Avitinib

CAS: 1557267-42-1

Ref. TM-T3024

Informação sobre produto

• Nome: Avitinib
• Sinónimos: AC0010
• CAS: 1557267-42-1

Descrição

Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.

• Marca: Targetmol

Propriedades químicas

• Peso molecular: 487.53
• Fórmula: C₂₆H₂₆FN₇O₂
• Pureza: 100%
• Cor/forma: Solid