Peptídeos

Applications A metabolite of Capecitabine.
References Arellano, M., ET AL.: Br. J. Cancer, 77, 79 (1998), Budman, D., ET AL.: J. Clin. Oncol., 16, 1795 (1998), Khanna, R., et al.: Cancer Res., 60, 4725 (2000), Charasson, V., et al.: Drug Metab. Dispos., 30, 731 (2002),

Applications H-GLU-LYS-OH (cas# 5891-53-2) is a useful research chemical.

Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);

Applications [Leu5]-Enkephalin is a neurotransmitter used in molecular dynamics studies for the insertion of neurotransmitters into lipid bilayer membranes and their implication on membrane stability.
References Shen, C., et al.: ChemPhysChem, pages ahead of print (2017)

Applications N-Boc-L-proline is a useful synthetic intermediate. It is used to synthesize Daclatasvir (D101500) which nhibits the HCV protein NS5A. Daclatasvir (D101500) can be used as a drug candidate for the treatment of hepatitis C (HCV).
References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Applications Ilomastat is a metalloprotease inhibitor.
References Dietrich, C., et. al.: J. Immunol., 192, 5382 (2014)

Applications Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator.

Stability Moisture Sensitive
Applications L-Cysteine is a non-essential amino acid that can be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. L-Cysteine is commonly used as a precursor in the food and pharmaceutical industries. L-Cysteine is used as a processing aid for baking, as an additive in cigarettes, as well as in the preparation of meat flavours.
References Hui, N. et al.: Meat Sci. Appl., 74 (2001); Kiviharju, K. et al.: J. Biotechnol., 117, 299 (2005); Pecivova, P. et al.: J. Sci. Food Agric., 90, 1681 (2010);

Applications H-GAMMA-GLU-GLU-OH (cas# 1116-22-9) is a useful research chemical.

Applications Poly(ethylene Glycol) ~400 is a polymer of ethylene oxide with a molecular weight of ~400 Daltons. Poly(ethylene Glycol) ~400 is considered a low molecular weight polyethylene glycol, and is used as a hydrophilic molecular probe for measuring intestinal permeability. Poly(ethylene Glycol) ~400 is also used as a hydrophilic plasticizer.
References Lu, E., et al.: J. Control. Release, 92, 375 (2003); Ma, T., et al.: Gastroenterology, 98, 39 (1990)

Stability Moisture Sensitive
Applications Amino reactive biotin reagent for preparing biotinylated surfaces or polypeptides.
References Ngo, T.T., et al.: Applied Biochem. Biotech, 7, 443 (1982), Wojchowski, D.M., et al.: J. Immunol. Methods, 90, 173 (1986);

Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),

Applications Thyrotropin-Releasing Hormone is a hypothalamic hypophysiotropic neuropeptide, which has the ability to stimulate the release of thyroid-stimulating hormone in mammals. It is proven that Thyrotropin-Releasing Hormone can be used to accelerate wound healing.
References Kanasaki, H., et al.: Neuropeptides., 54, 73 (2015); Nie, C., et al.: J. Surg. Res., 189, 364 (2014);

Stability Air Sensitive
Applications L-Cysteinylglycine, is a biologically important compound since it is formed during the γ-glutamyl cycle. It is a cysteinyl peptide, that can be used in the studies of many peptides and important proteins.
References Marvin D., et al.: New J. Org. Synth., 12, 185 (1980); Sheehan, J. C., et al.: New Synth. Cysteinyl Peptide, 1159 (1958);

Stability Hygroscopic
Applications H-ALA-ASP-OH (cas# 20727-65-5) is a useful research chemical.

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 6000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013)

Stability Hygroscopic
Applications H-Asp-Leu-OH (cas# 3062-14-4) is a useful research chemical.

Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.
References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);

Applications N-L-GAMMA-GLUTAMYL-L-LEUCINE (cas# 2566-39-4) is a useful research chemical.

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Stability Hygroscopic
Applications gamma-Polyglutamic acid - sodium salt (cas# 25513-46-6) is a useful research chemical.

Applications N-Glycylproline was found to exhibit anti-ischemic effects on the metabolism of neuroactive amino acids and indices of energy turnover in the neocortex of rats after experimental brain ischemia.
References Bashun, Z.N., et al.: Neurochem. J., 7, 39 (2013);

Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.
References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);

Applications L-Carnosine is a naturally-occurring histidine-containing compound and the biological role of this dipeptide is to act as cytosolic buffering agents. Other roles ascribed to L-Carnosine include actions as neurotransmitters, modulation of enzymic activities and chelation of heavy metals.
References Quinn, P.J., et al.: Mol. Aspects. Med., 13, 379 (1992); Aruoma, O.I., et al.: Biochem. J., 264, 863 (1989);

Applications Kollisolv PEG 300 is used as a thickening agent and gel binder in the pharmaceutical industry.

Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.
References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)

Applications AEBSF Hydrochloride is an irreversible serine protease inhibitor.
References Diatchuk, V., et. al.: J. Biol. Chem., 272, 13292 (1997)

Applications An Amadori compound having the potential to alter cellular adhesion, inhibit cancer metastasis and induce apoptosis.
References Horiuchi, T., et al.: Agric. Biol. Chem., 55, 333 (1991), Sosnovsky, G., et al.: J. Pharm. Sci., 82, 649 (1993), Glinsky, G., et al.: Cancer Res., 56, 5319 (1996),

Applications N-Glycylglycine is a derivative of Glycine (G615990), a non-essential amino acid that enhances N-methyl-D-aspartate (NMDA) receptor mediated synaptic potentials in the neocortex of rats. Glycine is also being used as adjuvant therapy for the treatment of schizophrenia.
References Logan, W. & Snyder, S.: Brain Res., 42, 413 (1972); Rosse, R., et al.: Clin. Neuropharmacol., 12, 416 (1989)

Applications An obstetric drug used to control postpartum hemorrhaging.
References Sanz-Nebot, V., et al.: Anal. Bioanal. Chem., 377, 306 (2003), Gimpl, G., et al.: Eur. J. Pharmacol., 510, 9 (2005), Handler, J., et al.: Theriogenol., 66, 1397 (2006), Klenerova, V., et al.: J. Physiol. Pharmacol., 60, 57 (2009),

Applications Cyclo(Leu-Gly) is an antimicrobial compound produced by Latobacillus plantarum.
References Niku-Paavola, M., et al.: J. Appl. Microbiol., 86, 29 (1999)

Applications 6-Azidohexanoic Acid is a reagent that is useful for click chemistry.
References Alleti, R.,et al.: J. Org. Chem., 75, 5895 (2010); Daumar, P., et al.: Bioconjug. Chem., 23, 1557 (2012)

Applications Lactoferrin is a multifunctional protein of transferin family. A glycoprotein present in various secretions including milk, saliva and tears. Antiviral agent, it binds to liproproteins of cell membranes dispersing virus molecules from host cells.
References Sánchez L. et al.: Arch. Dis. CHild., 67, 657 (1992); Harmsen MC. et al.: J. Infect. Dis., 172, 380 (1995);

Applications L-Alanyl-L-alanyl-L-alanine (cas# 5874-90-8) is a useful research chemical.

Applications MG-101 (ALLN) is a potent inhibitor of cysteine proteases including caplains and cathespins. Used in the treatment of genotoxic agents or replication stress of cells. Neuroprotective product.
References Wang, H. et al.: Biochem., 54, 5781 (2015); Fukunaga, Y. et al.: Neurosci. Res., 101, 6 (2014);

Applications DOTA-tris (t-Bu ester), is a Bifunctional chelator, that can be used in the preparation of gadolinium complexes as MRI blood contrast agents.

Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).
References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)

Applications Urolithin A is a major metabolite of ellagitannin and exhibits anti-inflammatory and antioxidant properties.
References Ishimoto, H., et. al.: Bioorg. Med. Chem. Lett., 21, 5901 (2011);

Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.