1990), Craig, J.C., et al.: Antiviral Res., 16, 295 (1991),<br></p>Fórmula:C38H41D9N6O5Cor e Forma:NeatPeso molecular:679.90
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