Moduladores enzimáticos
Moduladores de enzimas são compostos que podem aumentar ou inibir a atividade de enzimas, regulando assim a taxa de reações bioquímicas. Esses moduladores desempenham um papel crucial no controle de vias metabólicas, sinalização celular e vários processos fisiológicos. Os moduladores de enzimas são amplamente utilizados em pesquisa e desenvolvimento de medicamentos para estudar as funções enzimáticas e desenvolver agentes terapêuticos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de enzimas de alta qualidade para apoiar sua pesquisa em regulação enzimática e descoberta de medicamentos.
Subcategorias de "Moduladores enzimáticos"
Foram encontrados 693 produtos de "Moduladores enzimáticos"
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Sacubitril calcium
CAS:Inhibitor of metalloendopeptidase neprilysinFórmula:C24H29NO5•Ca0Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:431.53 g/molTipifarnib
CAS:Tipifarnib is a farnesyltransferase inhibitor, which is a synthetic compound designed for experimental cancer treatment. It functions by targeting farnesyltransferase, an enzyme involved in the post-translational modification of proteins through the attachment of a farnesyl group to the protein's cysteine residue. This modification is crucial for the activity of several proteins, including those in the Ras signaling pathway, which is often dysregulated in cancer.Fórmula:C27H22Cl2N4OPureza:Min. 95%Peso molecular:489.4 g/molSGX 523
CAS:Inhibits c-MET tyrosine kinasesFórmula:C18H13N7SPureza:Min. 95%Cor e Forma:SolidPeso molecular:359.41 g/molBYL 719
CAS:A selective inhibitor of PI3Kα. Inhibits cancer cell proliferation by blocking the G0/G1 phase of the cell cycle. Anti-tumor effect of BYL 719 has been demonstrated in models of tumors with PI3KCA mutation and amplification in vivo. BYL 719 also suppresses tumor growth in pre-clinical models of osteosarcoma.
Fórmula:C19H22F3N5O2SPureza:Min. 95%Cor e Forma:PowderPeso molecular:441.47 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Fórmula:C13H11Cl2N5O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:372.16 g/molLinsitinib
CAS:Dual IGF-1R and InsR kinase inhibitor; antineoplastic
Fórmula:C26H23N5OPureza:Min. 95%Cor e Forma:Off-White To Yellow SolidPeso molecular:421.49 g/molLetrozole - Bio-X ™
CAS:Produto ControladoLetrozole is an aromatase inhibitor drug that is used in the treatment of breast cancer in postmenopausal women. It is a non-steroidal type II inhibitor that blocks the active site and thus blocking the electron transfer chain of CYP19A1. As a result of this, the conversion of androgen to estrogen is inhibited.Fórmula:C17H11N5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:285.3 g/molPD 0325901
CAS:A potent non ATP-competitive inhibitor of MAP/ERK kinase (MEK). Has anti-tumor activity in melanoma and papillary thyroid cancer cells with B-Raf mutations. Enhances generation and survival of induced pluripotent stem cells (iPSCs).Fórmula:C16H14F3IN2O4Pureza:Min. 95%Peso molecular:482.19 g/molTacrolimus monohydrate - Bio-X ™
CAS:Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.Fórmula:C44H69NO12·H2OPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:822.03 g/molCaspase Modulator I, 1541
CAS:Caspase Modulator I, 1541 is a chemical compound designed to modulate the activity of caspases, a family of cysteine proteases critical in the regulation of apoptosis and inflammation. This product is synthesized through advanced chemical processes to ensure high specificity and potency. Its mode of action involves the selective inhibition and modulation of caspase activity, thereby influencing apoptotic pathways and immune responses.Fórmula:C24H17N3O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:411.41 g/mol9-(4-Chlorobenzyl)-6- methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol
CAS:novel tricyclic indole; promising new treatment for a variety of diseases
Fórmula:C20H19ClN2OPureza:Min. 99 Area-%Cor e Forma:Slightly Brown PowderPeso molecular:338.83 g/molEtoricoxib - Bio-X ™
CAS:Produto ControladoEtoricoxib is a cyclooxygenase-2 (COX-2) inhibitor, which is a type of nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme COX-2 that is involved in the production of certain hormones called prostaglandins. These hormones are involved in the inflammation (swelling and heat) associated with conditions such as arthritis. By blocking the action of the COX-2 enzyme, Etoricoxib reduces the production of prostaglandins and thus, reduces the inflammation and pain. Etoricoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C18H15ClN2O2SPureza:Min. 95%Cor e Forma:PowderPeso molecular:358.84 g/molTofacitinib
CAS:JAK3 enzyme inhibitorFórmula:C16H20N6OPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:312.37 g/molFloctafenine
CAS:Nonsteroidal anti-inflammatory (NSAID)Fórmula:C20H17F3N2O4Pureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:406.36 g/molLomeguatrib
CAS:Inhibitor and pseudosubstrate of DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). It is used as a sensitizer for the treatment of advanced solid tumors, including prostate, colorectal and central nervous system malignancies. Lomeguatrib inhibits the repair mechanism of DNA damage induced by alkylating agents such as temozolomide, and therefore potentiates its anti-cancer effects.Fórmula:C10H8BrN5OSPureza:Min. 95%Cor e Forma:SolidPeso molecular:326.17 g/molMLN120B
CAS:Inhibitor of IKKβ serine kinaseFórmula:C19H15ClN4O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:366.8 g/molEpalrestat - Bio-X ™
CAS:Epalrestat is a carboxylic acid derivative that is used for the treatment of diabetic neuropathy. This drug is an aldose reductase inhibitor and aims to reduce the accumulation of intracellular sorbitol. Studies in rats have shown this drug to improve morphological abnormalities of nerves.Fórmula:C15H13NO3S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:319.4 g/molUbenimex - Bio-X ™
CAS:Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.Fórmula:C16H24N2O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:308.37 g/molSU 5416
CAS:Inhibitor of Flk-1/KDR receptor tyrosine kinases, a vascular endothelial growth factor receptor (VEGF) receptor expressed on precursor and mature forms of endothelial cells. SU 5416 also inhibits other tyrosine kinases, including c-KIT and FLT-3. Has therapeutic potential as an anti-angiogenic agent for the treatment of cancer.Fórmula:C15H14N2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:238.28 g/molDecitabine - Bio-X ™
CAS:Decitabine is a synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. It has demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Also, it has anti-growth effects on solid tumor cell lines. Decitabine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C8H12N4O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:228.21 g/molMevastatin - Bio-X ™
CAS:Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.
Fórmula:C23H34O5Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:390.51 g/mol1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
CAS:Inhibitor of glycogen phosphorylase and alpha-glucosidasesFórmula:C5H11NO3·HClPureza:Min. 96 Area-%Cor e Forma:PowderPeso molecular:169.61 g/molSquarunkin A
CAS:Selective inhibitor of the interaction between the UNC119 chaperone and its cargo. Squarunkin A inhibits activation of Src kinase by interrupting the interaction between the myristoylated peptide at the N-terminus of the Src kinase and UNC119A chaperone (IC50 = 10 nM). Squarunkin A impairs the UNC119-mediated enrichment of plasma membrane with non-receptor protein tyrosine kinase Src, resulting in the decrease in Src autophosphorylation and decreased oncogenic Src signalling.Fórmula:C25H32F3N5O4Pureza:Min. 95%Cor e Forma:SolidPeso molecular:523.55 g/molOrlistat - Bio-X ™
CAS:Orlistat is a drug that has been approved for the treatment of obesity. It inhibits gastric and pancreatic lipases, which are enzymes that break down dietary fats into smaller molecules to facilitate absorption. Orlistat has been shown to reduce coronary heart disease in patients with type 2 diabetes. Orlistat has also been shown to have a significant upregulation of gene expression associated with disease activity when injected into the skin of patients with primary pulmonary hypertension. Orlistat is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C29H53NO5Cor e Forma:PowderPeso molecular:495.73 g/molKLSDW (EYGF-33)
During extraction of lecithin from egg yolk, peptide by-products can be isolated and purified by gel filtration. Within the by-products this has led to the discovery of biologically active value-added products. The egg yolk gel filtration (EFGF) fractions were analysed for their antioxidant and angiotensin converting enzyme (ACE) inhibitory activities. EYGF-33 predominantly contained 3 peptides - KLSDW, YPSPV, and MPVHTDAD). KLSDW in EYGF-33 was found to have strong antioxidant activity linked to the presence of the tryptophan residue. KLSDW had nearly comparable activity to the synthetic antioxidant BHA. KLSDW did not show any notable angiotensin converting enzyme (ACE) inhibitory activity.Pureza:Min. 95%Peso molecular:646.3 g/molKU 55933
CAS:Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.Fórmula:C21H17NO3S2Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:395.06499[G]-JAK1 peptide (1015-1027)
This peptide is phosphorylated by Janus kinase 1 (JAK1) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This JAK1 substrate peptide contains an N-terminal glycine-residue.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,630.8 g/molMBMT (136-147) human
MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA repair enzyme that plays an important role in chemoresistance to alkylating agents. MGMT repairs the toxic DNA O6-Methylguanine lesion caused by Temozolomide (TMZ), an oral alkylating agent used for the treatment of glioblastoma. MGMT repairs damaged guanine nucleotides by transferring the methyl at O6 site of guanine to its cysteine residues, thus avoiding gene mutation, cell death and tumorigenesis. The expression of MGMT gene is mainly regulated by epigenetic modification. Loss of MGMT expression is due to methylation of the CpG island of MGMT promoter.Pureza:Min. 95%Peso molecular:1,314.7 g/molAMARA peptide
CAS:AMARA peptide is a fragment containing the phosphorylation site for AMP activated protein kinase (AMPK) and is a substrate for all AMPK subfamily kinases. As such it is used to measure AMPK related kinase activity.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,541.9 g/molBAY 73-6691
CAS:Potent inhibitor of phosphodiesterase type 9 (PDE9), tested in human and murine in vitro assays (IC50 values: 55 nM and 100 nM, respectively). BAY 73-6691 induces long-term potentiation and improves memory in rodents. BAY 73-6691 has been studied as a potential therapy for Alzheimer’s disease.
Fórmula:C15H12ClF3N4OPureza:Min. 95%Cor e Forma:PowderPeso molecular:356.73 g/molCilastatin
CAS:Cilastatin is a renal dehydropeptidase inhibitor, which is a compound sourced from synthetic processes designed to augment the pharmacokinetic profile of certain beta-lactam antibiotics. Its primary mode of action is to inhibit the enzyme dehydropeptidase I (DHP-I), located in the renal brush border. This enzyme typically degrades antibiotics, like imipenem, within the renal tubules. By inhibiting DHP-I, cilastatin prevents the inactivation of these antibiotics, thereby prolonging their active presence in the body and enhancing their antimicrobial efficacy.Fórmula:C16H26N2O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:358.45 g/molJTZ 951
CAS:Inhibitor of HIF prolyl hydroxylaseFórmula:C17H16N4O4Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:340.33 g/molPD 98059
CAS:MAP kinase kinase (MEK) inhibitor. Binds to MEK-1, preventing phosphorylation and activation by Raf or MEK kinase. PD 098059 enhances self-renewal in stem cells. Has anti-growth and anti-proliferative effects on AML cells. Anti-apoptotic effect on AML cells observed in synergy with Nutlin-3a.
Fórmula:C16H13O3NPureza:Min. 95%Cor e Forma:Off-White PowderPeso molecular:267.28 g/molLRRKtide amide
LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site.LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell where it is found associated with intracellular membranes and vesicular structures. Its multiple cellular locations suggest that LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson's disease.This peptides has an amidated C-terminal end.Pureza:Min. 95%Peso molecular:1,929.1 g/molPARP1 (487-496)
Amino acids 487-496 of Poly(ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear DNA repair enzyme that binds to DNA when damage is detected. PARP1 coordinates double and single strand break repair by first cleaving NAD+ into nicotinamide and ADP-ribose, and then synthesising poly-(ADP-ribose) (PAR) chains from ADP-ribose on target proteins (PARylation). PARylation of histone proteins mediates relaxation of the chromatin and recruitment of DNA-break repair enzymes.PARP1 can also act as a transcriptional co-activator, modulating the expression of itself and many other genes by direct binding to or PARylation of enhancers and promoters. PARP1 is also involved in maintaining mtDNA.PARP1 belongs to the PARP family which has 7 known and 10 putative members. PARP1 accounts for >85% of the PARP activity in cellular systems.Pureza:Min. 95%Peso molecular:1,065.6 g/molVeliparib
CAS:Potently inhibits PARP-1 and PARP-2 enzymes, orally bioavailable and crosses blood-brain barrier. Sensitises cancer cells to DNA-damaging chemotherapy and radiotherapy. Combination therapies investigated in clinical trials for solid and blood malignancies.
Fórmula:C13H16N4OPureza:Min. 95%Cor e Forma:White PowderPeso molecular:244.29 g/molCilastatin sodium salt - Bio-X ™
CAS:Cilastatin is a renal dehydropeptidase inhibitor drug that is used to prevent degradation of imipenem. It is used to treat a variety of infections in combination with imipenem. This drug blocks the mechanism of imipenem which is hydrolyzed by dehydropeptidase-I.
Fórmula:C16H26N2O5S•NaPureza:Min. 95%Cor e Forma:PowderPeso molecular:381.44 g/molT 3364366
CAS:A potent, reversible and slow-binding inhibitor of delta-5 desaturases (D5Ds), by binding to the desaturase domain. Inhibiting D5D has therapeutic applications in inflammatory diseases. This is due to the increase in anti-inflammatory DGLA-derived eicosanoids and decrease in pro-inflammatory AA-derived eicosanoids.
Fórmula:C18H16F3N3O3S2Pureza:Min. 95%Cor e Forma:SolidPeso molecular:443.47 g/mol1,3,4,6-Tetra-O-acetyl-2-deoxy-2-(2,2,2-trifluoroacetylamino)-D-glucopyranoside
CAS:Potent, selective and cell-permeable tool for modulation of O-GlcNAcylation. Ac4GlcNAcF3 is a dual modulator of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ac4GlcNAcF3 perturbates the GlcNAc cycling as OGT can incorporate GlcNAcF3 onto proteins but subsequently, it cannot be removed by OGA. In a mouse embryogenic fibroblast cell line, Ac4GlcNAcF3 increased the level of protein O-GlcNAcylation.Fórmula:C16H20F3NO10Pureza:Min. 95%Cor e Forma:PowderPeso molecular:443.33 g/molDaun02
CAS:A prodrug of the DNA-intercalating agent daunorubicin with anti-tumoral activity, used for suicide gene therapy and activity-dependent ablation of cells. Daun02 is an inactive form of the toxin, which gets activated upon cleavage with prodrug-activating enzyme β-galactosidase, yielding daunorubicin. Genetic constructs have been designed carrying the lacZ gene, coding for β-galactosidase, under control of application-specific promoters. The cells expressing the β-gal undergo cell death since the enzyme hydrolizes the prodrug into the active toxin.Fórmula:C41H44N2O20Pureza:Min. 95%Cor e Forma:Red To Brown SolidPeso molecular:884.24874Sildenafil - Bio-X ™
CAS:Sildenafil is a potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5), consequently preventing the degradation of cGMP in the smooth muscle cells of the pulmonary vasculature and penis. For this reason Sildenafil can be used to increase blood flow, decrease inflammation and mucus production in the lungs and also can be used in the treatment of erectile dysfunction in men. This is largely due to the increased availability of cGMP which can cause the relaxation of the smooth muscles to be prolonged.
Fórmula:C22H30N6O4SPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:474.58 g/molBortezomib
CAS:Selective and reversible inhibitor of the multicatalytic 26S proteasome. The inhibition of protein breakdown affects several metabolic pathways and leads to cell death. The compound is effective in treating multiple myeloma because it prevents the binding of myeloma cells to bone marrow stroma and inhibits osteoclast differentiation.Fórmula:C19H25BN4O4Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:384.24 g/mol[CGG]-GSK3B (Human 359-409)
Amino acids 359-409 of human glycogen synthase kinase 3 β (GSKβ), a multifunctional serine/threonine kinase widely expressed in most mammalian cells. GSKβ is highly active under basal conditions and acts downstream of phosphoinositide 3-kinase (PI3K) signalling. PI3K activation results in Akt phosphorylation and the subsequent phosphorylation of GSKβ at serine-9 and its inactivation. GSKβ in turn activates the production of pro-inflammatory cytokines including IL-1β, IL-6, IL-12, IL-17, TNFalpha and IFNγ, and supresses the production of IL-10, IL-1Ra, and IFNβ by immune cells. Under resting conditions, GSKβ is constitutively active due to tyrosine-216 phosphorylation, and it phosphorylates and inhibits a diverse group of pro-oncogenic substrates, such as: β-catenin- cyclin D1- c-Jun- c-Myc and CREB. GSKβ is also involved in Wnt signalling pathways.Aberrant expression of GSKβ has been shown to promote cell growth in some cancers and to suppress it in others. GSKβ inhibition leads to the accumulation of β-catenin in the nucleus, enhancing the progression of many cancers. However the inhibition of GSKβ also induces apoptosis in various types of cancers, such as pancreatic, colorectal and bladder cancer. Inhibition of GSKβ can also have neuroprotective effects on dopaminergic neurons such as in Parkinson's disease.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,658.8 g/molAutocamtide-2 Related Inhibitory Peptide
Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor.CAMK represents a class of Ca2+/calmodulin-dependent protein kinase enzymes. CAMKs are activated by increases in the concentration of intracellular calcium ions (Ca2+) and transfers phosphates from ATP to defined serine or threonine residues in other proteins. Activated CAMK is involved in the phosphorylation of transcription factors and therefore, in the regulation of expression of responding genes.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,707.1 g/molPTP1B Substrate
Substrate peptide for protein tyrosine phosphatase 1B (PTP1B)- an ubiquitously expressed non-receptor tyrosine phosphatase. PTP1B negatively regulates signalling pathways controlling metabolic homeostasis, cell proliferation and immunity (such as leptin and insulin receptor signalling), making PTP1B an interesting target for type 2 diabetes mellitus (T2DM) and obesity treatment. PTP1B also has important leptin-independent metabolic effects, playing a critical role in the regulation of inflammation, cell proliferation, differentiation and invasion. Therefore PTP1B is also interesting as a therapeutic target for inflammatory and autoimmune diseases and cancer.-For application data please see: Figure 2 supplement 1C.Pureza:Min. 95%Peso molecular:1,327.5 g/molZaltoprofen
CAS:Cyclooxygenase inhibitor; anti-inflammatory; antipyretic; analgesicFórmula:C17H14O3SPureza:Min. 95%Peso molecular:298.36 g/molKetoprofen - Bio-X ™
CAS:Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been used to treat pain and inflammation. Ketoprofen inhibits the production of inflammatory prostaglandins, which are released by platelets in response to injury or infection. The main mechanism of action is inhibition of cyclooxygenase enzymes COX 1 and COX 2 at the level of transcriptional activation. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation.Fórmula:C16H14O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:254.28 g/molPhosphorylated LRRKtide
LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. This peptide contains the phosphorylated threonine residue.LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell, associated with intracellular membranes and vesicular structures- suggesting LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson's disease.The threonine residue at position 9 of this peptide has been phosphorylated.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:2,009.1 g/molNeratinib - Bio-X ™
CAS:Neratinib is a protein kinase inhibitor that is used in the treatment of breast cancer. This drug binds to and inhibits EGFR, HER2 and HER4. As a result of this, it prevents autophosphorylation of tyrosine residues and reduces oncogenic signalling.Fórmula:C30H29ClN6O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:557.04 g/molPARP1 (487-496) peptide
Amino acids 487-496 of Poly(ADP-ribose) polymerase 1 (PARP1). PARP1 is a nuclear DNA repair enzyme that binds to DNA when damage is detected. PARP1 coordinates double and single strand break repair by first cleaving NAD+ into nicotinamide and ADP-ribose, and then synthesising poly-(ADP-ribose) (PAR) chains from ADP-ribose on target proteins (PARylation). PARylation of histone proteins mediates relaxation of the chromatin and recruitment of DNA-break repair enzymes.PARP1 can also act as a transcriptional co-activator, modulating the expression of itself and many other genes by direct binding to or PARylation of enhancers and promoters. PARP1 is also involved in maintaining mtDNA.PARP1 belongs to the PARP family which has 7 known and 10 putative members. PARP1 accounts for >85% of the PARP activity in cellular systems.Pureza:Min. 95%Cor e Forma:PowderPeso molecular:1,106.6 g/mol
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