Flavonoides e Polifenóis

<p>Stability Light Sensitive<br>Applications One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.<br>References Ingolfsson, H., et al.: FEBS Lett., 585, 3101 (2011),<br></p>

<p>Stability Hygroscopic<br>Applications Dihydrogenistein is a derivative of Genistein (G350000), a compound that exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase.<br>References McLaughlin, J.M., et al.: Cancer. Prevent. Res., 5, 496 (2012); Magiera, S., et al.: J. Pharma. Biomed. Anal., 56, 93 (2011);<br></p>

<p>Applications Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger.<br>References Zlelinska-Przyyjemska, M., et al.: Phytother. Res., 20, 115 (2006); Milan, M., et al.L Anal. Chimica. Acta., 486, 125 (2003); Liu, Y.Z., et al.: Chin. Herb. Med., 4, 237 (2012);<br></p>

<p>Applications Isovitexin is known as a flavones, a class of flavonoids. Isovitexin have been studied for their antiradical activities in the process of metabolisms. Isovitexin have also been studied for beneficial effcts against atherosclerosis, osteoporosis and certain cancers.<br>References Cermak, R., et al.: Expert. Opin. Drug. Metab. Toxicol., 4, 17 (2008); Ma, X., et al.: J. Agri. Food. Chem., 60, 10844 (2012); Li, H., et al.: Food. Chem., 135, 2942, (2012);<br></p>

<p>Applications o-Isopropoxyphenol is used in the synthesis of α1-adrenoreceptor antagonist activity of tamsulosin analogues. Also used in the preparation of 5-HT1A receptor agonists.<br>References Sagratini, G. et al.: Eur. J. Med. Chem., 45, 5800 (2010); Franchini, S. et al.: Bioorg. Med. Chem. Lett., 2017 (2010);<br></p>

<p>Applications A lignan (phenylpropanoid) with significant estrogenic activity.<br>References Fokialakis, N. et al.: Planta Medica, 69, 566 (2003); Lei, B. et al.: Mol. Cell. Endocrinol., 193, 81 (2002);<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin M7 is an intestinal microbial metabolite of ellagitannins.<br>References Garcia-Villalba, R., et al.: J. Agr. Food Chem., 61, 8797 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Eugenol is a dental compound which shows cytotoxicity to human oral squamous cell carcinoma and oral cells. When glucosylated, this compound exhibits anti-inflammatory activity.<br>References Koh, T. et al.: In Vivo, 27, 85 (2013); Zhang, P. et al.: Arch. Pharm. Res., 36, 109 (2013);<br></p>

<p>Applications Thiochrome is a selective M4 muscarinic receptor enhancer of acetylcholine affinity.<br>References Mohsen, Z., et al.: Food and chemical toxicology, 49 (2011); Lazareno, S., et al.: Molecular pharmacology, 65 (2004);<br></p>

<p>Applications The aglucon of Naringin. Inhibitory mechanism of Naringenin against carcinogenic acrylamide formation and nonenzymic browning in Maillard model reactions.<br>References Lomovskaya, N., et al.: J. Bacteriol., 181, 305 (1999), Chung, L., et al.: J. Antibiot., 54, 250 (2001), Kim, D., et al.: Biochemistry, 43, 981 (2004), Kumar, S., et al.: J. Biol. Chem., 280, 19569 (2005),<br></p>

<p>Stability Light Sensitive<br>Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol<br>References Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987), O'Dell, T.J., et al.: Nature, 353, 588 (1991), Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1992), Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1992), Yoshida, H., et al.: Biochim. Biophys. Acta, 1137, 321 (1992), Uckun, F.M., et al.: Science, 267, 886 (1995), Merck Index 12th ed. 4395, Huang, R.Q.; Fang, M.J.; Dillon, G.H., Mol. Brain Res. 67: 177-183 (1999)<br></p>

<p>Applications BENZYL CINNAMATE (cas# 103-41-3) is a useful research chemical.<br></p>

<p>Applications Narcissoside is a flavonoid from Nitraria tangutorum. Narcissoside may have antiproliferative activity in human colon cancer cell line (HT29).<br>References Wu, Z., et. al.: Chem. Nat. Compnd., 49, 1125 (2014); Serra, A.T., et. al.: Food Res. Int., 54, 892 (2013)<br></p>