Nucleosídeos e Nucleotídeos
Os nucleosídeos são compostos formados por uma base nitrogenada ligada a um açúcar (ribose ou desoxirribose). Quando um grupo fosfato é adicionado ao nucleosídeo, forma-se um nucleotídeo. Esses compostos são essenciais na biologia celular, pois os nucleotídeos são os blocos fundamentais do DNA e RNA, responsáveis pelo armazenamento e transmissão da informação genética. Os nucleosídeos têm aplicações no tratamento de doenças virais, atuando como inibidores da replicação viral. Os nucleotídeos, além do seu papel estrutural nos ácidos nucleicos, participam de processos energéticos, como a síntese de ATP.
Na CymitQuimica, oferecemos uma ampla gama de nucleosídeos e nucleotídeos essenciais para pesquisa em biologia molecular, virologia e farmacologia.
Foram encontrados 3429 produtos de "Nucleosídeos e Nucleotídeos"
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Abacavir
CAS:Produto Controlado<p>Impurity Abacavir API<br>Applications Abacavir (Abacavir API) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>Fórmula:C14H18N6OCor e Forma:Off WhitePeso molecular:286.338-Hydroxyacyclovir
CAS:Produto Controlado<p>Applications Acyclovir (A192400) is the parent compound for 8-Hydroxyacyclovir. Acyclovir (ACV), an anti-virus drug, was widely detected in natural water at concns. . ranging from ng L-1 to μg L-1 due to inefficient biol. treatments in sewage treatment plant.<br>References Zhang, Q., et al.: Journal of Radioanalytical and Nuclear Chemistry, 320, 823 (2019);<br></p>Fórmula:C8H11N5O4Cor e Forma:NeatPeso molecular:241.2046-Hydroxytryptamine Creatinine Sulfate
CAS:Produto Controlado<p>Applications A tryptamine derivative, a neurotransmitter agonist.<br>References Dalton, T., et al.: Br. J. Pharmacol., 65, 579 (1979), Kang, S., et al.: Mol. Pharmacol., 16, 1031 (1979), Wallis, D., et al.: Eur. J. Pharmacol., 70, 381 (1981),<br></p>Fórmula:C10H12N2O·C4H9N3O2·H2O4SCor e Forma:White To Light BrownPeso molecular:405.43Emtricitabine Monophosphate Triethylammonium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of (-)-Emtricitabine (E525000).<br>References Paff, M. et al.; Antimicrob. Agents Ch. 38, 1230 (1994)<br></p>Fórmula:C8H11FN3O6PS·(C6H15N)Cor e Forma:White To Off-WhitePeso molecular:327.23 + x(101.19)6-Amino-9-methylpurine(9-Methyl Adenine)
CAS:Produto Controlado<p>Applications A receptor adenine derivative binding membrane brain animal cell line.<br>References Camaioni, E., et al.: Bioorg. Med. Chem., 6, 523 (1998), Kelly, M., et al.: Br. J. Pharmacol., 125, 979 (1998), Redzic, Z., et al.: Brain Res., 888, 66 (2001), Levy, D., et al.: J. Med. Chem., 46, 2177 (2003),<br></p>Fórmula:C6H7N5Cor e Forma:NeatPeso molecular:149.153,4,5,6-Tetrahydrouridine (>80%)
CAS:<p>Stability Light Sensitive<br>Applications 3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.<br>References Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Funamizu, N., PLoS One, 37424 (2012);<br></p>Fórmula:C9H16N2O6Pureza:>80%Cor e Forma:NeatPeso molecular:248.23N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine
CAS:Produto Controlado<p>Impurity Abacavir EP Impurity F<br>Applications N6-Cyclopropyl-9-[(1R,4S)-4-[(1,1-dimethylethoxy)methyl]-2-cyclopenten-1-yl]-9H-purine-2,6-diamine (Abacavir EP Impurity F) is an impurity of Abacavir (A104990), a guanosine analog that inhibits reverse transcriptase (NRTI) (1,2).<br>References (1) Hanumegowda, U., et al.: Chem. Res. Toxicol., 23, 749 (2010) (2) Prasse, C., et al.: Environ. Sci. Technol., 44, 1728 (2010)<br></p>Fórmula:C18H26N6OCor e Forma:OrangePeso molecular:342.4386Adenosine-3',5'-cyclic-13C5 Monophosphate
CAS:<p>Stability Hygroscopic<br>Applications Labelled Adenosine-3’,5’-cyclic Monophosphate (A280455). Adenosine-3’,5’-cyclic Monophosphate is an Adenosine (A280400) derivative useful as anticancer agent.<br>References Keast, R., et al.: Pharma. Res., 19, 1019 (2002),<br></p>Fórmula:C5C5H12N5O6PCor e Forma:NeatPeso molecular:334.1692Nicotinamide Riboside Triflate, α/β mixture
CAS:Produto Controlado<p>Stability Very Very Hygroscopic<br>Applications Nicotinamide (N407750) analog. Nicotinamide riboside (β-NAR) is an intermediate in one biosynthetic pathway by which Nicotamide is converted into NAD (Nicotinamide Adenine Dinucleotide)<br>References Friedlos, F., et al.: J. Biochem. Pharmacol., 44, 25 (1992), Ong, S., et al.: Biochemistry, 11210 (1992), Zhang, X., et al.: J. Biol. Chem., 278, 13503 (2003),<br></p>Fórmula:C12H15F3N2O8SCor e Forma:NeatPeso molecular:404.32Pterine-6-carboxylic Acid
CAS:Produto Controlado<p>Applications Pterine-6-carboxylic Acid is a degradation product of Folic acid (F680300).<br>References Akhtar, M., et al.: J. Pharm. Biomed. Anal., 19, 269 (1999), Andrisano, V., et al.: J. Pharm. Biomed. Anal., 32, 983 (2003), Patro, B., et al.: Bioorg. Med. Chem. Lett., 15, 67 (2005),<br></p>Fórmula:C7H5N5O3Cor e Forma:NeatPeso molecular:207.15Adenosine 5'-Diphosphate Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Adenosine 5'-diphosphate monosodium salt (cas# 20398-34-9) is a useful research chemical.<br></p>Fórmula:C10H15N5O10P2·x(Na)Cor e Forma:White To Off-WhitePeso molecular:427.20 + x(22.99)2’-Deoxy Cytidine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.<br>References Hecht, S., et al.: Chem. Res. Toxicol., 17, 588 (2004); Choi, J., et al.: J. Biol. Chem., 281, 38244 (2006); Lao, Y., et al.: Chem. Res. Toxicol., 20, 246 (2007);<br></p>Fórmula:C9H13N3O4Cor e Forma:NeatPeso molecular:227.22(1R,3R,4R)-Entecavir
CAS:Produto Controlado<p>Applications (1R,3R,4R)-Entecavir is an isomeric impurity of Entecavir (E558900).<br></p>Fórmula:C12H15N5O3Cor e Forma:NeatPeso molecular:277.285-Methyl-2’-deoxy Cytidine-d3
CAS:Produto Controlado<p>Applications A labelled Cytidine (C998300) analog and also an isostere of Thymidine (T412000).<br>References Sabini, E., et al.: J. Med. Chem., 51, 4219 (2008), Sabini, E., et al.: J. Mol. Biol., 378, 607 (2008),<br></p>Fórmula:C10H12D3N3O4Cor e Forma:White To Off-WhitePeso molecular:244.26Cytarabine
CAS:<p>Applications Cytarabine is used as an antineoplastic and antiviral. It is a selective inhibitor of DNA synthesis. Does not inhibit RNA synthesis.Cytarabine, or cytosine arabinoside, is a chemotherapy agent used mainly in the treatment of cancers of white blood cells such as acute myeloid leukemia (AML) and non-Hodgkin lymphoma. It is also known as Ara-C (Arabinofuranosyl Cytidine). It destroys cancer cells by interfering with DNA synthesis.<br>References Donehower, R.C., et al.: Cancer Treat. Rep., 70, 1059 (1986);<br></p>Fórmula:C9H13N3O5Cor e Forma:NeatPeso molecular:243.22Cytarabine-13C3 5’-Monophosphate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A labelled derivative of Cytarabine, a potent cytotoxic-antiviral nucleoside.<br>References Kufe, D., et al.: J. Biol. Chem., 255, 8997 (1980), Ross, D., et al.: Cancer Res., 50, 2658 (1990), Bhalla, K., et al.: Blood, 80, 2883 (1992), Tonetti, D., et al.: J. Biol. Chem., 269, 23230 (1994),<br></p>Fórmula:C6C3H14N3O8PCor e Forma:NeatPeso molecular:326.175-Fluoro Cytosine-13C,15N2
CAS:Produto ControladoFórmula:CC3H4F15N2NOCor e Forma:White To Light BrownPeso molecular:132.07Lamivudine (R)-Sulfoxide
CAS:Produto Controlado<p>Impurity Lamivudine EP Impurity H<br>Stability Hygroscopic<br>Applications Lamivudine (R)-Sulfoxide (Lamivudine EP Impurity H) is a metabolite of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has been used for treatment of chronic hepatitis B.<br>References Morris, D.M., J. Pharm. Biomed. Anal., 12, 255 (1944); Nevens, B.F., et al.: Gastroenterology, 113, 1258 (1997); Perry, C.M., et al.: Drugs, 53, 657 (1977)<br></p>Fórmula:C8H11N3O4SCor e Forma:NeatPeso molecular:245.26Ribavirin
CAS:Produto Controlado<p>Applications Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Fórmula:C8H12N4O5Cor e Forma:WhitePeso molecular:244.201-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxylic Acid Methyl Ester(Ribavirin Impurity H)
CAS:Produto ControladoFórmula:C9H13N3O7Cor e Forma:NeatPeso molecular:275.22N-Nitroso Abacavir
CAS:Produto ControladoFórmula:C14H17N7O2Cor e Forma:Light Yellow To YellowPeso molecular:315.339-Carboxymethoxymethylguanine
CAS:Produto Controlado<p>Applications 9-Carboxymethoxymethylguanine is a metabolite of Acyclovir (A192400) which is an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses.<br>References Gunness, P., et al.: Transl. Res., 158, 290 (2011); Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979), Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988), Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992),<br></p>Fórmula:C8H9N5O4Cor e Forma:Light Orange Colour SolidPeso molecular:239.192-Hydroxytetrahydrofuran
CAS:Produto Controlado<p>Applications 2-Hydroxytetrahydrofuran (cas# 5371-52-8) is a compound useful in organic synthesis.<br></p>Fórmula:C4H8O2Cor e Forma:NeatPeso molecular:88.11Cabotegravir
CAS:<p>Applications Cabotegravir is a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015);<br></p>Fórmula:C19H17F2N3O5Cor e Forma:Off-WhitePeso molecular:405.35Doxifluridine
CAS:Produto Controlado<p>Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B<br>Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.<br>References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)<br></p>Fórmula:C9H11FN2O5Cor e Forma:NeatPeso molecular:246.192-Hydroxy-2,3-tetrahydrofuranyl Entecavir (Mixture of Diastereomers)
Produto Controlado<p>Applications 2-Hydroxy-2,3-tetrahydrofuranyl Entecavir is an impurity of Entecavir (E558900).<br></p>Fórmula:C12H15N5O4Cor e Forma:NeatPeso molecular:293.283'-Chloro-3'-Deoxythymidine
CAS:Produto Controlado<p>Impurity Zidovudine EP Impurity B<br>Applications 3'-Chloro-3'-deoxythymidine (Zidovudine EP Impurity B) is an impurity of 3'-Azido-3'-deoxythymidine (A825000), a potent and selective inhibitor of HIV-1 replication and a potential antiviral agent.<br>References Navaneethan, G., et al.: J. Food. Drug Anal., 20, 446 (2012); Srivastav, N.C., et al.: Bioorg. Med. Chem., 18, 7542 (2010); Shakya, N., et al.: J. Med. Chem., 53, 4130 (2010); Fukushima, M., et al.: BIochem. Pharmacol., 59, 1227 (2000);<br></p>Fórmula:C10H13ClN2O4Cor e Forma:BeigePeso molecular:260.672'-Deoxyadenosine Monohydrate-13C5
CAS:Produto Controlado<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>Fórmula:C513C5H13N5O3•H2OCor e Forma:Off-WhitePeso molecular:274.22Cytidine 5'-Phosphoromorpholidate N,N'-Dicyclohexyl-4-morpholinecarboximidamide
CAS:Produto Controlado<p>Applications Intermediate in the preparation of Citicoline (C508050), a naturally occurring nucleotide.<br></p>Fórmula:C13H20N4O8P·C17H32N3OCor e Forma:NeatPeso molecular:685.752,6-Diaminopurine-2’-deoxyriboside
CAS:<p>Applications 2,6-Diaminopurine-2’-deoxyriboside is a nucleoside analogs synthesized to interfere with DNA metabolism. A derivative of 2,6-Diaminopurine (D416580), which can be used as analyte for biological and analytical studies of incorporation of unnatural nucleotides into mutant tRNA and proteins.<br>References Kaminski, P. A., et al.: J. Biol. Chem., 288, 6534-6541 (2013); Ptacin, J., et al.: PCT Int. Appl., WO 2016115168 A1 20160721 (2016);<br></p>Fórmula:C10H14N6O3Cor e Forma:NeatPeso molecular:266.26Azathioprine-d3
CAS:Produto Controlado<p>Applications Azathioprine-d3, is the labeled analogue of Azathioprine (A803350), an immunosuppressive antimetabolite, also active as disease modifying antirheumatic drug (DMARD).<br>References Mitrou, P.S., et al.: Arzneim.-Forsch., 29, 483, 662 (1979), Ding, T.L., et al.: Drug. Metab. Dispos., 7, 373 (1979), Chan, G.L.C., et al.: Pharmacotherapy, 7, 165 (1987), Sandborn, W.J., et al.: : Scand. J. Gastroenterol., 33, Suppl. 225, 92 (1998,)<br></p>Fórmula:C9H4D3N7O2SCor e Forma:NeatPeso molecular:280.28Gemcitabine Diphosphate Triethylamine Salt (>90%)
CAS:Produto Controlado<p>Applications Gemcitabine Diphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.<br>References Baker, C., et al.: J. Med. Chem., 34, 1879 (1991), Huang, P., et al.: Cancer Res., 51, 6110 (1991), Plunkett, W., et al.: Nucleosides Nucleotides, 16, 1261 (1997),<br></p>Fórmula:C27H58F2N6O10P2Pureza:>90%Cor e Forma:White To Off-WhitePeso molecular:726.735-Azacytidine
CAS:<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>Fórmula:C8H12N4O5Cor e Forma:Off-WhitePeso molecular:244.20N-Nitroso-N-(phosphonomethyl)glycine
CAS:<p>Applications N-Nitroso-N-(phosphonomethyl)glycine is used as herbicide.<br>References Khan, S.U., et al.: J. Agr. Food Chem., 27, 1398 (1979), Ambrus, A., et al.: Pure Appl. Chem., 75, 937 (2003),<br></p>Fórmula:C3H7N2O6PCor e Forma:Off White SolidPeso molecular:198.07Etravirine-d8
CAS:Produto Controlado<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>Fórmula:C202H6H9BrN6OCor e Forma:NeatPeso molecular:441.316-Thioinosine Phosphate (>85%)
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of 6-Mercaptopurine.<br>References Parker, W., et al.: Cancer Res., 51, 2386 (1991) , Munagala, N., et al.: J. Biol. Chem., 275, 37072 (2000), Guddat, L., et al.: Protein Sci., 11, 1626 (2002), Pinkel, D., et al.: J. Clin. Oncol., 11, 1826 (1993), Tripathy, D., et al.: Oncologist, 12, 375 (2007),<br></p>Fórmula:C10H13N4O7PSPureza:>85%Cor e Forma:NeatPeso molecular:364.271-C-[4-Chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol
CAS:Produto Controlado<p>Applications Open ring Dapagliflozin. Dapagliflozin (D185370) impurity.<br></p>Fórmula:C21H27ClO7Cor e Forma:NeatPeso molecular:426.8883-Methyl Cytidine Methosulfate
CAS:Produto Controlado<p>Applications Cytidine derivative.<br>References Ueda, T., et al.: Chem. Pharmaceut. Bull., 22, 2377 (1974),<br></p>Fórmula:C10H16N3O5·CH3O4SCor e Forma:NeatPeso molecular:369.35Stavudine
CAS:Produto Controlado<p>Impurity Zidovudine EP Impurity A<br>Applications Stavudine (Zidovudine EP Impurity A) is used as an antiviral. A reverse transcriptase inhibitor.<br>References Mansuri, M.M., et al.: Antimicrob. Ag. Chemother., 34, 637 (1990), Cretton, E.M., et al.: Antimicrob. Ag. Chemother., 37, 1816 (1993), Browne, M.J., et al.: J. Infec. Dis., 167, 21 (1993)<br></p>Fórmula:C10H12N2O4Cor e Forma:WhitePeso molecular:224.21Melamine-13C3,15N3
CAS:Produto Controlado<p>Applications Isotope labelled Melamine (M208703), which forms synthetic resins with formaldehyde. It remains largely non-metabolized in male Wistar rats with 90% of the administered dose excreted in the urine (1,2) and thus acts as a non-protein nitrogen food additive found in milk (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Mast, R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10.2. Smith, J. et al.: Toxicol Appl Pharmacol. 1994 Apr;125(2):296-308.3. Anirudhan, T. et al.: Food Chem. 2017 Jul 15;227:85-92.<br></p>Fórmula:C3H6N315N3Cor e Forma:NeatPeso molecular:132.082’,2’-Difluoro-2’-deoxyuridine-13C,15N2
CAS:Fórmula:C813CH10F215N2O5Cor e Forma:White To Off-WhitePeso molecular:267.16Lamivudine Monophosphate Triethylammonium Salt
CAS:Produto Controlado<p>Applications A metabolite of Lamivudine (L172500).<br>References Soudeyns, H., et al.: Antimicrob. Agents Chemother., 35, 1386 (1991), Denapoli, L., et al.: Nucleosides Nucleotides, 12, 21 (1993),<br></p>Fórmula:C8H12N3O6PSC6H15NPureza:>90%Cor e Forma:NeatPeso molecular:410.138891’-Epi Gemcitabine Hydrochloride
CAS:<p>Impurity Gemcitabine EP Impurity B<br>Applications 1’-Epi Gemcitabine Hydrochloride (Gemcitabine EP Impurity B) is an α-Anomer of Gemcitabine.<br>References Hertel, L.W., et al.: Cancer Res., 50, 4417 (1990), Abbruzzese, J.L., et al.: J. Clin. Oncol., 9, 491 (1991), Ruiz, V.W.T., et al.: Biochem. Pharmacol., 46, 762 (1993),<br></p>Fórmula:C9H12ClF2N3O4Cor e Forma:Off White SolidPeso molecular:299.669-Carboxymethoxymethylguanine-13C2,15N
CAS:<p>Stability Hygroscopic<br>Applications 9-Carboxymethoxymethylguanine-13C2,15N is the labelled analog of 9-Carboxymethoxymethylguanine (C179990) which is a metabolite of Acyclovir (A192400-an antiviral, orally active acyclic nucleoside with inhibitory activity towards several herpes viruses).<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992); Gunness, P., et al.: Transl. Res., 158, 290 (2011);<br></p>Fórmula:C2C6H915NN4O4Cor e Forma:Light Beige SolidPeso molecular:242.167Floxuridine
CAS:Produto Controlado<p>Applications Floxuridine is an antiviral; antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harris, M., et al.: Biophys. J., 4, 203 (1964),<br></p>Fórmula:C9H11FN2O5Cor e Forma:NeatPeso molecular:246.19Dapagliflozin Keto Impurity
CAS:<p>Applications Dapagliflozin Keto Impurity is an impurity of Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.<br>References Kasichayanula, S., et al.: Diabetes, Obesity and Metabolism 13, 47 (2011);<br></p>Fórmula:C21H23ClO7Cor e Forma:Off-WhitePeso molecular:422.865-Azacytidine 2’,3’5’-O-triacetate
CAS:<p>Applications 5-Azacytidine 2’,3’5’-O-triacetate is a useful compound for the treatment and prevention of cancer and disorders related to abnormal cell proliferation, hematological disorders, and myelodysplastic syndromes (MDS). It can be also used to synthesize 2'3'5'triacetyl-5-azacytidine which is a prodrug for azacitidine. Azacitidine is a FDA-appproved DNA metnyltransferase (DNMT) inhibitor.<br>References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)<br></p>Fórmula:C14H18N4O8Cor e Forma:White To Off-WhitePeso molecular:370.313'-Azido-3'-deoxythymidine 5’-Monophosphate Sodium Salt
CAS:Produto Controlado<p>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br>References Brehm, J., et al.: Biochem., 47, 14020 (2008), von Kleist, M., et al.: Eur. J. Pharm. Sci., 36, 532 (2009),<br></p>Fórmula:C10H13N5O7P·NaCor e Forma:NeatPeso molecular:369.20Clofarabine
CAS:<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>Fórmula:C10H11ClFN5O3Cor e Forma:White To Off-WhitePeso molecular:303.68
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