APIs para pesquisa e impurezas

<p>Valdecoxib dimer is a drug product that has been custom synthesized to meet the customer's requirements. It is an analytical standard and is available in high purity. Valdecoxib dimer has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Valdecoxib dimer also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture. The drug product may also be used as a pharmacopoeia impurity standard for HPLC analysis of natural products.</p>

<p>Cefotaxime sodium impurity D is a cephalosporin-type antibiotic that is produced by the chemical reaction of cephalosporin with acetic acid. Cefotaxime sodium impurity D, also known as deacylated cefotaxime sodium, is not active against gram-negative bacteria. The relevance and importance of this compound are limited to its role in the metabolism and excretion of cephalosporins. Cefotaxime sodium impurity D can be used as an inhibitor in the study of antimicrobial agents, such as cephalosporins, which are important for treating bacterial infections.</p>

<p>Rapamycin is a natural product from Streptomyces hygroscopicus. It has been shown to inhibit T- and B-lymphocyte proliferation, induce apoptosis of lymphocytes, and suppress both humoral and cell-mediated immune responses. Rapamycin is also an immunosuppressant that decreases the incidence of rejection in organ transplant patients.<br>Rapamycin is used as a drug product in the form of a sterile solution for injection. The purity of rapamycin should be at least 99%, with less than 1% impurities, such as 42-O-tert-butyldimethylsilyloxyethyl rapamycin (TBDMS). Rapamycin is not currently available on the market as an API, but it may be custom synthesized for research purposes or for clinical trials.</p>

<p>17-o-(Acetyl-d3)-6-methylprednisolone is a drug product that belongs to the group of corticosteroids. It is used for the treatment of inflammatory conditions and autoimmune diseases. This API is used as an impurity standard in analytical methods such as HPLC, and it can be synthesized from natural sources or synthetically. 17-o-(Acetyl-d3)-6-methylprednisolone can also be used in R&amp;D for the development of drugs targeting niche markets, such as those with high purity requirements.</p>

<p>N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is an analytical standard that is used for the determination of formamide in pharmaceutical formulations. N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is a synthetic compound and has a natural impurity which may be present at levels up to 10%. The CAS number for this compound is 911805-54-4. N-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-formamide is an impurity standard for HPLC analysis. It has been synthesized and characterized by the United States Drug Enforcement Agency (DEA). It can be used as a reference substance in pharmacopoeia standards.</p>

<p>2,2-Bis[4-(2-diethylaminoethoxy)phenyl]-1,2-diphenylethanone (bis-DEA) is a synthetic metabolite that has been shown to inhibit human liver microsomal cytochrome P450 enzymes. This product is intended for use as an analytical reference standard for the purity of drug products. It is also used in pharmacological and metabolic studies.</p>

<p>Please enquire for more information about 4'-Bromo-2-(diethylamino)-2',6'-acetoxylidide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Meclizine ortho chloro isomer bishydrochloride salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>O-Acetyl silodosin is a synthetic, natural metabolite of silodosin. It is a nicotinic acid derivate that inhibits the activity of phosphodiesterase type 5 (PDE5) and has been used as a research and development standard for PDE5 inhibitors. O-Acetyl silodosin is an impurity in the commercial drug product, Silodosin®.</p>

<p>4-Hydroxymethyl-5-methylimidazol (HMMI) is a corrosion inhibitor that is used in the production of nanomaterials. It has been shown to be an effective treatment for wastewater containing hydrochloric acid and organic solvents. The reaction between HMMI and the acids in wastewater forms a complex that prevents the corrosion of metal surfaces. HMMI can be synthesized by reacting aesculus with formaldehyde in an organic solvent, such as acetone or chloroform, at room temperature. HMMI has also been shown to have antiviral potency and is used in skin care products, such as lotions and shampoos, due to its ability to penetrate the skin barrier. Magnetic resonance spectroscopy (MRS) was used to study the effect of HMMI on skin cells, while electrochemical methods were used to investigate how it inhibits viral activity.</p>

<p>Tetrahydro-3-[2-[4-(6-hydroxy-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (THPP) is a drug product that belongs to the class of drugs used for research and development. It has been shown to have antiinflammatory properties in animal models. THPP is a metabolite of metoprolol and has been shown to be an impurity of metoprolol. The analytical properties of THPP are not yet known. Tetrahydro-3-[2-[4-(6-hydroxy-1,2-benzisoxazol-3--yl)-1--piperidinyl]ethyl]-2--methyl--4H--pyrido[1,2--a]pyrimidin--4one</p>

<p>Synucleozid is an anticancer drug that has shown promising results in the treatment of tumors. It is derived from geniposide, a medicinal compound found in Chinese herbal medicine. Synucleozid works by inhibiting cancer cell growth and inducing apoptosis, or programmed cell death, in cancer cells. This drug also acts as a protein kinase inhibitor, which can help to prevent the spread of cancer cells. Synucleozid has been tested extensively in human urine samples and has shown significant activity against a range of different types of cancer cells. In addition to its potential as an anticancer agent, Synucleozid may have other therapeutic applications due to its unique analog structure.</p>

<p>4-Hydroxy-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1dioxide is a drug product that is used as an analytical reference material. It is a white to pale yellow powder that is soluble in water and has a molecular weight of 343.4 g/mol. The compound has been used for the development of drugs with therapeutic potential against cancer, diabetes, and other diseases. The following are some of the impurities that may be found in 4-hydroxy-N-2-pyridinyl-2H--1,2--benzothiazine--3--carboxamide--1,1dioxide: CAS No.: 65897 - 46 - 3 Molecular weight: 343.4 g/mol Melting point: Boiling point: Density: 1.7 g/cm</p>

<p>Please enquire for more information about Dehydro nicardipine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Oxolamine citrate salt is a pharmaceutical drug used for the treatment of scleroderma. It acts as an iron chelator and inhibits the production of the cytotoxic agent, podophyllotoxin, by inhibiting its conversion to epipodophyllotoxin. Oxolamine citrate salt has been shown to have a beneficial effect on Alzheimer's disease and may have therapeutic potential in other neurological diseases such as Parkinson's disease. The compound has been shown to inhibit acetonitrile-induced hyperactivity in mice. Oxolamine citrate salt has also been found to be effective against Pseudomonas aeruginosa and Staphylococcus aureus isolates that are resistant to oxacillin, ginkgetin, or pseudoephedrine. This drug can be analyzed using liquid chromatography with an acetonitrile gradient and a hypersil C18 column.</p>

<p>9-Desfluoro-9(11)-epoxy triamcinolone acetonide is a synthetic metabolite of the natural drug product 9-desfluoro-9(11)-epoxy triamcinolone acetonide. It is a white to yellowish crystalline powder that is soluble in acetone, ethanol, and chloroform. It has been used as an analytical standard for HPLC and GC analysis. The purity of 9-desfluoro-9(11)-epoxy triamcinolone acetonide should be greater than 98% with less than 0.1% impurities determined by NMR spectroscopy or by high performance liquid chromatography (HPLC).</p>

<p>Clomiphene is a drug that is used to treat female infertility. It binds to estrogen receptors and blocks the natural production of estrogen, which is necessary for ovulation. Clomiphene has been shown to have toxicological effects on human serum, including the induction of metabolic disorders such as hyperlipidemia and hyperglycemia. It also has an adverse effect on the matrix effect in vitro, which may be due to its ability to inhibit enzymes involved in citrate metabolism. Clomiphene has been shown to increase the risk of developing type 2 diabetes mellitus in women with pre-diabetes or gestational diabetes mellitus, although this risk was reduced by the use of metformin. Trans-clomiphene is a synthetic form of clomiphene that may have fewer side effects.</p>

<p>Balsalazide 3-isomer (BZ3) is a diacid that is used as an anti-hypertensive drug. BZ3 has been shown to be a prodrug of balsalazide, which is converted in vivo to the active form by hydrolysis of the ester linkage. The prodrug approach was designed to provide an orally available agent for use in patients with colitis and ulcerative colitis. The synthetic process begins with the reaction of salicylic acid and bisoprolol to form the ester product, which then undergoes a second reaction with acetyl chloride to form the acyl chloride intermediate. This intermediate reacts with balsalazide and yields BZ3 when heated to high temperatures. BZ3 contains no impurities because it is synthesized from pure starting materials, whereas commercially available balsalazide may contain impurities such as salicylic acid or colitis.</p>

<p>Procaine is a local anesthetic that is used to block nerve conduction in the peripheral nervous system. Procaine is soluble in water, alcohol, and propylene glycol but insoluble in ether and chloroform. It is active at low concentrations and has long-lasting effects. In addition, procaine can be given by intramuscular injection or intravenously. It has been shown to be effective for the treatment of thromboses and as a preventive measure for people with heart disease who are prone to blood clots. Procaine also inhibits noradrenaline release from sympathetic nerve terminals and blocks the uptake of noradrenaline into sympathetic neurons at synapses.</p>

<p>Please enquire for more information about 5-Deoxy-Δ5,6-8-epi-tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Trifenofos is a potent protein kinase inhibitor that has shown promising anticancer activity in preclinical studies. It targets specific kinases involved in tumor growth and survival, leading to apoptosis or programmed cell death of cancer cells. Trifenofos is an analog of a natural toxin found in Chinese urine, which has been used for centuries in traditional medicine to treat various ailments. In addition to its anticancer properties, trifenofos also shows potential as an inhibitor of other diseases involving abnormal protein kinase activity. Its effectiveness has been demonstrated in human cancer cell lines and animal models. With its ability to selectively target cancer cells, trifenofos holds great promise as a potential therapeutic agent for the treatment of various cancers.</p>

<p>Paclitaxel impurity 2 is an analytical standard for the measurement of paclitaxel purity. Paclitaxel impurity 2 is a natural metabolite of paclitaxel, and its presence in a drug product is indicative of a higher level of contamination with paclitaxel. The impurity is found in concentrations greater than 10% up to 100%.</p>

<p>(R)-1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline is a potent inhibitor of kinases that play key roles in cancer. It is an analog of a natural product found in human urine and has been shown to have anticancer activity in tumor models. This compound works by inhibiting the activity of protein kinases involved in cell proliferation and survival, leading to apoptosis or programmed cell death. (R)-1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline has potential as a medicinal agent for the treatment of cancer due to its ability to inhibit cancer cell growth and promote apoptosis. Its unique structure makes it a promising candidate for further development as a kinase inhibitor.</p>

<p>WH-4-025 is a potent kinase inhibitor that has shown promising results in the treatment of various cancers. It is derived from Chinese medicinal herbs and has been extensively studied for its anticancer properties. WH-4-025 works by inhibiting the activity of specific kinases that are involved in tumor growth and cell cycle regulation. It has been shown to induce apoptosis in cancer cells, leading to their death, and also inhibit the growth of leukemia cells. This protein inhibitor has been found to be effective against a wide range of human cancers and is currently being investigated as a potential therapy for cancer patients. WH-4-025 is excreted through urine, making it an attractive candidate for further development as an anticancer drug.</p>

<p>DL-threo-Ritalinic Acid is a dopamine receptor agonist that has been shown to be effective in treating hyperactivity, or attention deficit disorder (ADHD). It has been found to be more efficacious than dextro-amphetamine, another stimulant drug used for the treatment of ADHD. DL-threo-Ritalinic Acid is believed to work by affecting the neurotransmitters in the brain and altering the balance of dopamine receptors. In a two-way crossover study, preschool children were given either 0.5mg/kg of DL-threo-Ritalinic Acid or placebo for three days. The results showed that this drug was more effective than placebo and significantly improved reaction time. DL-threo-Ritalinic Acid also increased α1 acid glycoprotein levels in plasma, which may account for its effectiveness as an antihypertensive agent.</p>

<p>Hexyl ((4-aminophenyl)(imino)methyl)carbamate hydrochloride is a research and development impurity standard that has been shown to be synthetically derived. It is used as an analytical reference standard for HPLC analysis of drug products and metabolites. Hexyl ((4-aminophenyl)(imino)methyl)carbamate hydrochloride is a metabolite of the prescription drug, phenytoin (Dilantin). It is also a metabolite of the anti-inflammatory drug, naproxen (Naprosyn).</p>

<p>3'-Des(dimethylamino)-3'-keto azithromycin is a prodrug that is hydrolyzed in vivo to the active form of azithromycin. 3'-Des(dimethylamino)-3'-keto azithromycin has an elution time of about 10 minutes on a C18 column, which is considerably longer than the 5-minute elution time for azithromycin. The chromatogram of 3'-Des(dimethylamino)-3'-keto azithromycin shows two peaks, one at 6 minutes and another at 10 minutes. These two peaks are due to impurities in the drug product, namely itraconazole and fluconazole. 3'-Des(dimethylamino)-3'-keto azithromycin has shown bioequivalence with its parent molecule, azithromycin.</p>

<p>6-Chloro-5-nitro-2-(propylthio)-4(1H)-pyrimidinone is a compound that is commonly used as an intermediate in the synthesis of various chemicals. It is known for its impurities, including methanol, sulfadiazine, and hydrochloric acid. This compound has been studied for its potential therapeutic applications, including its ability to activate interferon and promote hematopoiesis. Additionally, it has been found to exhibit antioxidant activity and can help prevent lipid peroxidation. 6-Chloro-5-nitro-2-(propylthio)-4(1H)-pyrimidinone also shows promise as a photodegradation agent for certain herbicides and prasugrel. Its reactive nature makes it suitable for various chemical reactions and applications in research and development.</p>

<p>Rac-N-Demethylpromethazine is an inorganic compound with a diameter of 0.15 nm. It has been used as a buffer for chromatographic methods, analytical methods, and to validate the particle size analyzer. The powder form of Rac-N-Demethylpromethazine can be analyzed using a liquid chromatography method. This method can be used to analyze the concentration of Rac-N-Demethylpromethazine in different samples and to measure the amount of time it takes for Rac-N-Demethylpromethazine to travel through the chromatograph.</p>

<p>Please enquire for more information about (9R)-9-(2-Pyridinyl)-6-oxaspiro[4.5]decane-9-ethanamine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about H3Resca-TFP including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Benzylpenicillin diethylaminoethyl ester hydroiodide is a potent broad-spectrum antimicrobial agent that inhibits the growth of bacteria by inhibiting protein synthesis. It is used to treat microbial infections and has been shown to be effective against Streptococcus species, including Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus viridans. Benzylpenicillin diethylaminoethyl ester hydroiodide binds to the 50S ribosome subunit of bacteria and prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis. This binding prevents protein synthesis and cell division.</p>

<p>Bazedoxifene 5-β-D-glucuronide is an analog of bazedoxifene, a selective estrogen receptor modulator used in the treatment of osteoporosis. This compound has shown promising anticancer properties and has been studied extensively in Chinese hamster ovary cells. Bazedoxifene 5-β-D-glucuronide has been found to induce apoptosis in cancer cells and inhibit the activity of kinases involved in tumor growth. It is a potent inhibitor of several human protein kinases, including cyclin-dependent kinase 2 (CDK2) and glycogen synthase kinase 3 beta (GSK3β), which are important targets for medicinal chemists developing kinase inhibitors. This compound is excreted primarily in urine and may have potential as a therapeutic agent for various types of cancer.</p>

<p>7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester is an impurity in the synthesis of drugs. It is a white to off-white powder or crystalline solid with a melting point of 114°C. 7-Aminopyrazolo[1,5-a]pyrimidine-3,6-dicarboxylic acid 3,6-diethyl ester has been studied for its metabolism and toxicity. It is not naturally occurring and was synthesized in the laboratory. It may be used as a reference material for pharmacopoeia standards.</p>

<p>(-)-Nefopam is a medicinal compound that acts as an inhibitor of kinases, which are enzymes involved in many cellular processes. It has been shown to inhibit the growth of cancer cells by inducing apoptosis, or programmed cell death. In Chinese hamster ovary cells, (-)-Nefopam has been found to inhibit the uptake of xylose into the cell, suggesting that it may have an effect on carbohydrate metabolism. This compound has also been shown to interfere with the cell cycle and protein synthesis in human cancer cells. Overall, (-)-Nefopam shows promise as a potential therapeutic agent for cancer treatment.</p>

<p>Please enquire for more information about rac Clavam-2-carboxylic acid sodium salt including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluticasone Impurity D is a sulfoxide that is found in the drug fluticasone. It is a conjugate of fatty acid and fatty alcohol, which are esters of irritants. Fluticasone Impurity D is an experimental model for inflammatory diseases. It can be used as a pharmaceutical dosage to enhance the effects of other drugs by increasing their absorption through the skin. The effects of this drug have been tested on tissues and experimental models, but not on humans.</p>

<p>Sudan R-d3 is a medicinal compound that acts as a kinase inhibitor, targeting kinases involved in cancer cell growth and proliferation. It has been shown to inhibit the activity of several kinases in human urine and cancer cells. Sudan R-d3 is an analog of a Chinese herbal medicine used for its anticancer properties. This compound induces apoptosis, or programmed cell death, in tumor cells by inhibiting the activity of specific proteins involved in cell survival and proliferation. As such, Sudan R-d3 shows potential as an anticancer agent and may be useful for developing new cancer treatments.</p>

<p>Fadolmidine hydrochloride is a drug that has been shown to increase the movement of bowel contents in people with constipation. It may also be used to treat bone cancer, although it is not yet known if this drug will work as well as the current treatment options. Fadolmidine hydrochloride belongs to a class of drugs called antinociceptive agents, which have been shown to be effective in reducing pain and inflammation in patients with inflammatory bowel disease. The metabolic rate of fadolmidine hydrochloride is slow, and its side-effect profile is low. Pharmacokinetic properties include good chemical stability, rapid absorption from the GI tract, and moderate distribution throughout the body.</p>

<p>Please enquire for more information about O4-Desmethyl O3-desethyl apremilast including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ornidazole-hydroxy is a drug product that is manufactured using HPLC. It is used to be the standard for Drug development, Natural, Custom synthesis, Research and Development, Metabolite, Impurity standard, analytical, API impurity and Synthetic. The metabolite of ornidazole-hydroxy is an impurity in the pharmacopoeia. Ornidazole-hydroxy has been shown to inhibit bacterial growth in vitro by inhibiting protein synthesis through inhibition of ornithine decarboxylase. Ornidazole-hydroxy also showed good activity against Clostridium difficile in animal models of infection.</p>

<p>Ganciclovir mono-o-propionate is an analytical reference standard for HPLC analysis. It is also a drug development intermediate, an API impurity, and a metabolite of ganciclovir. Ganciclovir mono-o-propionate is a crystalline solid with a melting point of 119°C and a molecular weight of 312.5. This compound can be found in the USP/NF (2009) as an impurity in the ganciclovir product. Ganciclovir mono-o-propionate has been used by companies to synthesize ganciclovir or other analogues for research purposes. The natural form of this compound can be found in plants such as apple leaves and grape leaves, but it can also be synthesized from chloroacetic acid and propionic acid.</p>

<p>Trazodone Hydrochloride BP Impurity A is an unproven impurity of Trazodone. It inhibits the uptake of serotonin by 5-HT receptors, which may be important in the treatment of depression. This compound also inhibits platelet aggregation and has been found to inhibit the activity of tricyclic compounds, such as piperazine and propionic acid.</p>

<p>This product is an organic compound that has a molecular formula of C6H7N3O2. It is a white solid with a melting point of 76.5 °C and an elution time of 7 minutes (range, 1-10 minutes). The detection method is based on the color change from yellow to blue in the presence of dimethylformamide (DMF). This product is used as a solvent for various chemical reactions and can be used in the synthesis of other products. 3-(Formylamino)-1H-pyrazole-4-carboxamide is used in analytical chemistry to determine substances such as pH, ionic strength, and concentration. In addition, this product can be used to quantify substances such as drugs or pharmaceuticals.</p>

<p>Pyridine-2-methanol methiodide is a drug product that is used as an HPLC standard. It is also used in the development of new drugs, natural products, and research and development. Pyridine-2-methanol methiodide has been shown to have anti-inflammatory properties in metabolism studies. This compound has a niche application as an API impurity standard for analytical purposes. The CAS number for this compound is 3313-51-7. Synthetic methods are required to produce this substance. It is a high purity chemical with pharmacopoeia applications.</p>

<p>Please enquire for more information about 4-Acetyl-3,4-dihydro-2H-pyrido[3,2-b]oxazine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-(N,N-Dipropylsulfamoyl)benzamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>K-(D-1-Nal)-fwll-NH2 is a drug product that is custom synthesized to order. It has been shown to have high purity, analytical and metabolic studies. The metabolite of K-(D-1-Nal)-fwll-NH2 is D-1-nal. This product has been shown to be used in the development of drugs for niche markets and as an impurity standard for HPLC analysis. K-(D-1-Nal)-fwll-NH2 is also a synthetic drug that belongs to the class of naphthyridines. It has a CAS number of 1394288-22-2 and an impurity standard that can be used for research and development purposes.</p>

<p>Please enquire for more information about Allyl ester of atorvastatin cyclic (isopropyl) impurity including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Hygrine-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Misoprostol Impurity 13 is a mixture of diastereomers from the synthesis of misoprostol. This material is not found in nature, and is not an impurity in any drug product. It has been synthesized for research purposes, to study the metabolism of misoprostol. The material is an analytical standard for HPLC, and can be used as a reference material for pharmacopoeia or drug development studies. Misoprostol Impurity 13 can also be used as a synthetic impurity standard for analytical HPLC.</p>

<p>Irinotecan is a drug product that is used in the treatment of cancer. It is a prodrug that must be activated by metabolism to its active form, SN-38. Irinotecan lactone impurity is an impurity standard and has been shown to have analgesic properties in mice. It has also been shown to inhibit the growth of colon cancer cells.</p>

<p>Please enquire for more information about Pinacol-d12 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2,3,6,7-Tetrachlorobiphenylene is a potent inhibitor of kinases that are involved in cancer cell growth and proliferation. It is an analog of tolvaptan, a drug used to treat hyponatremia by increasing urine output. This compound has been shown to induce apoptosis in cancer cells and inhibit tumor growth. Studies have found that 2,3,6,7-Tetrachlorobiphenylene inhibits the activity of human protein kinases and may be effective against various types of cancer. This Chinese compound has promising anticancer properties and could potentially be used as a therapeutic agent for cancer treatment.</p>

<p>N-Hydroxy-6-(trifluoromethoxy)-2-benzothiazolamine (NHTB) is a drug that has been shown to have clinical use as an anticonvulsant. NHTB is a metabolite of diazepam, which is used to treat seizures and anxiety. It binds to the GABA receptor and increases the duration of time that the chloride channel remains open, leading to inhibition of neural activity and in turn seizure control. NHTB has been found to be more potent than diazepam and has also been shown to bind to other receptors, such as dopamine receptors.</p>

<p>Erythromycin impurity K is a synthetic impurity of erythromycin, which is an antibiotic drug product. It is typically found in pharmaceutical products that are made from natural sources and is used as a research and development (R&amp;D) standard for the pharmacopoeia. Erythromycin impurity K can be purified by HPLC or other means to create high purity standards for analytical purposes. The chemical name of this compound is 3-[[[3-(2-Amino-4-thiazolyl)-1,2,4-triazol-5-yl]amino]methyl]-1H-indole.</p>

<p>8-Bromoadenosine 3',5'-cyclic monophosphothioate sp-isomer sodium (8-bromo-cAMP) is a cyclic nucleotide that functions as a second messenger for the activation of protein kinases. It binds to the regulatory subunit of desmoplakin and causes it to release from the catalytic subunit, which then activates the catalytic subunit. 8-Bromo-cAMP is localized in apical cells of mononuclear phagocytes and in cytoplasmic granules of neutrophils. This compound has been shown to activate protein kinases in immunostained human neutrophils and thus regulate inflammatory responses.</p>

<p>Please enquire for more information about N-Desmethyl eletriptan hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fluocortolone Impurity 8 is a drug product. It is an impurity standard for fluocortolone and has been purified from natural sources. Fluocortolone Impurity 8 is a metabolite of fluocortolone and has been synthesized for research purposes. Fluocortolone Impurity 8 is also a drug product that has been developed by the Pharmaceutical Research and Development team at the company with CAS No. 87-69-2. Fluocortolone Impurity 8 can be used as an analytical standard, API impurity, or pharmacopoeia reference material in metabolic studies.</p>

<p>Pantoprazole sulfone N-oxide is a prodrug that is converted to the active form pantoprazole in the stomach where it inhibits gastric acid secretion. Pantoprazole sulfone N-oxide has been shown to be genotoxic, and can cause polyvinyl chloride to degrade when stored together. Reconstituted solution of this drug should be used within 24 hours after reconstitution, as the chemical stability of this drug decreases rapidly. Validation studies have been conducted on different analytical methods for determining pantoprazole concentrations in reconstituted solutions, and these methods have been harmonized with those published by the United States Pharmacopeia (USP). The pump inhibitor activity of pantoprazole sulfone N-oxide has been demonstrated in dogs, and it is also useful for treating acid reflux disease in humans. Pantoprazole sulfone N-oxide is unstable at high temperatures (&gt;25°C), so should not be refrigerated or</p>

<p>Hydrocortisone EP Impurity H is an analytical standard that is used as an impurity in the production of hydrocortisone. It has been shown to have a purity level of 99.5% and can be used as a reference standard for HPLC analysis. Hydrocortisone EP Impurity H can also be used as a reference standard for drug product development, API impurities, and drug metabolite identification.</p>

<p>Isoleucine valsartan is a drug product that is chemically synthesized from the natural amino acid isoleucine. The chemical synthesis of this drug product is carried out in an impurity-free environment and under strict quality control. Isoleucine valsartan has been developed for research and development purposes and as an analytical standard. It can be used for the production of high purity, pharmacopoeia grade API or as an impurity standard for HPLC analysis.</p>

<p>Tamsulosin sulfonic acid is a drug product that belongs to the class of synthetic drugs and is used for the treatment of urinary tract disorders. It has an analytical purity greater than 99% and is metabolized in the body to produce a metabolite. Tamsulosin sulfonic acid was originally developed as a lead compound for the treatment of BPH, but was never approved. Tamsulosin sulfonic acid is also known as a niche drug because it has limited application in comparison to other drugs.</p>

<p>1-Benzyl-4-phenylpiperidine-4-carboxylic acid (1BPPC) is a soluble guanylate cyclase activator that is used as a research tool. It was shown to activate the soluble guanylate cyclase, which generates cyclic GMP from GTP. The activation of this enzyme leads to an increase in intracellular cGMP levels, which triggers the relaxation of smooth muscle cells and improves erectile function. 1BPPC has also been shown to enhance the sensitivity of the rat prostate gland to testosterone. This effect may be due to the inhibition of phosphodiesterase type 5 (PDE5), which degrades cGMP.</p>

<p>GPI-16552 is an inhibitor that has shown potential as an anticancer agent. It induces apoptosis in cancer cells by disrupting the cell cycle and inhibiting the activity of certain proteins. Studies have shown that GPI-16552 can inhibit tumor growth in human cancer cell lines, making it a promising candidate for future cancer treatments. Additionally, this inhibitor has been found in Chinese urine samples and may have potential as a natural source of vitamin-like compounds. Overall, GPI-16552 is a powerful inhibitor with exciting potential for both cancer research and health supplementation.</p>

<p>Dibenzazepine-10,11-dione is a dibenzazepine that has been used as a solvent in pharmacopoeias. It has been shown to stabilize the solvents and increase the rate of dissolution of other compounds. Dibenzazepine-10,11-dione can be sublimed or recrystallized from solvents such as chloroform, acetone, ethanol, benzene, ethers, and halogenated hydrocarbons. The compound is orthorhombic at room temperature and can be converted to monoclinic by heating or cooling. This compound has not been extensively studied because it is insoluble in water.</p>

<p>1-[2-(3-Chloro-2-hydroxypropoxy)phenyl]-3-phenyl-1-propanone is a synthetic drug product. It is an impurity standard for HPLC, and drug development and research. This compound is also used as an analytical reference. The CAS number for this chemical is 165279-79-8.</p>

<p>(R)-(+)-1,1,2-Triphenyl-1,2-ethanediol is a heterocyclic compound with a five-membered ring. It is chiral and has two stereogenic centers in its structure. This chemical can be prepared by the reaction of hexane with phosgene and oxygen atoms in the presence of silicon. The preparative method for the synthesis of (R)-(+)-1,1,2-triphenyl-1,2-ethanediol involves the use of chiral phosphonates to produce a mixture that contains just one enantiomer.</p>

<p>DC-5163 is a protein analog that has shown potent anticancer activity in preclinical studies. It inhibits the activity of kinases, which are enzymes involved in cancer cell growth and survival. DC-5163 has been shown to induce apoptosis, or programmed cell death, in various types of cancer cells, including those from human tumors and Chinese hamster ovary cells. This compound also acts as a toxin for cancer cells by interfering with their ability to divide and grow. In addition, DC-5163 has shown promising results as an inhibitor of tumor growth in animal models. Its potential as a therapeutic agent for cancer treatment is currently being investigated.</p>

<p>2-Demethoxy-2-chloro urapidil is an analytical standard that is used in drug development and research. It is a synthetic compound with a high purity that is extensively used as an impurity standard in the manufacture of other drugs. The CAS number for 2-demethoxy-2-chloro urapidil is 34661-73-9.</p>

<p>Foxy 5 trifluoroacetic acid is a nanofiber that can be used to create a cancer-fighting drug. It is made of polymers and has been shown to have the ability to absorb electromagnetic fields from all directions. Foxy 5 trifluoroacetic acid is packaged in a small, easy-to-handle container that releases the drug when the package is positioned against the tumor. This drug can be used for colon cancer and colorectal cancer because it targets only cells with efflux proteins, which are proteins that promote cancer cell metastasis. In addition, Foxy 5 trifluoroacetic acid has been shown to be effective against prostate and breast cancers by targeting specific receptors on these cells.</p>

<p>Amoxicillin EP Impurity K is a synthetic impurity found in amoxicillin. Amoxicillin is an antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit. Amoxicillin EP Impurity K is a metabolite of amoxicillin, which has been shown to inhibit protein synthesis and cell division. This impurity can be used as a reference material for analytical purposes or as a standard in drug development.</p>

<p>(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol is a synthetic drug product that has been found as an impurity in other drugs. It has a natural origin and can be synthesized by chemical methods. This compound is used in chemical analysis to determine the purity of the drug product. This compound is also used in research and development to develop drugs for niche markets. (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol has high purity and meets pharmacopoeia standards.</p>

<p>Please enquire for more information about 2′,4′′-Bis-O-(trimethylsilyl)-erythromycin 9-[O-(1-ethoxy-1-methylethyl)oxime] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ergoline-8β-carboxylic acid methyl ester hydrochloride is a drug product that has been developed for research and development. It is an analytical standard, impurity standard, and HPLC standard. Ergoline-8β-carboxylic acid methyl ester hydrochloride is a metabolite of ergometrine, which is an ergot alkaloid with pharmacological properties similar to those of ergonovine. Ergoline-8β-carboxylic acid methyl ester hydrochloride is used as an impurity in the synthesis of ergometrine. The purity of this compound meets the requirements of pharmacopoeia standards for use as an analytical reference substance.</p>

<p>Profluthrin is a potent analog of the Chinese medicinal herb, Chrysanthemum indicum. It acts as an inhibitor of protein kinases involved in the regulation of cell cycle and apoptosis. Profluthrin has been shown to have anticancer properties by inducing apoptosis in cancer cells and inhibiting tumor growth. This compound also shows potential as a urinary inhibitor for the prevention of urinary tract infections. Its unique chemical structure allows it to act selectively on specific protein kinases, making it a promising candidate for targeted cancer therapy.</p>

<p>Brobactam is a potent inhibitor of beta-lactamase enzymes and is often used in combination with other antibiotics to enhance their efficacy. It has been shown to be effective against gram-negative bacteria, including those that are resistant to other antibiotics. Brobactam has also been investigated for its potential use in cancer treatment. Studies have shown that brobactam can induce apoptosis in cancer cells by inhibiting kinase activity, which is essential for cell survival and proliferation. In addition, brobactam analogs have been developed that show promising anticancer activity against human cancer cell lines and Chinese hamster ovary cells. Overall, brobactam has the potential to be a valuable tool in the fight against both bacterial infections and cancer.</p>

<p>Azathioprine impurity B is an analog of the immunosuppressant drug azathioprine. It has been found to have potent anticancer activity in vitro, including against cancer cells from human and Chinese hamster origins. Azathioprine impurity B has been shown to inhibit kinases, which are enzymes that play a key role in cell signaling pathways that regulate cell growth and survival. This inhibition induces apoptosis, or programmed cell death, in cancer cells. Azathioprine impurity B is also a potent inhibitor of nifedipine-sensitive calcium channels, which may contribute to its anticancer activity by disrupting intracellular calcium signaling.</p>

<p>N-(Aminosulphonyl)-2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methylsulphinyl]propanimidamide (NTSX) is an analytical standard and a metabolite of the drug product N-(aminosulphonyl)-2-[[[2-[(aminothiazolyl)methyl]sulfinyl]propanimidamide (NTST). The CAS number is 109467-06-3. NTSX is a white to off-white crystalline powder that is soluble in water and has a molecular weight of 296.37. It has been shown to be active against ampicillin resistant strains of Staphylococcus aureus, but not against methicillin resistant strains. NTSX can be synthesized from the drug NTST or obtained as an impurity from the synthesis of NTST.</p>

<p>1,4-Bis[(tetrahydro-2-furanyl)carbonyl]-piperazine is a synthetic drug product. It is used as an analytical standard to help elucidate the metabolic pathway of drugs and their metabolites. This compound has been shown to be metabolized by various enzymes including CYP450, glutathione reductase, and esterases. It can also be synthesized from 1,4-dihydropyridine and 2-furancarboxaldehyde. The physical properties of 1,4-bis[(tetrahydro-2-furanyl)carbonyl]-piperazine are: white powder; mp 178°C; IR max 1710 cm−1 (CO); UV max 221 nm (EtOH). The impurities in this product are: 1-(2H)-Quinolinone (CAS No. 2467-94-1) which may have a maximum concentration</p>

<p>Please enquire for more information about Rpr121056-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>O-Desmethyl urapidil is an impurity of the drug product, urapidil. It is a synthetic compound that is not found in nature. This compound has been used as an analytical reference standard for HPLC and as a metabolite in metabolism studies.</p>

<p>(8aS)-2-(2,6-Dimethylphenyl)-3,3-dimethylhexahydroimidazo(1,5-A)pyridin-1(5H)-one is a synthetic compound that is used as an impurity standard to help detect and quantify other compounds in the research and development of new drugs. The drug product contains this impurity at a concentration no greater than 10%. This substance is also used for analytical purposes and can be found in natural products. Metabolism studies have shown that this substance is metabolized by cytochrome P450 enzymes. (8aS)-2-(2,6-Dimethylphenyl)-3,3-dimethylhexahydroimidazo(1,5-A)pyridin-1(5H)-one has been shown to inhibit protein synthesis.</p>

<p>Vinorelbine N'B-oxide is a drug product that is used as an analytical or impurity standard. It is a natural product and its chemical structure has been determined by HPLC. Vinorelbine N'B-oxide is metabolized in vivo to vinorelbine and N'-desmethylvinorelbine, which are metabolites of vinorelbine. It has been shown to be useful for metabolism studies.</p>

<p>N-(4-Chlorophenyl)-2-hydroxy-3-[(4-methoxyphenyl)sulfonyl]-2-methylpropanamide (CAS No. 338424-26-3) is a drug product with high purity, analytical and CAS number 338424-26-3. Metabolism studies of this drug are required for its development as a drug. The metabolite of this drug is 2-[(4-chlorophenyl)sulfonyl]-N-(3,4,5-trimethoxyphenyl)-2HCl. It is a natural product that has been synthesized for the first time in our lab. This chemical substance belongs to the class of synthetic compounds that are used as an impurity standard for HPLC analysis.</p>

<p>Baclofen inhouse impurity is an analog of baclofen that has been shown to have potent anticancer properties. It acts as a kinase inhibitor, specifically inhibiting the activity of certain kinases that are involved in cancer cell growth and proliferation. In preclinical studies, this compound has demonstrated significant tumor growth inhibition and induction of apoptosis in human cancer cell lines. This medicinal compound is commonly used in Chinese medicine for its anti-cancer effects. Baclofen inhouse impurity can be isolated from urine or synthesized chemically. Its potential as a protein kinase inhibitor makes it a promising candidate for further development as an anticancer agent.</p>

<p>BAMEA-O16B is a human analog with potent anticancer properties. This Chinese medicinal compound has been shown to induce apoptosis in tumor cells and inhibit the growth of cancer cells. BAMEA-O16B acts as an inhibitor of protein kinases, which play a key role in cell cycle regulation and are often overexpressed in cancer cells. This compound has been found to be effective against a range of cancers, including breast, lung, and colon cancer. In addition, BAMEA-O16B has been shown to have low toxicity and is excreted primarily in urine. This makes it a promising candidate for further development as an anticancer therapy.</p>

<p>N-Methyl mitomycin A is an aziridine compound that is used as a cytotoxic agent to treat inflammatory diseases, such as cavity. It is also used to treat cancer and autoimmune diseases. N-Methyl mitomycin A inhibits the growth of tumor cells by cross-linking DNA in the target tissue, which prevents replication of the cell. This drug has been shown to induce lymphocytic leukemia in some animals by binding with DNA sequences and preventing RNA synthesis. N-Methyl mitomycin A also inhibits protein synthesis, leading to the death of the cell.</p>

<p>4,7-Dihydro megestrol acetate is a drug product that has been custom synthesized for research and development purposes. It is an analytical standard with a purity of ≥99% and a CAS number of 14994-27-5. Metabolism studies have been conducted in both rats and mice to determine the metabolic pathway of 4,7-dihydro megestrol acetate. The metabolites found in this study were 4,7-dihydro megestrol and the acetate ester of 4,7-dihydro megestrol. Metabolite standards are used to identify substances produced by metabolism or chemical reactions in biological samples. These standards are used as reference points for measuring the concentration or quantity of other substances in biological samples. Pharmacopoeia standards are used to verify the quality of drugs, food additives, ingredients, and other substances. They also serve as reference points for identifying impurities in substances that may be harmful</p>

<p>FR183998 is an anticancer drug that is derived from Chinese urine. It is a potent inhibitor of human tumor cell growth and has been shown to induce apoptosis in cancer cells. FR183998 works by inhibiting kinases, which are proteins that play a critical role in cell division and proliferation. This drug has been found to be effective against a wide range of cancers, including breast, lung, and colon cancer. Additionally, FR183998 has analogs that have been developed as kinase inhibitors for the treatment of various types of cancer. The use of FR183998 as an anticancer agent shows great promise in the development of new treatments for cancer patients.</p>

<p>3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]sulfinyl]-N-(aminosulfonyl)propanimidamide is a drug product that is custom synthesized. It has a purity of ≥ 98% and is used in analytical, metabolism studies, natural drug development, pharmacopoeia, and research and development. 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]sulfinyl]-N-(aminosulfonyl)propanimidamide has an impurity standard of 5% and can be found under CAS No. 90237-03-9.</p>