CBR-5884

CAS: 681159-27-3

Ref. TM-T14884

Informação sobre produto

• Nome: CBR-5884
• Sinónimos: CBR5884
• CAS: 681159-27-3

Descrição

CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH

• Marca: Targetmol

Propriedades químicas

• Peso molecular: 336.39
• Fórmula: C₁₄H₁₂N₂O₄S₂
• Pureza: 100%
• Cor/forma: Solid
• SMILES: CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C