Esteroides e Derivados
Os esteroides são compostos orgânicos que possuem uma estrutura de quatro anéis fundidos, conhecida como núcleo esteroide. Esse núcleo pode estar ligado a vários grupos funcionais que modificam suas propriedades e funções biológicas. Os esteroides desempenham um papel fundamental na regulação dos processos metabólicos e hormonais. São utilizados na medicina para tratar distúrbios inflamatórios, doenças autoimunes e desequilíbrios hormonais. Além disso, alguns derivados de esteroides possuem potentes propriedades anti-inflamatórias, como os corticosteroides. Em terapias específicas, são utilizados para reduzir a inflamação e controlar a dor em diversas doenças.
Na CymitQuimica, oferecemos uma variedade de esteroides e seus derivados para pesquisa e desenvolvimento farmacêutico.
Foram encontrados 4967 produtos de "Esteroides e Derivados"
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Dexamethasone-d5
CAS:Produto Controlado<p>Applications A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>Fórmula:C222H5H24FO5Cor e Forma:NeatPeso molecular:397.49Desogestrel-13C2,d2 (Major)
CAS:Produto Controlado<p>Applications A labelled progestogen with low androgenic potency.<br>References Viinikka, L., et al.: Eur. J. Clin. Pharmacol., 15, 349 (1979), Bergink, E.W., et al.: J. Steroid Biochem., 14, 175 (1981)<br></p>Fórmula:C2013C2H28D2OCor e Forma:NeatPeso molecular:314.47Cholesterol
CAS:<p>Applications Cholesterol is a major component of all biological membranes; ~25% of total brain lipid is Cholesterol. Cholesterol is the principal sterol of the higher animals. Cholesterol was found in all body tissues, especial in the brain, spinal cord, and in animal fats or oils. Cholesterol is the main constituent of gallstones. This compound is a contaminant of emerging concern (CECs).<br>References Rosin, Z., et al.: Physiol. Chem., 124, 282 (1923), Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934), Gemant, et al.: Life Sci., 1, 233 (1962), Johnson, K., et al.: 4, 457 (1964),<br></p>Fórmula:C27H46OCor e Forma:WhitePeso molecular:386.6511-β,16-α,17-α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Fórmula:C21H28O6Cor e Forma:NeatPeso molecular:376.44trans-Diethyl Stilbestrol
CAS:Produto Controlado<p>Stability And Ether., Chloroform, Isomerizes Rapidly In Benzene<br>Applications A synthetic, nonsteroidal estrogen.Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References White, W. A. et. al.: J. Agric. Food Chem. 19(2), 388-390 (1971).<br></p>Fórmula:C18H20O2Cor e Forma:NeatPeso molecular:268.356-β-Hydroxy Eplerenone
CAS:<p>Applications A metabolite of Eplerenone, which is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.<br></p>Fórmula:C24H30O7Cor e Forma:White To Off-WhitePeso molecular:430.49Dydrogesterone
CAS:Produto Controlado<p>Applications A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998), Rupprecht, R., et al.: Steroids, 64, 83 (1999), Uzunova, V., et al.: Brain Res., 976, 1 (2003), Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006),<br></p>Fórmula:C21H28O2Cor e Forma:NeatPeso molecular:312.45Spironolactone
CAS:Produto Controlado<p>Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.<br>References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),<br></p>Fórmula:C24H32O4SCor e Forma:Off-WhitePeso molecular:416.572-Hydroxy Atorvastatin-d5 Sodium Salt
CAS:Produto Controlado<p>Applications A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007),<br></p>Fórmula:C332H5H28FN2O6·2NaCor e Forma:NeatPeso molecular:623.63N-[4-Nitro-3-(trifluoromethyl)phenyl]-propanamide
CAS:Produto Controlado<p>Applications N-[4-Nitro-3-(trifluoromethyl)phenyl]-propanamide is an impurity of flutamide (F598850). Flutamide is a nonsteroidal antiandrogen drug; antineoplastic (hormonal).<br>References Neri, et al.: Endocrinology, 91, 427 (1972), Sogani, P.C., et al.: J. Urol., 122, 640 (1979), Greenway, B.A., et al.: Br. Med. J., 316, 1935 (1998),<br></p>Fórmula:C10H9F3N2O3Cor e Forma:Light Yellow SolidPeso molecular:262.19Betamethasone 6α-Bromo 17-Valerate
Produto Controlado<p>Applications Betamethasone 6α-Bromo 17-Valerate is an impurity of Betamethasone (B327000), which is a glucocorticoid used as an anti-inflammatory agent.<br>References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),<br></p>Fórmula:C27H36BrFO6Cor e Forma:NeatPeso molecular:555.479,11-Anhydrobudesonide(Mixture of Diastereomers)
CAS:Produto Controlado<p>Impurity Budesonide EP Impurity H<br>Applications 9,11-Anhydrobudesonide (Budesonide EP Impurity H) is an impurity of Budesonide (B689460), a non-halogenated glucocorticoid intended for the local treatment of lung disease.<br>References Ryrfeldt, Å., et al.: Eur. J. Respir. Dis., 122, 86 (1981); Vestbo, J., et al.: Lancet, 353, 1819 (1999)<br></p>Fórmula:C25H32O5Cor e Forma:NeatPeso molecular:412.5217-β-Hydroxy Exemestane
CAS:Produto Controlado<p>Applications A metabolite of Exemestane; exerts biological effects as an androgen.<br>References Howell, A., et al.: Lancet, 365, 60 (2005), Goss, P., et al.: Clin. Cancer Res., 10, 5717 (2004), Buzdar, A., et al.: Lancet Oncol., 7, 633 (2006), Coates, A., et al.: J. Clin. Oncol., 25, 486 (2007), Jordan, V., et al.: Steroids, 72, 7 (2007),<br></p>Fórmula:C20H26O2Cor e Forma:White To Light YellowPeso molecular:298.42Prednisolone 17-Ethyl Carbonate
CAS:<p>Applications A metabolite of Prednicarbate (P703700).<br>References Kumar, R., et al.: Steroids, 64, 310 (1999), Kauppi, B., et al.: Biol. Chem., 278, 22748 (2003), Buchwald, P., et al.: J. Med. Chem., 49, 883 (2006),<br></p>Fórmula:C24H32O7Cor e Forma:White To Off-WhitePeso molecular:432.51N-Demethyl Mifepristone
CAS:<p>Applications A metabolite of Mifepristone (M343975).<br>References Ringler, I., et al.: Metabolism, 13, 37 (1964), Gagne, D., et al.: J. Steroid. Biochem., 25, 315 (1986), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Hild, S., et al.: Hum. Reprod., 15, 822 (2000), Gainer, E., et al.: Steroids, 68, 1005 (2003),<br></p>Fórmula:C28H33NO2Cor e Forma:NeatPeso molecular:415.57Halcinonide
CAS:Produto Controlado<p>Applications Anti-inflammatory (topical).<br>References Kirshbaum, J., et al.: Anal. Profiles Drug Subs., 8, 251 (1979),<br></p>Fórmula:C24H32ClFO5Cor e Forma:NeatPeso molecular:454.966-Keto Ethynyl Estradiol
CAS:Produto Controlado<p>Impurity Ethinylestradiol EP Impurity G<br>Applications An oxidative tranformation product of Norethindrone Acetate (N675990) and Ethynyl Estradiol (E685100).<br>References Ekhato, I.V. et al.: Steroids, 67, 165 (2002); Lane. P.A. et al.: J. Pharmac. Sci., 76, 44 (1987);<br></p>Fórmula:C20H22O3Cor e Forma:Light Yellow To Light BrownPeso molecular:310.3925-Hydroxy Vitamin D3 3-Sulfate Sodium Salt (90%)
CAS:Produto Controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 25-Hydroxyvitamin D3 3-Sulfate is a metabolite of 24,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 (C125700).<br>References Higashi, T. et al.: Steroids, 65, 281 (2000); Higashi, T. et al.: Ann. Clin. Biochem., 36, 43 (1999);<br></p>Fórmula:C27H43NaO5SPureza:90%Cor e Forma:NeatPeso molecular:502.68Testosterone-2,2,4,6,6-d5 (1 mg/ml in Acetonitrile)
CAS:Produto ControladoFórmula:C192H5H23O2Cor e Forma:ColourlessPeso molecular:293.464-Methoxy Estrone-13C,d3
CAS:Produto Controlado<p>Applications Labelled 4-Methoxyestrone (M226135). An endogenous estrogen metabolite, risk-factor for development of breast cancer.<br>References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),<br></p>Fórmula:CC182H3H21O3Cor e Forma:Off-White To Light YellowPeso molecular:304.40Androsterone
CAS:Produto Controlado<p>Applications A steroid hormone with weak androgenic activity. It is metabolized from Testosterone (T155000) in the liver and is used in doping analysis to detect testosterone misuse. Controlled Substance.This compound is a contaminant of emerging concern (CECs).<br>References Park, J., et al.: J. Anal. Toxicol., 14, 66 (1990), Palonek, E., et al.: J. Steroid Mol. Biol., 55, 121 (1995), Aguilera, R., et al.: Clin. Chem. 47, 292 (2001), Flenker, U., et al.: Steroids, 73, 408 (2008),<br></p>Fórmula:C19H30O2Cor e Forma:White To Off-WhitePeso molecular:290.446-Oxo Norethindrone Acetate
CAS:<p>Impurity Norethindrone Acetate EP Impurity G<br>Applications 6-Oxo Norethindrone Acetate (Norethindrone Acetate EP Impurity G) is an oxidative product of Norethindrone acetate (N675990).<br>References Schroff, A.P., et al.: Anal. Profiles Drug Subs., 4, 268 (1975); Singh, H., et al.: Am. J. Obstet. Gynecol., 135, 409 (1979)<br></p>Fórmula:C22H26O4Cor e Forma:NeatPeso molecular:354.44Fluocortolone
CAS:Produto Controlado<p>Applications Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.<br>References Breuer, et al.: Arzneim.-Forsch., 15, 50 (1965), Domenico, et al.: Arzneim.-Forsch., 15, 46 (1965), Gerhards, et al.: Acta Endocrinol., 68, 98 (1971),<br></p>Fórmula:C22H29FO4Cor e Forma:Off-White To YellowPeso molecular:376.46(20S)-Dexamethasone Epimeric Glycolic Acid
CAS:Fórmula:C22H29FO6Cor e Forma:NeatPeso molecular:408.46(15S)-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound B<br>Applications An impurity of commercially prepared Latanoprost (L177280). Latanoprost USP Related Compound B.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993),<br></p>Fórmula:C26H40O5Cor e Forma:ColourlessPeso molecular:432.59Dienogest
CAS:Produto Controlado<p>Applications Derivative of 19-Nortestosterone. In combination with estrogen as oral contraceptive. Progestogen.<br>References Hubner, M., et al.: Arzneim.-Forsch., 30, 401 (1980), Spona, J., et al.: Contraception, 56, 185 (1997), Foster, R.H., et al.: Drugs, 56, 825 (1998),<br></p>Fórmula:C20H25NO2Cor e Forma:NeatPeso molecular:311.42(R)-Ostarine
CAS:Produto Controlado<p>Applications The R-enantiomer of nonsteroidal selective androgen receptor modulator (SARM) Ostarine (O703500).<br></p>Fórmula:C19H14F3N3O3Cor e Forma:Light Orange Colour SolidPeso molecular:389.3325-Hydroxyvitamin D3 3-Hemisuccinate
CAS:Produto Controlado<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 25-Hydroxyvitamin D3 3-Hemisuccinate is a conjugate of 5-Hydroxyvitamin D3 (C125700), the principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator. Also used in the preparation and synthesis of antisera to be used in the immunoassay of 25-Hydroxyvitamin D3.<br>References Morii, et al.: Arch. Biochem. Biophys., 120, 513 (1967), Blunt, et al.: Biochemistry, 7, 3317 (1968), Liu, et al.: Science, 311, 1770 (2006),<br></p>Fórmula:C31H48O5Cor e Forma:NeatPeso molecular:500.71Betamethasone-∆17,20 21-Aldehyde(Mixture of Isomers)
CAS:Produto Controlado<p>Applications A degradation and metabolic intermediate of Betamethasone (B3270000).<br></p>Fórmula:C22H27FO4Cor e Forma:NeatPeso molecular:374.45Fulvestrant
CAS:Produto ControladoFórmula:C32H47F5O3SCor e Forma:White To Off-WhitePeso molecular:606.774-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenyl-benzenebutanamide
CAS:Produto Controlado<p>Impurity Atorvastatin Diketo Amide Impurity<br>Applications An Atorvastatin intermediate. Atorvastatin is a selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Winters, R., et al.: J. Med. Chem., 36, 1735 (1993), Hagmann, W., et al.: Bioorg. Med. Chem. Lett., 10, 1975 (2000), Istvan, E., et al.: Science, 292, 1160 (2001)<br></p>Fórmula:C26H24FNO3Cor e Forma:White To Off-WhitePeso molecular:417.474-Hydroxy Atorvastatin Hemicalcium Salt
CAS:<p>Applications 4-Hydroxyatorvastatin is a hydroxylated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.<br>References Smith, S. et al.: Am. J. Cardiol., 80, 10H (1997); Jacobsen, W. et al.: Drug Metab. Dispos., 28, 1369 (2000); Istvan, E. et al.: Science, 292, 1160 (2001); Tabernero, L. et al.: J. Biol. Chem., 278, 19933 (2003); Bratton, L. et al.: Bioorg. Med. Chem., 15, 5576 (2007);<br></p>Fórmula:C66H68CaF2N4O12Pureza:>90%Cor e Forma:NeatPeso molecular:1187.345,6-Dehydro-17b-dutasteride
CAS:Produto Controlado<p>Impurity Dutateride EP Impurity G<br>Applications 5,6-Dehydro-dutasteride (Dutateride EP Impurity G) is an impurity in the synthesis of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005),<br></p>Fórmula:C27H28F6N2O2Cor e Forma:NeatPeso molecular:526.51Testosterone-d3 β-D-Glucuronide Monosodium Salt
CAS:Produto Controlado<p>Applications Labelled Metabolite of Testosterone (T155000).<br>References Shibata, N., et al.: Biochem. J., 368, 783 (2002), Sonneveld, E., et al.: Toxicol. Sci., 83, 136 (2005), Schulze, J., et al.: J. Clin. Endocrinol. Metab., 93, 2500 (2008), Sten, T., et al.: Drug<br></p>Fórmula:C25H32D3NaO8Cor e Forma:Off-WhitePeso molecular:489.55trans-Latanoprost
CAS:<p>Impurity Latanoprost USP Related Compound A<br>Stability Temperature Sensitive<br>Applications Prostaglandin analog; prodrug of active acid metabolite. It is a synthetic derivative of the natural prostaglandin PGF2α, used as an anti-glaucoma agent that is effective in various types of glaucoma and ocular hypertension. Latanoprost USP Related Compound A.<br>References Resul, B., et al.: J. Med. Chem., 36, 2242 (1993), Toris, C., et al.: Ophthalmology, 100, 1297 (1993), Holmstrom, S., et al.: Curr. Med. Res. Op., 21, 1875 (2005),<br></p>Fórmula:C26H40O5Cor e Forma:ColourlessPeso molecular:432.595,6-trans Travoprost
CAS:<p>Applications An 5,6-trans isomeric impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600).<br></p>Fórmula:C26H35F3O6Cor e Forma:NeatPeso molecular:500.556-Oxo D-(-)-Norgestrel
CAS:Produto Controlado<p>Impurity Levonorgestrel EP Impurity J<br>Applications 6-Oxo D-(-)-Norgestrel (Levonorgestrel EP Impurity J) is an impurity of D-(-)-Norgestrel (N689510).<br></p>Fórmula:C21H26O3Cor e Forma:NeatPeso molecular:326.43Andarine
CAS:Produto Controlado<p>Applications It is a potent and tissue-selective androgen receptor modulator (SARM) used as antiosteoporotic agent.<br>References Samnegard, E., et al.: Bone, 28, 414 (2001), Hanada, K., et al.: Biol. Pharm. Bull., 26, 1563 (2003), Kearbey, J., et al.: Xenobiotica, 34, 273 (2004), Kearbey, J., et al.: Xenobiotica, 34, 273 (2004), Kearbey, J., et al.: Pharm. Res., 24, 328 (2007),<br></p>Fórmula:C19H18F3N3O6Cor e Forma:Light YellowPeso molecular:441.3621-Deoxy Cortisone
CAS:Produto Controlado<p>Applications A Cortisone derivative, a glucocorticoid.<br>References Mickelson, K., et al.: Biochemistry, 20, 6211 (1981), Westphal, U., et al.: J. Steroid Biochem., 19, 1 (1983),<br></p>Fórmula:C21H28O4Cor e Forma:NeatPeso molecular:344.44Calcipotriol Monohydrate
CAS:Produto Controlado<p>Applications Calcipotriol Monohydrate is a synthetic derivative of calcitriol, which is a biologically active form of Vitamin D3 (1). Calcipotriol Monohydrate can be used to treat psoriasis (2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Kim, D. H., et al.: Ann Dermatol. 24, 341 (2012) (2) Queille-Roussel, C., et al.: Clin Drug Investig (2016)<br></p>Fórmula:C27H40O3·H2OCor e Forma:NeatPeso molecular:430.627 α-Thiomethyl Spironolactone
CAS:Produto Controlado<p>Applications A metabolite of Spironolactone.<br>References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),<br></p>Fórmula:C23H32O3SCor e Forma:NeatPeso molecular:388.56δ-5(6)-Norethindrone Acetate
CAS:Produto Controlado<p>Impurity Norethindrone Acetate EP Impurity C<br>Applications Δ-5(6)-Norethindrone Acetate (Norethindrone Acetate EP Impurity C) is an impurity of Norethindrone Acetate (N675990).<br></p>Fórmula:C22H28O3Cor e Forma:NeatPeso molecular:340.46Dexamethasone 21-Mesylate
CAS:Produto Controlado<p>Stability Moisture Sensitive<br>Applications Dexamethasone 21-Mesylate is a derivative of Dexamethasone (D298800), a glucocorticoid used as an anti-inflammatory agent.<br>References Kim, T.H., et al.: J. Nanosci. Nanotech., 13, 7325 (2013); Joshi, T., et al.: Brit. J. Pharmacol., 172, 1360 (2015);<br></p>Fórmula:C23H31FO7SCor e Forma:NeatPeso molecular:470.55Testosterone Enol Diacetate
CAS:Produto Controlado<p>Applications Controlled substance.<br></p>Fórmula:C23H32O4Cor e Forma:NeatPeso molecular:372.5Mifepristone
CAS:Produto Controlado<p>Applications Mifepristone is a progesterone receptor antagonist with partial agonist activity. Abortifacient.<br>References Healy, D.L., et al.: J. Clin. Endocrinol. Metab., 57, 863 (1983), Rauch, M., et al.: Eur. J. Biochem., 148, 213 (1985), Baulieu, E.E., et al.: Science, 245, 1351 (1989), Brogden, R.N., et al.: Drugs, 45, 384 (1993)<br></p>Fórmula:C29H35NO2Cor e Forma:White To Light YellowPeso molecular:429.594-Hydroxy Ospemifene (Ospemifene Impurity)
CAS:<p>Applications 4-Hydroxy Ospemifene is an Ospemifene (O703000) impurity, used to treat dyspareunia. It is a selective estrogen receptor modulator (SERM) acting similarly to an estrogen.<br>References Rutanen, E., et al.: Menopause, 10, 433 (2003);<br></p>Fórmula:C24H23ClO3Cor e Forma:NeatPeso molecular:394.89Estrone 3-Sulfate Sodium Salt, Stabilized with TRIS
CAS:Fórmula:C18H21O5S·NaCor e Forma:NeatPeso molecular:372.41
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