Flavonoides e Polifenóis

<p>Applications Phenolphthalein can be used as an inhibitor and pH indicator. It also induces centrosome amplification and tubulin depolymerization in vitro.<br>References Matsumoto, Kaori., et al.: Eur. J. Drug Metab. Ph., (2014); Heard, Pamela L., et al.: Environ. Mol. Mutagen., 54(5), 308-316 (2013)<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications A metabolite of cis Resveratrol.<br>References Schroder, H., et al.: Clin. Nutr., 20, 429 (2001), Yu, C., et al.: Pharm. Res., 19, 1907 (2002), Rimando, A., et al.: J. Agric. Food Chem., 52, 4713 (2004), Walle, T., et al.: Drug Metab. Dispos., 32, 1377 (2004), Ito, H., et al.: Br. J. Nutr., 94, 500 (2005),<br></p>

<p>Applications A protected caffeine metabolite with high antioxidant activity. It is a very sensitive biomarker for the consumption of relatively small amount of coffee.<br>References Buchanan, C., et al.: J. Sci. Food Agric., 71, 459 (1996), Andreasen, M., et al.: J. Agric. Food Chem., 49, 5679 (2001), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008),<br></p>

<p>Applications Used as a broad range pesticide against insects, fungi, vegetation and bacteria. It has become a common environmental contaminant and probable human carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gulcan, H., et al.: Chem. Res. Toxicol., 21, 1503 (2008), Toropov, A., et al.: Bioorg. Med. Chem., 16, 5999 (2008), Franco, A., et al.: Envir. Toxicol. Chem., 28, 2018 (2009), Jensen, S., et al.: J. Agric. Food Chem., 57, 5872 (2009),<br></p>

<p>Applications A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.Curcumin is currently being examined as a possible therapeutic for the treatment of Alzheimers disease. Neuroprotective. Dyes and metabolites.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)<br></p>

<p>Applications 2-Phenyl-2-propanol is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.<br>References Kostjuk, S.V., et al.: Eur. Polym. J., 43, 968-979 (2007); Liu, X., et al.: J. Mol. Catal. A: Chem., 252, 176-180 (2006);<br></p>

<p>Applications Urolithin E is an intestinal microbial metabolite of ellagitannins.<br>References Garcia-Villalba, R., et al.: J. Agr. Food Chem., 61, 8797 (2013);<br></p>

<p>Applications 1-Methoxy-4-(1E)-1-propen-1-ylbenzene is a component of essential oils extracted from natural sources. It is also a possible inhibitor of protein kinase CK2α and CK2α’.<br>References Liang, Zhi-yuan, et al.: Shizhen Guoyi Guoyao, 25(7), 1602-1604 (2014);Benelli, Giovanni, et al.: Indus. Crops and Prod., 124, 236-243 (2018);Baier, Andrea, et al.: Phytochem., 136, 39-45 (2017)<br></p>

<p>Applications Thiochrome is a selective M4 muscarinic receptor enhancer of acetylcholine affinity.<br>References Mohsen, Z., et al.: Food and chemical toxicology, 49 (2011); Lazareno, S., et al.: Molecular pharmacology, 65 (2004);<br></p>