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APIs para pesquisa e impurezas

APIs para pesquisa e impurezas

Os Ingredientes Farmacêuticos Ativos (APIs) são as substâncias nos medicamentos responsáveis por seus efeitos terapêuticos. Nesta seção, você encontrará uma ampla variedade de APIs destinados a uso em pesquisa. Esses compostos são essenciais para o desenvolvimento, teste e validação de novas formulações farmacêuticas. Na CymitQuimica, oferecemos APIs de alta qualidade para apoiar a pesquisa em descoberta e desenvolvimento de medicamentos.

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  • 9-Oxo azithromycin B


    9-Oxo azithromycin B is a metabolite of azithromycin. It is an analytical standard for the HPLC analysis of azithromycin and its metabolites. 9-Oxo azithromycin B has been shown to bind to the ribosomes of bacteria, and inhibit protein synthesis. This drug also has antibiotic activity against Mycobacterium avium and Mycobacterium tuberculosis. 9-Oxo azithromycin B can be used in niche research or as an API impurity.br>
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    Fórmula:C37H68N2O12
    Pureza:Min. 95%
    Peso molecular:732.94 g/mol

    Ref: 3D-IO137491

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  • Cetirizine propanediol ester impurity


    Cetirizine is a drug product that is metabolized to cetirizine propanediol ester. This impurity has been identified in the drug and is not expected to cause any adverse effects in humans. Cetirizine propanediol ester can be synthesized and purified through high-purity, analytical, and natural methods. The pharmacopoeia defines cetirizine propanediol ester as a metabolite of cetirizine. It can also be used as an impurity standard for HPLC analysis.

    Fórmula:C24H31ClN2O4
    Pureza:Min. 95%
    Peso molecular:446.97 g/mol

    Ref: 3D-IC57783

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  • Colchicine EP Impurity B


    Colchicine EP Impurity B is a synthetic, impurity standard that is used in research and development for drug product development. It is also used as an analytical reagent. Colchicine EP Impurity B has been shown to be a metabolite of colchicine, which is found in the natural environment. This impurity can be synthesized by reacting 4-hydroxybenzaldehyde with nitroethane and sodium nitrite in the presence of hydrochloric acid. Analytical methods to detect this impurity include HPLC and GC-MS.

    Pureza:Min. 95%

    Ref: 3D-IC181038

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  • N-Hydroxy-11-azaartemisinin

    Produto Controlado
    CAS:
    Fórmula:C15H23NO5
    Cor e Forma:White
    Peso molecular:297.35

    Ref: TR-H804500

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  • (E/Z)-It-603

    CAS:

    Please enquire for more information about (E/Z)-It-603 including the price, delivery time and more detailed product information at the technical inquiry form on this page

    Fórmula:C11H9BrN2O3S
    Pureza:Min. 95%
    Peso molecular:329.17 g/mol

    Ref: 3D-SLA16890

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  • 4-(Phthalazin-1-yloxy)aniline

    CAS:

    4-(Phthalazin-1-yloxy)aniline is an analog of cyclin-dependent kinase (CDK) inhibitors that has shown promising anticancer activity. It inhibits the activity of CDKs, which are enzymes involved in regulating cell division and proliferation. This compound has been tested on Chinese hamster ovary cells and has demonstrated potent antiproliferative activity against various cancer cell lines. 4-(Phthalazin-1-yloxy)aniline induces apoptosis in tumor cells, leading to their death. This compound may be a potential candidate for the development of novel anticancer drugs that target CDKs and promote tumor cell death. Additionally, this compound can be detected in urine samples, making it a useful biomarker for cancer diagnosis and monitoring.

    Fórmula:C14H11N3O
    Pureza:Min. 95%
    Peso molecular:237.26 g/mol

    Ref: 3D-ZFA36540

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  • 1-Phenyl-1,2,3,4-tetrahydro-isoquinoline

    CAS:

    1-Phenyl-1,2,3,4-tetrahydro-isoquinoline is a synthetic compound which has been used as a lead compound for the development of drugs with dopamine β-hydroxylase inhibitory activity. In vitro studies have shown that 1-phenyl-1,2,3,4-tetrahydro-isoquinoline inhibits human serum dopamine β-hydroxylase and can be used to study the possible role of this enzyme in Parkinson's disease. This drug is racemized in the body and has been found to be effective against Parkinson's disease in rats. It is also an enantiomer that has industrial applications for the production of polyurethane foam insulation coatings.

    Fórmula:C15H15N
    Pureza:Min. 95%
    Cor e Forma:Powder
    Peso molecular:209.29 g/mol

    Ref: 3D-IP14816

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  • N-Desmethyl trimeprazine

    CAS:

    N-Desmethyl trimeprazine is a synthetic compound, which is an impurity of the drug product. It is not active and does not possess any biological activity. It is a metabolite of the parent drug, Trimeprazine. N-Desmethyl trimeprazine has been studied for its pharmacological properties and metabolism in the body, but no conclusive results have been found. The chemical structure and purity of N-Desmethyl trimeprazine are not listed in the USP or BP. This compound can be custom synthesized on request.

    Fórmula:C17H20N2S
    Pureza:Min. 95%
    Peso molecular:284.40 g/mol

    Ref: 3D-XAA73204

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  • Pirtenidine

    CAS:

    Pirtenidine is a potent and selective kinase inhibitor that has been shown to inhibit the activity of cyclin-dependent kinases. It has demonstrated promising results in preclinical studies as an anticancer agent, inducing apoptosis in cancer cells. Pirtenidine is an analog of protein kinase inhibitors, which have been used to treat various types of tumors. It has been found to be effective against human cancer cell lines and has shown significant tumor growth inhibition in animal models. Pirtenidine has also been reported to be a potent urine inhibitor of Chinese hamster ovary cells, making it a promising candidate for the treatment of urinary tract cancers.

    Fórmula:C21H38N2
    Pureza:Min. 95%
    Peso molecular:318.5 g/mol

    Ref: 3D-DEA92327

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  • Acrolein-d4

    CAS:

    Please enquire for more information about Acrolein-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page

    Fórmula:C3H4O
    Pureza:Min. 95%
    Peso molecular:60.09 g/mol

    Ref: 3D-IBA98405

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  • N-Methyl metribuzin

    CAS:

    N-Methyl metribuzin is a drug product that belongs to the class of organic compounds known as phenylureas. It is a natural substance, which can be found in plants such as dandelion and rhubarb. Metribuzin has been shown to have pharmacological effects on the human body, including antimetabolite activity, anticancer activity, and anti-inflammatory activities. Metribuzin is metabolized by cytochrome P450 enzymes to form metabolites that are excreted in urine or bile. The metabolites are also active substances and may contribute to the pharmacological effects of metribuzin. Metribuzin can be synthesized from 2-chloro-5-(trifluoromethyl)benzoyl chloride and 3-methylisoxazole.
    Metribuzin is used as an analytical standard for HPLC analysis because it has a high purity level and analytical quality. It is also used in

    Fórmula:C9H16N4OS
    Pureza:Min. 95%
    Cor e Forma:Powder
    Peso molecular:228.32 g/mol

    Ref: 3D-GCA74245

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  • 4-Desmethyl 5-methyl vortioxetine hydrochloride

    CAS:

    Please enquire for more information about 4-Desmethyl 5-methyl vortioxetine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

    Fórmula:C18H23ClN2S
    Pureza:Min. 95%
    Peso molecular:334.9 g/mol

    Ref: 3D-MKD72214

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  • Xanthoxin

    CAS:

    Xanthoxin is a medicinal compound with potent anticancer properties. It has been shown to induce apoptosis, or programmed cell death, in cancer cells. Xanthoxin has been tested in various cancer cell lines, including Chinese and human cells, and has demonstrated strong inhibitory effects on the tumor cycle. This compound works by inhibiting kinases and other proteins involved in cancer cell growth and proliferation. Xanthoxin is also known to be an inhibitor of certain urinary proteins that are associated with cancer progression. Overall, Xanthoxin shows great potential as a natural product for the development of novel anticancer therapies.

    Fórmula:C15H22O3
    Pureza:Min. 95%
    Peso molecular:250.33 g/mol

    Ref: 3D-IAA06607

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  • CPI 0610

    CAS:

    CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.

    Fórmula:C20H18ClN3O3
    Pureza:Min. 95%
    Peso molecular:383.8 g/mol

    Ref: 3D-VYC72614

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  • Fonofos

    CAS:

    Fonofos is a potent inhibitor that has been shown to induce apoptosis in Chinese hamster ovary cells. It is also known to inhibit chitin kinase, a protein that plays an important role in the biosynthesis of chitin, which is essential for the formation of cell walls in fungi and insects. Fonofos has medicinal properties and has been studied as a potential anticancer agent due to its ability to inhibit tumor growth. In vitro studies have shown that Fonofos can inhibit the growth of human cancer cells by inhibiting heparin-binding proteins. Additionally, it has been found to have inhibitory effects on several other enzymes involved in cancer development and progression. Although not approved for use in humans, Fonofos may hold promise as a therapeutic agent for the treatment of certain cancers.

    Fórmula:C10H15OPS2
    Pureza:Min. 95%
    Peso molecular:246.3 g/mol

    Ref: 3D-AAA94422

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  • Simvastatin acid

    CAS:

    Simvastatin acid is the active form of simvastatin, a drug used to lower blood cholesterol levels. Simvastatin acid inhibits HMG-CoA reductase, the enzyme that converts HMG-CoA to mevalonate. This conversion is a rate-limiting step in the synthesis of cholesterol and other lipids. Simvastatin acid binds to polymerase chain and drug transporter proteins, which leads to cell lysis. The concentration–time curve for simvastatin acid is linear and the half-life is approximately 12 hours. When simvastatin acid is administered with drugs that are potent inducers of CYP3A4 or UGT1A1 enzymes, there may be an increased risk for drug interactions. Simvastatin acid has shown no significant human pharmacokinetic interactions with food or grapefruit juice at doses up to 200 mg/day. There are limited data on the pharmacokinetics of simvastatin

    Fórmula:C25H40O6
    Pureza:Min. 95%
    Cor e Forma:White Powder
    Peso molecular:436.58 g/mol

    Ref: 3D-IS63828

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