Nucleosídeos e Nucleotídeos
Os nucleosídeos são compostos formados por uma base nitrogenada ligada a um açúcar (ribose ou desoxirribose). Quando um grupo fosfato é adicionado ao nucleosídeo, forma-se um nucleotídeo. Esses compostos são essenciais na biologia celular, pois os nucleotídeos são os blocos fundamentais do DNA e RNA, responsáveis pelo armazenamento e transmissão da informação genética. Os nucleosídeos têm aplicações no tratamento de doenças virais, atuando como inibidores da replicação viral. Os nucleotídeos, além do seu papel estrutural nos ácidos nucleicos, participam de processos energéticos, como a síntese de ATP.
Na CymitQuimica, oferecemos uma ampla gama de nucleosídeos e nucleotídeos essenciais para pesquisa em biologia molecular, virologia e farmacologia.
Foram encontrados 3428 produtos de "Nucleosídeos e Nucleotídeos"
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O6-Benzylguanine
CAS:Produto Controlado<p>Applications An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.<br>References Dolan, M.E., et al.: Proc. Natl. Acad. Sci. USA, 87, 5356 (1990), Goodtzova, K., et al.: Biochemistry, 33, 385 (1994), Elder, R.H., et al.: Biochem. J., 298, 231 (1994)<br></p>Fórmula:C12H11N5OCor e Forma:NeatPeso molecular:241.25α-Ribavirin (Ribavirin Impurity B)
CAS:Produto ControladoFórmula:C8H12N4O5Cor e Forma:NeatPeso molecular:244.205'-Deoxy-5'-(methylthio)adenosine
CAS:<p>Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).<br>References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),<br></p>Fórmula:C11H15N5O3SCor e Forma:White To Off-WhitePeso molecular:297.333'-Azido-3'-deoxythymidine β-D-glucuronide, Sodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications A metabolite of the potent and selective inhibitor of HIV-1 replication, AZT.<br></p>Fórmula:C16H20N5O10·NaCor e Forma:White To Light YellowPeso molecular:465.35Cabotegravir O-β-D-Glucuronide
CAS:Produto Controlado<p>Applications Cabotegravir O-β-D-Glucuronide is a metabolite of Cabotegravir (C050100), a long acting HIV-1 integrase inhibitor with action against a broad range of HIV subtypes.<br>References Yoshinaga, T. et al.: Antimicrob, Agents Chemother., 59, 397 (2015); Andrews, C. et al.: Sci. Transl. Med., 7, 270 (2015)<br></p>Fórmula:C25H25F2N3O11Pureza:>80%Cor e Forma:NeatPeso molecular:581.48Acyclovir Formacetal Dimer (>90%)
<p>Impurity Aciclovir EP Impurity R<br>Applications Acyclovir Formacetal Dimer is a dimer impurity of Acyclovir (A192400); an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also antiviral. (Aciclovir EP Impurity R)<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>Fórmula:C17H22N10O6Pureza:>90%Cor e Forma:NeatPeso molecular:462.422’-Deoxyadenosine
CAS:<p>Applications 2prime-Deoxyadenosine is a nucleoside adenosine derivative with mutagenic properties.<br></p>Fórmula:C10H13N5O3Cor e Forma:White To Off-WhitePeso molecular:251.242N-Nitrosodiethylamine (100 ug/mL in Methanol)
CAS:Produto ControladoFórmula:C4H10N2OCor e Forma:Single SolutionPeso molecular:102.14Famciclovir
CAS:Produto Controlado<p>Applications Used as an antiviral. Prodrug of Penciclovir (P221500).<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989),<br></p>Fórmula:C14H19N5O4Cor e Forma:Off-WhitePeso molecular:321.33Ribavirin-13C5
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Labelled Ribavirin (R414475). Purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>Fórmula:C5C3H12N4O5Cor e Forma:NeatPeso molecular:249.17Flavine Adenine Dinucleotide Disodium Salt
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase.<br>References DeLuca, K., et al.: J. Biol. Chem., 223, 569 (1956), Yagi, K., et al.: Biochemistry, 19, 1553 (1980), Li, G., et al.: J. Phys. Chem., 112, 4573 (2008),<br></p>Fórmula:C27H31N9O15P2·2NaCor e Forma:NeatPeso molecular:829.516,6'-Thiobis-9H-purine
CAS:Produto Controlado<p>Applications 6,6'-Thiobis-9H-purine is used in the study of the activity of topoisomerase IIα.<br>References Jensen, L.H., et al.: Molecular Pharmacology, 70, 1503 (2006);<br></p>Fórmula:C10H6N8SCor e Forma:NeatPeso molecular:270.27Adenosine-1'-13C
CAS:Produto ControladoFórmula:CC9H13N5O4Cor e Forma:White To Off-WhitePeso molecular:268.234Adenosine 5'-Triphosphate Disodium Salt
CAS:<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A metabolite of Adenosine (A280400), a multifunctional nucleoside triphosphate used in cells as a coenzyme of intracellular energy transfer. It transports chemical energy within cells for metabolism.<br>References Knowles, J., et al.: Annu. Rev. Biochem., 49, 877 (1980),<br></p>Fórmula:C10H14N5O13P3·2NaCor e Forma:NeatPeso molecular:569.162’-Deoxy Cytidine-5,6-d2
CAS:Produto ControladoFórmula:C9D2H11N3O4Cor e Forma:NeatPeso molecular:229.23Hypoxanthine
CAS:Produto Controlado<p>Applications A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),<br></p>Fórmula:C5H4N4OCor e Forma:NeatPeso molecular:136.11Ademethionine 1,4-Butanedisulfonate
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Ademethionine 1,4-Butanedisulfonate is used in the synthesis of sulfonio-adenosyl-L-methionine (SAMe) salts.<br></p>Fórmula:C15H22N6O5S·3C4H10O6S2Cor e Forma:NeatPeso molecular:1451.62epi-Canagliflozin
CAS:Produto Controlado<p>Applications epi-Canagliflozin is an epimeric impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity.<br>References Chao, E. et al.: Drug Fut., 36, 351 (2011); Sha, S. et al.: Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S.: Clin. Invest., 1, 145 (2011);<br></p>Fórmula:C24H25FO5SCor e Forma:NeatPeso molecular:444.52(1R,2R,5R)-2-Isopropyl-5-methylcyclohexanol
CAS:<p>Applications (1R,2R,5R)-2-Isopropyl-5-methylcyclohexanol is used in the tetrahydropyranylation of alcohols.<br>References Magyar, A. et al.: Catal. Lett., 145, 1876 (2015);<br></p>Fórmula:C10H20OCor e Forma:NeatPeso molecular:156.27Creatinine-d3
CAS:Produto Controlado<p>Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.<br>References Folin, et al.: J. Biol. Chem., 17, 463 (1914),<br></p>Fórmula:C42H3H4N3OCor e Forma:Off-WhitePeso molecular:116.14Adenosine-3'-monophosphate
CAS:Produto Controlado<p>Applications Adenosine-3'-monophosphate (cas# 84-21-9) is a useful research chemical.<br></p>Fórmula:C10H14N5O7PCor e Forma:NeatPeso molecular:347.22125-(Hydroxymethyl)-2’-deoxycytidine
CAS:Produto Controlado<p>Applications 4-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in duplex DNA. 4-(Hydroxymethyl)-2’-deoxycytidine can be analyzed to quantify DNA hydroxymethylation levels in biological samples<br>References Peng, X. et al.: J. Am. Chem. Soc., 130, 10299 (2008); Berkner, K. et al.: J. Biol. Chem., 252, 3185 (1977); Le, T. et al.: Anal. Biochem., 412, 203 (2011);<br></p>Fórmula:C10H15N3O5Cor e Forma:NeatPeso molecular:257.241’-epi-Entecavir
CAS:Produto Controlado<p>Impurity Entecavir EP Impurity A<br>Applications An epimeric impurity of the antiviral drug Entecavir (E558900).<br></p>Fórmula:C12H15N5O3Cor e Forma:NeatPeso molecular:277.279D-Ribose
CAS:Produto Controlado<p>Applications D-Ribose is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.<br>References Ostrowski, S., et al.: Science, 305, 71 (2004), Vavilin, D., et al.: Biochim. Biophys. Acta, 1708, 91 (2005), Fletcher, J., et al.: Anal. Chem., 79, 2199 (2007), Weissleder, R., et al.: Nature, 452, 580 (2008),<br></p>Fórmula:C5H10O5Cor e Forma:NeatPeso molecular:150.132-Phenylamino Adenosine
CAS:Produto Controlado<p>Applications A selective A2-adenosine receptor agonist. Coronary vasodilator, antihypertensive and antipsychotic following systemic administration in vivo.<br>References Martin, et al.: Pharmacol. Biochem. Behav., 45, 951 (1993<br></p>Fórmula:C16H18N6O4Cor e Forma:NeatPeso molecular:358.35Adenosine 2’,3’-Cyclic Phosphate Triethylammonium Salt
CAS:<p>Applications A 2',3'-cyclic nucleotide phosphodiester.<br>References Voegtli, W., et al.: Biochemistry, 39, 15365 (2000), Bernstein, N., et al.: Mol. Cell, 17, 657 (2005), Blondal, T., et al.: J. Biol. Chem., 280, 5188 (2005), Shenoy, A., et al.: J. Mol. Biol., 365, 211 (2007),<br></p>Fórmula:C16H27N6O6PCor e Forma:NeatPeso molecular:430.48-Cyclopentyl-1,3-dipropylxanthine
CAS:Produto Controlado<p>Applications DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist.<br>References Gessi, S., et al.: Mol. Pharmacol., 67, 2137 (2005), Minor, T.R., et al.: Behav. Neurosci., 122, 1236 (2008), Gracia, E., et al.: J. Neurochem., 107, 161 (2008), Gessi, S., et al.: Biochem. Pharmacol., 75, 562 (2008),<br></p>Fórmula:C16H24N4O2Cor e Forma:NeatPeso molecular:304.391-Chloro-2-[(4-ethoxyphenyl)methyl]benzene
CAS:Produto ControladoFórmula:C15H15ClOCor e Forma:NeatPeso molecular:246.732Adenosine Monophosphate (mixture of 2'(3')-phosphate isomers)-13C5 Sodium Salt
CAS:Produto Controlado<p>Applications Labelled AMP mixture<br>References Jackson, E.K. et al.: Hypertension, 56, 151 (2010); Jackson, E.K. et al: J. Bio. Chem., 284, 33097 (2009);<br></p>Fórmula:C513C5H14N5O7P•x(Na)Cor e Forma:NeatPeso molecular:352.182299Lamivudine-15N2,13C
CAS:Produto ControladoFórmula:CC7H1115N2NO3SCor e Forma:White To BeigePeso molecular:232.241'-Epi 2',2'-Difluoro-2'-deoxyuridine
CAS:<p>Applications The epimer of the degradation product of Gemcitabine (G305000), a new antitumor agent.<br>References Anliker, S.L., et al.: J. Pharmaceut. Sci., 83, 716 (1994),<br></p>Fórmula:C9H10F2N2O5Cor e Forma:Light Yellow SolidPeso molecular:264.18Nicotinic Acid Riboside
CAS:Produto Controlado<p>Applications An effective agent for increasing nicotinamide adenine dinucleotide (NAD) concentrations in mammalian cells.<br>References Yang, T. et al.: J. Med. Chem., 50, 6458 (2007);<br></p>Fórmula:C11H13NO6Cor e Forma:NeatPeso molecular:255.225-Methoxyuracil
CAS:Produto Controlado<p>Impurity Fluorouracil EP Impurity D<br>Applications 5-Methoxyuracil (Fluorouracil EP Impurity D) is methoxylated uracil, a component of nucleid acid. 5-Methoxyuracil is used in the preparation of nucleosides.<br>References Vorbrueggen, H. et al.: Chem. Ber., 114, 1279 (1981); Novacek, A. et al.: Coll. Czech. Chem. Comm., 32, 1045 (1967);<br></p>Fórmula:C5H6N2O3Cor e Forma:NeatPeso molecular:142.11Eritadenine
CAS:Produto Controlado<p>Applications Hypocholesterolemic isolated from shiitake mushrooms, effecting phospholipid and linoleic acid metabolisms. Specifically, Eritadenine is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), decreasing total cholesterol levels in plasma.<br>References Fukada, S., et al.: J. Nut., 136, 2797 (2006), Vilar, S., et al.: J. Med. Chem., 49, 1118 (2006), Yamada, T., et al.: Biochem. Pharmacol., 73, 981 (2007), Enman, J., et al.; J. Agric. Food Chem., 56, 2609 (2008),<br></p>Fórmula:C9H11N5O4Cor e Forma:Off White SolidPeso molecular:253.21Acyclovir Acetate
CAS:<p>Impurity Valaciclovir EP Impurity I/ Aciclovir USP Related Compound A<br>Applications Acyclovir Acetate (Valaciclovir EP Impurity I) is an Acyclovir (A192400) impurity, Aciclovir EP Impurity A<br>References Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999); Chang, J., et al.: Pharm. Res., 17, 670 (2000),<br></p>Fórmula:C10H13N5O4Cor e Forma:NeatPeso molecular:267.24(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
CAS:Produto ControladoFórmula:C15H12BrClO2Cor e Forma:NeatPeso molecular:339.6122-Amino-6-chloropurine
CAS:<p>Impurity Famciclovir USP Related Compound F<br>Applications Famciclovir USP Related Compound F<br></p>Fórmula:C5H4ClN5Cor e Forma:YellowPeso molecular:169.57(S)-N-[4-[[((S)-2-Amino-6,7,8,9-tetrahydro-8-methyl-4,9-dioxo-4H-pyrazino[1,2-a]-1,3,5-triazin-7-yl)
<p>Applications An impurity of Levomefolate (L375720), the natural form of folic acid.<br>References Verlinde, P.H.C.., et al.: J. Agr. Food. Chem., 57, 6803 (2009); Whiteley, J.M., et al.: Biochem. Biophy. Res. Comm., 101, 1259 (1981);<br></p>Fórmula:C20H23N7O7Cor e Forma:NeatPeso molecular:473.44Dapagliflozin-d5
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Dapagliflozin-D5 is a labelled analogue of Dapagliflozin (D185370), a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes.<br>References List, J., et al.: Diabetes Care, 32, 650 (2009); Meng, W., et al.: J. Med. Chem., 51, 1145 (2008); Wilding, J., et al.: Diabetes Care, 32, 1656 (2009)<br></p>Fórmula:C21H20D5ClO6Cor e Forma:White To Off-WhitePeso molecular:413.9Gemcitabine Monophosphate
CAS:<p>Applications Gemcitabine Monophosphate is a gemcitabine derivative. It is an antineoplastic agent.<br>References Balzarini, J., et al.: Biochem. Pharmacol., 37, 897 (1988), Abbruzzese, J., et al.: Investig. New Drugs, 7, 195 (1989), Balzarini, J., et al.: J. Biol. Chem., 264, 6127 (1989), Chu, C., et al.: Antimicrob. Agents Chemother., 39, 979 (1995)<br></p>Fórmula:C9H12F2N3O7PCor e Forma:White To Off-WhitePeso molecular:343.18Dihydroxy Melphatalan
CAS:Produto Controlado<p>Applications Dihydroxy Melphatalan is an analogue of Melphalan (M216900), an antineoplastic.<br>References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980);<br></p>Fórmula:C13H20N2O4Cor e Forma:NeatPeso molecular:268.31T-705 Ribofuranose
CAS:<p>Applications T-705 Ribofuranose is a reagent used for the preparation of pyrazine-ribofuranose derivatives as antiviral agents that are useful in the treatment of viral infections.<br>References Zhong, B., et al.: Faming Zhuanli Shenqing, 2014:924257 (2014)<br></p>Fórmula:C10H12FN3O6Cor e Forma:NeatPeso molecular:289.226-Mercaptopurine Disulfide
CAS:Produto Controlado<p>Applications 6-Mercaptopurine Disulfide is an impurity of 6-Mercaptopurine (M225450, monohydrate) which is an immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.<br>References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004)<br></p>Fórmula:C10H6N8S2Cor e Forma:Yellow To Dark YellowPeso molecular:302.343'-[3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxy-thymidine
CAS:Produto Controlado<p>Impurity Zidovudine USP Related Compound G<br>Stability Light Sensitive<br>Applications 3'-[3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxy-thymidine (Zidovudine USP Related Compound G) is used in the biological studies and in the preparation of N-3-substituted thymidine nucleosides as virucides as it has anti-HIV activity.<br>References Adams, D.R., et al.: J. Med. Chem., 40, 1550 (1997), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),<br></p>Fórmula:C20H25N7O8Cor e Forma:NeatPeso molecular:491.45N-Acetyl Glyphosate
CAS:<p>Stability Very Hygroscopic<br>Applications A metabolite of the pesticide Glyphosphate (G765000).<br>References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);<br></p>Fórmula:C5H10NO6PCor e Forma:White To Off-WhitePeso molecular:211.11Adenosine-2’,3’-cyclic Monophosphate Sodium Salt
CAS:Produto ControladoFórmula:C10H11N5O6P·NaCor e Forma:NeatPeso molecular:351.188Gemcitabine Triphosphate Ditriethylamine
CAS:Produto Controlado<p>Stability Hygroscopic, Temperature Sensitive<br>Applications Gemcitabine Triphosphate is a phosphorylated metabolite of Gemcitabine (G305000), an antineoplastic agent.<br>References Kennedy., E.P., et al.: J. Biol. Chem., 222, 193 (1956),<br></p>Fórmula:C21H44F2N5O13P3Cor e Forma:NeatPeso molecular:705.52
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![(S)-N-[4-[[((S)-2-Amino-6,7,8,9-tetrahydro-8-methyl-4,9-dioxo-4H-pyrazino[1,2-a]-1,3,5-triazin-7-y…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTR%2Fthumb-webp%2FA629750.webp&w=3840&q=75)
