Sais e Derivados de API
Os sais dos Ingredientes Farmacêuticos Ativos (API) são compostos formados pela reação de um ácido com uma base, resultando em um equilíbrio iônico. Esses sais frequentemente melhoram a solubilidade e a estabilidade dos APIs, facilitando sua absorção no organismo. Os derivados de API são variantes químicas de um princípio ativo que podem apresentar propriedades aprimoradas ou modificadas para otimizar a eficácia terapêutica. Os sais de APIs são utilizados na formulação de medicamentos orais, injetáveis e tópicos. Além disso, os derivados de API podem melhorar a farmacocinética dos fármacos, permitindo, por exemplo, a liberação controlada de substâncias ativas.
Na CymitQuimica, oferecemos sais e derivados de APIs com a pureza e qualidade necessárias para pesquisa e desenvolvimento de formulações farmacêuticas.
Foram encontrados 79464 produtos de "Sais e Derivados de API"
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Tolvaptan-d7
CAS:Produto Controlado<p>Applications Labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).<br>References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000), Udelson, J., et al.: Circulation, 104, 2417 (2001), Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005), Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006),<br></p>Fórmula:C26H18D7ClN2O3Cor e Forma:NeatPeso molecular:455.98R-(+)-Warfarin-d5
CAS:Produto Controlado<p>Applications R-(+)-Warfarin-d5 is the isotope labelled analog of R-(+)-Warfarin, an enantiomer of Warfarin (W498500). Coumarin anticoagulant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hagan, E.C., et al.: J. Am. Pharm. Assoc. Sci. Ed., 42, 379 (1953), Bell, R.G., et al.: Biochemistry, 11, 1959 (1972), Valente, J.E., et al.: J. Med. Chem., 20, 1489 (1977), Back, N., et al.: Pharmacol. Res. Commun., 10, 445, (1978), Babhair, S.A., et al.: Anal. Profiles Drug Subs., 14, 423 (1985), Takahashi, H., et al.: Echizen, Clin. Pharmacokinet., 40, 587 (2001),<br></p>Fórmula:C192H5H11O4Cor e Forma:White To Off-WhitePeso molecular:313.359Triethyl Phosphonoacetate
CAS:Produto Controlado<p>Applications Reagent used for Horner-Emmons modification.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hediger, M., et al.: Bioorg. Med. Chem., 12, 4995 (2004), Kim, J., et al.: Nat., 452, 239 (2008),<br></p>Fórmula:C8H17O5PCor e Forma:ColourlessPeso molecular:224.19Allopurinol-13C,15N2
CAS:Produto Controlado<p>Applications Allopurinol-13C,15N2, is the labeled analogue of Allopurinol (A547300), acting as an Xanthine oxidase inhibitor, and used in treatment of hyperuricemia and chronic gout.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Fórmula:C413CH4N215N2OCor e Forma:NeatPeso molecular:139.09Febuxostat-d7
CAS:Produto Controlado<p>Applications Febuxostat-d7, is the labeled analogue of Febuxostat-d7 (F229000), a Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Fórmula:C16H9D7N2O3SCor e Forma:NeatPeso molecular:323.424-Demethoxy-4-hydroxy Apixaban
CAS:Produto Controlado<p>Applications 4-Demethoxy-4-hydroxy Apixaban is a metabolite of Apixaban (A726700) which is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Fórmula:C24H23N5O4Cor e Forma:NeatPeso molecular:445.47Ivermectin-d2
CAS:Produto Controlado<p>Applications Isotope labelled Ivermectin, is the labeled analogue of Ivermectin (I940800), which is a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980), Campbell, W.C., et al.: Science, 221, 823 (1983), Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988), Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995), ; Caly, L., et al.: Antivir. Res., 178<br></p>Fórmula:C48H72D2O14Cor e Forma:NeatPeso molecular:877.113’-Amino-2’-Hydroxy-[1,1’]biphenyl-3-carboxylic Acid
CAS:Produto Controlado<p>Applications 3’-Amino-2’-Hydroxy-[1,1’]Biphenyl-3-carboxylic Acid is used in the synthesis of monoethanolamine salts. A hydrazine cleavage product from Eltrombopag (E508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C13H11NO3Cor e Forma:NeatPeso molecular:229.231Ticagrelor Amine Derivative
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Ticagrelor Amine Derivative is a metabolite of Ticagrelor (T437700). Ticagrelor is a reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Fórmula:C23H29F2N7O3SCor e Forma:White To Off-WhitePeso molecular:521.582-Chloro-N-phenylacetamide
CAS:Produto Controlado<p>Applications 2-Chloro-N-phenylacetamide is used as a reagent in the synthesis of indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones which exhibit anticancer and antimicrobial activities in vitro.<br>References Gali, R., et al.: Bioorg. Med. Chem. Lett., 24, 4239 (2014)<br></p>Fórmula:C8H8ClNOCor e Forma:NeatPeso molecular:169.03Ramipril Diketopiperazine
CAS:Produto Controlado<p>Impurity Ramipril EP Impurity D<br>Stability Hygroscopic<br>Applications Ramipril Diketopiperazine (Ramipril EP Impurity D) is a metabolite of Ramipril (R111000).<br>References Tabata, S., et al.: J. Biopharm. Sci., 1, 235 (1990),<br></p>Fórmula:C23H30N2O4Cor e Forma:WhitePeso molecular:398.50Eltrombopag Ethyl Ester
Produto Controlado<p>Applications Eltrombopag Ethyl Ester, is a metabolite of Eltrombopag (E508000), which is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008),<br></p>Fórmula:C27H26N4O4Cor e Forma:NeatPeso molecular:470.522,6-Bis(thiocyanatomethyl)-4-methylanisole
CAS:Fórmula:C12H12N2OS2Pureza:98%Cor e Forma:SolidPeso molecular:264.362-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester
CAS:<p>Applications 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic Acid Ethyl Ester, can be used for the synthesis of Febuxostat (F229000), an antipodagrics.<br>References Zheng, F., et al.: Zhongguo Yiyao Gongye Zazhi, 40, 726 (2009);<br></p>Fórmula:C14H12N2O3SCor e Forma:NeatPeso molecular:288.321-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic Acid
CAS:Fórmula:C25H24N4O5Cor e Forma:Light Orange ColourPeso molecular:460.48Ramiprilat
CAS:Produto Controlado<p>Impurity Ramipril EP Impurity E<br>Stability Hygroscopic<br>Applications Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)<br>References 1. Teetz, V. et al.: Arzneimittelforschung. 1984;34(10B):1399-401.2. Ruggenenti, P. et al.: Lancet. 1998 Oct 17;352(9136):1252-6.3. Badrinath, P. et al.; BMJ. 2002 Aug 24; 325(7361): 439.<br></p>Fórmula:C21H28N2O5Cor e Forma:Light YellowPeso molecular:388.46ent-Rivaroxaban
CAS:<p>Applications ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Fórmula:C19H18ClN3O5SCor e Forma:White To Off-WhitePeso molecular:435.8815-Keto Travoprost
CAS:Produto Controlado<p>Stability Light Sensitive<br>Applications An impurity of the selective FP prostaglandin receptor agonist Travoprost (T715600) used as an ocularly applied intraocular pressure reducing agent.<br></p>Fórmula:C26H33F3O6Cor e Forma:NeatPeso molecular:498.533-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Allopurinol EP Impurity C / Allopurinol USP Related Compound C<br>Applications 3-(4H-1,2,4-Triazol-4-yl)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity C) is an impurity of Allopurinol (A547300).<br></p>Fórmula:C6H6N6OCor e Forma:Off-WhitePeso molecular:178.15N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester
CAS:<p>Applications N-Nitro-1,2,3,4-tetradehydro Argatroban Ethyl Ester is an intermediate in the preparation of Argatroban (A769000).<br></p>Fórmula:C25H35N7O7SCor e Forma:Off White SolidPeso molecular:577.65Ivermectin B1a (>85%)
CAS:Produto Controlado<p>Applications Ivermectin B1a is a major component of Ivermectin (I940800), a semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca). An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);; Caly, L., et al.: Antivir. Res., 178<br></p>Fórmula:C48H74O14Pureza:>85%Cor e Forma:NeatPeso molecular:875.092-[2-[[4-[(5S)-5-[[[(5-Chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl]amino]ethoxy]-acetic Acid Hydrochloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 2-[2-[[4-[(5S)-5-[[[(5-chloro-2-thienyl)carbonyl]amino]methyl]-2-oxo-3-oxazolidinyl]phenyl]amino]ethoxy]-acetic Acid Hydrochloride is a metabolite of Rivaroxaban (R538000) which is a novel antithrombotic agent. Rivaroxaban is also a highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005)<br></p>Fórmula:C19H20ClN3O6S·HClCor e Forma:White Light RedPeso molecular:453.9036463-(Formylamino)-1H-pyrazole-4-carboxamide
CAS:Produto Controlado<p>Impurity Allopurinol EP Impurity B / Allopurinol USP Related Compound B<br>Stability Hygroscopic<br>Applications 3-(Formylamino)-1H-pyrazole-4-carboxamide (Allopurinol EP Impurity B) is an impurity of Allopurinol (A547300) with inhibitory effects on human hypoxanthine phosphoribosyltransferase.<br>References Krenitzky, T.A. et al.: J. Biol. Chem., 244, 1263 (1969);<br></p>Fórmula:C5H6N4O2Cor e Forma:White To Off-WhitePeso molecular:154.127N-Nitrosodiclofenac
CAS:Fórmula:C14H10Cl2N2O3Cor e Forma:Off-White To Light YellowPeso molecular:325.152-Oxo-ivabradine Hydrochloride
CAS:Produto ControladoFórmula:C27H34N2O6·ClHCor e Forma:NeatPeso molecular:519.034-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
CAS:Produto ControladoFórmula:C22H19N3O6Cor e Forma:NeatPeso molecular:421.40N-(2,6-Dichlorophenyl)aniline
CAS:Produto Controlado<p>Applications N-(2,6-Dichlorophenyl)aniline is an analog of Diclofenac (D436450), a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.<br>References Moser, P. et al.: J. Med. Chem., 33, 2358 (1990); Encinas, S. et al.: Photochem. Photobiol., 68,640 (1998); Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004), Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008), Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009),<br></p>Fórmula:C12H9Cl2NCor e Forma:WhitePeso molecular:238.114-Chlorobenzal Chloride
CAS:<p>Applications 4-Chlorobenzal Chloride is an impurity that is formed in the synthesis of Benoxaprofen (B165300); a non-steroidal anti-inflammatory ophthalmic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cockerill, A.F., et al.: J. Chromatogr., 129, 339 (1976); Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003); Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007); Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009)<br></p>Fórmula:C7H5Cl3Cor e Forma:NeatPeso molecular:195.471,2-Bismethylphenidate (Mixture of Diastereomers)
Produto Controlado<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Fórmula:C23H27NO4Cor e Forma:NeatPeso molecular:381.46Diclofenac Carboxylic Acid (Diclofenac Metabolite)
CAS:Produto Controlado<p>Applications Metabolite of Diclofenac.<br>References Duffy, J.C., et al.: J. Pharm. Pharmacol., 48, 883 (1996), Oza, V., et al.: J. Med. Chem., 45, 321 (2002), Bajaj, S., et al.: Bioorg. Med. Chem., 12, 3695 (2004), Teffera, Y., et al.: Drug Metabolism Lett., 2, 35 (2008),<br></p>Fórmula:C13H9Cl2NO2Cor e Forma:Off-WhitePeso molecular:282.12Diclofenac Methyl Ester
CAS:Produto Controlado<p>Impurity Aceclofenac EP Impurity B<br>Applications Diclofenac Methyl Ester is the methyl ester analogue of Diclofenac (D436450), a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Aceclofenac EP Impurity B<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dannhardt, G., et al.: Eur. J. Med. Chem., 36, 109 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001), Sorbera, L., et al.: Drug Future, 26, 133 (2001),<br></p>Fórmula:C15H13Cl2NO2Cor e Forma:NeatPeso molecular:310.182-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid
CAS:Produto Controlado<p>Applications 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.<br>References Kadivar, M.H.,e t al.: J. Pharm. Biomed. Anal., 56, 749 (2011);<br></p>Fórmula:C16H17NO5SCor e Forma:White SolidPeso molecular:335.37Desisobutyl Febuxostat
CAS:Produto ControladoFórmula:C12H8N2O3SCor e Forma:Light Yellow SolidPeso molecular:260.27Apixaban Dimer
CAS:Produto Controlado<p>Applications Apixaban Dimer is an impurity compound of Apixaban (A726700). Apixaban is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful in the prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J. M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Fórmula:C40H34N10O6Cor e Forma:NeatPeso molecular:750.783-Descyano-3-((hydroxyimino)methyl) Febuxostat
CAS:Produto ControladoFórmula:C16H18N2O4SCor e Forma:NeatPeso molecular:334.39Cyclosporin D
CAS:Produto Controlado<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C63H113N11O12Cor e Forma:Off-WhitePeso molecular:1216.644a-Hydroxy Ivermectin
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications 4a-Hydroxy Ivermectin is an impurity of Ivermectin (I940800), an antiparasitic drug that is active against a wide variety of nematode and arthropod parasites and is used to treat scabies and lice in humans. An invitro inhibitor of SARS-CoV-2/ Covid-19.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Campbell, W., et al.: Science, 221, 823 (1983); Glaziou, P., et al.: Trop. Med. Parasitol., 45, 253 (1994); Meinking, T., et al.: New Engl. J. Med., 333, 26 (1995); Caly, L., et al.: Antivir. Res., 178<br></p>Fórmula:C48H74O15Cor e Forma:NeatPeso molecular:891.09
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