Moduladores enzimáticos
Moduladores de enzimas são compostos que podem aumentar ou inibir a atividade de enzimas, regulando assim a taxa de reações bioquímicas. Esses moduladores desempenham um papel crucial no controle de vias metabólicas, sinalização celular e vários processos fisiológicos. Os moduladores de enzimas são amplamente utilizados em pesquisa e desenvolvimento de medicamentos para estudar as funções enzimáticas e desenvolver agentes terapêuticos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de enzimas de alta qualidade para apoiar sua pesquisa em regulação enzimática e descoberta de medicamentos.
Subcategorias de "Moduladores enzimáticos"
Foram encontrados 693 produtos de "Moduladores enzimáticos"
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Sorafenib - Bio-X ™
CAS:Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. Sorafenib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C21H16ClF3N4O3Pureza:Min. 98%Cor e Forma:PowderPeso molecular:464.82 g/molMLN 4924
CAS:MLN 4924 is a selective small molecule that acts as an inhibitor of the Nedd8-activating enzyme. This compound is synthetically derived and functions by inhibiting the conjugation of Nedd8 to cullin proteins. By blocking this pathway, MLN 4924 disrupts the activity of the SCF (Skp, Cullin, F-box containing complex) E3 ubiquitin ligase, leading to an accumulation of proteins that can induce apoptosis and cell cycle arrest.
Fórmula:C21H25N5O4SPureza:Min. 95%Cor e Forma:White PowderPeso molecular:443.52 g/molN-Desmethyl ibandronate sodium
CAS:N-Desmethyl ibandronate sodium is a white crystalline solid with a melting point of 238-240 °C. It has versatile building block, complex compound and research chemicals applications. It is an intermediate used in the synthesis of other compounds, such as speciality chemicals, useful intermediates and useful scaffolds. N-Desmethyl ibandronate sodium can be used in reactions that require high quality and high purity products.Fórmula:C8H20NO7P2·xNaPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:327.18 g/molSeratrodast - Bio-X ™
CAS:Seratrodast is a thromboxane receptor antagonist that is used to treat asthma. However, this drug does not affect thrombus formation as other thromboxane synthase inhibitors do such as ozagrel.Fórmula:C22H26O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:354.44 g/molEpacadostat
CAS:Inhibitor of dioxygenase IDO1Fórmula:C11H13BrFN7O4SPureza:Min. 95%Cor e Forma:White PowderPeso molecular:438.23 g/molXL184
CAS:Pan-tyrosine kinase inhibitor (VEGFR2, c-MET, RET, KIT); anti-neoplasticFórmula:C28H24FN3O5Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:501.51 g/molAminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Fórmula:C19H20N8O5Pureza:Min. 97 Area-%Cor e Forma:Slightly Yellow PowderPeso molecular:440.41 g/molFinasteride - Bio-X ™
CAS:Finasteride is an antiandrogenic drug that belongs to the group of 5-alpha reductase inhibitors, which are used for the treatment of benign prostatic hyperplasia and male pattern baldness. The conversion of testosterone to 5α-dihydrotestosterone (DHT) is blocked by type II 5α-reductase inhibition, which then results in significant increase in prostatic testosterone concentrations and minimal to moderate increases in serum and tissue DHT concentrations. A reduction in DHT concentration will cause a reduction in prostatic volume as DHT appears to be the main androgen responsible for stimulating prostatic growth.
Fórmula:C23H36N2O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:372.54 g/molRofecoxib - Bio-X ™
CAS:Produto ControladoRofecoxib is a non-steroidal anti-inflammatory drug that is used to treat osteoarthritis, acute pain and migraine attacks. This drug is also a COX-2 inhibitor. As a result, it reduces inflammation and pain.Fórmula:C17H14O4SPureza:Min. 95%Cor e Forma:PowderPeso molecular:314.36 g/molSacubitril sodium
CAS:Inhibitor of metalloendopeptidase neprilysinFórmula:C24H28NNaO5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:433.47 g/molIbandronate sodium monohydrate
CAS:Farnesyl pyrophosphate synthase inhibitorFórmula:C9H24NNaO8P2Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:359.23 g/molLestaurtinib
CAS:Lestaurtinib is a multitarget tyrosine kinase inhibitor of the JAK, FLT-3 and TrkA families of tyrosine kinases at nanomolar concentrations. It inhibits proliferation and induces apoptosis in vitro. Lestaurtinib is a FDA approved orphan drug for acute myeloid leukemia.Fórmula:C26H21N3O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:439.46 g/molBL 918
CAS:A potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.
Fórmula:C23H15F8N3OSPureza:Min. 95%Cor e Forma:PowderPeso molecular:533.44 g/molRosuvastatin calcium - Bio-X ™
CAS:Rosuvastatin is a drug that belongs to the group of statins. It is used for the treatment of high cholesterol and as an adjunct therapy for patients with coronary heart disease. Rosuvastatin reduces serum cholesterol by inhibiting HMG-CoA reductase, which is the rate-limiting enzyme in the production of cholesterol. Furthermore, this drug has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.Fórmula:C22H27FN3O6SCaPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:500.57 g/molCP 671305
CAS:Inhibitor of PDE4 enzyme
Fórmula:C23H19FN2O7Pureza:Min. 95%Cor e Forma:SolidPeso molecular:454.4 g/molSNS 314 mesylate
CAS:Inhibitor of Aurora kinases A, B and CFórmula:C18H15ClN6OS2•CH4O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:527.04 g/molWM 8014
CAS:Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values of 8 nM and 28 nM, respectively. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and potentiates senescence in vitro and in zebrafish model of hepatocellular carcinoma. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.Fórmula:C20H17FN2O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:384.43 g/molOxaprozin - Bio-X ™
CAS:Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis and rheumatoid arthritis. This drug relieves swelling and inflammation by inhibiting the enzyme cyclooxygenase which in turn inhibits prostaglandin synthesis.Fórmula:C18H15NO3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:293.32 g/molKV 37
CAS:Inhibitor of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase)Fórmula:C23H25NO3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:363.45 g/molTenatoprazole
CAS:H+/K+ ATPase inhibitorFórmula:C16H18N4O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:346.41 g/molCamostat mesylate - Bio-X ™
CAS:Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Fórmula:C20H22N4O5•CH4O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:494.52 g/molN-Butyldeoxynojirimycin
CAS:Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.Fórmula:C10H21NO4Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:219.28 g/molGefitinib - Bio-X ™
CAS:Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.Fórmula:C22H24ClFN4O3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:446.9 g/molPentoxifylline
CAS:Produto ControladoPhosphodiesterase inhibitorFórmula:C13H18N4O3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:278.31 g/molO6-Benzylguanine - Bio-X ™
CAS:O6-Benzylguanine is a guanine analog that is an antineoplastic agent. It works by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase. This results to an interruption of DNA repair so that damage can occur to local tumor targets.Fórmula:C12H11N5OPureza:Min. 95%Cor e Forma:PowderPeso molecular:241.25 g/mol3-(4-Phenylbutyl)-4-propyloxetan-2-one
CAS:Cis/trans-form of GK 563 [2351820-19-2]Fórmula:C16H22O2Pureza:Min. 95%Cor e Forma:SolidPeso molecular:246.34 g/molTrilostane
CAS:Produto ControladoInhibitor of 3β-hydroxysteroid dehydrogenase in steroid biosynthesis
Fórmula:C20H27NO3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:329.43 g/molMK 4827
CAS:Inhibitor of PARP1 and PARP2 enzymes
Fórmula:C19H20N4OPureza:Min. 96 Area-%Cor e Forma:White PowderPeso molecular:320.39 g/molRucaparib camsylate
CAS:Inhibitor of poly (ADP-ribose) polymerase enzyme; antineoplasticFórmula:C19H18FN3O•C10H16O4SPureza:Min. 95%Cor e Forma:Off-White To Yellow SolidPeso molecular:555.66 g/molAbiraterone acetate - Bio-X ™
CAS:Produto ControladoAbiraterone is an antiandrogen drug used in the treatment of metastatic prostate cancer. It is a derivative of steroidal progesterone. This drug inhibits the enzyme CYP17 irreversibly, thus inhibiting the synthesis of androgen. It specifically inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone to decrease serum levels of testosterone and other androgens.Fórmula:C26H33NO2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:391.55 g/molEtoposide phosphate
CAS:Topoisomerase II inhibitor; chemotherapeutic drugFórmula:C29H33O16PPureza:Min. 95%Cor e Forma:PowderPeso molecular:668.54 g/molDiacerein - Bio-X ™
CAS:Diacerein is a slow-onset anthraquinone IL-1 inhibitor that is used in the treatment of joint diseases such as osteoarthritis. This drug is also being studied for the treatment of insulin resistance and diabetes mellitus. Diacerein works to decrease inflammation and cartilage destruction by reducing the level of interleukin-1.Fórmula:C19H12O8Pureza:Min. 95%Cor e Forma:PowderPeso molecular:368.29 g/molFlurbiprofen
CAS:Inhibitor of cytochrome P450; inhibitor of prostaglandin synthesis
Fórmula:C15H13FO2Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:244.26 g/molImiquimod - Bio-X ™
CAS:Imiquimod is a toll-like receptor 7 agonist drug that is used for the treatment of genital warts, basal cell carcinoma and condyloma acuminata. This drug works by relieving and controlling wart production. Studies in mice have shown that this drug may induce cytokines such as interleukins. Imiquimod helps to increase apoptosis of diseased tissues and an infiltration of lymphocytes into tumor lesions.Fórmula:C14H16N4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:240.3 g/molBrivanib alaninate
CAS:VEGFR2 a tyrosine kinase receptor inhibitor; antineoplasticFórmula:C22H24FN5O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:441.18123Lenalidomide - Bio-X ™
CAS:Produto ControladoLenalidomide is a thalidomide derivative that is used to treat multiple myeloma and anemia. This drug exerts immunomodulatory effects by altering cytokine production. Lenalidomide also directly inhibits the cullin ring E3 ubiquitin ligase complex.Fórmula:C13H13N3O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:259.26 g/molLeflunomide - Bio-X ™
CAS:Produto ControladoLeflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.Fórmula:C12H9F3N2O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:270.21 g/molSU 0268
CAS:Inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.059 μM and excellent specificity over other DNA repair enzymes. OGG1 and its substrate 8-oxoguanine are involved in mutagenesis, genotoxicity, inflammation and cancer. The compound can cause accumulation of 8-oxoguanine in DNA in vitro and is a potent tool for the study of OGG1 biology.Fórmula:C26H25N3O4SPureza:Min. 95%Cor e Forma:White PowderPeso molecular:475.56 g/molGboxin
CAS:Inhibitor of oxidative phosphorylation which acts on the F0F1 ATP synthase in the inner mitochondrial membrane and causes acute increase in mitochondrial membrane potential. Gboxin was shown to accumulate in mitochondria of cancer cells, to cause cellular toxicity and cell growth inhibition in mouse glioblastoma. However, Gboxin did not inhibit growth of mouse embryonic fibroblasts or neonatal astrocytes.Fórmula:C22H33N2O2•ClPureza:Min. 95%Cor e Forma:SolidPeso molecular:392.96 g/molArbutin - Synthetic origin
CAS:Inhibitor of tyrosinase in melanocytes: skin whitener
Fórmula:C12H16O7Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:272.25 g/molNVP-BGJ398
CAS:Inhibits FGFR family of kinases; antineoplastic; anti-angiogenicFórmula:C26H31Cl2N7O3Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:560.48 g/molPravastatin sodium salt - Bio-X ™
CAS:Pravastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and manage cardiovascular events such as strokes and myocardial infarction. This drug inhibits HMG-CoA reductase allowing for a reduction in the level of cholesterol.Fórmula:C23H35NaO7Pureza:Min. 95%Cor e Forma:PowderPeso molecular:446.51 g/molSB 1317
CAS:Inhibitor of CDK2, JAK2 and FLT3; anticancerFórmula:C23H24N4OPureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:372.46 g/molD,L-Carbidopa
CAS:Produto ControladoInhibits aromatic amino acid decarboxylaseFórmula:C10H14N2O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:226.23 g/molAdefovir dipivoxil - Bio-X ™
CAS:Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analogue that works by blocking reverse transcriptase. This drug is used to treat infections associated with Hepatitis B.Fórmula:C20H32N5O8PPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:501.47 g/molGSK 1120212B
CAS:Inhibits MEK1 and MEK2 kinases; targeted therapy for melanomaFórmula:C26H23FIN5O4•C2H6OSPureza:Min. 95%Cor e Forma:PowderPeso molecular:693.53 g/molPomalidomide - Bio-X ™
CAS:Produto ControladoPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies. Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C13H11N3O4Pureza:Min. 99 Area-%Cor e Forma:PowderPeso molecular:273.24 g/molFebuxostat - Bio-X ™
CAS:Febuxostat is a non-purine xanthine oxidase inhibitor that is used for the treatment and management of hyperuricemia and chronic gouty arthritis. Febuxostat inhibits the uptake of uric acid from the blood into cells and thereby reduces its concentration in plasma. Additionally, this drug has been shown to have anti-inflammatory and antioxidant effects.Fórmula:C16H16N2O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:316.38 g/molIrinotecan
CAS:Inhibitor of DNA topoisomerase IFórmula:C33H38N4O6Pureza:Min. 98 Area-%Cor e Forma:Beige PowderPeso molecular:586.68 g/molCilastatin
CAS:Cilastatin is a renal dehydropeptidase inhibitor, which is a compound sourced from synthetic processes designed to augment the pharmacokinetic profile of certain beta-lactam antibiotics. Its primary mode of action is to inhibit the enzyme dehydropeptidase I (DHP-I), located in the renal brush border. This enzyme typically degrades antibiotics, like imipenem, within the renal tubules. By inhibiting DHP-I, cilastatin prevents the inactivation of these antibiotics, thereby prolonging their active presence in the body and enhancing their antimicrobial efficacy.Fórmula:C16H26N2O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:358.45 g/mol
