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4-Amino-5-Bromopyrrolo[2,3-D]Pyrimidine (5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-amine) is a marine derived natural products found in Echinodictyum sp.

7-Bromoquinazoline-2,4(1H,3H)-Dione (7-Bromo-2,4(1H,3H)-quinazolinedione) is a marine derived natural products found in Pyura sacciformis.

2,4,6-Triphenylaniline (5'-Phenyl-[1,1':3',1''-terphenyl]-2'-amine) is a marine derived natural products found in Alternaria longipes.

<p>AC-PHE-OME (Methyl N-acetyl-L-phenylalaninate) is a marine derived natural products found in Family Jaspidae.</p>

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) is a marine derived natural products found in Niphates digitalis.

<p>5,6-dibromo-1H-indole-3-carboxylic acid (5,6-dibromo-1H-indole-3-carboxylicAcid) is a marine derived natural products found in Smenospongia sp.</p>

<p>6-Chloro-2,4-dibromophenol (2,4-dibromo-6-chlorophenol) is a marine derived natural products found in Pseudoalteromonas luteoviolacea.</p>

6-Bromoindole-3-acetonitrile (2-(6-bromo-1H-indol-3-yl)acetonitrile) is a marine derived natural products found in Pseudosuberites hyalinus.

<p>3-chloro-1H-indole (ZINC6117681) is a marine derived natural products found in Ptychodera flava.</p>

<p>Lauric Acid Diethanolamide (Lauric diethanolamide) is a marine derived natural products found in Bacillus sp.</p>

<p>3-Chloro-6-Bromo Indole (3-CHLORO-6-BROMOINDOLE) is a marine derived natural products found in Ptychodera flava.</p>

9H-Carbazole, 1-methyl- (1-methyl carbazole) is a marine derived natural products found in Tedania (Tedania) ignis.

<p>2-Chlorobenzene-1,3,5-triol (2-Chlorophloroglucinol) is a marine derived natural products found in Rhabdonia verticillata.</p>

Methyl 5,6-dibromo-1H-indole-3-carboxylate (5,6-Dibromo-1H-indole-3-carboxylic acid methyl ester) is a marine derived natural products found in Smenospongia sp.

5-BroMo-1H-pyrrole-2-carboxylic acid (5-Bromopyrrole-2-carboxylic Acid) is a marine derived natural products found in Agelas cerebrum.

<p>Ethyl6-bromo-1H-indole-3-carboxylate (Ethyl 6-Bromoindole-3-carboxylate) is a marine derived natural products found in Pleroma menoui.</p>

<p>2-Methyladenosine (2-methyl adenosine) is a marine derived natural products found in Family Tethyidae.</p>

<p>3-bromopyrrole-2,5-dione (ZINC13379821) is a marine derived natural products found in marine sponge Axinella brevistyla.</p>

<p>Pseudane V (2-pentylquinolin-4-ol) is a marine derived natural products found in Pseudoalteromonas sp. M2.</p>

<p>Tetrahydroharmine (Leptaflorine): a MAO-A inhibitor found in Banisteriopsis caapi 'Da Vine'.</p>

<p>Acacetin-7-O-beta-D-galactopyranoside is a natural product found in Chrysanthemum indicum.</p>

<p>Ellagic acid 3-O-α-L-rhamnopyranoside is a natural product found in the tuberous roots of Potentilla anserina.</p>

<p>Galdosol is a natural product found in Perovskia abrotanoides.</p>

<p>Isochiisanoside is a natural product found in the leaves of Acanthopanax chiisanensis NAKAI.</p>

<p>Magnoloside F is a natural product found in the stem bark of Magnolia officinalis.</p>

<p>4,6-Benzilidine-D-Glucose is a clinical antitumor compound showing antitumor activity in rats with chemically induced hepatocellular carcinoma.</p>

<p>Diformylphloroglucinol, from Eucalyptus nigra leaves, is a precursor for antioxidant and antiulcer resorcinol compounds.</p>

2,5-Dihydroxy-1,4-benzoquinone: a natural antimicrobial that hinders growth and spore germination in various fungi.

6-Bromovanillin is a biochemical reagent that can be used in the synthesis of caridopa, an aromatic amino acid decarboxylase inhibitor.

2',3',4'-Trimethoxyacetophenone is a raw material for the preparation of chalcone compounds with anti-inflammatory activity.

<p>3,5-Dibromo-4-methoxybenzoic acid was isolated from the Malagasy sponge Amphimedon sp.</p>

2,2'-Dihydroxy chalcone inhibits β-glucuronidase (IC50=1.6 μM) and lysozyme (IC50=1.4 μM), and fights E. coli, S. fowleri, S. albicans, S. aureus.

2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular

<p>2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.</p>

3β-Acetoxyurs-12-en-11-one (11-Ketoamyrinacetate) is an ursane triterpene natural product found in the stem bark of Morus mesozygia and the leaves of Ficus

11-oxo-alpha-amyrin (Neoilexonol) is a triterpene compound extracted from Leonurus japonicus (Lamiaceae) and is a natural compound .

<p>Baihuaqianhuoside is a coumarin glycoside with anti-inflammatory properties, extracted from Passiflora and Hindenia roots.</p>

Butylchlorogenate is a natural compound isolated from Lonicera japonica, Urceola rosea.

<p>Di-O-methylhonokiol: Magnolia's phenolic, antimicrobial, and antioxidant; affects Gram-positive, acid-resistant bacteria, fungi.</p>

<p>pegamine is a natural product found in Peganum harmala and Peganum nigellastrum, which are novel alkaloids.</p>

<p>Pseudobaptigenin (Psi-baptigenin) is an isoflavone, a flavonoid lipid molecule that is a natural product found in Pterocarpus marsupium, Dalbergia spruceana.</p>

Prenyletin is a natural product found in the multilobed bimodal, multihorned pterosaurs.

<p>4-methoxylonchocarpin, from Abrus precatorius roots, inhibits NF-κB, LPS/TLR4 in macrophages, and mouse colitis.</p>

<p>Cephalandole B, an indole alkaloid from cyanide, inhibits IL-17A gene and suppresses its reporter in Jukat cells dose-dependently.</p>

5,7-dimethoxy-2-benzofuran-1(3H)-one (5,7-dimethoxyphthalide) is a phthalide isolated from Italian waxflower with good anti-inflammatory activity.

<p>Sanguinarine citrate (Pseudochelerythrine chloride) from Sanguinaria Canadensis has antibacterial activity and is used to treat stomatitis.</p>

<p>Erinacine A ((+)-Erinacin A) is a cyanoalkane diterpene derived from the monkey fungus, a neuroprotective agent with anticancer activity.</p>

<p>Annatto: natural colorant from Bixa orellana, has antitumor properties; high doses may cause mutations. Used in drinks, baking, foods.</p>

5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) can be isolated from indica rice and has an inhibitory effect on Staphylococcus aureus, which can be

Fallaxsaponin A is isolated from the alkaline hydrolysis products of total saponins in Radix Palygalae.

Egg PG is a major anionic phospholipid in food, bacterial, and animal cell membranes, and a substrate in sPMCA reactions.

<p>DMPS-Na is an arsenicolytic agent with toxicity that can be used to study cell membranes.</p>

3-Sulfopropanoic acid, a major metabolite of treprostinil and its prodrug ALZ-801, is an endogenous molecule present in the cerebrospinal fluid (CSF) of AD

Limocitrin 3-O-sophoroside is a compound that can be used in biological research.

<p>Torachrysone tetraglucoside is a phenolic glycoside isolated from the leguminous plant cassia with antioxidant and antimicrobial activities.</p>

<p>Nor-rubrofusarin gentiobioside is a natural product found in the leguminous plant Cassia vulgaris.</p>

Torachrysone Triglucoside is a glucoside isolated from cassia seeds with potential antitumor activity.

<p>Olivetol Dimethyl Ether is a monoacylglycerol with analgesic activity and potential anti-inflammatory activity that inhibits fatty acid synthesis.</p>

Oligolacetic acid (OLA) is extracted from cannabis and shows anticonvulsant activity in a mouse model of Dravet syndrome.

Torachrysone gentiobioside is a phenolic glycoside isolated from cassia seeds.

(E,E)-Farnesol ((2E,6E)-Farnesol) is a sesquiterpene acyclic alcohol produced by bacteria, fungi, plants, and animals. (E,E)-Farnesol promotes vasodilation.

Venuloside A (ESK246), from Pittosporum venulosum, is a LAT3 inhibitor and a leucine uptake inhibitor and may be used in the study of prostate cancer.

3-Methylcytidine (methosulfate), a derivative of cytidine, serves as an internal standard for HPLC and is recognized for its epigenetic modification in tRNA, although its cellular role remains unclear. Research has explored its utility as a cancer biomarker, with findings indicating a notable increase in the urine of breast cancer patients.

Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).

<p>Z3-Dodecenyl E2-butenoate, a female sex pheromone of the sweet potato weevil (C. formicarius), is utilized for baiting and trapping male sweet potato weevils. This method aids in managing their populations in agricultural fields while minimizing insecticide use.</p>

Tridocosahexaenoylglycerol (TG-DHA), an orally active dietary supplement, enhances outcomes in autoimmune encephalomyelitis among mice, exhibits beneficial impacts on neurodegenerative conditions, and fosters macular function improvement in diabetic retinopathy. It is applicable for investigating neurological, inflammatory immune, and metabolic diseases [1] [2] [3].

<p>Naringenin-7-O-β-D-glucuronide, a metabolite of the flavonoid naringenin, is predominantly synthesized through the action of UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A3, UGT1A6, and UGT1A9.</p>

7-Methoxy Apigeninidin, a 3-deoxyanthocyanin fungicide and derivative of apigeninidin, was originally isolated from Sorghum. It exhibits activity against the radial growth of G. sorghi and spore germination of P. oryzae, with an IC50 of 50 ppm for both.

Hexadecatetraenoic acid, an unsaturated fatty acid, is derived from sardine oil [1].

<p>16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml.</p>

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

Cannabinol methyl ether, a phytocannabinoid, serves as an analytical reference standard. This compound can be obtained through isolation from Cannabis plants, derived from cannabinol, or synthesized. The physiological and toxicological properties of cannabinol methyl ether remain unknown. It is designed exclusively for research and forensic applications.

<p>Milbemycin A4, a distinguished member of the macrocyclic lactones family featuring a unique spiroketal group, is derived from the fermentation of the soil bacterium Streptomyces hygroscopicus subsp. aureolacrimosus. It acts by enhancing the opening of glutamate and GABA-gated chloride channels, rendering it effective as both a nematocide and insecticide.</p>

Gilvocarcin V, a metabolite from Actinomycete DO-38, exhibits potent antibacterial, antifungal, and antiviral activity.

Lagochiline, a diterpene compound, serves as a promising hemostatic agent and can be extracted from plants belonging to the Lagochilus species [1] [2].

4-Chloro-α-cyanocinnamic acid (Cl-CCA), a phenylpropanoid derivative of cinnamic acid synthesized from phenylalanine by plants, exhibits a propensity for co-crystallization with a range of biomolecules, including peptides and nucleic acids.

(±)-7-epiJasmonic acid, the primary metabolite in the 12-oxo phytodienoic acid pathway of 13(S)-hydroperoxy linolenic acid metabolism in plants, is synthesized initially as the more active (+)-7-epijasmonic acid. It quickly epimerizes to the more stable (−)-7-jasmonic acid isomer, demonstrating its biological relevance. Acting as a plant growth regulator, (±)-7-epiJasmonic acid triggers various signal transduction pathways, which can either promote growth or inhibit it, likely as a response to stress conditions.

(14Z)-14-Eicosenoic acid, an unsaturated fatty acid, has been isolated from sponges [1].

<p>N-Cyclohexanecarbonylpentadecylamine (Compound 1), an inhibitor of N-Acylethanolamine hydrolyzing acid amidase (NAAA) with an inhibition concentration (IC50) of 4.5 μM, is utilized in inflammation and pain research [1].</p>

Methyl 7(Z)-hexadecenoate, a sex pheromone of Trogoderma glabrum, elicits attraction and sexually excitatory responses in male Trogoderma glabrum [1].

<p>Methyl pentacosanoate, a chemical compound, can be isolated from the leaves of hawthorn [1].</p>

Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 µM. This potency places it nearly on par with xestospongin C in obstructing the IP3 receptor's activity.

Minosaminomycin, an antibiotic, originates from Streptomyces.

<p>Fluostatin B, a fluorenone discovered in Streptomyces, is an inhibitor of dipeptidyl peptidase 3 (DPP-3; IC50= 24 µg/ml).</p>

Glutathione S-Transferase (GST) π-class inhibitor acts to inhibit a specific class within the GST enzyme family, targeting the π variant. This compound selectively blocks the activity of this enzyme, which plays a critical role in the detoxification of compounds by catalyzing their conjugation with glutathione.

<p>Glutathione S-Transferase (GST) π class inhibitor is a chemical compound designed to inhibit the action of the π class of GST enzymes.</p>

Lentztrehalose A, a disaccharide microbial metabolite identified in Lentzea, exhibits a range of biological activities. This compound specifically inhibits M. smegmatis trehalase—an enzyme involved in trehalose metabolism—more effectively than trehalase from porcine kidney, with IC50 values of 0.67 mM and >20 mM, respectively. Additionally, Lentztrehalose A at a concentration of 100 mM promotes autophagy in MeWo melanoma and OVK18 ovarian cancer cells. When administered at 50 mg/kg daily, it enhances survival rates and impedes tumor growth in a Sarcoma 180 murine sarcoma model.

Lentztrehalose B, a microbial disaccharide metabolite isolated from Lentzea, exhibits a range of biological activities. At a concentration of 100 µM, it demonstrates antioxidant properties in an oxygen radical absorbance capacity (ORAC) assay. Furthermore, Lentztrehalose B at 10 mM inhibits porcine kidney trehalase, an enzyme involved in trehalose metabolism. Additionally, it induces autophagy in MeWo melanoma and OVK18 ovarian cancer cells when applied at 100 mM.

Cyanidin 3-xyloside, an anthocyanin, is extractable from the hulls of purple sunflower [1].

Dimethyl isorosmanol (11,12-Di-O-methylisorosmanol), a compound obtainable from Rosmarinus officinalis, exhibits antioxidant activity [1].

<p>11,12-Di-O-methylcarnosol, also known as Comp 7, is a nolic diterpene lactone isolated from the leaves of Rosmarinus officinalis L. (rosemary) [1].</p>

Kibdelone A, a natural heterocyclic polyketide, was first isolated from the soil actinomycete Kibdelosporangium. It exhibits potent and selective cytotoxicity against various human tumor cell lines, in addition to showing significant antibacterial and nematocidal activity.

<p>Cedarwood terpenes, a natural mixture of terpenes, are extracted from cedar wood [1].</p>

<p>(±)-Silybin, a racemate of Silybin, demonstrates a range of biological activities including inducing apoptosis and possessing hepatoprotective, antioxidant, anti-inflammatory, and anti-cancer properties [1] [2].</p>

2-Deoxyribose 5-phosphate disodium acts as a substrate for the enzyme 2-deoxyribose-5-phosphate aldolase (DERA), which is categorized under class I aldolases. DERA efficiently facilitates the reversible aldol condensation reaction independently, without the need for any cofactors [1].

1,2,4,5-Tetrachloro-3,6-dimethoxybenzene is an active compound utilized in the research of various biochemical studies [1].

<p>(+)-Secoisolariciresinol is a natural lignan exhibiting inhibitory activity against α-amylase (IC50=9.5 μM).</p>

<p>24-Methylcholesterol, a trans-ferulate ester extracted from rice bran, significantly inhibits TPA-induced inflammation [1].</p>

(R)-(+)-Tetrahydroberberine, the inactive isomer of (S)-(-)-Tetrahydroberberine, serves as an experimental control. The latter, an alkaloid and intermediate in berberine biosynthesis, exhibits insecticidal activity [1].

<p>(+)-Butin, the R enantiomer of butin, is a significant flavonoid extracted from Dalbergia odorifera's heartwood, exhibiting potent antioxidant, antiplatelet, and anti-inflammatory properties [1].</p>