PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate

CAS: 130663-39-7 136676-91-0

Ref. TR-P217475

Informação sobre produto

• Nome: PD-123319 Bis(Trifluoroacetic Acid Salt) Hydrate
• Sinónimos: (6S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic Acid Bis(trifluoroacetate) Salt Hydrate, (S)-(+)-PD 123319 Bis(trifluoroacetate) Salt Hydrate

Descrição

Applications A selective and potent non-peptide angiotensin II type 2 (AT2) receptor antagonist. Potential treatment of cardiac hypertrophy as blockage of AT2 receptor prevents thyroxine-mediated cardiac hypertrophy by blocking Akt activation. Studies show that it has protective effect against tumor necrosis factor-α-induced damage to human renal proximal tubular epithelial cells
References Carmeiros-Ramos, M.S. et al.: Bas. Res, Cardiol., 105, 325 (2010); Kagawa, T. et al.: Nephrol., 13, 309 (2008); Cohen, E.P. et al.: Transl. Res., 150, 106 (2007);

• Marca: TRC

Propriedades químicas

• Peso molecular: 736.66 (anhydrous salt)
• Fórmula: C₃₁H₃₂N₄O₃·2C₂HF₃O₂·xH₂O
• Cor/forma: Neat
• InChI: InChI=1S/C31H32N4O3.C2HF3O2/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;3-2(4,5)1(6)7/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);(H,6,7)/t28-;/m0./s1
• Chave InChI: InChIKey=ODNCUUDQKVCVBG-JCOPYZAKSA-N
• SMILES: Cc1cc(Cn2cnc3c2C[C@@H](C(=O)O)N(C(=O)C(c2ccccc2)c2ccccc2)C3)ccc1N(C)C.O=C(O)C(F)(F)F