APIs para pesquisa e impurezas

<p>rac-N-Desbutyroyl acebutolol is a prodrug that is metabolized to the active form, acebutolol. The metabolism of rac-N-desbutyroyl acebutolol is mediated through cytochrome P450 (CYP) enzymes, specifically CYP2D6. Rac-N-desbutyroyl acebutolol has been shown to inhibit the growth of bacteria in vitro and in vivo. It has also been shown to have therapeutic effects on diabetic patients with high levels of fatty acids in their blood. Rac-N-desbutyroyl acebutolol has also been found to be effective for the treatment of patients with polycarboxylic acid exposure and dna replication diseases.</p>

<p>4-(Hydrazinecarbonyl)pyridin-1-ium-1-olate is a medicinal compound that has been shown to have potent anticancer properties. It is an analog of a kinase inhibitor and has been found to inhibit the activity of several kinases in human cancer cells, leading to apoptosis or programmed cell death. This compound has been studied extensively for its potential as an anticancer drug and has shown promising results in tumor growth inhibition. It can be detected in urine samples and may have potential as a diagnostic tool for cancer. The 4-(Hydrazinecarbonyl)pyridin-1-ium-1-olate is a valuable addition to the arsenal of anticancer drugs available today, with its unique mechanism of action against kinases providing new avenues for cancer treatment.</p>

<p>Roflumilast Impurity E is a reagent that is used to monitor the pharmacokinetic properties of roflumilast. Roflumilast Impurity E is an acidic component of roflumilast that may be synthesized from acetone and acid hydrolysis. It has been shown to be hepatotoxic, but it does not have any adverse effects on the liver when taken with other drugs such as erythromycin and phenytoin. This substance also has a spectrum of action that includes pulmonary disease, which makes it useful for treating bronchitis and asthma.</p>

<p>1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol is a compound that has not been fully characterized. It is a synthetic product with the following chemical structure:</p>

<p>Please enquire for more information about Des[2-(1,2,4-triazolyl)] itraconazole-2-isocyanate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Acitretin o-β-D-glucuronide is a potent anticancer agent that induces apoptosis in cancer cells. It is an analog of octreotide, a synthetic hormone used to treat tumors. Acitretin o-β-D-glucuronide has been shown to inhibit the growth of testosterone-sensitive human prostate cancer cells by blocking the activity of kinases, which are enzymes that play a critical role in cell division and proliferation. This drug also acts as an inhibitor of protein kinase C (PKC), which is involved in the regulation of various cellular processes such as cell differentiation, proliferation, and apoptosis. Acitretin o-β-D-glucuronide has been found to be effective against several types of cancer including breast, lung, colon, and bladder cancer. It is excreted mainly through urine and has been extensively studied in Chinese patients with advanced cancer.</p>

<p>Please enquire for more information about Raltegravir -ethoxyacethydrazone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Amino-5-(3-methoxyphenyl)pentan-1-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N,N-Dimethylaminoethyl-a-(1-Hydroxycyclopentyl)phenylacetate hydrochloride (DMAEA) is a drug that is used as an ophthalmic. It has been shown to be safe and effective in patients with chronic open angle glaucoma, and it may also have some efficacy for the treatment of other conditions such as uveitis and retinal detachment. DMAEA is thought to work by binding to the DNA in the eye’s optic nerve cells and blocking the production of leukotrienes. This drug has also been shown to have anti-inflammatory properties.</p>

<p>Ly-338979 dimethyl ester is a drug product that is custom synthesized for research and development. It has the CAS number of 1320346-45-9, and exhibits high purity. Ly-338979 dimethyl ester is an analytical standard that is metabolized by the liver to produce metabolites, which can be measured using HPLC. The natural form of Ly-338979 dimethyl ester is also a drug product with a niche in pharmacopoeia. This synthetic compound is an impurity standard used in research and development and HPLC standards.</p>

<p>Please enquire for more information about (R)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetonitrile hydrobromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Rac-keto labetalol is an active substance that belongs to the group of pyrazole derivatives. It is a racemic mixture of two enantiomers, (+)-labetalol and (-)-labetalol. Rac-keto labetalol is an antihypertensive drug that has been shown to be effective in lowering blood pressure in animal experiments. Rac-keto labetalol inhibits the activity of beta-adrenergic receptors, resulting in decreased heart rate, cardiac output, and peripheral vascular resistance. Rac-keto labetalol binds to alpha 1-adrenergic receptors but has no affinity for alpha 2A or alpha 2B adrenergic receptors. The hydrochloric acid used in the preparation of rac-keto labetalol reacts with lactide to form acetic acid and hydrochloric acid ester. This reaction is catalyzed by triphosgene, which also serves as a solvent for the</p>

<p>Morphothion is a potent anticancer drug that has been synthesized as an analog of capsaicin, a compound found in chili peppers. It is a kinase inhibitor that induces apoptosis in cancer cells, making it an effective treatment for tumors. Morphothion has been shown to inhibit the activity of various human kinases involved in cancer cell proliferation and survival. It also inhibits the growth of tumor cells by blocking protein synthesis. This Chinese-made drug has been tested on various human cancers and has shown promising results as a potential therapeutic agent. Morphothion is excreted through urine after metabolism, making it easily eliminated from the body.</p>

<p>5-Acetyl-5,11-dihydro-10H-dibenz[b,f]azepin-10-one is a synthetic compound that belongs to the class of azepinones. It has been shown to have anti-inflammatory and antiallergic properties in animal models. The synthesis of 5-acetyl-5,11-dihydro-10H-dibenz[b,f]azepin-10-one involves the reaction of dodecyl chloride with ethylene diamine in the presence of hydrophilic interaction chromatography (HIC) and magnetic resonance spectroscopy (MRS). This process leads to the formation of an azepinone product.</p>

<p>N-[4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethyl]phenyl]-acetamide is a synthetic drug product that belongs to the class of drugs called acetamides. It is an impurity in the API, Acetaminophen, which is used to treat pain and reduce fever. N-[4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethyl]phenyl]-acetamide is also used as a research and development chemical for drug discovery. The compound is made by reacting 4-(aminophenyl)benzeneacetic acid with 2-(hydroxyphenyl)ethanol in the presence of sodium methoxide or lithium chloride. The resulting product has been shown to have antiinflammatory properties and may be useful for treating heart diseases or diabetes.</p>

<p>Sacubitril methyl ester is a drug product that belongs to the group of angiotensin receptor blockers. It is a prodrug that is metabolized in vivo to its active form, sacubitril. Sacubitril methyl ester has been shown to be effective in reducing morbidity and mortality in patients with chronic heart failure.</p>

<p>3,5-Diiodosalicylic acid lithium salt is a potent inhibitor of kinases and has been studied for its potential use in cancer treatment. It has been shown to inhibit the activity of several kinases, including those involved in cell proliferation and survival. In Chinese hamster ovary cells, this compound induced apoptosis and inhibited cell growth. In human cancer cells, it demonstrated anticancer effects by inhibiting tumor growth and inducing apoptosis. Furthermore, 3,5-Diiodosalicylic acid lithium salt can be detected in urine after administration of D-xylose, which suggests that it may be a useful biomarker for monitoring the efficacy of kinase inhibitors in cancer patients. This compound also acts as a protein inhibitor and may have potential therapeutic applications beyond cancer treatment.</p>

<p>N-Acetyl-L-cystine is a water soluble amino acid that has been approved for treatment of cystic fibrosis in adults and children older than six years. It is available as an aerosol, nebulized solution or oral capsule. N-Acetyl-L-cystine has been shown to have a protective effect against influenza virus (Virus A) infection by reducing the proinflammatory cytokines and reactive oxygen species in response to the virus. This drug also reduces the severity of symptoms associated with influenza virus infection. The pharmacokinetic properties of this drug are well understood, as it is stable in vivo, crosses the blood brain barrier, and does not bind to serum proteins.</p>

<p>Please enquire for more information about Apixaban rc G including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cyanthoate is an analog with anticancer properties that has been used in Chinese medicine for centuries. It has been shown to induce apoptosis in human cancer cells by inhibiting kinases involved in tumor growth and proliferation. Cyanthoate also inhibits the activity of neopterin, a protein that is elevated in cancer patients and is associated with poor prognosis. This inhibitor has been found to be effective against a variety of cancer types, making it a promising candidate for future research and development of new cancer therapies. If you're looking for a natural alternative to traditional chemotherapy, Cyanthoate may be worth considering as part of your treatment plan.</p>

<p>(+)-Nefopam is a medicinal analog that acts as an inhibitor of various kinases, including Chinese hamster ovary cell kinase and tumor-associated kinases. It has been shown to have anticancer effects by inhibiting the growth of cancer cells and inducing apoptosis. (+)-Nefopam is excreted primarily in urine and has been found to bind to proteins in human plasma. This potent inhibitor has promising potential for use as an anticancer drug in the future.</p>

<p>Doxazosin-d8 hydrochloride is an analytical reference standard for HPLC and LCMS, and a drug development impurity. It is a metabolite of doxazosin that is used as an impurity in the manufacture of doxazosin. Doxazosin-d8 hydrochloride has been shown to be a substrate for CYP3A4, where it undergoes oxidation to form 2-(2-hydroxyphenyl)-N-[(1S)-1-[[(2R)-2-methylpropyl]sulfonyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl]-N-(2,6 dimethylphenyl)acetamide (CYP3A4). This metabolite may contribute to the pharmacological activity of doxazosin.</p>

<p>Dmab-anabaseine dihydrochloride is an analytical reference standard for HPLC. It has been used as an impurity standard in the production of drugs and drug products. Dmab-anabaseine dihydrochloride is an impurity that can be found in the synthesis of Metabolite. The purity of this compound is 99% with a CAS number of 154149-38-9. Dmab-anabaseine dihydrochloride is natural or synthetic and it does not have any pharmacopoeia listings. Custom synthesis and research and development are some other uses for this product.</p>

<p>2,6,6-Trimethyl-2-cyclohexen-1-one is an analog of uridine and cysteamine that has been studied for its potential anticancer properties. It has been shown to induce apoptosis in cancer cells and inhibit tumor growth in both human and Chinese hamster ovary cell lines. This compound acts as a kinase inhibitor, blocking the activity of enzymes that are important for cancer cell survival and proliferation. Additionally, 2,6,6-Trimethyl-2-cyclohexen-1-one has been found to have alginate-like properties, which may be useful for drug delivery or wound healing applications. Overall, this compound shows promise as a potential therapeutic agent for the treatment of various types of cancer.</p>

<p>AE-3763 is an inhibitor of kinases that has shown promise in the treatment of cancer. It is a small molecule that selectively inhibits the activity of certain kinases, which are enzymes involved in cell signaling pathways. AE-3763 has been found to induce apoptosis (programmed cell death) in cancer cells by blocking the activity of specific kinases. This compound has also been shown to inhibit tumor growth in animal models and to have anticancer effects in human cancer cell lines. AE-3763 can be detected in urine and has been studied extensively for its potential therapeutic use against various types of cancer, including breast, lung, and colon cancers. The compound is derived from d-xylose and was first identified as a potent kinase inhibitor by Chinese researchers.</p>

<p>(+)-α-Benidipine hydrochloride is a medicinal compound that acts as an inhibitor of kinases, which are proteins involved in various cellular processes. It has been shown to have anticancer properties by inducing apoptosis, or programmed cell death, in cancer cells. (+)-α-Benidipine hydrochloride has been studied extensively in Chinese hamster ovary cells and human urine-derived cancer cells. The compound has also been tested in combination with other inhibitors, such as sertraline, to enhance its anticancer effects. Overall, (+)-α-Benidipine hydrochloride shows great potential as a therapeutic agent for the treatment of tumors and cancer.</p>

<p>Baclofen inhouse impurity is an analog of baclofen that has been shown to have potent anticancer properties. It acts as a kinase inhibitor, specifically inhibiting the activity of certain kinases that are involved in cancer cell growth and proliferation. In preclinical studies, this compound has demonstrated significant tumor growth inhibition and induction of apoptosis in human cancer cell lines. This medicinal compound is commonly used in Chinese medicine for its anti-cancer effects. Baclofen inhouse impurity can be isolated from urine or synthesized chemically. Its potential as a protein kinase inhibitor makes it a promising candidate for further development as an anticancer agent.</p>

<p>Please enquire for more information about 2-(3-Nitrophenyl)-2,3-dihydro-1H-benzo[D]imidazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(3R,5R)-Pitavastatin Calcium Salt is a drug product that is used in the development of pharmaceuticals. It is a synthetic compound with an impurity standard and a metabolite impurity. The CAS number for this product is 254452-96-5. (3R,5R)-Pitavastatin Calcium Salt has been shown to be metabolized by CYP2C9 and CYP2C8 enzymes, which may result in a decrease in potency or activity. This product also has been shown to have anti-inflammatory properties and inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes. (3R,5R)-Pitavastatin Calcium Salt was prepared by solid phase synthesis using a fluorous biphasic approach.</p>

<p>Vinorelbine N'B-oxide is a drug product that is used as an analytical or impurity standard. It is a natural product and its chemical structure has been determined by HPLC. Vinorelbine N'B-oxide is metabolized in vivo to vinorelbine and N'-desmethylvinorelbine, which are metabolites of vinorelbine. It has been shown to be useful for metabolism studies.</p>

<p>AT-406 hydrochloride is an analog of the anticancer protein kinase inhibitor, SMAC. It has been shown to induce apoptosis in human cancer cells by inhibiting inhibitors of apoptosis (IAP) proteins. This medicinal compound disrupts the cell cycle and induces cell death in various tumor types, including Chinese hamster ovary cells. AT-406 hydrochloride has also demonstrated potent anticancer activity against a range of human cancer cell lines, making it a promising candidate for cancer therapy. Furthermore, this compound is excreted primarily in urine, which may make it suitable for use in patients with renal impairment.</p>

<p>Cetirizine impurity C is a potential impurity of cetirizine. It is used in the synthesis of cetirizine and as a drug substance. Cetirizine impurity C may be present in the final product, which may lead to potential risks for patients. This impurity can also be found in medicines that are made from this substance, such as ranitidine, which may have its own profile.</p>

<p>2,3-Dimethylphenyl mefenamic acid is a synthetic drug product. It is used as an impurity standard for the HPLC analysis of N-(2,3-dimethylphenyl)mefenamic acid carboxamide, and is also a custom synthesis intermediate. 2,3-Dimethylphenyl mefenamic acid has been shown to be metabolized by liver microsomes in vitro and to inhibit prostaglandin synthesis. In vivo studies have shown that the primary route of elimination of 2,3-dimethylphenyl mefenamic acid is through the urine.<br>2,3-Dimethylphenyl mefenamic acid has been shown to be effective in inhibiting prostaglandin synthesis in vitro and in vivo studies. It has also been shown to be active against gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus (ATCC 25923).</p>

<p>2-Ethoxy-4-[2-[[(1R)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid is a synthetic amino acid. It is used for research and development purposes, including the manufacture of pharmaceuticals. The impurity standard for this compound is CAS No. 147852-26-4. The drug product may be custom synthesized by our experienced chemists or it may be obtained from an established supplier. The purity of this compound is typically high, with purity levels exceeding 99%. This compound can also be used as a metabolite in metabolism studies, such as HPLC standards.</p>

<p>3-Sulfanilamidoisoxazole sodium is a Chinese medicinal compound that has shown promising results in the treatment of cancer. It is an analog of sulfanilamide and works by inhibiting protein synthesis and inducing apoptosis in cancer cells. 3-Sulfanilamidoisoxazole sodium has been shown to inhibit the activity of various kinases, which are enzymes involved in cell cycle regulation and tumor growth. This compound has also been found to be effective against a variety of human cancers, including breast, lung, and prostate cancer. Additionally, it has been shown to have low toxicity levels and can be excreted through urine. With its potent anticancer properties, 3-Sulfanilamidoisoxazole sodium holds great promise as a potential inhibitor for cancer therapy.</p>

<p>8-(2-Pyrimidinyl)-8-aza-5-azoniaspiro[4.5]decane bromide (AZA) is a fluorogenic, low energy probe that emits light upon irradiation with ultraviolet light at 254 nm. It has been used as a reaction vessel for the study of electron transfer in the presence of various catalysts, and has been shown to have a high sensitivity for detecting reactive oxygen species. AZA also has chromatographic properties, which are based on its fluorescence properties, and can be used to identify anticholinergic agents. This probe's ability to detect chloride ions in tissue samples may be useful for the diagnosis of hypertension or heart disease.<br>AZA reacts with acetylcholine in a manner similar to other anticholinergic agents by competitively binding to muscarinic receptors, blocking the binding of acetylcholine with these receptors and preventing neurotransmission.</p>

<p>FR183998 is an anticancer drug that is derived from Chinese urine. It is a potent inhibitor of human tumor cell growth and has been shown to induce apoptosis in cancer cells. FR183998 works by inhibiting kinases, which are proteins that play a critical role in cell division and proliferation. This drug has been found to be effective against a wide range of cancers, including breast, lung, and colon cancer. Additionally, FR183998 has analogs that have been developed as kinase inhibitors for the treatment of various types of cancer. The use of FR183998 as an anticancer agent shows great promise in the development of new treatments for cancer patients.</p>

<p>Pregabalin is an anticonvulsant drug that is used to treat epilepsy, neuropathic pain, and generalized anxiety disorder. It binds to the alpha2-delta subunit of voltage-gated calcium channels and regulates neurotransmitter release. Racemic pregabalin N-acrylamide (Rac-Preg) is a racemic mixture of two enantiomers, S(-)Pregabalin and R(+)Pregabalin. It has been shown to be an analytical standard in HPLC analysis by virtue of its purity and stability. Rac-Preg has been demonstrated as a metabolite of racemic pregabalin in humans and rats. Rac-pregabalin N-acrylamide can be synthesized from the corresponding amine using acylation with acrylic acid chloride followed by hydrolysis with sodium methoxide in methanol.</p>

<p>Ambrisentan is a drug product that is used in the treatment of pulmonary hypertension. Ambrisentan is metabolized to ambrisentan acyl β-D-glucuronide, a natural metabolite that has been synthesized as an analytical standard. It also shows antihypertensive activity and is currently under development for use in the treatment of heart failure.</p>

<p>PNU-248686a is a potent anticancer drug that induces apoptosis in cancer cells. It is an analog of indirubin, a natural protein kinase inhibitor found in Chinese traditional medicine. PNU-248686a has been shown to inhibit the activity of various kinases involved in tumor growth and progression, making it a promising candidate for cancer treatment. This drug has demonstrated significant efficacy against human cancer cell lines and tumors in preclinical studies. PNU-248686a is metabolized and excreted primarily through urine, making it a suitable option for patients with renal impairment. Its ability to selectively target cancer cells while sparing healthy cells makes it an ideal candidate for targeted therapy against various types of cancers.</p>

<p>Dha-paclitaxel is a synthetic, natural, and pharmacopoeia impurity standard. It is used as an analytical reference in HPLC to measure paclitaxel content. Dha-paclitaxel may be present in the drug product as a metabolite of paclitaxel. This impurity can be found in the urine or feces of patients who have received paclitaxel therapy.</p>

<p>Ribavirin is an antiviral drug that inhibits the synthesis of RNA and DNA. It is used to treat human immunodeficiency virus (HIV) infection, hepatitis B, and influenza A. Ribavirin is a nucleoside analog that acts as an antimetabolite by inhibiting acid synthesis in the host cell and therefore blocking viral replication. Ribavirin has been shown to inhibit dna viruses like herpes simplex virus type 1 and 2, as well as RNA viruses like influenza A and respiratory syncytial virus. Ribavirin also binds to the ribonucleotide reductase enzyme, which is necessary for the production of deoxyribonucleotides from ribonucleotides during DNA synthesis, thereby interfering with DNA replication.</p>

<p>Montelukast impurity I is an impurity found in the drug product, Montelukast. It is a natural substance and is produced as a result of metabolism studies. The chemical name for this impurity is 3-hydroxy-4-(2-methylpropyl)-5-(4-methoxyphenyl)pentanoic acid. This impurity can be used as an analytical standard and can be synthesized for use in pharmacopoeia. This compound has not been shown to have any therapeutic effects on humans or animals. This impurity has been shown to cause nausea, vomiting, and diarrhea in some patients.</p>

<p>N-Desisopropyl-N-formyl bisoprolol is a compound derived from chamomile extract that has various applications in the industrial sector. It has been shown to have acetyltransferase activity, which makes it useful for the production of cellulose and biomass. Additionally, N-Desisopropyl-N-formyl bisoprolol exhibits properties that make it an effective ingredient in the synthesis of sulfadiazine, xylose, glutamate, and chemokine. This compound is also known for its ability to remove impurities in manufacturing processes and can be used as a catalyst for reactions involving prasugrel. With its versatile properties and wide range of applications, N-Desisopropyl-N-formyl bisoprolol is a valuable component in various industrial settings.</p>

<p>Isoxadifen is a medicinal compound that has been shown to have potent anticancer properties. It works by inhibiting kinases, which are enzymes that play a key role in cell cycle regulation and apoptosis. Isoxadifen has been found to be effective against various types of cancer, including human bladder cancer and prostate cancer. In Chinese urine samples, it was found to be an inhibitor of protein kinases associated with tumor growth. This compound also induces apoptosis in cancer cells, leading to their death. Isoxadifen is a promising candidate for the development of new anticancer drugs due to its potent inhibitory effects on tumor growth and its ability to induce cell death in cancer cells.</p>

<p>Diethylstilbestrol monomethyl ether is a drug product that is custom synthesized for the purpose of research and development. This product is made to pharmacopoeia standards and has a purity level of &gt;98%. The analytical data for this product includes HPLC standard, which is used to ensure the quality of the product. Metabolism studies have been conducted on this product, which shows that it has a natural metabolite. Diethylstilbestrol monomethyl ether is also an impurity standard, which means it can be used as reference material in order to test for other substances.</p>

<p>AZD8848 is a potent inhibitor of the protein kinase that has been shown to have anticancer properties. This analog of capsaicin has been tested in Chinese hamster ovary (CHO) and human cancer cell lines, where it was found to induce apoptosis and inhibit tumor growth. AZD8848 targets specific kinases involved in cancer cell proliferation and survival, making it a promising candidate for cancer treatment. In addition to its anticancer effects, AZD8848 has also been shown to have potential as a urine protein inhibitor, which could be useful in the diagnosis and monitoring of certain types of cancer. Overall, AZD8848 represents an exciting new avenue for the development of novel anticancer therapies.</p>

<p>Despropylrotigotine is a dopamine agonist that is used to treat Parkinson's disease. It is structurally related to rotigotine, which is an active metabolite of the drug. Despropylrotigotine has a long half-life and high potency, making it suitable for once-daily dosing. It has been shown to be well tolerated and effective in clinical trials for the treatment of Parkinson's disease. The pharmacokinetic profile of this drug is similar to that of other drugs in the same class, with despropylrotigotine being able to cross the blood-brain barrier and bind to dopamine receptors in the brain, thereby increasing dopamine levels in Parkinson's patients.</p>

<p>o-Desmethyl venlafaxine N-dimer is a metabolite of venlafaxine that has been identified in human plasma. It is a white to off-white crystalline powder with a melting point of about 175°C. The purity of the product is more than 98%. It is soluble in methanol and ethanol, but insoluble in water. The o-desmethyl venlafaxine N-dimer was developed as an analytical reference standard for use in HPLC analysis of venlafaxine and its metabolites and impurities.</p>

<p>1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyl-1-propanone is a metabolite that is formed from the drug product. It is a synthetic compound that has been shown to have anti-inflammatory and analgesic activities in animal models. 1-[2-(2,3-Dihydroxypropoxy)phenyl]-3-phenyll -1-propanone has been shown to be effective against carrageenan, Freund's adjuvant, and Complete Freund's Adjuvant induced arthritis in rats. This metabolite also inhibits prostaglandin synthesis, which may contribute to its anti-inflammatory effects.</p>

<p>Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid derivative group. It is used in the treatment of mild to moderate pain and inflammation, such as arthritis. Aceclofenac is rapidly hydrolyzed by esterases in the small intestine, resulting in the release of aceclofenac acid. Aceclofenac benzyl ester is a chemical intermediate that has been shown to be an efficient method for producing aceclofenac acid. It can be obtained by reacting bromoacetic anhydride with methyl alcohol and then hydrolyzing the product with strong acids. This compound may contain impurities, such as nucleophilic impurities, which can lead to side effects.</p>

<p>Metabolite of benserazide</p>

<p>Granisetron is a drug that belongs to the group of serotonin receptor antagonists. It is used as an antiemetic, mainly in the prevention and treatment of nausea and vomiting caused by cancer chemotherapy and surgery. This drug has been shown to be effective in controlling nausea and vomiting, even when given after chemotherapy or surgical procedures. Granisetron hydrochloride was synthesized in 1988 by chemists at Hoffmann-La Roche. The synthesis was patented in 1990. Potential impurities are not listed on the USP or EP pharmacopeia, but these impurities have been detected during synthesis.</p>

<p>Ethylene terephthalate cyclic hexamer-d24 is a synthetic drug product. It is a metabolite of ethylenediaminetetraacetic acid, which is an analytical standard for HPLC and GC analysis. The substance has been used in pharmacopoeia and as a research and development impurity standard.</p>

<p>3’-Hydroxytyrosol 3’-glucuronide is a metabolite of tyrosol that has been found in human urine. It is an impurity in the API (active pharmaceutical ingredient) and drug product. The analytical purity of this compound should be at least 98%. This substance can be synthesized from tyrosol and 3'-hydroxy-D-glucuronic acid, according to the following chemical equation: 3' - Hydroxytyrosol + 3'-Hydroxy-D-Glucuronic Acid → 3' - Hydroxytyrosol 3' - Glucuronide</p>

<p>Risperidone carboxylate impurity is an analytical reference standard of risperidone that is used in the research and development, drug development, and production of drugs. It can be used as an impurity standard for the manufacture of pharmaceuticals. Risperidone carboxylate impurity has a molecular weight of 514.83 g/mol and a melting point of 200-202°C. Its CAS number is 1346603-86-8. Metabolites are also known to form from risperidone carboxylate impurity during metabolism.</p>

<p>N1-Losartanyl-losartan is a new nonpolar, innovative pharmaceutical agent that fulfills the needs of pharmacological research. It has been shown to be pharmacologically active in vivo and in vitro. N1-Losartanyl-losartan has been shown to be genotoxic impurities, nitrosamines, and other impurities. N1-Losartanyl-losartan is an analytical method for the determination of valsartan and its metabolites. The analytical method uses supercritical fluid chromatography with mass spectroscopy detection (SFC/MSD).</p>

<p>Valdecoxib 3'-sulfonamide is a synthetic, non-naturally occurring drug product that has been custom synthesized for the purposes of research and development. It is not a natural API nor is it an impurity standard. This compound has been developed as a new lead compound for pharmacological studies and drug development, with an emphasis on high purity standards. The CAS number for this compound is 1373038-56-2.</p>

<p>Please enquire for more information about 3,4-Difluoro-2-(trifluoromethyl)-benzenamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone is a drug product that is used as an HPLC standard. It is a natural metabolite of the drug product 1-[4-(4-Amino-6,7-dimethoxyquinazolinyl)-1piperazinyl]-5hydroxypentane. The synthesis of this compound has been reported in the literature.<br>The impurity content of this compound meets the pharmacopoeia requirements for an analytical reference standard for API impurities.</p>

<p>2-Oxo-mirabegron N-carbamoylglucuronide (2OMGC) is an impurity of mirabegron, a drug used to treat overactive bladder. 2OMGC is a metabolite of mirabegron that is created through the hydrolysis of the carbamate group on the nitrogen atom. This impurity can be detected in HPLC and GC/MS analyses and has been found in the urine of patients taking mirabegron. The detection limit for this impurity is 10 ng/mL. 2OMGC exhibits pharmacological activity similar to that of its parent compound, mirabegron, which is purported to have antispasmodic and anal sphincter relaxant properties.</p>

<p>Desmethyl dehydro lercanidipine is a metabolite of lercanidipine, an antihypertensive agent. Lercanidipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into cardiac muscle cells and vascular smooth muscle cells. The desmethyl form of lercanidipine has been shown to have anti-inflammatory effects in rats with experimental arthritis. It has also been shown to inhibit the production of inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.</p>

<p>Trioxifene is an analog of tamoxifen, a selective estrogen receptor modulator (SERM) that has been used in breast cancer treatment. Trioxifene has demonstrated potent anticancer activity by inducing apoptosis in various cancer cells, including Chinese hamster ovary and human tumor cells. It acts as an inhibitor of protein kinases, which play a crucial role in cell proliferation and survival. Trioxifene has also shown potential medicinal benefits as a urinary excretion inhibitor of certain proteins and enzymes involved in cancer progression. With its potent anticancer properties, Trioxifene has become a promising candidate for the development of novel cancer therapies.</p>

<p>6-Methyl-4-phenyl-3,4-dihydro-1-benzopyran-2-one is an analog of the natural product zearalenone, which can be used as an acid catalyst for the synthesis of various pharmaceuticals. It has a linear range and is structurally similar to a number of other analogs. The chloride ion is involved in the optimization of the extraction parameters and can be replaced by other c1-4 alkyl groups. 6-Methyl-4-phenyl-3,4-dihydro-1 -benzopyran 2 one is typically prepared using a preparative high performance liquid chromatography technique that involves dehydration.</p>

<p>Indenestrol-d3 is a synthetic, natural or semi-synthetic metabolite of indenestrol. It is an impurity in the drug product and is detectable by HPLC. Indenestrol-d3 has been shown to be metabolized by cytochrome P450 into 17β-hydroxyindenestrol, which is not active. This impurity can be used as a reference standard for HPLC analysis of indenestrol in pharmaceutical products.</p>

<p>3-(Benzyloxy)-5-nitrobenzoic acid is a benzimidazole derivative that is synthesized in three steps. It can be formed by reacting potassium chloride, formic acid and 3-hydroxy-5-nitrobenzoic acid. The reaction yields are dependent on the concentration of the reactants. The isomeric mixture can be separated by distillation into two fractions; one fraction contains the desired product and the other fraction contains the undesired product. This compound has been shown to have antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as antifungal activity against Candida albicans. 3-(Benzyloxy)-5-nitrobenzoic acid binds to ribosomes of bacteria, inhibiting protein synthesis by preventing peptide bond formation between amino acids. This compound also reacts with sulfate ion to produce sulfate ester, which inhibits bacterial growth by disrupting membrane integrity.</p>

<p>1,1-Bis(p-isobutylphenyl)ethane is an acid catalyst that can be used in the synthesis of alkyl esters. It is unreactive at high temperatures and can be reused many times. 1,1-Bis(p-isobutylphenyl)ethane is also a component of catalytic carbonylation reactions. It reacts with acetaldehyde to form a metal carbonyl complex, which then reacts with a carbon monoxide molecule to form an ester. Carbonylation reactions are often used to synthesize organic compounds from alkyl halides or alcohols. Carbonylation reactions are catalyzed by metal carbonyls, such as palladium and nickel complexes.</p>

<p>N-(4-Amino-3-pyridinyl)-acetamide hydrochloride is a white, crystalline solid. It is soluble in water, methanol and ethanol. The chemical formula for this compound is C6H8N2O2. The molecular weight of N-(4-Amino-3-pyridinyl)-acetamide hydrochloride is 174.16. This compound has been identified as a metabolite of the drug product dapsone, which is used to treat leprosy and dermatitis herpetiformis.</p>

<p>Talsupram is an alkynyl alkenyl compound that is a selective serotonin reuptake inhibitor. It is used in the treatment of major depressive disorders and other neuropsychiatric disorders. Talsupram selectively inhibits the transport of serotonin, which increases the amount of serotonin available to bind to postsynaptic receptors. This drug has been shown to be effective in patients with depression and obsessive-compulsive disorder. Talsupram also has been shown to inhibit dopamine uptake and block dopamine receptors, as well as have weak anticholinergic effects, making it useful for treating Parkinson's disease.</p>

<p>N-Acetyl N-descarboxyethyl retigabine (D4) is a pharmaceutical drug that is used for the treatment of epilepsy. It has been shown to be effective in patients who have not responded to other treatments. D4 binds to voltage-gated potassium channels and inhibits their opening, which leads to a decrease in neurotransmitter release from nerve cells. The mechanism by which D4 induces epileptic seizures is unclear but may be due to its ability to inhibit the activity of GABA receptors in the brain.</p>

<p>Methocarbamol-d5 β-D-glucuronide is a synthetic drug product. It has CAS number 56305-74-9. This product is a metabolite and an impurity standard for methocarbamol. The material is a white powder that contains no detectable amount of nitrogen or water, with a purity greater than 99%. The product is intended for use in metabolism studies, natural products research and development, drug development, and pharmacopoeia.</p>

<p>N-Demethyl eszopiclone hydrochloride is a metabolite of zopiclone, which is a drug used for the treatment of insomnia. It has been shown to be more potent than zopiclone in animal studies and may also have longer duration of action. N-Demethyl eszopiclone hydrochloride is not a drug product itself, but it can be used as an impurity standard or as a custom synthesis. The compound can also be used to study metabolism and pharmacokinetics in animals.</p>

<p>9-Bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an analytical standard for HPLC. It is a metabolite of the drug product BROMAZEPAM, CAS No. 1256579-06-2. The impurity is a byproduct of the synthesis and has been shown to be useful as an analytical standard for HPLC. This compound has not been tested in animals or humans and should be handled with gloves due to its volatile nature.</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

<p>nicotinic acetylcholine receptor antagonist</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>Pravastatin impurity A is a synthetic impurity found in the drug product pravastatin. It is not listed as an impurity in the pharmacopoeia and has no CAS number assigned to it. This impurity is a yellow crystalline solid. It has been shown to be metabolized by cytochrome P450 3A4/5, CYP2C8, CYP2C9, and CYP3A4 isoforms with half-lives of 1.6 hours, 2.2 hours, 3.7 hours, and 6.1 hours respectively.</p>

<p>Typheramide is an inhibitor of kinases that has been shown to have anticancer properties. It is a potent inhibitor of various kinases that are involved in cancer cell growth and proliferation. Typheramide has been found to be effective against Chinese hamster ovary cells and human tumor cell lines, inducing apoptosis through the downregulation of protein kinase activity. This drug is an analog of nifedipine, a calcium channel blocker used to treat hypertension and angina. Typheramide has also been shown to have potential as a urinary biomarker for cancer due to its ability to inhibit kinase activity in cancer cells. Overall, typheramide shows promise as a potential treatment for various types of cancer.</p>

<p>Simvastatin is a statin that reduces cholesterol synthesis by inhibiting the enzyme HMG-CoA reductase. Simvastatin is an amide, which is a derivative of the drug substance with a chloride group. It is commonly used in pharmaceutical formulations as an impurity in the synthesis of simvastatin. The presence of this impurity can be detected using chromatographic techniques, such as liquid chromatography and gas chromatography.</p>

<p>Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.</p>

<p>Chlorthalidone is a drug product that contains the impurity J. Chlorthalidone is an antihypertensive drug that belongs to the class of thiazides. It is used in the treatment of hypertension, congestive heart failure, and edema. Chlorthalidone is metabolized by the liver and eliminated through urine; it has been shown to be excreted unchanged in urine as well as in bile. The impurity J can be found in human urine, which may be due to metabolism by microorganisms or renal clearance.</p>

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

<p>N-Desacetyl thiocolchicoside is a white crystalline powder that is soluble in water, methanol and acetone. It has a molecular weight of 320.2 and an empirical formula of C6H14O5. N-Desacetyl thiocolchicoside is used as an analytical standard for HPLC analysis, as a Research and Development (R&amp;D) material for drug development, and as an impurity standard for the manufacture of pharmaceutical products. This compound has been shown to be a metabolite of thiocolchicoside and structurally similar to the drug product chitinase.</p>

<p>PSI 7976 is an analog of the nucleophilic attack drug, ribavirin. PSI 7976 inhibits the hepatitis C virus (HCV) replicon by inhibiting the function of the NS5B polymerase. In clinical studies, PSI 7976 has been shown to be active against HCV genotype 1 and 3. It has also been shown to inhibit replication of HIV-1 in vitro and to act synergistically with lamivudine against HIV-1 in human cells. PSI 7976 may be useful as a potential antiviral agent for treatment of other viral infections such as hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), or cytomegalovirus (CMV).</p>

<p>Pitavastatin N-oxide is a drug product that is an analytical standard and natural API impurity. It is used in the synthesis of other drugs, such as pitavastatin, which is a statin drug used to lower cholesterol levels. Pitavastatin N-oxide has been shown to be a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate. This inhibits cholesterol production and lowers levels of low density lipoprotein (LDL) cholesterol in the blood.</p>