Des-(4-(1-piperidinyl)-2-Butenamide) Dacomitinib-5-hydroxypyrrolidin-2-one

CAS: 2190490-31-2

Ref. TR-D101275

Informação sobre produto

• Nome: Des-(4-(1-piperidinyl)-2-Butenamide) Dacomitinib-5-hydroxypyrrolidin-2-one
• Sinónimos: 1-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-5-hydroxypyrrolidin-2-one

Descrição

Applications Des-(4-(1-piperidinyl)-2-Butenamide) Dacomitinib-5-hydroxypyrrolidin-2-one is a derivative of Dacomitinib (D101575), which is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.
References Williams, J. et al.: PLoS., 9, e98557 (2014); Peters, S. et al.: Canc. Treatment Rev., 40, 917 (2014);

• Marca: TRC

Propriedades químicas

• Peso molecular: 402.807
• Fórmula: C₁₉H₁₆ClFN₄O₃
• Cor/forma: Neat
• InChI: InChI=1S/C19H16ClFN4O3/c1-28-16-8-14-11(7-15(16)25-17(26)4-5-18(25)27)19(23-9-22-14)24-10-2-3-13(21)12(20)6-10/h2-3,6-9,17,26H,4-5H2,1H3,(H,22,23,24)
• Chave InChI: InChIKey=YYROAISCXBYHNT-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1N1C(=O)CCC1O