Moduladores enzimáticos
Moduladores de enzimas são compostos que podem aumentar ou inibir a atividade de enzimas, regulando assim a taxa de reações bioquímicas. Esses moduladores desempenham um papel crucial no controle de vias metabólicas, sinalização celular e vários processos fisiológicos. Os moduladores de enzimas são amplamente utilizados em pesquisa e desenvolvimento de medicamentos para estudar as funções enzimáticas e desenvolver agentes terapêuticos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de enzimas de alta qualidade para apoiar sua pesquisa em regulação enzimática e descoberta de medicamentos.
Subcategorias de "Moduladores enzimáticos"
Foram encontrados 644 produtos para "Moduladores enzimáticos".
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Dabrafenib mesylate
CAS:Inhibitor of B-Raf kinase mutant
Fórmula:C23H20F3N5O2S2·CH4O3SPureza:Min. 95%Cor e Forma:White/Off-White SolidPeso molecular:615.67Mirodenafil dihydrochloride
CAS:Mirodenafil dihydrochloride is a potent phosphodiesterase-5 (PDE5) inhibitor, which is a synthetic compound with a primarily chemical origin. Its mode of action involves the inhibition of the enzyme PDE5, which predominantly resides in the smooth muscle cells lining blood vessels. By inhibiting PDE5, Mirodenafil dihydrochloride effectively increases the levels of cyclic guanosine monophosphate (cGMP), leading to the relaxation of smooth muscle tissues and vasodilation.Fórmula:C26H39Cl2N5O5SPureza:Min. 97 Area-%Cor e Forma:White PowderPeso molecular:604.59 g/molMefenamic acid
CAS:COX1 inhibitor; blocker of Ca2+-activated non-selective cation channelsFórmula:C15H15NO2Pureza:Min. 99 Area-%Cor e Forma:White PowderPeso molecular:241.29 g/molMetformin HCl - Bio-X ™
CAS:Metformin is a widely used anti-hyperglycemic (anti-diabetic) agent for the treatment of type 2 diabetes mellitus. This is due to it decreasing blood glucose by decreasing hepatic glucose product by activation of the AMP-activated protein kinase AMPK. Studies have also demonstrated Metformin to have anti-cancer activity, attributed to several mechanisms such as inhibition of mammalian target of rapamycin (mTOR), cancer stem cells and inflammation.Fórmula:C4H11N5•HClPureza:Min. 95%Cor e Forma:PowderPeso molecular:165.62 g/molLenvatinib mesylate - Bio-X ™
CAS:Lenvatinib is an anti-cancer drug that is a multi-kinase inhibitor for VEGFR1, VEGFR2 and VEGFR. It has been shown to be effective against several cancers such as thyroid cancer and is currently in clinical trials for the treatment of leukaemia and prostate cancer. Furthermore, Lenvatinib also inhibits the activity of other protein kinases, including those involved in inflammatory responses.Fórmula:C22H23ClN4O7SPureza:Min. 95%Cor e Forma:PowderPeso molecular:522.96 g/molPexidartinib
CAS:Inhibitor of CSF1R receptor
Fórmula:C20H15ClF3N5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:417.81 g/molTH 5487
CAS:Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.
Fórmula:C19BrH18IN4O2Pureza:Min. 95%Cor e Forma:SolidPeso molecular:541.18 g/molPitavastatin lactone
CAS:Inhibitor of HMG-CoA reductaseFórmula:C25H22FNO3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:403.45 g/molN-ω-Propyl-L-arginine
CAS:Neuronal selective nitric oxide synthase inhibitorFórmula:C9H20N4O2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:216.28 g/molZoledronic acid, disodium salt, tetrahydrate
CAS:Farnesyl pyrophosphate synthase inhibitor; hepatic de novo lipogenesis inhibitorFórmula:C5H8N2Na2O7P2·4H2OPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:388.11 g/molUNC 3230
CAS:Inhibitor of PIP5K1C
Fórmula:C17H20N4O2SPureza:Min. 95%Cor e Forma:SolidPeso molecular:344.43 g/molIrinotecan hydrochloride trihydrate - Bio-X ™
CAS:Irinotecan hydrochloride trihydrate is a topoisomerase I inhibitor that is used as chemotherapy drug for colorectal cancer. By inhibiting topoisomerase I, Irinotecan hydrochloride trihydrate prevents the replication of DNA in cells, and stops the cancer cells from growing and dividing. When used for chemotherapy, Irinotecan hydrochloride trihydrate is usually part of combination therapy with other chemotherapy drugs, such as 5-fluorouracil (5-FU) and leucovorin for other cancers.Fórmula:C33H38N4O6•HCl•(H2O)3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:677.18 g/molLenvatinib base - Bio-X ™
CAS:Lenvatinib is a tyrosine kinase inhibitor that is used to treat cancers such as solid tumours. This drug inhibits the activity of VEGR receptors. It also inhibits other receptors such as fibroblast growth factor.
Fórmula:C21H19ClN4O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:426.85 g/molTandutinib
CAS:Tyrosine kinase inhibitor; antineoplastic activity; pro-apoptotic
Fórmula:C31H42N6O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:562.7 g/molVorinostat - Bio-X ™
CAS:Vorinostat is a histone deacetylase inhibitor which interferes with gene transcription regulatory mechanisms. It is used to treat cutaneous manifestations in patients with progressive, persistent, or recurrent cutaneous T- cell lymphoma (CTCL) following prior systemic therapies. This drug inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II).
Fórmula:C14H20N2O3Pureza:Min. 99 Area-%Cor e Forma:PowderPeso molecular:264.32 g/molDarapladib
CAS:Inhibitor of lipoprotein-associated phospholipase A2Fórmula:C36H38F4N4O2SPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:666.77 g/molQuizartinib
CAS:Inhibitor of FLT3 receptor tyrosine kinases; anti-neoplastic
Fórmula:C29H32N6O4SPureza:Min. 95%Cor e Forma:White PowderPeso molecular:560.67 g/molAzaserine
CAS:Glutamine analogue and antagonist of glutamine-dependent amidotransferases, with antibiotic and antifungal properties. Inhibits purine biosynthesis, FGAM synthetase and glucosamine-6-phosphate isomerase that contributes to its antineoplastic property. Azaserine can also act as a carcinogen, by inducing DNA carboxymethylation. Protects endothelial cells from inflammation under hyperglycemic conditions, via antioxidant mechanisms, independent of hexosamine biosynthetic pathway.Fórmula:C5H7N3O4Pureza:Min. 98 Area-%Cor e Forma:Slightly Yellow PowderPeso molecular:173.13 g/mol(Z)-PugNAc
CAS:PUGNAc (O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate) is a potent inhibitor of O-GlcNAcase, the enzyme that removes O-linked N-acetylglucosamine from intracellular proteins. It increases global O-GlcNAcylation levels by blocking O-GlcNAcase and is widely used to study the biological effects of altered O-linked protein glycosylation. PUGNAc also inhibits the related lysosomal enzyme β-hexosaminidase, which is mainly of interest in research to understand lysosomal function, glycoconjugate metabolism, or the role of hexosaminidases in pathogens, such as bacteria and parasites that use similar enzymes to process sugars.Fórmula:C15H19N3O7Pureza:Min. 97 Area-%Cor e Forma:White PowderPeso molecular:353.33 g/molAZ 960
CAS:ATP competitive JAK2 inhibitorFórmula:C18H16F2N6Pureza:Min. 95%Cor e Forma:PowderPeso molecular:354.36 g/mol
