Monossacáridos

Inhibits β-N-acetylglucosaminidase, also known as O-GlcNAcase (OGA), which cleaves the O-linked glycans from glycoproteins. Interferes with O-GlcNAc cycling and leads to the accumulation of O-GlcNAcylated proteins. Thiamet G elicits neuroprotective effects by modulating microglia/macrophages and inhibiting hyperphosphorylation of the microtubule-associated protein tau in models of stroke and Alzheimer’s disease. Thiamet G also has implications on diabetes and cardiovascular pathologies.

<p>Donor for Koenigs-Knorr type mannosylation and other anomeric substitutions</p>

1,2,3,6-Tetra-O-benzyl-β-D-glucopyranoside is a synthetic compound that is produced by the modification of natural sugars. It was first synthesized by a team of chemists led by Professor Robert Burns Woodward. This molecule has been modified with methyl groups and fluorine atoms to improve its stability and to provide a more convenient method for its analysis. 1,2,3,6-Tetra-O-benzyl-β-D-glucopyranoside can be used in the synthesis of oligosaccharides and polysaccharides.

4-O-Methyl-D-glucose is an acidic sugar that is found in the cell walls of plants. It has been shown to have structural studies on plant cells, with ion-exchange and ester linkages. 4-O-Methyl-D-glucose is metabolized by microorganisms, including bacteria, fungi, and yeast. This sugar can be oxidized to form acid or oligosaccharides as well as oxidation products such as methylglyoxal. 4-O-Methyl-D-glucose is also used in the synthesis of mucopolysaccharides which make up the connective tissue of tumor cells. This sugar can be synthesized from D-mannose by a diazonium salt reaction followed by oxidation with sodium hypochlorite. The hydroxyl group on this sugar can be acetylated to form acetylated 4-O methyl glucose.

1,3,5-Tri-O-benzoyl-2-deoxy-2-bromo-alpha-L-arabinofuranose is a complex monosaccharide that can be used as a building block in the synthesis of various compounds. It is a derivative of the sugar arabinose, with the addition of benzoyl and bromo groups at specific positions. The compound has potential applications in the fields of organic chemistry and medicinal chemistry and is available for research.

1-Deoxy-1-(hydroxyethylamino)-D-glucitol (DEG) is a sugar alcohol that has been used as a transport inhibitor for the efflux of galactitol. It competitively inhibits the uptake of galactitol in the cell, resulting in a decrease in intracellular levels of this sugar. The uptake of other sugars is not affected by DEG, which makes it an effective tool for studying the transport mechanisms for these sugars. DEG is also chiral and has been used to study the uptake of chiral molecules. This research was done by using Drosophila melanogaster as an animal model, showing that DEG can be used to investigate how cells take up different molecules. These studies have led to insights into how cells metabolize different sugars and fats.

<p>4-Aminophenyl a-D-mannopyranoside is a compound that has been shown to have anti-inflammatory properties. It is also used as a starting material in the synthesis of other drugs. Rats with chronic kidney disease were given 4-aminophenyl a-D-mannopyranoside daily for three weeks, and it was found that this compound prevented the development of kidney injury markers. This drug has also been shown to be effective against mouse strains with nervous system diseases. 4-Aminophenyl a-D-mannopyranoside binds to lysine residues on proteins and prevents the interactions between these residues and the amino acid glutathione, which is required for glut1 uptake in brain cells. This uptake is essential for cellular function, and therefore 4-aminophenyl a-D-mannopyranoside may be useful as chemotherapeutic treatment for brain cancer.</p>

<p>2,3,4,6-Tetra-O-acetyl-b-D-thiogalactopyranose is a synthetic sugar that is prepared by the fluorination of D-galactopyranose and subsequent acetylation. This compound can be used for glycosylation reactions and as a substrate for click chemistry. It is an oligosaccharide with four monosaccharides in its backbone. The CAS number of 2,3,4,6-Tetra-O-acetyl-b-D-thiogalactopyranose is 50615-66-2.</p>

Methyl a-L-idopyranosiduronic acid sodium salt is an impedance sensor that has been developed for use in electroanalytic research. The sensor consists of a monolayer of mammalian cells that are grown on a microfabricated substrate and visualized using microscopy. Methyl a-L-idopyranosiduronic acid sodium salt is used to measure the biophysical properties of muscle cells, such as their phenotype, by measuring the electrical resistance of the cell membrane. This can be used to characterize muscle disorders and identify new drug targets for regenerative medicine.

Methyl 2,4-di-O-methyl-b-D-glucopyranoside is a selectively protected glucose glycoside

<p>4-O-Acetyl-3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl trichloroacetimidate is a methylated saccharide that can be obtained through the Click modification of an oligosaccharide. It is a custom synthesis that has been modified with fluorination. This product is available in high purity and has been glycosylated. It is also a synthetic carbohydrate with a complex structure.</p>

D-Maltose 1-phosphate dipotassium salt is a disaccharide that can be used in the synthesis of oligosaccharides and polysaccharides. It is also an excellent candidate for further modification.

<p>1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-L-mannopyranose is a carbohydrate that is synthesized by the modification of the glycosylation process. It is a methylated and fluorinated oligosaccharide with a high purity. This product is available for custom synthesis in order to meet specific customer requirements.</p>

Ethyl 2,3-di-O-benzoyl-4,6-O-benzylidene-b-D-thiogalactopyranoside is a high purity custom synthesis sugar. This product contains the Click modification, fluorination and glycosylation modifications. It can be used in the synthesis of oligosaccharides, monosaccharides and saccharides. Ethyl 2,3-di-O-benzoyl-4,6-O-benzylidenebDthiogalactopyranoside is used to synthesize complex carbohydrates.

<p>3,4-Di-O-acetyl-D-arabinal is a spiroketal monofluoride that is known to be an efficient method for the synthesis of β-unsaturated aldehydes. It can be prepared by the hydration of enantiopure allyl chloroformate followed by reductive elimination with triflic acid and acidic hydrolysis. 3,4-Di-O-acetyl-D-arabinal has been used in the synthesis of biologically active molecules such as polyketides, peptides and natural products.</p>

4-Methoxyphenyl 2,3,4,6-tetra-O-acetyl-b-D-galactopyranoside is a white crystalline powder. It is soluble in water and ethanol. This chemical has been used as a reagent for the methylation of saccharides and oligosaccharides with 4-methoxybenzene sulfonate. It is also an excellent substrate for click chemistry reactions.

9-O-Acetyl-N-acetyl-neuraminic acid is a sialic acid produced by the human body. It can be found in human serum and has been shown to have inhibitory properties against viruses, such as hepatitis B and C viruses. 9-O-Acetyl-N-acetylneuraminic acid binds to the α1-acid glycoprotein in the blood, which can reduce its ability to bind to other molecules. This leads to a lower concentration of 9-O-acetylneuraminic acid in the blood. This molecule also has chemical biology properties that are being studied for their effects on biological processes such as histological analysis, receptor molecule binding, polymerase chain reaction (PCR), and mucin gene transcription. 9-O-Acetylneuraminic acid also has antihistamine activities that may be due to its ability to block histamine receptors or inhibit histamine release.

2,3,4,6-Tetra-O-pivaloyl-D-glucopyranosyl amine is a monosaccharide that is custom synthesized and modified with fluorination. It also has saccharide properties such as methylation and glycosylation. This product can be used in the synthesis of complex carbohydrates or polysaccharides. It is a high purity compound with CAS No. 888963-33-5.

N-Acetyl D-mannosamine (ManNAc) is an aldohexose (2-acetamido-2-deoxymannose) in which the axial hydroxyl group at position 2 is replaced by a N-acetyl group (Collins, 2006). It has been reported that N-acetyl D-mannosamine supplementation, may provide novel means to break the link between obesity and hypertension (Peng, 2019). N-Acetyl-D-mannosamine and N-acetyl-D-glucosamine are the essential precursors of sialic acid, the specific monomer of polysialic acid, a bacterial pathogenic determinant, for example, Escherichia coli K1 uses both amino sugars as carbon sources. Glycoproteins normally have some level of glycan sialylation, but incomplete sialylation can reduce their therapeutic effect when produced recombinantly. To improve performance, cell lines and culture media can be adjusted. The GNE enzyme controls the efficiency of sialylation in human cell lines, making it crucial for producing effective recombinant glycoprotein drugs. Adding ManNAc and other supplements to culture media improves sialylation, which boosts drug yield, increases stability and half-life, and lowers immune reactions by reducing antibody formation.It has also been reported that ManNAc can be used as a treatment for hereditary inclusion body myopathy, an adult-onset, progressive neuromuscular disorder and also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane (Galeano, 2007).

<p>1,2-Isopropylidene-D,L-myo-inositol is a modification of the natural product myo-inositol. It is synthesized by methylation and glycosylation of inositol with methanol. This chemical compound has been modified to include fluorination and saccharide.</p>