Peptídeos
Subcategorias de "Peptídeos"
Foram encontrados 29634 produtos de "Peptídeos"
H-LGFEDGSVLK^-OH
Peptide H-LGFEDGSVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
N-formylated PSMalpha3
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides. Peptides starting with an N-formylated methionyl group constitute a unique hallmark of bacterial as well as mitochondrial metabolism, and professional phagocytes of our innate immune system recognise this microbial/mitochondrial pattern as a danger signal that guides innate immune cells.All PSMα peptides have the same basic functions and promote virulence through effects on discrete neutrophil functions (i.e. chemotaxis) and by being cytotoxic at higher concentrations. PSMα2 and PSMα3 can both bind to FPR2 and trigger superoxide release in neutrophils at low nanomolar concentrations. In addition, at high nanomolar concentrations they display cytotoxicity selectively on apoptotic neutrophil membranes and this occurs in an FPR2 independent manner.Cor e Forma:PowderPeso molecular:2,633.4 g/molH-NDPTQQIPK^-OH
Peptide H-NDPTQQIPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Liraglutide acetate
CAS:Liraglutide is a glucagon-like peptide-1 analog that has been shown to be an effective treatment for obesity. Liraglutide targets the adipose tissue and reduces the amount of glucose in the blood by increasing insulin sensitivity, lowering food intake, and reducing appetite. In addition, Liraglutide has been shown to suppress postprandial hyperglycemia and lower plasma glucose levels in patients with type 2 diabetes mellitus. Liraglutide also inhibits neuronal death induced by apoptotic stimuli, which may have potential use as a model system for neurodegenerative diseases such as Parkinson's disease. Liraglutide has also been shown to be an effective therapy for infectious diseases including Crohn's disease and ulcerative colitis. This drug has shown some effectiveness against atherosclerosis in animal models by inducing apoptosis in macrophages that are associated with lesions.Fórmula:C172H265N43O51Pureza:Min. 95%Peso molecular:3,751.29 g/molSRC-1 (676-700)
Steroid Receptor Coactivator - 1 (676-700).
Cor e Forma:PowderPeso molecular:2,797.4 g/molAngiotensin II (1-8)
Angiotensin II (Ang-II) is a key signalling peptide of the renin angiotensin system (RAS) which is involved in regulating blood pressure, cardiovascular function and energy balance. RAS activity is elevated in obesity and is widely studied in relation to lifestyle-related diseases.Ang-II is produced from angiotensinogen (AGT) via the intermediate angiotensin I (Ang-I). AGT is cleaved by the aspartyl-protease, renin, to produce Ang-I, which is then cleaved by the dicarboxyl-peptidase angiotensin converting enzyme (ACE). ACE removes a histidine and a leucine from the C-terminus of Ang-I to form Ang-II.Ang-II exerts its affect by binding to the G-protein-coupled receptors- Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors. Ang-II plays central roles in glucose metabolism and blood pressure. Increased levels of Ang-II have also been associated with Alzheimer's disease, and certain cancers including oesophageal squamous cell carcinoma (ESCC), brain cancers and breast cancers. The effects of Ang-II appear to be supressed by another branch of the RAS- the ACE2/Ang-(1-7)/Mas pathway.Peso molecular:1,045.5 g/molUBA3 (59-72) peptide
Peptide derived from the ubiquitin-activating enzyme 3 (UBA3), the catalytic subunit of the NEDD8-activating enzyme (NAE).Cor e Forma:PowderPeso molecular:1,495.8 g/molH-Ser-Phe-Leu-Leu-Arg-Asn-OH
CAS:H-Ser-Phe-Leu-Leu-Arg-Asn-OH is a biocompatible polymer that has been shown to have strong antioxidative properties. This polymer has been used in the development of a new class of drug for the treatment of inflammatory bowel disease, which may be due to its ability to inhibit toll-like receptor activity. H-Ser-Phe-Leu-Leu-Arg-Asn-OH also has potent immunosuppressive and antiinflammatory activities, and is stable at doses up to 200mg/kg. These properties make this polymer an attractive candidate for use as a therapeutic agent in treating bowel disease.Fórmula:C34H56N10O9Pureza:Min. 95%Peso molecular:748.87 g/molYSA acid
YSA binds to the extracellular domain of ephrin type-A receptor 2 (EphA2) with high affinity and selectivity. YSA binding activates EphA2 and its tumour suppressing downstream signalling pathways (including inhibition of the PI3K/Akt and ERK pathways), and promotes receptor internalisation.EphA2 is highly expressed in many types of solid tumour, and the level of EphA2 expression is positively correlated with malignancy and poor prognosis in some cancer types.YSA has been shown to be an effective targeting peptide of chemotherapeutic drugs to EphA2 expressing tumours. YSA-drug conjugates are able to selectively target EphA2 expressing tumours, both activating tumour supressing downstream signalling pathways, and becoming effectively internalised by cancer cells to further increase the potency of the chemotherapeutic drug. YSA-drug conjugates have been shown to be dramatically more effective at inhibiting tumour growth than chemotherapy alone. Selective tumour targeting with YSA could also reduce the systemic toxicity caused by nonselective and highly toxic chemotherapy agents, and thus reduce adverse side effects of chemotherapy.Peso molecular:1,346.6 g/molMBP Ac1-9 (4Y)
This peptide constitutes the acetylated N-terminal region of murine myelin basic protein (MBP) and displays high affinity for major histocompatibility complexes (MHC). This high MHC affinity is due to substitution of the native lysine at position 4 for a tyrosine. Substitution increases the MHC binding affinity of the peptide by around 1 million fold, therefore creating a superagonist ligand. MBP is an integral component of myelin found in the central nervous system (CNS) vital for the development and stability of the myelin sheath where it plays a role in membrane adhesion. MBP may be targeted by auto-antibodies in diseases such as multiple sclerosis. The low affinity of the native lysine containing MBP 1-9 peptide for MCH class II may result in MBP auto-reactive T cells escaping central-tolerance where self reactive T cells are usually eliminated. MBPs constitute an extraordinarily varied collection of splice isoforms which show a myriad of post-translational modifications.
Cor e Forma:PowderPeso molecular:1,133.22 g/molInsulin A Chain (A12-21)
Type I diabetes is an autoimmune condition caused by the destruction of insulin-producing β cells. The initiation mechanism is unclear but involves activating autoreactive T cells against the β-cell-specific antigen, insulin.RIP-B7.1 mice express CD80 on pancreatic β cells and are a model for studying de novo induction of diabetogenic CD8 T cells. Immunization of RIP-B7.1 mice with preproinsulin (ppins)-encoding plasmid DNA induces experimental autoimmune diabetes (EAD). EAD is associated with significant induction of CD8 T cells specific for the (A12-21) restricted epitope leading to the destruction of β cells.The Insulin A Chain (A12-21) epitope is recognised by pancreas-infiltrating CD8 T cells isolated from immunized, diabetic RIP-B7.1 mice as shown by flow cytometry. The Insulin A Chain (A12-21) epitope can also be used to stimulate inducible IFN- expression of ppins-primed CD8 T cells ex vivo as determined by flow cytometry. GFP fusion has shown the expression of insulin A chain (A12-21) epitope in HeLa cells.Peso molecular:1,246.3 g/molAbz-Ala-Phe-Arg-Phe-Ser-Gln-EDDnp
CAS:Abz-Ala-Phe-Arg-Phe-Ser-Gln-EDDnp is a peptide that belongs to the group of picolinic acid. It has been shown to cause neuronal death and synergistic cell lysis in vitro. Abz-Ala-Phe-Arg-Phe-Ser-Gln-EDDnp inhibits the mitochondrial membrane potential, which leads to cytochrome c release, caspase activation, and subsequent apoptosis. Abz also inhibits basic protein synthesis and causes proteolytic degradation of cellular proteins.Fórmula:C50H63N15O13Pureza:Min. 95%Peso molecular:1,082.15 g/molTetanus Toxin P2 (830 - 844)
Tetanus Toxin P2 (830 - 844) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.The P2 protein has antigenic properties that are reflective of the neurotoxin released by Clostridium tetani. Therefore, P2 is a suitable epitopes for CD4+ T cells and can be used to stimulate the release of IFNg, which is a cytokine that promotes macrophage activity and coordinates lymphocyte endothelium interactions.
Cor e Forma:PowderPeso molecular:1,724 g/molChloromethylated Polystyrene Resin (100-200 mesh) 1% DVB
CAS:Chloromethylated polystyrene resin (CMSR) is a chemical that is used in the synthesis of organic chemicals. It has been shown to have a higher reactivity than polystyrene resin, which leads to shorter reaction times and increased yields. Reaction solution containing CMSR and hydrogen fluoride are used for the synthesis of amides from nitrobenzene, aniline, formaldehyde, and ammonia. This chemical also has been shown to be effective against cancer cells in tissue culture studies. Chloromethylated polystyrene resin reacts with redox potentials such as pyrazole rings or fluorescence probes to produce a fluorescent product. This type of reaction can be used in vitro assays or biological studies as well as other applications.Pureza:Min. 95%IFNB1 (118-132) Human
Recombinant human interferon-β (IFNB) is a therapeutic for certain stages of multiple sclerosis (MS). However, a significant portion of patients develop neutralising antibodies within 2 years and prevent clinical efficacy of the treatment, this was correlated to a specific rise in IgG. Sequencing of IFNB1 revealed a CD4+ T cell epitope residues (118-132) that contains critical T cell activation residues. The identification of this sequences can now allow it to be manipulated to hopefully provide new interferon treatments that reduces the capacity for induction of neutralising antibodies in MS patients. The IFNB1 (118-132) epitope can be used for immunological investigations such as T cell activation, antibody recognition via immunoassays and immunohistochemistry. This may provide further insights into certain haplotypes correlating to IFNB responses in MS treatment.Peso molecular:1,906.23 g/molAc-RLR-[AMC] Proteasome Substrate
Fluorogenic substrate peptide to assay trypsin-like activity. In its intact state this peptide is non-fluorescent, however when aminomethylcoumarin (AMC) is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing trypsin-like enzyme activity.AMC is a fluorescent dye with excitation maxima at around 360 nm and emission maxima at around 450 nm. AMC can be excited with a mercury lamp and observed using a UV filter set.Peso molecular:642.4 g/molBiotin-PEG2-Claudin-9
Biotin-PEG2-Claudin-9 is derived from the tight junction protein Claudin-9 which is encoded by the CLDN6 gene and can be found within epithelial cell to cell contacts. Structurally, the Claudin family, of which Claudin-9 is a member, are transmembrane proteins containing two extracellular loops and are involved in maintaining cell polarity and controlling paracellular ion flux.Reduction in the number of Claudins has been associated with tumour formation. This may be due to Claudin role in maintaining cell detachment and migration.Claudin-9 has been shown to be overexpressed in hepatocellular carcinoma (HCC) and has the ability to increase the metastasis of hepatocytes. It further influences the activation of the Stat3 signalling pathway through tyrosine kinase 2. Overall CLDN9 demonstrates itself to be a HCC proto-oncogene.This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains a polyethylene glycol spacer (PEG2).Cor e Forma:PowderPeso molecular:2,881.5 g/molACTH (7-38) Human
Segment 7-38 of adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.Peso molecular:3,659.11 g/molPantinin-2
Pantinin-2, like other pantinin peptides, has high activity against Gram-positive bacteria yet weak activity against Gram-negative bacteria. Pantinin-2 also displays activity against Candida tropicalis and has relatively mild haemolytic activity against human red blood cells.Cor e Forma:PowderPeso molecular:1,403.8 g/molTKD (450-463)
Heat shock proteins (Hsps) are highly conserved and stress inducible. Hsp70 has been found in tumour cell lines to be highly expressed with a higher plasma membrane localisation. This is correlated to the cell sensitivity to natural killer (NK) cell-mediated lysis. Investigation identified that Hsp70 N-terminal extended peptide TKD (450-463) was critical for this to occur. TKD (450-463) with low dose interleukin (IL-2) has the same capacity to induce NK cell proliferation and activity as the full-length protein Hsp70. Excess of Hsp70 and TKD (450-463) both inhibit cytolytic activity by NK cells. Other related sequences tested did not lead to NK cell-mediated lysis. Further study with the TKD (450-463) epitope could elucidate how NK cells are activated by Hsp70s as the mechanism remains unclear.Peso molecular:1,562.8 g/mol[Aurora™ Fluor 647]-RGD peptide
The RGD motif has been found in wide range of eukaryotic proteins allowing cell adhesion to the ECM. The tripeptide RGD is the primary domain to bind integrin found in extracellular matrix (ECM) proteins including fibronectin, fibrinogen and osteopontin. It has been shown to effectively adhere various cell types to a wide range of biomaterials. This is a key research tool in the flourishing area of tissue engineering and wound healing using synthetic peptides that are either inert or can be potentially beneficial. RGD is a suitable ligand for targeting nanomolecules and cancer drugs to specific tissues due to its biocompatibility and safety.This RGD peptide is supplied with an Aurora Fluor 647 fluorophore attached and produced to research grade quality. Aurora Fluor 647 excitation suited to 594nm and emission peaked at 671nm. The Molecular Probes Alexa Fluor dyes provide a number of benefits including: more intense fluorescence than other spectrally similar conjugates better photostability, allowing more time for image capture availability of conjugates in an array of distinct fluorescent colours from blue to infrared- and pH insensitivity that enables the dyes to remain highly fluorescent over a broad pH range and high water solubility.Cor e Forma:PowderLasioglossin-III
Lasioglossin-III (Lasio-III) is a naturally-occurring salt-resistant anti-microbial peptide (AMP) found in-Lasioglossum laticeps-(broad-faced furrow bee). Lasioglossin-III has broad spectrum anti-microbial activity and anti-biofilm properties against Gram negative and Gram positive bacteria, including strong anti-microbial activity against-E. coli,-S. aureus, and-P aeruginosa-under physiological salt concentration, with low toxicity.AMPs form an important part of the innate immune system in plants, animals and insects-and are reported to be effective even against several antibiotic resistant strains due to differing modes of pathogen killing from those of conventional antibiotics. Lasio-III has a membranolytic mode of action. It can bind both the outer and inner membranes of bacteria. Lasio-III possesses a fast killing ability toward both Gram positive and negative bacteria compared to many other active AMPs.Peso molecular:1,764.2 g/mol[5-FAM]-VGB4
Antagonist peptide of VEGF-A and VEGF-B reproducing two binding regions of VEGF-B (loop 1 and loop3) linked together by a receptor binding region of VEGF-A (loop3). Binds to both VEGFR1 and VEGFR2 and inhibits VEGF-A driven proliferation, migration and tube formation in HUVECs. It contains 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.Peso molecular:3,066.5 g/mol[5-FAM]/[Lys(Dabcyl)]-CoV Main Protease (Mpro) Substrate
FRET peptide substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro). The substrate sequence is derived from residues P4-P5' of the SARS-CoV Mpro N-terminal autoprocessing site which has the sequence AVLQSGFRK. SARS-CoV Mpro is a key antiviral target.This peptide contains an N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag and the Dabcyl fluorescence quencher. When the peptide is intact, fluorescence is undetectable due to the proximity of the Dabcyl quencher to the 5-FAM fluorophore. However upon cleavage of the peptide by SARS-CoV Mpro, the 5-FAM group and the Dabcyl quencher are separated and fluorescence can be detected. This therefore represents a useful tool for investigating SARS-CoV Mpro activity.Cor e Forma:PowderPeso molecular:1,740.8 g/molAc-CYEQPKYTPEKETLE-NH2
Peptide Ac-CYEQPKYTPEKETLE-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-R^F-OH
Peptide H-R^F-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Thrombin Receptor Antagonist
Thrombin is the main effector of the coagulation cascade- it is a serine protease. Thrombin binds to active protease activated receptor 1 (PAR-1) which belongs to a subfamily of G-protein coupled receptors (GPCR). However, thrombin generated during cardiopulmonary bypass can activate PAR-1 leading to platelet dysfunction and unwanted bleeding. FLLRN is found to be a potent PAR-1 antagonist. Use of FLLRN and variants has aided the study of platelet aggregation dynamics. Further study may provide a suitable clinical application.Peso molecular:661.4 g/mol[Azhx]-ANP (Human)
ANP (human) is derived from the atrial natriuretic peptide (ANP) which is a cardiac hormone involved in maintaining cardio-renal homeostasis. This occurs through the activation of the guanylyl cyclase-coupled receptor, resulting in the increased concentration of cyclic guanylate monophosphate. Moreover its function in the processes of anti-proliferation and anti-angiogenesis allow it to take part in cardiovascular remodelling.ANP is a member of the natriuretic peptide family and it is encoded by the NPPA gene, located on chromosome 1. Once synthesized from the 151 amino acid pre-prohormone into its biologically active form, ANP is secreted by the atrial cardiomyocytes in the circulating forms: ANP (1-98) and ANP (99-126). This synthesis process involves the signal peptide being removed from the pre-prohormone resulting in pro-ANP (1-126) which is converted into the circulating forms by the type II transmembrane serine protease Corin.At the N-terminus Azhx, 6-azidohexanoic acid, is present.
Peso molecular:3,219.5 g/molH-TAVEQAAAELGDTGR^-OH
Peptide H-TAVEQAAAELGDTGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.LCBiot-KKRYDREFLLGF-OH
Peptide LCBiot-KKRYDREFLLGF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.(Ala1)-PAR-4 (1-6) amide (mouse)
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C34H48N8O7Peso molecular:680.8 g/molTAT-NR2B (C-ter)
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity- learning and memory- neuronal development and circuit formation. NMDARs have been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits. NR2B is the predominant subunit found in the postnatal brain, however over time the number of NRA2 subunits increase and eventually outnumber NR2B subunits in a process known as the NR2B-NR2A developmental switch. The greater ratios of the NR2B subunit in post-natal brains leads to NMDA receptors which remain open longer compared to those with more NR2A subunits, this may be related to the greater memory abilities in the immediate postnatal period compared to late in life. NR2B improves synaptic plasticity and memory when over-expressed in neurones. The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.The TAT peptide is present due to its properties as a cell penetrating cationic peptide (CPP). It derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). As a CPP, TAT is able facilitate the delivery of NR2B (C-ter) across the plasma membrane.Cor e Forma:PowderPeso molecular:2,517.4 g/moln-Octylpolyoxyethylene
CAS:n-Octylpolyoxyethylene (n-OPEO) is a synthetic surfactant that is used as an antimicrobial agent. It has been shown to be effective against a wide variety of bacteria, including Mycobacterium tuberculosis and Staphylococcus aureus. The mechanism by which n-OPEO exerts its antibacterial efficacy is not yet fully understood. It may inhibit the growth of bacteria by disrupting their cell membranes, or it may interfere with the synthesis of proteins needed for bacterial growth.Fórmula:C8H18O(C2H4O)nCor e Forma:Clear LiquidPeso molecular:174.28TAT-TRPV1 (736-745)
TAT-TRPV1 (736-745) is a cell-permeable TRPV1 fragment (capsaicin receptor and the vanilloid receptor 1), that can inhibit the interaction of TRPV1 and A-kinase anchoring protein 79 (AKAP79). TAT- TRPV1 (736-745) consists of amino acids 736-749 from the TRPV1 C-terminal domain, combined with amino acids 47-57 of TAT to promote uptake across neuronal cell membranes. TAT-TRPV1 (736-745) inhibits both the first and the second phase of pain behaviour in the formalin test, implying an effect on both acute and inflammatory pain.A-kinase anchoring protein 79 (AKAP79) is a protein that targets kinases to TRPV1. Inflammation causes hyperalgesia but can be reduced when TRPV1 is blocked. a key region on AKAP79, amino acids 326-336, is responsible for its interaction with TRPV1. TAT-TRPV1 (736-745) promotes uptake across the cell membrane and TRPV1 (736-745) inhibited inflammatory hyperalgesia in mice. TAT-TRPV1 (736-745) did not affect pain thresholds in the absence of inflammation. These results suggest that antagonizing the TRPV1-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia and TAT is an effective delivery system.
Peso molecular:2,927.6 g/molPEN-FFW
Sal-like4 (SALL4) derived peptide able to antagonise the SALL4-NuRD complex in hepatocellular carcinoma, turning SALL4 from a dual transcription repressor-activator to a singular transcription activator. Displays antitumour effects in xenograft mouse models.Cor e Forma:Powder[5-FAM] Kemptide
Kemptide is a synthetic substrate of the PKA catalytically active subunit (PKAc), and can bind along with ATP to PKAc. It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:1,129.5 g/mol(Arg)9
(Arg)9 is a cationic cell-penetrating peptide (CPP)consisting of 9 arginines. Arginine rich CPPs enter cells in a passive manner through membrane multilamellarity and fusion. Evidently as a CPP, (Arg)9 can function to deliver specific molecules to target cells and can be used for drug delivery purposes.Peso molecular:1,423.69 g/molPepstatin A Biotin
Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments. Biotin is C-terminally linked to this peptide for convenient detection and purification. The polyethylene glycol (PEG) linker improves the water solubility of biotin labelled proteins.Peso molecular:1,041.7 g/molFSY tripeptide
Angiotensin I-converting enzyme (ACE) plays a critical role in blood pressure regulation. There is a rise in conditions linked to hypertension such as heart attacks, strokes, and dementia. This has led to search for novel inhibitors of ACE to regulate blood pressure. Food-derived bioactive peptides have been identified and utilised for their health-promoting abilities. The tripeptide FSY (Phe-Ser-Tyr) was identified from shrimp (Pandalus borealis) protein hydrolysate as a highly potent inhibitor of ACE activity. FSY is capable of being absorbed in the digestive tract to be transported in the blood to the receptors which is a useful feature for clinical application. Further study can provide deeper understanding of FSY potency on ACE function and may lead to drug development.Peso molecular:415.2 g/molCyclo(-RGDyK)
The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anti-cancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.
Peso molecular:619.3 g/molAc-CISQAIPKKKKVLE-OH
Peptide Ac-CISQAIPKKKKVLE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VEAEVQIDR-OH
Peptide H-VEAEVQIDR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-EFIAWLVK^-OH
Peptide H-EFIAWLVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Dab-Pip
H-Dab-Pip is a peptidase inhibitor that inhibits the enzyme known as dipeptidyl peptidase. It also inhibits the enzyme known as dipeptidyl peptidase, which is involved in the breakdown of dipeptides. H-Dab-Pip is an inhibitor of this enzyme and can be used to regulate blood pressure by inhibiting the breakdown of angiotensin II, a potent vasoconstrictor. H-Dab-Pip may also be used for diabetes treatments or for the treatment of inflammatory bowel disease.Fórmula:C9H19N3OPureza:Min. 95%Peso molecular:185.27 g/molCyclo(Arg-Gly-Asp-D-Phe-Lys)
CAS:Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a small molecule drug that binds to the integrin receptor and blocks the growth of solid tumours. It has been shown to inhibit angiogenesis, especially in choroidal neovascularization in mice. Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a cyclic peptide with biological properties that are similar to those of the natural amino acids found in protein. This drug has been shown to be safe for use in humans and animals, with no observed toxicity or side effects.
Fórmula:C27H41N9O7Pureza:Min. 95%Peso molecular:603.68 g/molDes-n-Octanoyl-[Ser3]-Ghrelin (Rat)
The peptide Des-n-octanoyl-[Ser3]-ghrelin (DOG) is a synthetic analogue of ghrelin, the only known natural ligand for the growth hormone secretagogue receptor. DOG binds to the ghrelin receptor and activates it, thereby stimulating growth hormone release from the anterior pituitary gland. In a rat model, DOG counteracts weight gain caused by high-fat diet. It also increases insulin sensitivity in diabetic rats and acts as an appetite suppressant in non-diabetic rats. As such, this peptide has potential as a therapeutic agent for obesity and diabetes.Fórmula:C139H231N45O41Pureza:Min. 95%Peso molecular:3,188.67 g/molCodesane
Codesane (COD), is a cationic α-helical amphipathic-anti-microbial-peptide isolated from the venom of the wild bee Colletes daviesanus (Hymenoptera Colletidae). COD exhibits-anti-microbial-activity against Gram-positive and Gram-negative bacteria and Candida albicans but also noticeable haemolytic activity.COD peptide works by permeating both the outer and inner cytoplasmic membranes of Escherichia coli.Peso molecular:1,915.2 g/mol
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