Ésteres e Derivados

<p>Impurity Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A<br>Applications 4-Chloro-4’-hydroxybenzophenone (Fenofibrate EP Impurity A; Fenofibrate USP Related Compound A) the impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner.<br>References Barter, P.J.: Arterioscler. Thromb. Vasc. Biol., 25, 1095 (2005)<br></p>

<p>Impurity Fusidic Acid EP Impurity H<br>Applications 11-Keto Fusidic Acid (Fusidic Acid EP Impurity H) is a metabolite of Fusidic Acid.<br>References Godtfredsen, W.O., et al.: J. Med. Chem., 9, 15 (1966), Perry, M.J., et al.: J. Antibiot., 36, 1659 (1983),<br></p>

<p>Applications Isotope labelled Urethane (U82500), which is a naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen (1) despite being an additive in some alcoholic beverages and foods (2). It binds covalently with DNA however due to its low unavoidable daily intake, it is considered of negligible concern (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mirvish, S. et al.: Adv. Cancer Res. 1968;11:1-42.2. Battaglia R. et al.: Food Addit Contam. 1990 Jul-Aug;7(4):477-96.3. Zimmerli B. et al.: Mutat Res. 1991 Mar-Apr;259(3-4):325-50.<br></p>

<p>Impurity Guaifenasin EP Impurity C<br>Applications 1,7-Di(2-methoxyphenoxy)-2,6-dihydroxy-4-oxaheptane is an impurity of Atenolol l (A790075), a cardioselective β-adrenergic blocker.<br>References Caplar, V., et al.: Anal. Profiles Drug Subs., 13, 1 (1984),<br></p>

<p>Applications Labelled Benzylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Applications Coronary vasodilator. Antianginal.<br>References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),<br></p>

<p>Applications Isopropanol is a volatile organic compound (VOC) that is widely used in the rubber, cosmetics, pharmaceutical, and chemical industries worldwide. Isopropanol’s ability to dissolve a variety of compounds, and its fast evaporation time make it an ideal solvent to work with in the laboratory. Isopropanol is used as a disinfectant in the medical field, and is also utilized for the preservation of biological specimens.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Adams, D., et al.: J. Hosp. Infect., 61, 287 (2005); Bustard, M., et al.: Extremophiles, 6, 319 (2002); Herman, C.: Jour. Lab. &amp; Clin. Med., 26, 1788 (1941)<br></p>

<p>Applications Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.<br>References Collignon, P., et al.: Int. J. Antimicrob. Agents, 12, S45 (1999), Di Marco, R., et al.: J. Autoimmun., 13, 187 (1999), Price, C.T., et al.: J. Antimicrob., Chemother., 44, 57 (1999),<br></p>