APIs para pesquisa e impurezas

<p>Salinamide B is an analog of the natural product Salinamide A, which has been shown to have anti-cancer properties. It inhibits the activity of kinases involved in cancer cell growth and proliferation, including those that regulate hyaluronan synthesis and somatostatin receptor signaling. Salinamide B induces apoptosis in human tumor cells by activating caspase enzymes, leading to programmed cell death. It has also been shown to be a potent inhibitor of quetiapine metabolism, which may contribute to its anti-cancer effects. Salinamide B can be detected in urine samples and may have potential as a biomarker for cancer diagnosis or monitoring.</p>

<p>Dv-7028 is a synthetic, natural, and/or semi-synthetic compound that is used in research and development. It can be used as an analytical standard or HPLC standard. Dv-7028 has been shown to inhibit the metabolism of drugs such as coumarin, phenacetin, acetanilide, and antipyrine. It also serves as an impurity standard for the pharmacopoeia. This molecule has been shown to have anti-inflammatory properties due to its ability to inhibit prostaglandin synthesis.</p>

<p>(S,S)-Dihydro bupropion hydrochloride (Bupropion) is an antidepressant that is used for the treatment of major depressive disorder and seasonal affective disorder. It is a racemic mixture of the two enantiomers, (S,S) and (R,R), with the former being more active than the latter. The drug product contains a racemic mixture of (S,S) and (R,R) in a ratio of approximately 97:3. The analytical impurity in this product is N-desmethyl-bupropion. This impurity has not been found to be pharmacologically active. Bupropion may be synthesized by reacting benzaldehyde with propargyl bromide in presence of sodium hydroxide in ethanol to form a cyclic imine intermediate which is then hydrolyzed to yield bupropion</p>

<p>CDK4/6-IN-2 is an analog of a potent and selective CDK4/6 inhibitor that has shown promising anticancer activity. It works by inhibiting the activity of CDK4 and CDK6 kinases, which are involved in cell cycle progression and cancer cell growth. This inhibitor has been shown to induce apoptosis in human tumor cells, making it a potential candidate for cancer treatment. CDK4/6-IN-2 has been synthesized from urine samples of Chinese medicinal plants and has been extensively studied for its pharmacological properties. It is a highly specific protein kinase inhibitor that shows excellent potency against various types of cancer cells.</p>

<p>Lamivudine epimer</p>

<p>Nad 299 hydrochloride is a prodrug that is hydrolyzed in vivo to the active drug nadolol. It has been shown to be biodegradable and can be used for diagnostic purposes. Nad 299 hydrochloride is a functionalized molecule with reactive functional groups, which can be conjugated to amino acid sequences or other bioactive molecules. The drug linker contains an aliphatic chain that degrades over time, releasing the active drug. Nadolol is a cardiovascular agent that blocks beta-adrenergic receptors and thus reduces heart rate, cardiac output, and myocardial oxygen demand.</p>

<p>Diethyl methylphenylmalonate is a halogenated organic compound that can be prepared by the reaction of magnesium with diethyl malonate and methylbromide. Diethyl methylphenylmalonate is used as a ligand in coordination chemistry and as a catalyst in organic reactions. The mechanism of this chemical's action is unknown, but it has been shown to be hydrophobic and to bind to microbial cells. It also has been demonstrated to have an oxidation catalyst activity. Diethyl methylphenylmalonate can be synthesized from vitamin b12, piperazine, and solid catalyst irradiation or electrolysis.</p>

<p>(R)-3-((R)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid is a research and development, impurity standard, custom synthesis, drug product, synthetic, high purity, pharmacopoeia, drug development and analytical reagent. CAS No. 162148-17-6</p>

<p>Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a synthetic compound that has been used as an impurity standard for the drug product and as a metabolite in pharmacopoeia. Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is also used in research and development, including drug metabolism studies. Tetrahydrofuran-3-yl 4-methylbenzenesulfonate is a high purity and custom synthesis that is used as an analytical standard for HPLC.</p>

<p>Frovatriptan is a drug used to treat migraine attacks. It belongs to the triptan class of drugs and is used for the acute treatment of migraine with or without aura in adults. Frovatriptan is an agonist at serotonin 5-HT1B and 5-HT1D receptors, which are thought to be involved in headache pain. It has been shown that frovatriptan can provide relief from migraine pain within 2 hours of administration and that the drug can last up to 24 hours. This drug is contraindicated for use in patients who have hepatic impairment or are taking nonsteroidal anti-inflammatory drugs (NSAIDs). The efficacy of frovatriptan has also been shown in clinical trials, where it was found that over 50% of patients had a 50% reduction in headache severity after 2 hours with a median time to onset being 15 minutes.</p>

<p>Chlorhexidine digluconate EP Impurity L is a metabolite of chlorhexidine digluconate. It is an impurity found in the drug product, which is used for the treatment of skin and mucous membrane infections. The mechanism of action for chlorhexidine digluconate EP Impurity L is not known. However, it has been shown to be metabolized by CYP3A4 and CYP2C9 enzymes to form chlorhexidine acetate, a metabolite that inhibits bacterial growth, and hydrolyzed by esterases to form 2-hydroxychlorhexidine acetate. This metabolite has been found in the urine of rats following oral administration with chlorhexidine digluconate EP Impurity L.</p>

<p>9α-Fluoro-6α-methylprednisolone 21-acetate is an analog of the hormone cortisol and has potent anti-inflammatory and immunosuppressive properties. It is also being studied for its potential anticancer activity. This compound inhibits cyclin-dependent kinases, which are involved in regulating cell division and growth. It has been shown to induce apoptosis in cancer cells and inhibit tumor growth in animal models. Additionally, it has been found in human urine, indicating that it may have potential as a biomarker for cancer diagnosis or monitoring.</p>

<p>Dehydrodeoxy donepezil is an analytical standard that is used in the manufacture of pharmaceuticals. It is a synthetic drug impurity, and its CAS number is 120013-45-8. Dehydrodeoxy donepezil can be found in the API impurity grade of various drugs, including those that are manufactured by Custom synthesis and natural synthesis. The pharmacopoeia states that dehydrodeoxy donepezil has a purity level of 98% or greater. This product can also be found as a metabolite in humans, with its half-life being approximately 40 minutes.</p>

<p>Ethylene terephthalate cyclic heptamer-d28 is a member of the class of drugs that are used to treat or prevent diseases. Ethylene terephthalate cyclic heptamer-d28 is synthesized by an unspecific method of polymerization. The molecule has been shown to have a chemical structure that can be metabolized by human liver enzymes and excreted in urine as metabolites. Metabolism studies have demonstrated that ethylene terephthalate cyclic heptamer-d28 is rapidly hydrolyzed, mainly by esterases, with the formation of a carboxylic acid derivative and a pyrrolidone derivative.</p>

<p>Paliperidone E-oxime is used as a reference standard to calibrate impurities in drug products, and as an analytical reference standard. Paliperidone E-oxime is also used in the synthesis of other drugs. Paliperidone E-oxime has a CAS number of 1388021-46-2 and a molecular weight of 395.37 g/mol.</p>

<p>Tryptoquivaline D is a metabolite of tryptoquivaline A, which is an impurity in the drug product. Tryptoquivaline D can be used as a standard for research and development or for custom synthesis. This compound has been shown to have anti-inflammatory effects and may also act as an analgesic. It has also been shown to inhibit the production of prostaglandin E2 from arachidonic acid, thereby reducing inflammation.</p>

<p>2-[(1-Hydroxy-1-propyl)butyl]-6-methoxynaphthalene is a versatile compound that has various applications in different industries. It can be used as an ingredient in pharmaceuticals, cosmetics, and even as a flavoring agent. This compound exhibits potent antioxidant properties, making it beneficial for skincare products. It also has antimicrobial properties, which can help in the formulation of hygiene and personal care products. Additionally, 2-[(1-Hydroxy-1-propyl)butyl]-6-methoxynaphthalene has been found to have anti-inflammatory effects, making it suitable for use in topical creams and ointments for soothing irritated skin. With its diverse range of benefits, this compound is a valuable addition to any product formulation.</p>

<p>Rosuvastatin is a natural, synthetic and semi-synthetic drug product. It is the active ingredient in an investigational drug called Iressa. Rosuvastatin is also known as a cholesterol-lowering agent and belongs to the class of statins. Rosuvastatin inhibits HMG-CoA reductase, an enzyme responsible for synthesizing cholesterol from acetyl CoA. The isoamyl ester form has been shown to have a high degree of stability in human plasma. This product is available as an analytical standard that can be used to generate reference values for metabolism studies or pharmacopoeia (e.g., USP).</p>

<p>Scopine-2,2-dithienyl glycolate is a catalyst that belongs to the class of dithienyl glycolates. Scopine-2,2-dithienyl glycolate is used in the pharmaceutical industry as an average catalyst for reactions and can be used to recover dimethylbenzene. The method of detection for scopine-2,2-dithienyl glycolate is based on its ability to absorb light at a wavelength of 360 nm. The reaction solution must be monitored carefully during the synthetic process because it has been shown that it can react with water or air and form hydrogen sulfide gas. If this happens, the reaction solution will become cloudy or turbid. This product is a white crystalline solid that appears as tiny needles and has a melting point of 173 degrees Celsius (340 degrees Fahrenheit).</p>

<p>Olodaterol is a drug product that has been synthesized using natural and synthetic methods. It is an API impurity that is present in the CAS No. 869478-13-7, which is a custom synthesis of olanzapine. The impurity standard for olodaterol benzyl ether is available as a Synthetic High Purity HPLC Standard. The purity of this product has been tested by HPLC and found to be &gt; 98%. Olodaterol can be used to develop drugs for niche markets, such as research and development or pharmacopoeia.</p>

<p>Quinovin is a Chinese medicinal compound that has been shown to have potent anticancer properties. It works by inhibiting kinases, which are enzymes that play a crucial role in the growth and proliferation of cancer cells. Quinovin has been found to induce apoptosis, or programmed cell death, in various types of cancer cells. This compound is an analog of other kinase inhibitors that have been developed for the treatment of cancer in humans. Quinovin has also been found to inhibit the growth of tumors in animal models and to be excreted in urine after administration. Overall, Quinovin represents a promising candidate for the development of new anticancer therapies.</p>

<p>Secologanin acetal is a lonicerae japonicae schisandrae fruit extract that is used in traditional Chinese medicines. It has been shown to have anti-inflammatory, anti-tumor, and antiviral activities. Secologanin acetal inhibits the production of nitric oxide and pro-inflammatory cytokines in polymorphonuclear cells (PMNs) by inhibiting the activation of NF-κB. Structural formula:</p>

<p>Impurity F is a metabolite of Fexofenadine. It is an impurity that can be found in the drug product and is used as a research and development standard for impurities. Impurity F has been shown to be a metabolite of Fexofenadine in human liver microsomes, and this metabolite has also been shown to have antihistamine properties. This impurity is used as a pharmacopoeia reference standard for HPLC analysis of fluoroquinolones, but it does not have any therapeutic value.</p>

<p>Please enquire for more information about 3-(Diethylamino)-8-methyl-2(1H)-quinolinone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-Hydroxy-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(2R,2R,Trans)-saxagliptin is a drug product that is synthesized using natural ingredients. It is a custom synthesis and has high purity. The CAS number for this compound is 1564266-03-0. (2R,2R,Trans)-saxagliptin is an analytical standard that can be used in metabolism studies and drug development. This compound has been shown to be metabolized in humans through the cytochrome P450 system or glucuronidation pathways. Metabolites of this compound have been identified as 2-(3-hydroxyphenyl)benzothiazole and 2-(3-hydroxyphenyl)benzoxazole. Impurities have been found in the HPLC standard for this compound at concentrations of 0.0025%.</p>

<p>Imipramine N-oxide hydrate is a drug product that is used in the synthesis of other drugs. It has been shown to be metabolized by cytochrome P450 enzymes and glucuronidases, as well as oxidative metabolites. Imipramine N-oxide hydrate is a metabolite of imipramine.</p>

<p>Please enquire for more information about BCL6-IN-5 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-[4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl]-7-hydroxy-1,2,3,4-tetrahydro-carbostyril (1HHC) is a synthetic drug that is used as a research tool in the study of metabolism. It has been shown to be metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. 1HHC also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>Please enquire for more information about 4-Desmethyl 5-methyl vortioxetine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(5aR,10aR)-Tetrahydro-3H,5H,8H,10H-bisthiazolo[3,4-a:3',4'-d]pyrazine-5,10-dione is a drug product that is an impurity standard for the API (Active Pharmaceutical Ingredient) 5α-tetrahydrospiro[benzofuran-1(3H),2'(3'H)]pyrido-[2,1'-cyclohexan]-6β,7β-(1'H)-dione. It is a metabolite of this API and can be used as a research and development analytical standard for HPLC. The CAS number for this compound is 72744-67-3. This substance has been found in natural products such as the seeds of Sesamum indicum L., Cucurbita maxima Duchesne var.</p>

<p>Vinorelbine N-methiodide is a drug product that is used for the treatment of various types of cancer. It is an active form of vinorelbine, which is an anti-cancer drug that belongs to the class of vinca alkaloids. Vinorelbine N-methiodide can be found as a natural product or can be synthesized in the laboratory. It has been shown to inhibit DNA synthesis, protein synthesis, and cell division with high specificity. This drug is administered intravenously and can cause nausea, vomiting, diarrhea, anemia, bone marrow suppression, and liver damage. The most common side effects are anemia and constipation.</p>

<p>Adenosine cyclic 2',3'-phosphate 5'-phosphate is an inhibitor that has been shown to induce apoptosis in cancer cells. It is a urinary metabolite of nifedipine, an anti-hypertensive drug. Adenosine cyclic 2',3'-phosphate 5'-phosphate has anticancer activity and can inhibit protein kinase A, which plays a role in tumor growth and progression. This compound is an analog of cyclic adenosine monophosphate (cAMP) and can compete with cAMP for binding to regulatory subunits of protein kinases. Adenosine cyclic 2',3'-phosphate 5'-phosphate has been shown to inhibit the activity of several kinases, including protein kinase C, GSK-3β, and ERK1/2 in human cancer cells. It may have therapeutic potential as a targeted therapy for certain types of cancer.</p>

<p>N,N-Bis[2-(2-hydroxyethoxy)ethyl] quetiapine chloride is a synthetic drug product with a purity of &gt;98% and low impurity content, which is used in research and development. It can be custom synthesized to meet the needs of a particular research or development project. This compound has an analytical purity of &gt;98% and low impurity content, making it suitable for use as an API impurity standard. N,N-Bis[2-(2-hydroxyethoxy)ethyl] quetiapine chloride is not currently regulated by any pharmacopoeia.</p>

<p>Please enquire for more information about NSC 116339 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fosfomycin trometamol EP impurity A disodium is a research and development impurity standard. It is a custom synthesis that is used as a drug product, synthetic, high purity, pharmacopoeia, drug development, metabolite, niche, analytical and natural. Fosfomycin trometamol EP impurity A disodium has been shown to have an HPLC standard and CAS No. 84954-80-3(free base).</p>

<p>Ivacaftor is a drug product that is used for the treatment of cystic fibrosis. It is an active ingredient of Kalydeco, which is a combination therapy to treat cystic fibrosis. Ivacaftor is the first FDA-approved drug for the treatment of CF in patients with specific mutations. The metabolism of ivacaftor has been studied by analytical methods and it has been shown to have natural impurities. The API impurity and synthetic impurity standards are available for custom synthesis and can be ordered from a specialty manufacturer. Ivacaftor requires high purity and pharmacopoeia-grade standards for research and development as well as niche markets, such as HPLC standard or high purity.</p>

<p>OPC-167832 is a potent medicinal compound that has shown promising results in the treatment of cancer. It is an inhibitor of protein kinases, which are enzymes involved in cell cycle regulation and tumor growth. OPC-167832 induces apoptosis, or programmed cell death, in various cancer cell lines including Chinese hamster ovary cells and human tumor cells. This compound has been shown to have anticancer properties by inhibiting the growth of tumors and reducing their size. Additionally, OPC-167832 can be detected in urine samples, making it a useful tool for monitoring treatment response in cancer patients. Overall, this inhibitor shows great potential as a therapeutic agent for the treatment of various types of cancer.</p>

<p>Propafenone beta-D-glucuronide is a drug product that is used as an analytical reference standard. It has been shown to be metabolized in the rat, dog, and human by hydrolysis of the glucuronide group. The natural form of propafenone is found in various plants and fruits. Research and Development includes the synthesis of Propafenone beta-D-glucuronide from synthetic precursors. CAS No. 91411-76-6 is a Metabolite impurity standard for API Impurities testing which is found in pharmaceuticals, including propafenone, as an impurity.</p>

<p>Aripiprazole EP Impurity E is a potential impurity of aripiprazole, which is an antipsychotic drug. It has been detected as a major impurity in the drug. Aripiprazole EP Impurity E has been found to be present in human plasma and it is thought that this impurity may have pharmacological effects on humans similar to those of aripiprazole. The detection of this impurity has been achieved using LC-MS/MS methods. This method can be used for wastewater treatment due to the matrix effect of nitrogen atoms. Aripiprazole EP Impurity E may have significant implications in the diagnosis, prevention, and treatment of obesity and other metabolic disorders.</p>

<p>Please enquire for more information about 1-[4-Chloro-2-(2-fluorobenzoyl)phenyl]-2-methyl-1H-imidazole-5-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Lp-PLA2-IN-3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Chlorthalidone impurity A is an impurity in Chlorthalidone. It was found to be a flow rate marker with an analytical method that has been implemented and calibrated. The calibration curve is linear and the particle size of this compound is between 2-4 microns. This compound can be detected by using a particle size analyzer (PSA) or rp-hplc. In order to analyze this compound, the calibration must be done with ammonium acetate as the mobile phase and acetonitrile as the stationary phase. The wavelength for detection is 220 nm and the runtime is 1 minute. Analytical methods such as chromatographic methods, ultraviolet spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectroscopy may also be used to identify this compound.</p>

<p>25-Hydroxy previtamin D3 is a metabolite of vitamin D3. It is a natural compound that is synthesized in the skin by exposure to sunlight. 25-Hydroxylase activity converts vitamin D3 to 25-hydroxyvitamin D3, which then undergoes hydroxylation at position 1 by cytochrome P450 enzymes in the liver and kidney. 25-Hydroxy previtamin D3 can be used as an impurity standard for HPLC analysis of vitamin D compounds.</p>

<p>Ozagrel impurity I is a protein analog that has been shown to have anticancer properties. It acts as an inhibitor of kinases involved in cell cycle regulation and apoptosis, making it a potential candidate for cancer treatment. This impurity has been isolated from Chinese medicinal herbs and is present in human urine. Ozagrel impurity I has been tested against various cancer cell lines and has demonstrated significant growth inhibition. Its mechanism of action involves blocking the activity of proteins involved in tumor development and progression. Overall, Ozagrel impurity I shows promising potential as an anticancer agent.</p>

<p>Please enquire for more information about o-Cresol-d7 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1,4-Di-2-furoylpiperazine is a synthetic compound that has been shown to have anti-inflammatory and analgesic properties. It was originally developed as a pharmaceutical drug candidate for the treatment of arthritis and other inflammatory disorders. 1,4-Di-2-furoylpiperazine is an impurity in the synthesis of the drug product diclofenac. The compound is also found as a metabolite in humans after oral administration of diclofenac. 1,4-Di-2-furoylpiperazine binds to protein and inhibits protein synthesis by preventing amino acid incorporation into proteins. It also has nicotinic effects on acetylcholine binding sites and can be used as an analytical standard for HPLC analysis of drugs containing this molecule.</p>

<p>6-Acetoxymethyl-4-methoxy-5-methyl-3-pyridylmethanol o-toluate is a synthetic compound that is used as an analytical reference standard for the metabolism studies. It has been evaluated in a pharmacopoeia and has been found to be of high purity with no detectable impurities. This product can be used in drug development or research and development.</p>

<p>Please enquire for more information about (3R,4Z)-4-Ethylidenetetrahydro-5-oxo-3-furanacetaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bromfenac sodium imp-B is an analytical standard that is used in drug development and research to measure the concentration of bromfenac in pharmaceutical products. Bromfenac sodium imp-B is a white to off-white crystalline powder with a melting point of about 230°C. It is soluble in methanol, ethanol, and acetone, but insoluble in water. Bromfenac sodium imp-B can be synthesized from the corresponding bromo acid chloride.</p>

<p>Maraviroc-d6 is a medicinal compound that has been developed as an inhibitor of kinases, which are enzymes involved in cell cycle regulation and apoptosis. This molecule has been shown to have potent anticancer activity in human cancer cells, including those from Chinese origin. Maraviroc-d6 works by inhibiting the activity of protein kinases, which are involved in the regulation of cell proliferation and survival. This inhibition leads to the induction of apoptosis, or programmed cell death, in cancer cells. Additionally, this compound has been shown to be effective as an inhibitor of tumor growth in animal models. The use of Maraviroc-d6 may represent a promising strategy for the development of novel anticancer therapies.</p>

<p>Granisetron is a serotonin 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. It is used in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. Granisetron hydrochloride is a white to off-white powder with a molecular weight of 476.0. The chemical formula for granisetron hydrochloride is C22H24ClN2O2S. This drug has been shown to be efficient in the prevention and treatment of nausea and vomiting caused by cytotoxic chemotherapy, radiation therapy, or surgery. The potential impurities are as follows: <br>1) 1-Desmethyl 2-methyl granisetron <br>2) 2-Methyl granisetron <br>3) 2-Methyl 3-(4'-hydroxyphenyl)propionitrile <br>4) 2-(4'-Hydroxyphenyl)-3-(</p>

<p>Erythromycin E is a diluent that is used to make erythromycin solutions. It has been shown to have bioactive molecules by incubating it with chromatographic methods. These bioactive molecules are conjugates of erythromycin and methyl ethyl groups. Erythromycin E has also been shown to have genetic mechanisms, which may relate to its ability to inhibit the synthesis of inflammatory cytokines such as IL-1β and IL-8 in the airways. The acetate extraction method is used for the production of erythromycin E. This process involves extracting erythromycin from Streptomyces bacteria grown in an acetate buffer solution.</p>

<p>Clindamycin phosphate EP impurity G is a metabolite of clindamycin that can be found in the urine of patients taking clindamycin. It is a white to off-white crystalline solid with a melting point of about 205°C. Clindamycin phosphate EP impurity G has been used as an analytical reference standard for clindamycin, and it is also used as a synthetic intermediate in the drug development process. The CAS number for this compound is 719-72-4.</p>

<p>2-[3,5-Dichloro-4-(4-chlorobenzoyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione is a research and development impurity standard. It is a synthetic compound with purity of 99% that can be used as an impurity standard for drug product and a metabolite in pharmacopoeia. 2-[3,5-Dichloro-4-(4-chlorobenzoyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione has been used in metabolism studies to demonstrate the formation of 2-[3,5-dichloro-4-(4-fluorobenzoyl)phenyl]-1,2,4-triazine 3,5(2H, 4H)-dione.</p>

<p>Please enquire for more information about Zanubrutinib impurity-3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PBDE 197 is a medicinal compound that has shown potential as an anticancer agent. It is a kinase inhibitor, which means it blocks certain enzymes that are involved in cell signaling and growth. PBDE 197 has been found to induce apoptosis, or programmed cell death, in human cancer cells. This compound is an analog of other kinase inhibitors and has demonstrated potent inhibitory effects on protein kinases in vitro. In animal studies, PBDE 197 has shown promising results as a tumor growth inhibitor. It is excreted through urine and may have potential as a therapeutic option for cancer patients.</p>

<p>Atorvastatin is a potent inhibitor of the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. This inhibition reduces the production of cholesterol and other lipids in the liver. Metabolism studies have shown that atorvastatin undergoes extensive presystemic metabolism by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9. The drug is converted to inactive metabolites that are eliminated primarily through renal excretion. Atorvastatin has not been found to inhibit any of the following: cytochrome P450 1A1/2, 2C8/9, 2D6, 2E1, 3A4/5 or glucuronidases.</p>

<p>Ciprofloxacin impurity D hydrochloride is a drug product that is an analytical standard. It is also a natural impurity found in Ciprofloxacin. This compound has been synthesized and manufactured to be used as an impurity standard. It exhibits the same physical, chemical, and biological properties as Ciprofloxacin. The CAS number for this substance is 526204-10-4. Impurities such as Ciprofloxacin impurity D hydrochloride may be present in the finished drug product if they are not removed during the manufacturing process. Chemical reactions may also lead to the formation of these substances. The presence of these substances can affect the quality of the drug product and may lead to adverse effects for patients who use them.<br>CAS No.: 526204-10-4<br>Molecular Weight: 258.25<br>Formula: (C8H6ClF2NOS)</p>

<p>rac-N-Desbutyroyl acebutolol is a prodrug that is metabolized to the active form, acebutolol. The metabolism of rac-N-desbutyroyl acebutolol is mediated through cytochrome P450 (CYP) enzymes, specifically CYP2D6. Rac-N-desbutyroyl acebutolol has been shown to inhibit the growth of bacteria in vitro and in vivo. It has also been shown to have therapeutic effects on diabetic patients with high levels of fatty acids in their blood. Rac-N-desbutyroyl acebutolol has also been found to be effective for the treatment of patients with polycarboxylic acid exposure and dna replication diseases.</p>

<p>Please enquire for more information about 3,4-Dihydro naratriptan oxalate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>NBI 27914 hydrochloride is a small molecule that binds to and blocks the neurotransmitter receptor for norepinephrine, which is involved in the regulation of mood. This drug has been shown to have anxiolytic-like effects in animals and may be useful for treating anxiety disorders that are due to congenital adrenergic hyperactivity. NBI 27914 hydrochloride also has an anxiogenic effect at high doses, which may be due to its ability to bind and block beta-adrenergic receptors. It is also able to act as a specific agonist or antagonist of alpha-adrenergic receptors.</p>

<p>Diethatyl is an anticancer drug that induces apoptosis in human tumor cells. It works by inhibiting protein kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. Diethatyl is an analog of indirubin, a compound found in Chinese herbal medicine. It has been shown to be effective against various types of cancer cells, including breast, lung, and colon cancer. Diethatyl specifically targets cancer cells and does not affect normal cells. It is a promising new inhibitor in the fight against cancer.</p>

<p>N-Formyl-L-leucine (1S)-1-[[(2R,3R)-3-hexyl-4-oxo-2-oxetanyl] methyl] dodecyl ester is an impurity in the drug product. It can be used as a custom synthesis or natural standard and has been shown to have metabolites that are toxic to human cells. This impurity can be synthesized for HPLC analysis and research purposes.</p>

<p>(24R)-Calcipotriene is a synthetic analog of calcitriol, the active form of vitamin D3. It is a proapoptotic agent that inhibits tumor growth by causing mitochondrial membrane potential collapse in cancer cells. (24R)-Calcipotriene has been shown to inhibit tumor growth in animals and human cells in vitro. This drug also potentiates the effects of other anticancer drugs such as doxorubicin and etoposide. In addition, it has been shown to have minimal toxicity at high doses in mice.</p>

<p>Solifenacin Impurity D is a synthetic impurity of solifenacin. Solifenacin is an anti-cholinergic drug used to treat overactive bladder and urinary incontinence. The purity of this product is 99%. It is soluble in methanol, ethanol, chloroform, and acetone. Solifenacin Impurity D can be used as a reference material for analytical purposes or as an impurity standard in the development of new drugs.</p>

<p>4-(Phthalazin-1-yloxy)aniline is an analog of cyclin-dependent kinase (CDK) inhibitors that has shown promising anticancer activity. It inhibits the activity of CDKs, which are enzymes involved in regulating cell division and proliferation. This compound has been tested on Chinese hamster ovary cells and has demonstrated potent antiproliferative activity against various cancer cell lines. 4-(Phthalazin-1-yloxy)aniline induces apoptosis in tumor cells, leading to their death. This compound may be a potential candidate for the development of novel anticancer drugs that target CDKs and promote tumor cell death. Additionally, this compound can be detected in urine samples, making it a useful biomarker for cancer diagnosis and monitoring.</p>

<p>Risperidone pyrimidinone-N-oxide (ROPN) is a metabolite of risperidone. It is an impurity that is used as a reference standard for HPLC in the drug development process. ROPN can be synthesized from risperidone, but it is also found naturally in some plants and fungi. It has been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.</p>

<p>Please enquire for more information about 3’,4’-Bis(hydroxyethyl)rutoside including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-(4-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}butoxy)-3,4-dihydroquinolin-2(1H)-one is an analytical reference standard for HPLC. It is a white to light yellow crystalline powder that is soluble in water and ethanol. This compound has been synthesized from 4-(2,3-dichlorophenyl)piperazine and 3,4-dihydroquinoline 2(1H)-one. This molecule has been identified as an impurity in the drug product, Cefdinir (7-(2-(3,4-Dihydroxyphenoxy)propoxy)-3,4-dihydroquinolin-2(1H)-one). The purity of this chemical has been shown to be greater than 99.5% by high performance liquid chromatography (HPLC).</p>

<p>Please enquire for more information about (rac)-Bl-918 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pidotimod Diketopiperazine is a test substance that is a phosphoric acid salt of pidotimod with a diketopiperazine group. Pidotimod Diketopiperazine has an elution time of approximately 3 minutes, on the Agilent HPLC column. It is soluble in water and has a pH of around 1.5-2.5. Pidotimod Diketopiperazine is used to solubilize phosphoric acid and can be used as an eluant for phosphoric acid in HPLC analysis.</p>

<p>Pyrimisulfan is a medicinal compound that has shown potent anticancer activity in both human and Chinese hamster cancer cell lines. It is an analog of pyrimidine, a naturally occurring compound found in urine. Pyrimisulfan works by inhibiting the activity of protein kinases, which are enzymes that regulate cell cycle progression and promote cell growth. This inhibition leads to apoptosis, or programmed cell death, in cancer cells. Pyrimisulfan has been shown to be a highly selective inhibitor of certain protein kinases, making it a promising candidate for the development of targeted cancer therapies. Its unique mechanism of action and specificity make it a valuable addition to the arsenal of anticancer inhibitors currently available.</p>

<p>Doxylamine N-oxide is a drug product that is custom synthesized to meet the specific needs of the customer. It has a purity of &gt; 98% and is synthesized with natural starting materials. Doxylamine N-oxide inhibits bacterial growth through inhibition of protein synthesis, which may be due to its ability to inhibit methionine synthase. This drug also has been shown to be effective in the treatment of malaria, although it does not have significant anti-malarial properties. Doxylamine N-oxide has been used as a metabolite marker for other drugs and as an impurity standard for HPLC analysis.</p>

<p>Decitabine related compound A is an impurity that is found in the API, decitabine. It is an analytical standard for HPLC measurements and a reference material for impurity testing. It is also used as a pharmacopoeia standard for pharmacopoeias such as European Pharmacopoeia, USP, and Japanese Pharmacopoeia. Decitabine related compound A has been synthesized from natural sources such as plant-derived alkaloids and synthetically produced in the laboratory. CAS No. 1019659-87-0</p>

<p>Ethylene terephthalate cyclic hexamer-d24 is a synthetic drug product. It is a metabolite of ethylenediaminetetraacetic acid, which is an analytical standard for HPLC and GC analysis. The substance has been used in pharmacopoeia and as a research and development impurity standard.</p>

<p>Please enquire for more information about 4-o-Benzyl-3-acetyloxy tyrosol α-acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5α,6α-Epoxycholestanol-d7 is an impurity of a cholestatic drug product. It can be used as a research and development standard or as an impurity standard in the production of drugs. 5α,6α-Epoxycholestanol-d7 has been characterized by GC/MS and HPLC techniques. This compound is also useful for pharmacopoeia purposes, drug development, and metabolic studies.</p>

<p>Methotrexate-5-monomethyl ester is an analytical standard that is synthesized synthetically. The synthetic route used to produce the compound has been optimized for high purity, making this product suitable for use as a drug product or impurity standard. The structure of methotrexate-5-monomethyl ester was confirmed by 1H and 13C NMR spectroscopy and mass spectrometry. Methotrexate-5-monomethyl ester is an impurity found in the synthesis of methotrexate and is a metabolite of methotrexate. It has been shown to inhibit DNA synthesis and protein synthesis in animal cells, which may be due to its ability to inhibit transcription factors such as NFATc1, NFkB, STAT3, STAT5A and STAT5B.</p>

<p>Diethylstilbestrol monomethyl ether is a drug product that is custom synthesized for the purpose of research and development. This product is made to pharmacopoeia standards and has a purity level of &gt;98%. The analytical data for this product includes HPLC standard, which is used to ensure the quality of the product. Metabolism studies have been conducted on this product, which shows that it has a natural metabolite. Diethylstilbestrol monomethyl ether is also an impurity standard, which means it can be used as reference material in order to test for other substances.</p>

<p>Please enquire for more information about 16α-Methyl clobetasone butyrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Des(N-methyl-2-nitro-1,1-ethenediamino) N-methylureido nizatidine is a drug product that belongs to the group of ureidos. It has been used as an analytical standard for impurities in drugs and for HPLC standards. This compound has shown no toxicity in animal studies and is not metabolized by the human body. It does not bind to plasma proteins and is excreted unchanged in urine. The purity of this compound can be custom synthesized according to customer needs.</p>

<p>N-Formyl-D-leucine (1R)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester is a research and development impurity standard that can be custom synthesized for drug product development. It is an analytical standard for HPLC with high purity, pharmacopoeia, and drug development. It is a natural metabolite that has been studied as a niche metabolite in metabolism studies.</p>

<p>Elsinochrome A is a drug product that has not been approved for human use. It belongs to the class of drugs called natural products and has not been synthesized. Elsinochrome A is a metabolite of erythromycin, which is produced by the fungus Elsinoë sp. The chemical structure of this natural product was determined using spectral analysis, and it was found to be similar to the antibiotic erythromycin. Elsinochrome A has shown promising results in pharmacological studies as a potential drug candidate for tuberculosis treatment because it inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication.</p>

<p>Olopatadine methyl ester is a non-sedating antihistamine that is used to treat allergic symptoms. It has a rapid onset of action and is effective for 24 hours. Olopatadine methyl ester blocks the effects of histamine by inhibiting its binding to H1 receptors in the body. This drug also inhibits the release of prostaglandins and leukotrienes, which are mediators of inflammation, thereby providing relief from allergy symptoms.</p>

<p>N-Desmethyltoremifene is an anti-estrogen that has been shown to have genotoxic effects. It inhibits DNA synthesis and protein synthesis in human breast cancer cells. N-Desmethyltoremifene is a potent inducer of CYP3A4, which metabolizes many drugs. This drug also binds to α1-acid glycoprotein, which can lead to reduced plasma concentrations and pharmacokinetics. N-Desmethyltoremifene has been shown to inhibit the growth of renal cell carcinoma in animals, but not normal tissue, at high doses.</p>

<p>Please enquire for more information about 6-Hydroxy-4’-tert-butyldimethylsylyl raloxifene-d4 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lamivudine acid is a synthetic orotate prodrug that is converted to the active form, lamivudine. It inhibits the synthesis of viral DNA by inhibiting the reverse transcriptase enzyme and has been used as a treatment for HIV infection. Lamivudine acid is soluble in organic solvents such as acetone and cyclohexane. The crystal structure of this compound has been determined using X-ray crystallography and exhibits a zwitterion structure with a hydrogen bond between the carboxylate group and the amide nitrogen atom of the molecule.</p>